TOB1 and PABPC1

Number of citations of the paper that reports this interaction (PMID 17785442)
43

Data Source:
BioGRID (pull down, affinity chromatography technology)

		TOB1	PABPC1
Gene Name		transducer of ERBB2, 1	poly(A) binding protein, cytoplasmic 1
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Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm CCR4-NOT Complex	Nucleus Cytoplasm Cytosol Focal Adhesion Cytoplasmic Stress Granule Membrane Ribonucleoprotein Complex Cytoplasmic Ribonucleoprotein Granule Extracellular Vesicular Exosome Catalytic Step 2 Spliceosome
	Molecular Function	Transcription Corepressor Activity SH3/SH2 Adaptor Activity Protein Binding Receptor Tyrosine Kinase Binding SMAD Binding	Nucleotide Binding Protein Binding Protein C-terminus Binding Poly(A) Binding Poly(U) RNA Binding Translation Activator Activity Poly(A) RNA Binding
	Biological Process	SMAD Protein Import Into Nucleus Negative Regulation Of Cell Proliferation Positive Regulation Of Signal Transduction Negative Regulation Of Translation Negative Regulation Of BMP Signaling Pathway Negative Regulation Of Osteoblast Differentiation Negative Regulation Of Nuclear-transcribed MRNA Poly(A) Tail Shortening Positive Regulation Of Nuclear-transcribed MRNA Poly(A) Tail Shortening Positive Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Negative Regulation Of Nucleic Acid-templated Transcription	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Nuclear-transcribed MRNA Poly(A) Tail Shortening MRNA Splicing, Via Spliceosome MRNA Polyadenylation Translation Translational Initiation Gene Expression Gene Silencing By RNA Cellular Protein Metabolic Process Positive Regulation Of Translation MRNA Stabilization Positive Regulation Of Nuclear-transcribed MRNA Poly(A) Tail Shortening Positive Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Negative Regulation Of Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay
Pathways			Translation initiation complex formation Nonsense-Mediated Decay (NMD) Regulation of mRNA stability by proteins that bind AU-rich elements Deadenylation of mRNA Translation AUF1 (hnRNP D0) destabilizes mRNA L13a-mediated translational silencing of Ceruloplasmin expression Deadenylation-dependent mRNA decay Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) Eukaryotic Translation Initiation Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S Cap-dependent Translation Initiation Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
Drugs
Diseases
GWAS
Protein-Protein Interactions		19 interactors: APP CDC7 CNOT7 CORO7 DTL ERBB2 MAPK1 MAPK9 MARCKS PABPC1 SCMH1 SETDB1 SMAD1 SMAD2 SMAD3 SMAD4 SMAD5 SMAD6 SMAD9	43 interactors: ANAPC5 APBB1 ATXN2 CARM1 CHAF1A CNOT6 CNOT7 CSDE1 EIF4B EIF4G1 EIF4G3 GNB2L1 GSPT1 GSPT2 HBB HNRNPD HNRNPK IL7R ITCH MAPKAPK2 NDRG1 NFX1 PAIP1 PAIP2 PAIP2B PAN2 PAN3 PCBP1 PCBP2 PCSK7 PIN1 PRMT6 PXN RBM4 SREK1 STAU1 SYCP3 SYNCRIP TERT TOB1 U2AF1 WBP4 YWHAG
Entrez ID		10140	26986
HPRD ID		09273	05247
Ensembl ID		ENSG00000141232	ENSG00000070756
Uniprot IDs		P50616	E7EQV3 E7ERJ7 P11940
PDB IDs		2D5R 2Z15	1CVJ 1G9L 1JGN 1JH4 2K8G 2RQG 2RQH 2X04 3KTP 3KTR 3KUI 3KUJ 3KUR 3KUS 3KUT 3PKN 3PTH 4F02 4F25 4F26
Enriched GO Terms of Interacting Partners?		