PARD3B and GAA

Number of citations of the paper that reports this interaction (PubMedID 30217970)
38

Data Source:
BioGRID (two hybrid)

		PARD3B	GAA
Description		par-3 family cell polarity regulator beta	alpha glucosidase
Image		No pdb structure
GO Annotations	Cellular Component	Adherens Junction Bicellular Tight Junction Cell Cortex Endomembrane System Membrane Apical Plasma Membrane Cell Junction Protein-containing Complex Apical Junction Complex Anchoring Junction	Lysosome Lysosomal Membrane Plasma Membrane Membrane Azurophil Granule Membrane Lysosomal Lumen Extracellular Exosome Tertiary Granule Membrane Ficolin-1-rich Granule Membrane Autolysosome Lumen
	Molecular Function	Protein Binding Phosphatidylinositol Binding	Catalytic Activity Hydrolase Activity, Hydrolyzing O-glycosyl Compounds Alpha-1,4-glucosidase Activity Hydrolase Activity Hydrolase Activity, Acting On Glycosyl Bonds Carbohydrate Binding Alpha-glucosidase Activity
	Biological Process	Microtubule Cytoskeleton Organization Cell Adhesion Intracellular Protein Localization Establishment Of Cell Polarity Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Cell Division Establishment Of Centrosome Localization	Maltose Metabolic Process Regulation Of The Force Of Heart Contraction Diaphragm Contraction Heart Morphogenesis Carbohydrate Metabolic Process Glycogen Metabolic Process Glycogen Catabolic Process Disaccharide Metabolic Process Sucrose Metabolic Process Glucose Metabolic Process Striated Muscle Contraction Lysosome Organization Locomotory Behavior Tissue Development Aorta Development Vacuolar Sequestering Muscle Cell Cellular Homeostasis Neuromuscular Process Controlling Posture Neuromuscular Process Controlling Balance Cardiac Muscle Contraction Glycophagy
Pathways			Glycogen storage disease type II (GAA) Neutrophil degranulation Glycogen breakdown (glycogenolysis)
Drugs			Acarbose Miglitol AT2220 alpha-Arbutin
Diseases			Glycogen storage diseases (GSD), including: von Gierke disease (GSD type Ia); Pompe disease (GSD type II); Cori disease, Forbe disease (GSD type III); Andersen disease (GSD type IV); McArdle disease (GSD type V); Hers disease (GSD type VI); Tarui disease (GSD type VII); Phosphorylase kinase deficiency (GSD type IX); Fanconi-Bickel syndrome (GSD type XI); Glycogen synthase deficiency (GSD type 0)
GWAS		Adult body size ( 32376654) AIDS progression ( 21502085) Aluminium levels ( 26025379) Attention deficit hyperactivity disorder ( 30563984) Autism ( 22843504) Body mass index ( 28892062) Craniofacial microsomia ( 26853712) Diisocyanate-induced asthma ( 25918132) General risk tolerance (MTAG) ( 30643258) HDL levels x SSRI defined daily dose interaction in schizophrenia or bipolar disorder ( 33824429) Hip circumference adjusted for BMI ( 28552196) Hippocampal volume ( 25625606) Idiopathic dilated cardiomyopathy ( 29495422) Intracranial aneurysm ( 29531279) Intraocular pressure ( 29617998 31959993 30054594 29785010) Knee osteoarthritis ( 18471798) Nicotine dependence symptom count ( 25555482) Post bronchodilator FEV1/FVC ratio ( 26634245) Triglyceride levels ( 32902719) Venous thromboembolism adjusted for sickle cell variant rs77121243-T ( 28203683)	Blood protein levels ( 30072576) Platelet distribution width ( 32888494) Plateletcrit ( 32888494)
Interacting Genes		9 interacting genes: CASK GAA INSC MARK2 PARD6B RBM5 RPS6KA1 YWHAE YWHAG	11 interacting genes: CPEB2 CREBBP DYNC1LI2 EP300 HIVEP1 NCF1 NUMBL PARD3B RAB2A SH3GLB2 STAT2
Entrez ID		117583	2548
HPRD ID		09795	06006
Ensembl ID		ENSG00000116117	ENSG00000171298
Uniprot IDs		Q8TEW8	P10253
PDB IDs			5KZW 5KZX 5NN3 5NN4 5NN5 5NN6 5NN8 7P2Z 7P32
Enriched GO Terms of Interacting Partners?		Establishment Or Maintenance Of Apical/basal Cell Polarity Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Autolysosome Lumen Vacuolar Sequestering TORC1 Signaling Protein Domain Specific Binding Protein Sequestering Activity Protein Serine Kinase Activity Protein Serine/threonine Kinase Activity Sucrose Metabolic Process Maltose Metabolic Process Negative Regulation Of TOR Signaling TOR Signaling Regulation Of Heart Rate By Hormone Focal Adhesion	Histone H3K18 Acetyltransferase Activity N-terminal Peptidyl-lysine Acetylation Histone H3K27 Acetyltransferase Activity Peptide Lactyltransferase (CoA-dependent) Activity Peptidyl-lysine Acetylation N-terminal Protein Amino Acid Acetylation Regulation Of Cellular Response To Heat Acetyltransferase Activity Cellular Response To Lectin Stimulatory C-type Lectin Receptor Signaling Pathway Histone Acetyltransferase Complex Protein-lysine-acetyltransferase Activity Regulation Of Innate Immune Response Protein Acetylation Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Histone Acetyltransferase Activity Centrosome Localization Tau Protein Binding Transcription Coactivator Binding Protein Destabilization Canonical NF-kappaB Signal Transduction Peptidyl-lysine Propionylation Swimming Histone Lactyltransferase (CoA-dependent) Activity Peptidyl-lysine Butyrylation Peptidyl-lysine Crotonylation Histone H3K122 Acetyltransferase Activity Histone Butyryltransferase Activity Histone Crotonyltransferase Activity Negative Regulation Of Cytoplasmic Translational Elongation Damaged DNA Binding Response To Hypoxia Cell Surface Receptor Signaling Pathway Via JAK-STAT Cytoplasm P53 Binding Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Response To Decreased Oxygen Levels Response To Oxygen Levels Histone H2B Acetyltransferase Activity Cell Surface Receptor Signaling Pathway Via STAT Acetylation-dependent Protein Binding Peptide Butyryltransferase Activity Peptide 2-hydroxyisobutyryltransferase Activity Protein Propionyltransferase Activity Peptide Crotonyltransferase Activity Neutrophil-mediated Killing Of Fungus Chromatin DNA Binding Regulation Of Defense Response Cellular Response To UV Positive Regulation Of Protein Localization To Nucleus
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