TOB1 and CORO7

Number of citations of the paper that reports this interaction (PubMedID 21130766)
0

Data Source:
BioGRID (enzymatic study)

		TOB1	CORO7
Description		transducer of ERBB2, 1	coronin 7
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm CCR4-NOT Complex	Golgi Membrane Cytoplasm Golgi Apparatus Trans-Golgi Network Cytosol Membrane Cytoplasmic Vesicle
	Molecular Function	Transcription Corepressor Activity Protein Binding Receptor Tyrosine Kinase Binding SMAD Binding	Actin Binding Protein Binding
	Biological Process	Negative Regulation Of Cell Population Proliferation Regulation Of Gene Expression Negative Regulation Of Translation Negative Regulation Of BMP Signaling Pathway Negative Regulation Of Osteoblast Differentiation Negative Regulation Of DNA-templated Transcription Negative Regulation Of Nuclear-transcribed MRNA Poly(A) Tail Shortening Positive Regulation Of Nuclear-transcribed MRNA Poly(A) Tail Shortening Regulation Of SMAD Protein Signal Transduction Positive Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay	Golgi To Endosome Transport Actin Filament Organization Golgi Organization Protein Transport Cell Migration Establishment Of Cell Polarity Actin Filament Polymerization Positive Regulation Of Hippo Signaling
Pathways
Drugs
Diseases
GWAS			A body shape index ( 34021172) Eosinophil count ( 32888494) Erectile dysfunction ( 30583798) High light scatter reticulocyte percentage of red cells ( 32888494) Hip circumference adjusted for BMI ( 25673412 34021172) Lymphocyte count ( 32888494) Schizophrenia ( 28991256) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 30389748 34021172) Waist-to-hip ratio adjusted for BMI (additive genetic model) ( 30778226)
Interacting Genes		19 interacting genes: APP CDC7 CNOT7 CORO7 DTL ERBB2 MAPK1 MAPK9 MARCKS PABPC1 SCMH1 SETDB1 SMAD1 SMAD2 SMAD3 SMAD4 SMAD5 SMAD6 SMAD9	9 interacting genes: ACTB AP1M1 AP2M1 EPS15 KLHL20 SRC TOB1 WASL ZRANB1
Entrez ID		10140	79585
HPRD ID		09273	07975
Ensembl ID		ENSG00000141232	ENSG00000262246
Uniprot IDs		P50616	P57737
PDB IDs		2D5R 2Z15 5CI8 5CI9
Enriched GO Terms of Interacting Partners?		Heteromeric SMAD Protein Complex I-SMAD Binding SMAD Protein Complex SMAD Protein Signal Transduction Response To Growth Factor Embryonic Pattern Specification Positive Regulation Of Nucleobase-containing Compound Metabolic Process Intracellular Signaling Cassette Cellular Response To Growth Factor Stimulus Co-SMAD Binding Ureteric Bud Development Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Transforming Growth Factor Beta Receptor Signaling Pathway Mesonephric Tubule Development Mesonephric Epithelium Development Positive Regulation Of Macromolecule Metabolic Process Tube Development Positive Regulation Of RNA Metabolic Process Transcription Regulator Complex Positive Regulation Of Metabolic Process Kidney Epithelium Development Enzyme-linked Receptor Protein Signaling Pathway Regulation Of MiRNA Transcription R-SMAD Binding BMP Signaling Pathway Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of MiRNA Metabolic Process Positive Regulation Of Biosynthetic Process DEAD/H-box RNA Helicase Binding Intracellular Signal Transduction Regulation Of Macromolecule Metabolic Process Nucleoplasm Regulation Of RNA Metabolic Process Epithelium Development Regulation Of Primary Metabolic Process Regulation Of Cell Differentiation Osteoblast Differentiation Primary MiRNA Processing Regulation Of Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Cytoplasm Positive Regulation Of MiRNA Transcription Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Chromatin Binding Tissue Development Cardiac Conduction System Development Positive Regulation Of MiRNA Metabolic Process Cytosol	Organelle Organization Postsynaptic Neurotransmitter Receptor Internalization Regulation Of Endocytosis Vesicle Organization AP-2 Adaptor Complex Clathrin Adaptor Complex Golgi To Endosome Transport Cellular Component Assembly Clathrin Adaptor Activity Regulation Of Protein Localization Cytoskeleton Organization Regulation Of Synaptic Vesicle Endocytosis Regulation Of Synaptic Vesicle Recycling Regulation Of Vesicle-mediated Transport Glutamatergic Synapse Vesicle Budding From Membrane Intracellular Transport Polyubiquitin Modification-dependent Protein Binding Actin Cytoskeleton Positive Regulation Of Receptor-mediated Endocytosis Positive Regulation Of Norepinephrine Uptake Cellular Response To Cytochalasin B Cytosol Receptor Internalization Cellular Localization Clathrin-coated Pit Establishment Of Localization In Cell Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Type II Interferon Binding Endocytic Vesicle Membrane Actin Cytoskeleton Organization Clathrin-coated Vesicle Synapse Actin Filament Actin Filament-based Process Intracellular Protein Localization Regulation Of Norepinephrine Uptake Vesicle-mediated Transport In Synapse Negative Regulation Of Membrane Tubulation Protein K33-linked Ubiquitination Protein Deubiquitination Post-Golgi Vesicle-mediated Transport Transporter Regulator Activity Protein Transport Positive Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway Positive Regulation Of Clathrin-dependent Endocytosis Negative Regulation Of Nuclear-transcribed MRNA Poly(A) Tail Shortening Regulation Of Protein Localization To Plasma Membrane Symbiont Entry Into Host Cell Protein Modification By Small Protein Removal
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