TOB1 and MARCKS

Number of citations of the paper that reports this interaction (PubMedID 11327693)
0

Data Source:
HPRD (two hybrid, in vitro)

		TOB1	MARCKS
Description		transducer of ERBB2, 1	myristoylated alanine rich protein kinase C substrate
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm CCR4-NOT Complex	Nucleoplasm Cytoplasm Endoplasmic Reticulum Centrosome Cytosol Cytoskeleton Plasma Membrane Focal Adhesion Cilium Cell Cortex Actin Cytoskeleton Membrane Nuclear Speck Cell Junction Actin Filament Bundle Germinal Vesicle Organelle Extracellular Exosome
	Molecular Function	Transcription Corepressor Activity Protein Binding Receptor Tyrosine Kinase Binding SMAD Binding	Actin Binding Protein Kinase C Binding Calmodulin Binding Identical Protein Binding Actin Filament Binding
	Biological Process	Negative Regulation Of Cell Population Proliferation Regulation Of Gene Expression Negative Regulation Of Translation Negative Regulation Of BMP Signaling Pathway Negative Regulation Of Osteoblast Differentiation Negative Regulation Of DNA-templated Transcription Negative Regulation Of Nuclear-transcribed MRNA Poly(A) Tail Shortening Positive Regulation Of Nuclear-transcribed MRNA Poly(A) Tail Shortening Regulation Of SMAD Protein Signal Transduction Positive Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay	Apoptotic Process Mitochondrion Organization Actin Filament Organization Central Nervous System Development Neural Tube Development Neurogenesis Response To Endoplasmic Reticulum Stress Actin Filament Bundle Assembly Actin Crosslink Formation
Pathways			Acetylcholine regulates insulin secretion
Drugs
Diseases
GWAS			Alcohol dependence ( 33290381) Bipolar disorder (body mass index interaction) ( 24322204) Event free survival in diffuse large B-cell lymphoma treated with immunochemotherapy ( 26460308) Household income ( 31844048) Household income (MTAG) ( 31844048) Type 2 diabetes ( 25760438)
Interacting Genes		19 interacting genes: APP CDC7 CNOT7 CORO7 DTL ERBB2 MAPK1 MAPK9 MARCKS PABPC1 SCMH1 SETDB1 SMAD1 SMAD2 SMAD3 SMAD4 SMAD5 SMAD6 SMAD9	11 interacting genes: CALM2 CCNE1 CDK2 CDK4 CTSB NMT1 PKN1 PRKCA PRKCB SPP1 TOB1
Entrez ID		10140	4082
HPRD ID		09273	07519
Ensembl ID		ENSG00000141232	ENSG00000277443
Uniprot IDs		P50616	P29966 Q6NVI1
PDB IDs		2D5R 2Z15 5CI8 5CI9
Enriched GO Terms of Interacting Partners?		Heteromeric SMAD Protein Complex I-SMAD Binding SMAD Protein Complex SMAD Protein Signal Transduction Response To Growth Factor Embryonic Pattern Specification Positive Regulation Of Nucleobase-containing Compound Metabolic Process Intracellular Signaling Cassette Cellular Response To Growth Factor Stimulus Co-SMAD Binding Ureteric Bud Development Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Transforming Growth Factor Beta Receptor Signaling Pathway Mesonephric Tubule Development Mesonephric Epithelium Development Positive Regulation Of Macromolecule Metabolic Process Tube Development Positive Regulation Of RNA Metabolic Process Transcription Regulator Complex Positive Regulation Of Metabolic Process Kidney Epithelium Development Enzyme-linked Receptor Protein Signaling Pathway Regulation Of MiRNA Transcription R-SMAD Binding BMP Signaling Pathway Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of MiRNA Metabolic Process Positive Regulation Of Biosynthetic Process DEAD/H-box RNA Helicase Binding Intracellular Signal Transduction Regulation Of Macromolecule Metabolic Process Nucleoplasm Regulation Of RNA Metabolic Process Epithelium Development Regulation Of Primary Metabolic Process Regulation Of Cell Differentiation Osteoblast Differentiation Primary MiRNA Processing Regulation Of Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Cytoplasm Positive Regulation Of MiRNA Transcription Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Chromatin Binding Tissue Development Cardiac Conduction System Development Positive Regulation Of MiRNA Metabolic Process Cytosol	Histone H3T6 Kinase Activity Diacylglycerol-dependent Serine/threonine Kinase Activity Kinase Activity Cyclin E1-CDK2 Complex Calcium,diacylglycerol-dependent Serine/threonine Kinase Activity Protein Phosphorylation Protein Serine Kinase Activity Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Phosphorylation Cyclin-dependent Protein Kinase Holoenzyme Complex Protein Serine/threonine Kinase Activity Protein Kinase C Signaling Protein Kinase Activity G1/S Transition Of Mitotic Cell Cycle Cell Cycle G1/S Phase Transition Mitotic Nuclear Membrane Disassembly Response To Phorbol 13-acetate 12-myristate Positive Regulation Of Bone Resorption Nuclear Membrane Disassembly Membrane Disassembly Calyx Of Held Positive Regulation Of Mitotic Cell Cycle Positive Regulation Of Hormone Secretion Decidualization Nuclear Androgen Receptor Binding Presynaptic Cytosol Cyclin-dependent Protein Serine/threonine Kinase Activity Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity Cyclin Binding Regulation Of Mitotic Cell Cycle Protein Modification Process Regulation Of RNA Metabolic Process Regulation Of Cell Population Proliferation Regulation Of Hormone Levels Regulation Of Bone Resorption Regulation Of Cell Cycle Transferase Activity Response To Ketone Regulation Of Bone Remodeling Calcium Channel Regulator Activity Regulation Of Nucleobase-containing Compound Metabolic Process Protein Kinase C Binding Nuclear Membrane Organization G2/M Transition Of Mitotic Cell Cycle Regulation Of Hormone Secretion Chromatin Remodeling Cell Cycle G2/M Phase Transition Myristoyltransferase Activity Negative Regulation Of Collateral Sprouting Of Intact Axon In Response To Injury
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