PATJ and MAPK12

Number of citations of the paper that reports this interaction (PubMedID 16637659)
54

Data Source:
HPRD (in vitro)

		PATJ	MAPK12
Description		PATJ crumbs cell polarity complex component	mitogen-activated protein kinase 12
Image
GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Bicellular Tight Junction Membrane Apical Plasma Membrane Cell Junction Centriolar Satellite Apical Junction Complex Apical Part Of Cell Perinuclear Region Of Cytoplasm Extracellular Exosome Tight Junction Anchoring Junction	Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol
	Molecular Function	Protein Binding	Nucleotide Binding Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity MAP Kinase Activity Protein Binding ATP Binding Kinase Activity Peptidase Activator Activity Transferase Activity Metal Ion Binding Protein Serine Kinase Activity
	Biological Process	Establishment Of Apical/basal Cell Polarity Intracellular Signal Transduction Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Tight Junction Assembly	MAPK Cascade Signal Transduction Muscle Organ Development Cellular Response To Stress Intracellular Signal Transduction Signal Transduction In Response To DNA Damage Myoblast Differentiation Negative Regulation Of Cell Cycle Positive Regulation Of Muscle Cell Differentiation Regulation Of Cell Cycle
Pathways		Tight junction interactions SARS-CoV-2 targets PDZ proteins in cell-cell junction	NOD1/2 Signaling Pathway p38MAPK events Activation of PPARGC1A (PGC-1alpha) by phosphorylation VEGFA-VEGFR2 Pathway Myogenesis Myogenesis Negative regulation of MAPK pathway
Drugs			Minocycline Phosphonothreonine Phosphoaminophosphonic Acid-Adenylate Ester KC706 CEP-1347
Diseases
GWAS		3-month functional outcome in ischaemic stroke (modified Rankin score) ( 30582445) Autism spectrum disorders (social interaction) ( 32624584) Daytime nap ( 33568662) Excessive daytime sleepiness ( 27992416) Sleep traits (multi-trait analysis) ( 27992416) Type 2 diabetes ( 30297969)	Acne (severe) ( 24927181) Diverticular disease ( 30177863) Triiodothyronine levels and thyroxine levels ( 30843173)
Interacting Genes		35 interacting genes: ADGRB1 ASIC3 CACNG2 CEP57L1 CINP CLDN1 CNKSR2 CRB3 CRIPT DDX18 GIPC2 GLS2 GRIN2A GRIN2B GRIN2C GRIN2D HDAC7 HOMER1 KCNA4 KCNJ10 KCNJ15 KCNJ2 KIF1B MAPK12 NECAB2 NLGN2 NRXN2 PALS1 PARD3 PAX6 PHYH PRDM16 SCN4A SCN5A TJP3	30 interacting genes: CDK1 DLG1 DLG2 DLG3 DLG4 DUSP1 EEF2K ERBIN GRB2 GTF2I HTRA2 MAP2K3 MAP2K4 MAP2K6 MAPKAPK5 MAPT MBP PATJ PDGFRL PKN1 PTPN3 PTPN4 RCSD1 RGS3 SH3BP5 SIAH1 SNTA1 SNTB1 SRPK1 TERF1
Entrez ID		10207	6300
HPRD ID		04434	03868
Ensembl ID		ENSG00000132849	ENSG00000188130
Uniprot IDs		A0A2R8Y549 Q8NI35	P53778
PDB IDs		1VF6 2D92 2DAZ 2DB5 2DLU 2DM8 2DMZ 2EHR 4Q2N 6IRD	1CM8 4QUM 6UNA 7CGA
Enriched GO Terms of Interacting Partners?		Regulation Of Membrane Potential Positive Regulation Of Synaptic Transmission, Glutamatergic Monoatomic Cation Channel Activity Regulation Of Synaptic Transmission, Glutamatergic NMDA Glutamate Receptor Activity Metal Ion Transport NMDA Selective Glutamate Receptor Complex Monoatomic Cation Transmembrane Transport Inorganic Cation Transmembrane Transport Excitatory Chemical Synaptic Transmission Positive Regulation Of Excitatory Postsynaptic Potential Monoatomic Ion Channel Complex Inorganic Ion Transmembrane Transport Monoatomic Cation Transport Monoatomic Ion Transmembrane Transport Protein Localization To Cell Junction Modulation Of Chemical Synaptic Transmission Monoatomic Ion Channel Activity Modulation Of Excitatory Postsynaptic Potential System Process Glutamate Receptor Signaling Pathway Regulation Of Monoatomic Ion Transmembrane Transport Regulation Of Monoatomic Ion Transport Regulation Of Neuronal Synaptic Plasticity Monoatomic Ion Transport Protein Localization To Synapse Regulation Of Nervous System Process Chemical Synaptic Transmission Trans-synaptic Signaling Postsynaptic Membrane Ionotropic Glutamate Receptor Signaling Pathway Synaptic Signaling Positive Regulation Of Synaptic Transmission Dendritic Spine Ligand-gated Monoatomic Ion Channel Activity Glutamate-gated Calcium Ion Channel Activity Plasma Membrane Transmembrane Transport Regulation Of System Process Transmitter-gated Monoatomic Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential Glutamatergic Synapse Synapse Ligand-gated Ion Channel Signaling Pathway Synaptic Transmission, Glutamatergic Postsynaptic Density Membrane Protein Localization To Membrane Regulation Of Synaptic Plasticity Dendrite Membrane Depolarization Long-term Synaptic Potentiation	Establishment Or Maintenance Of Apical/basal Cell Polarity Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity MAPK Cascade Neuromuscular Junction Intracellular Signal Transduction MAP Kinase Kinase Activity Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Ionotropic Glutamate Receptor Binding Protein Serine/threonine Kinase Activity Establishment Or Maintenance Of Cell Polarity Protein Kinase Binding Intracellular Signaling Cassette Muscle Contraction Signal Transduction Protein Kinase Activity Receptor Localization To Synapse Receptor Clustering Protein Serine Kinase Activity Cytoplasm Cytosol Protein Localization To Synapse Muscle System Process Cellular Senescence Kinase Activity Protein Localization To Cell Junction Response To Metal Ion Calmodulin Binding Negative Regulation Of Cell Cycle Kinase Binding Postsynaptic Density Membrane Cytoplasmic Side Of Plasma Membrane Regulation Of Sodium Ion Transmembrane Transport Regulation Of Chromosome Organization NLRP1 Inflammasome Complex Assembly Phosphoprotein Phosphatase Activity Negative Regulation Of P38MAPK Cascade GMP Kinase Activity Cellular Response To Brain-derived Neurotrophic Factor Stimulus Cellular Response To Growth Factor Stimulus System Process GDP Metabolic Process Regulation Of Multicellular Organismal Process Chemical Synaptic Transmission Juxtaparanode Region Of Axon Response To Growth Factor Positive Regulation Of Organelle Organization Regulation Of Signal Transduction Regulation Of Sodium Ion Transport Cytoskeletal Protein Binding Cellular Response To Potassium Ion
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