TOB1 and CDC7

Number of citations of the paper that reports this interaction (PMID 23066029)
4

Data Source:
BioGRID (affinity chromatography technology, enzymatic study)

		TOB1	CDC7
Gene Name		transducer of ERBB2, 1	cell division cycle 7
Image
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm CCR4-NOT Complex	Nucleus Nucleoplasm Cytoplasm Microtubule Cytoskeleton Intercellular Bridge
	Molecular Function	Transcription Corepressor Activity SH3/SH2 Adaptor Activity Protein Binding Receptor Tyrosine Kinase Binding SMAD Binding	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Metal Ion Binding
	Biological Process	SMAD Protein Import Into Nucleus Negative Regulation Of Cell Proliferation Positive Regulation Of Signal Transduction Negative Regulation Of Translation Negative Regulation Of BMP Signaling Pathway Negative Regulation Of Osteoblast Differentiation Negative Regulation Of Nuclear-transcribed MRNA Poly(A) Tail Shortening Positive Regulation Of Nuclear-transcribed MRNA Poly(A) Tail Shortening Positive Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Negative Regulation Of Nucleic Acid-templated Transcription	G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Double-strand Break Repair Via Break-induced Replication DNA Replication DNA Replication Initiation Phagocytosis Positive Regulation Of Cell Proliferation Regulation Of Cell Shape Positive Regulation Of Nuclear Cell Cycle DNA Replication Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Peptidyl-serine Phosphorylation Cell Cycle Phase Transition Cell Division
Pathways			G1/S Transition G2/M Checkpoints Activation of ATR in response to replication stress Activation of the pre-replicative complex DNA Replication Pre-Initiation M/G1 Transition Cell Cycle Checkpoints Activation of the pre-replicative complex Mitotic G1-G1/S phases Cell Cycle, Mitotic
Drugs
Diseases
GWAS			Optic disc parameters ( 20548946 21307088)
Protein-Protein Interactions		19 interactors: APP CDC7 CNOT7 CORO7 DTL ERBB2 MAPK1 MAPK9 MARCKS PABPC1 SCMH1 SETDB1 SMAD1 SMAD2 SMAD3 SMAD4 SMAD5 SMAD6 SMAD9	24 interactors: APP CDK2 CDK4 CDK9 CDKN1A CDKN2A CHAF1A CLSPN DBF4 DBF4B DIAPH1 GPT GRHPR MCM10 MCM2 MCM3 MCM4 MCM5 MCM6 MCM7 ORC1 ORC5 ORC6 TOB1
Entrez ID		10140	8317
HPRD ID		09273	10345
Ensembl ID		ENSG00000141232	ENSG00000097046
Uniprot IDs		P50616	B2R6V2 J3KQS2 O00311
PDB IDs		2D5R 2Z15	4F99 4F9A 4F9B 4F9C
Enriched GO Terms of Interacting Partners?		Ureteric Bud Development Mesonephric Tubule Development Mesonephric Epithelium Development Mesonephros Development Cellular Response To Growth Factor Stimulus Positive Regulation Of Macromolecule Biosynthetic Process Transforming Growth Factor Beta Receptor Signaling Pathway Response To Growth Factor Positive Regulation Of Cellular Biosynthetic Process Kidney Epithelium Development SMAD Protein Complex Assembly Embryonic Pattern Specification Cellular Response To Transforming Growth Factor Beta Stimulus Response To Transforming Growth Factor Beta Gene Silencing Positive Regulation Of Gene Expression Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of Transcription, DNA-templated Posttranscriptional Regulation Of Gene Expression Cellular Macromolecule Biosynthetic Process Gene Silencing By RNA Macromolecule Biosynthetic Process Kidney Development Nucleobase-containing Compound Metabolic Process Renal System Development BMP Signaling Pathway Positive Regulation Of Cellular Metabolic Process RNA Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Primary MiRNA Processing Enzyme Linked Receptor Protein Signaling Pathway Cellular Nitrogen Compound Metabolic Process Urogenital System Development Gene Expression Gene Silencing By MiRNA Transcription, DNA-templated Regulation Of RNA Metabolic Process RNA Biosynthetic Process Posttranscriptional Gene Silencing Nitrogen Compound Metabolic Process Pattern Specification Process Biosynthetic Process Regulation Of Cell Differentiation Regulation Of Gene Expression Positive Regulation Of Cell Morphogenesis Involved In Differentiation Positive Regulation Of Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription	G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition DNA Replication Mitotic Cell Cycle Process Mitotic Cell Cycle DNA Replication Initiation DNA-dependent DNA Replication Cell Cycle Cell Cycle Process DNA Metabolic Process DNA Strand Elongation Involved In DNA Replication DNA Strand Elongation DNA Duplex Unwinding DNA Geometric Change DNA Unwinding Involved In DNA Replication DNA Conformation Change Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle G2/M Phase Transition Regulation Of Mitotic Cell Cycle Phase Transition Cellular Nitrogen Compound Metabolic Process Regulation Of Cell Cycle Phase Transition Nitrogen Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Regulation Of Cell Cycle Process Chromosome Organization Macromolecule Biosynthetic Process Regulation Of Cell Cycle Arrest Nucleobase-containing Compound Metabolic Process Positive Regulation Of Cell Cycle Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Mitotic Cell Cycle Biosynthetic Process Positive Regulation Of Cell Cycle Regulation Of Cell Cycle Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Cell Cycle Cellular Metabolic Process Cellular Response To DNA Damage Stimulus Positive Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Phosphorylation Positive Regulation Of Cell Cycle Phase Transition Positive Regulation Of Cell Cycle Arrest Regulation Of Phosphorus Metabolic Process Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Kinase Activity Cellular Response To Stress Organelle Organization Regulation Of Kinase Activity
Tagcloud ?		antiproliferative apro article autoimmune biomarker disorders diverse dorsal embryonic emphasis erbb2 experimental functions helper humans immune implicated implications linking member molecule mounted recently reviews sclerosis th17 transducer types underscoring	af ana antinuclear assignment beads blots cdc10 cdc2 cdc4 cdc5 cdc9 dilutions foundation immunodiffusion intensities jo monospecific originally purposes reagents reference rnp ro semiquantitative sera ss u1 weaker
Tagcloud (Difference) ?		antiproliferative apro article autoimmune biomarker disorders diverse dorsal embryonic emphasis erbb2 experimental functions helper humans immune implicated implications linking member molecule mounted recently reviews sclerosis th17 transducer types underscoring	af ana antinuclear assignment beads blots cdc10 cdc2 cdc4 cdc5 cdc9 dilutions foundation immunodiffusion intensities jo monospecific originally purposes reagents reference rnp ro semiquantitative sera ss u1 weaker
Tagcloud (Intersection) ?