TOB1 and CNOT7

Number of citations of the paper that reports this interaction (PMID 18056425)
46

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo, in vitro)

		TOB1	CNOT7
Gene Name		transducer of ERBB2, 1	CCR4-NOT transcription complex, subunit 7
Image
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm CCR4-NOT Complex	Cytoplasmic MRNA Processing Body Nucleus Cytosol Membrane CCR4-NOT Complex
	Molecular Function	Transcription Corepressor Activity SH3/SH2 Adaptor Activity Protein Binding Receptor Tyrosine Kinase Binding SMAD Binding	3'-5'-exoribonuclease Activity Sequence-specific DNA Binding Transcription Factor Activity RNA Binding Exoribonuclease Activity Poly(A)-specific Ribonuclease Activity Signal Transducer Activity Protein Binding Metal Ion Binding
	Biological Process	SMAD Protein Import Into Nucleus Negative Regulation Of Cell Proliferation Positive Regulation Of Signal Transduction Negative Regulation Of Translation Negative Regulation Of BMP Signaling Pathway Negative Regulation Of Osteoblast Differentiation Negative Regulation Of Nuclear-transcribed MRNA Poly(A) Tail Shortening Positive Regulation Of Nuclear-transcribed MRNA Poly(A) Tail Shortening Positive Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Negative Regulation Of Nucleic Acid-templated Transcription	Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Nuclear-transcribed MRNA Poly(A) Tail Shortening Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA Carbohydrate Metabolic Process Transcription, DNA-templated Regulation Of Translation Signal Transduction Positive Regulation Of Cell Proliferation Negative Regulation Of Cell Proliferation Gene Expression Negative Regulation Of Gene Expression Gene Silencing By RNA Cytoplasmic MRNA Processing Body Assembly Gene Silencing By MiRNA Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Nuclear-transcribed MRNA Poly(A) Tail Shortening Positive Regulation Of MRNA Catabolic Process RNA Phosphodiester Bond Hydrolysis, Exonucleolytic Positive Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay
Pathways			Deadenylation of mRNA Deadenylation-dependent mRNA decay
Drugs
Diseases
GWAS
Protein-Protein Interactions		19 interactors: APP CDC7 CNOT7 CORO7 DTL ERBB2 MAPK1 MAPK9 MARCKS PABPC1 SCMH1 SETDB1 SMAD1 SMAD2 SMAD3 SMAD4 SMAD5 SMAD6 SMAD9	16 interactors: APP BTG1 BTG2 BTG3 CDK1 CDK2 CDK4 CDK6 CNOT6 FOXC2 HOXD4 IKBKG PABPC1 TNRC6A TOB1 TOB2
Entrez ID		10140	29883
HPRD ID		09273	05370
Ensembl ID		ENSG00000141232	ENSG00000198791
Uniprot IDs		P50616	Q9UIV1
PDB IDs		2D5R 2Z15	2D5R 4GMJ
Enriched GO Terms of Interacting Partners?		Ureteric Bud Development Mesonephric Tubule Development Mesonephric Epithelium Development Mesonephros Development Cellular Response To Growth Factor Stimulus Positive Regulation Of Macromolecule Biosynthetic Process Transforming Growth Factor Beta Receptor Signaling Pathway Response To Growth Factor Positive Regulation Of Cellular Biosynthetic Process Kidney Epithelium Development SMAD Protein Complex Assembly Embryonic Pattern Specification Cellular Response To Transforming Growth Factor Beta Stimulus Response To Transforming Growth Factor Beta Gene Silencing Positive Regulation Of Gene Expression Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of Transcription, DNA-templated Posttranscriptional Regulation Of Gene Expression Cellular Macromolecule Biosynthetic Process Gene Silencing By RNA Macromolecule Biosynthetic Process Kidney Development Nucleobase-containing Compound Metabolic Process Renal System Development BMP Signaling Pathway Positive Regulation Of Cellular Metabolic Process RNA Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Primary MiRNA Processing Enzyme Linked Receptor Protein Signaling Pathway Cellular Nitrogen Compound Metabolic Process Urogenital System Development Gene Expression Gene Silencing By MiRNA Transcription, DNA-templated Regulation Of RNA Metabolic Process RNA Biosynthetic Process Posttranscriptional Gene Silencing Nitrogen Compound Metabolic Process Pattern Specification Process Biosynthetic Process Regulation Of Cell Differentiation Regulation Of Gene Expression Positive Regulation Of Cell Morphogenesis Involved In Differentiation Positive Regulation Of Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription	Regulation Of Translation Regulation Of Gene Expression Regulation Of Cell Proliferation Positive Regulation Of Gene Expression Posttranscriptional Regulation Of Gene Expression Positive Regulation Of Nuclear-transcribed MRNA Poly(A) Tail Shortening Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Positive Regulation Of MRNA 3'-end Processing Regulation Of MRNA 3'-end Processing Regulation Of Protein Metabolic Process Positive Regulation Of MRNA Catabolic Process Regulation Of Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Notch Signaling Pathway Positive Regulation Of Cellular Biosynthetic Process Negative Regulation Of Cell Proliferation G1/S Transition Of Mitotic Cell Cycle Regulation Of Mitotic Cell Cycle Negative Regulation Of Cell Cycle Gene Silencing By RNA Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Cellular Process Regulation Of Cell Cycle MRNA 3'-end Processing Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Negative Regulation Of Translation Regulation Of MRNA Processing Positive Regulation Of Cell Cycle Regulation Of Cell Differentiation Gene Silencing Regulation Of Nitrogen Compound Metabolic Process RNA 3'-end Processing Positive Regulation Of Mitotic Cell Cycle Dentate Gyrus Development Negative Regulation Of Cell Differentiation Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Nuclear-transcribed MRNA Poly(A) Tail Shortening Negative Regulation Of Gene Expression Positive Regulation Of Cell Proliferation Cell Division MRNA Polyadenylation Regulation Of Apoptotic Process Gene Silencing By MiRNA RNA Polyadenylation
Tagcloud ?		antiproliferative apro article autoimmune biomarker disorders diverse dorsal embryonic emphasis erbb2 experimental functions helper humans immune implicated implications linking member molecule mounted recently reviews sclerosis th17 transducer types underscoring	actr1a backgrounds bbs2 bovines c2orf29 cq cycling dnajc17 endometrium establishes friesian gapdh genorm holstein normalise normalised normfinder oestrus oxtr oxytocin ppia ranbp10 rps15a rps9 slc30a6 suitability suz12 uxt znf131
Tagcloud (Difference) ?		antiproliferative apro article autoimmune biomarker disorders diverse dorsal embryonic emphasis erbb2 experimental functions helper humans immune implicated implications linking member molecule mounted recently reviews sclerosis th17 transducer types underscoring	actr1a backgrounds bbs2 bovines c2orf29 cq cycling dnajc17 endometrium establishes friesian gapdh genorm holstein normalise normalised normfinder oestrus oxtr oxytocin ppia ranbp10 rps15a rps9 slc30a6 suitability suz12 uxt znf131
Tagcloud (Intersection) ?