Ureteric Bud Development Mesonephric Tubule Development Mesonephric Epithelium Development Mesonephros Development Cellular Response To Growth Factor Stimulus Positive Regulation Of Macromolecule Biosynthetic Process Transforming Growth Factor Beta Receptor Signaling Pathway Response To Growth Factor Positive Regulation Of Cellular Biosynthetic Process Kidney Epithelium Development SMAD Protein Complex Assembly Embryonic Pattern Specification Cellular Response To Transforming Growth Factor Beta Stimulus Response To Transforming Growth Factor Beta Gene Silencing Positive Regulation Of Gene Expression Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of Transcription, DNA-templated Posttranscriptional Regulation Of Gene Expression Cellular Macromolecule Biosynthetic Process Gene Silencing By RNA Macromolecule Biosynthetic Process Kidney Development Nucleobase-containing Compound Metabolic Process Renal System Development BMP Signaling Pathway Positive Regulation Of Cellular Metabolic Process RNA Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Primary MiRNA Processing Enzyme Linked Receptor Protein Signaling Pathway Cellular Nitrogen Compound Metabolic Process Urogenital System Development Gene Expression Gene Silencing By MiRNA Transcription, DNA-templated Regulation Of RNA Metabolic Process RNA Biosynthetic Process Posttranscriptional Gene Silencing Nitrogen Compound Metabolic Process Pattern Specification Process Biosynthetic Process Regulation Of Cell Differentiation Regulation Of Gene Expression Positive Regulation Of Cell Morphogenesis Involved In Differentiation Positive Regulation Of Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription	MRNA Metabolic Process MRNA Processing Regulation Of Translation Posttranscriptional Regulation Of Gene Expression RNA Processing Nuclear-transcribed MRNA Poly(A) Tail Shortening RNA Catabolic Process Nuclear-transcribed MRNA Catabolic Process MRNA Catabolic Process RNA Metabolic Process MRNA 3'-end Processing Regulation Of Protein Metabolic Process Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Gene Expression RNA 3'-end Processing Regulation Of Cellular Protein Metabolic Process Cellular Macromolecule Catabolic Process Aromatic Compound Catabolic Process Nucleobase-containing Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Translational Initiation Nitrogen Compound Metabolic Process RNA Splicing Negative Regulation Of Translation Regulation Of Gene Expression MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Cellular Metabolic Process Regulation Of Metabolic Process RNA Phosphodiester Bond Hydrolysis, Exonucleolytic Catabolic Process Viral Process Posttranscriptional Gene Silencing Regulation Of MRNA Stability Regulation Of RNA Stability Histone H3-R2 Methylation Gene Silencing By RNA Negative Regulation Of Translational Initiation Negative Regulation Of Cellular Metabolic Process Nuclear-transcribed MRNA Catabolic Process, No-go Decay Negative Regulation Of Gene Expression MRNA Stabilization Cellular Macromolecule Biosynthetic Process Negative Regulation Of Protein Metabolic Process Macromolecule Biosynthetic Process Positive Regulation Of Cytoplasmic MRNA Processing Body Assembly Gene Silencing Gene Silencing By MiRNA
Tagcloud ?		antiproliferative apro article autoimmune biomarker disorders diverse dorsal embryonic emphasis erbb2 experimental functions helper humans immune implicated implications linking member molecule mounted recently reviews sclerosis th17 transducer types underscoring	address adhesion arm comprised coprecipitated cytoplasm cytoplasmic desmoplakin desmosomes destabilized fxr1 g3bp gain mrnas outside particles pkp1 pkp2 pkp3 plakophilins posttranscriptional regulators repeat ribonucleoprotein rnase serve stabilized unaffected upf1
Tagcloud (Difference) ?		antiproliferative apro article autoimmune biomarker disorders diverse dorsal embryonic emphasis erbb2 experimental functions helper humans immune implicated implications linking member molecule mounted recently reviews sclerosis th17 transducer types underscoring	address adhesion arm comprised coprecipitated cytoplasm cytoplasmic desmoplakin desmosomes destabilized fxr1 g3bp gain mrnas outside particles pkp1 pkp2 pkp3 plakophilins posttranscriptional regulators repeat ribonucleoprotein rnase serve stabilized unaffected upf1
Tagcloud (Intersection) ?