PATJ and ASIC3

Number of citations of the paper that reports this interaction (PubMedID 11872753)
0

Data Source:
HPRD (two hybrid, in vitro)

		PATJ	ASIC3
Description		PATJ crumbs cell polarity complex component	acid sensing ion channel subunit 3
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Bicellular Tight Junction Membrane Apical Plasma Membrane Cell Junction Centriolar Satellite Apical Junction Complex Apical Part Of Cell Perinuclear Region Of Cytoplasm Extracellular Exosome Tight Junction Anchoring Junction	Cytoplasm Plasma Membrane Membrane
	Molecular Function	Protein Binding	Monoatomic Cation Channel Activity Sodium Channel Activity Ligand-gated Sodium Channel Activity Enterobactin Transmembrane Transporter Activity PH-gated Sodium Channel Activity PH-gated Monoatomic Ion Channel Activity
	Biological Process	Establishment Of Apical/basal Cell Polarity Intracellular Signal Transduction Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Tight Junction Assembly	Monoatomic Ion Transport Monoatomic Cation Transport Sodium Ion Transport Response To Heat Response To Mechanical Stimulus Response To Acidic PH Monoatomic Ion Transmembrane Transport Sodium Ion Transmembrane Transport Enterobactin Transport Detection Of Chemical Stimulus Involved In Sensory Perception Sensory Perception Of Sour Taste Detection Of Temperature Stimulus Involved In Sensory Perception Detection Of Temperature Stimulus Involved In Sensory Perception Of Pain Detection Of Mechanical Stimulus Involved In Sensory Perception Of Pain Detection Of Chemical Stimulus Involved In Sensory Perception Of Pain Detection Of Mechanical Stimulus Involved In Sensory Perception Establishment Of Localization In Cell Membrane Depolarization
Pathways		Tight junction interactions SARS-CoV-2 targets PDZ proteins in cell-cell junction	Stimuli-sensing channels
Drugs			Agmatine
Diseases
GWAS		3-month functional outcome in ischaemic stroke (modified Rankin score) ( 30582445) Autism spectrum disorders (social interaction) ( 32624584) Daytime nap ( 33568662) Excessive daytime sleepiness ( 27992416) Sleep traits (multi-trait analysis) ( 27992416) Type 2 diabetes ( 30297969)	Eyebrow thickness ( 26926045)
Interacting Genes		35 interacting genes: ADGRB1 ASIC3 CACNG2 CEP57L1 CINP CLDN1 CNKSR2 CRB3 CRIPT DDX18 GIPC2 GLS2 GRIN2A GRIN2B GRIN2C GRIN2D HDAC7 HOMER1 KCNA4 KCNJ10 KCNJ15 KCNJ2 KIF1B MAPK12 NECAB2 NLGN2 NRXN2 PALS1 PARD3 PAX6 PHYH PRDM16 SCN4A SCN5A TJP3	9 interacting genes: ASIC2 CSNK2A1 DLG4 GOPC LIN7B MAGI1 PATJ PRKACA STOM
Entrez ID		10207	9311
HPRD ID		04434	10626
Ensembl ID		ENSG00000132849	ENSG00000213199
Uniprot IDs		A0A2R8Y549 Q8NI35	A0A090N7X8 A0A090N8Q1 A0A090N8Z6 Q9UHC3
PDB IDs		1VF6 2D92 2DAZ 2DB5 2DLU 2DM8 2DMZ 2EHR 4Q2N 6IRD
Enriched GO Terms of Interacting Partners?		Regulation Of Membrane Potential Positive Regulation Of Synaptic Transmission, Glutamatergic Monoatomic Cation Channel Activity Regulation Of Synaptic Transmission, Glutamatergic NMDA Glutamate Receptor Activity Metal Ion Transport NMDA Selective Glutamate Receptor Complex Monoatomic Cation Transmembrane Transport Inorganic Cation Transmembrane Transport Excitatory Chemical Synaptic Transmission Positive Regulation Of Excitatory Postsynaptic Potential Monoatomic Ion Channel Complex Inorganic Ion Transmembrane Transport Monoatomic Cation Transport Monoatomic Ion Transmembrane Transport Protein Localization To Cell Junction Modulation Of Chemical Synaptic Transmission Monoatomic Ion Channel Activity Modulation Of Excitatory Postsynaptic Potential System Process Glutamate Receptor Signaling Pathway Regulation Of Monoatomic Ion Transmembrane Transport Regulation Of Monoatomic Ion Transport Regulation Of Neuronal Synaptic Plasticity Monoatomic Ion Transport Protein Localization To Synapse Regulation Of Nervous System Process Chemical Synaptic Transmission Trans-synaptic Signaling Postsynaptic Membrane Ionotropic Glutamate Receptor Signaling Pathway Synaptic Signaling Positive Regulation Of Synaptic Transmission Dendritic Spine Ligand-gated Monoatomic Ion Channel Activity Glutamate-gated Calcium Ion Channel Activity Plasma Membrane Transmembrane Transport Regulation Of System Process Transmitter-gated Monoatomic Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential Glutamatergic Synapse Synapse Ligand-gated Ion Channel Signaling Pathway Synaptic Transmission, Glutamatergic Postsynaptic Density Membrane Protein Localization To Membrane Regulation Of Synaptic Plasticity Dendrite Membrane Depolarization Long-term Synaptic Potentiation	Regulation Of Monoatomic Ion Transmembrane Transport Plasma Membrane Postsynaptic Density Membrane Regulation Of Monoatomic Ion Transport Bicellular Tight Junction Intracellular Protein Localization Cell Junction Establishment Of Protein Localization Regulation Of Cell Junction Assembly Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Establishment Or Maintenance Of Apical/basal Cell Polarity Protein Localization To Synapse Regulation Of Systemic Arterial Blood Pressure By Aortic Arch Baroreceptor Feedback Cellular Component Assembly Establishment Of Localization In Cell P2Y1 Nucleotide Receptor Binding Negative Regulation Of Anion Channel Activity Regulation Of Transport Neuromuscular Junction Protein Localization To Cell Junction Synapse PH-gated Sodium Channel Activity Monoatomic Ion-gated Channel Activity Anchoring Junction Cell Periphery Protein Kinase CK2 Complex Protein Transport Symbiont-mediated Disruption Of Host Cell PML Body Beta-1 Adrenergic Receptor Binding Regulation Of Grooming Behavior Negative Regulation Of Glycolytic Process Through Fructose-6-phosphate Protein Localization To Lipid Droplet Dendritic Spine Regulation Of System Process Positive Regulation Of Aggrephagy AMPA Glutamate Receptor Clustering Cell Projection Neuroligin Family Protein Binding MPP7-DLG1-LIN7 Complex Regulation Of Synapse Assembly NMDA Selective Glutamate Receptor Signaling Pathway Establishment Or Maintenance Of Cell Polarity CAMP-dependent Protein Kinase Activity
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