RBM12 and OPTN

Number of citations of the paper that reports this interaction (PubMedID 33961781)
97

Data Source:
BioGRID (two hybrid, two hybrid, affinity chromatography technology)

		RBM12	OPTN
Description		RNA binding motif protein 12	optineurin
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Ribonucleoprotein Complex	Golgi Membrane Nucleus Nucleoplasm Cytoplasm Endosome Autophagosome Golgi Apparatus Trans-Golgi Network Cytosol Cytoplasmic Vesicle Perinuclear Region Of Cytoplasm Recycling Endosome Recycling Endosome Membrane
	Molecular Function	Nucleic Acid Binding RNA Binding Protein Binding	Protein Binding Zinc Ion Binding Protein-macromolecule Adaptor Activity Polyubiquitin Modification-dependent Protein Binding Identical Protein Binding Metal Ion Binding K63-linked Polyubiquitin Modification-dependent Protein Binding
	Biological Process	Regulation Of RNA Splicing	Negative Regulation Of Receptor Recycling Immune System Process Autophagy Golgi Organization Signal Transduction Intracellular Protein Localization Cell Death Positive Regulation Of Autophagy Protein Localization To Golgi Apparatus Cellular Response To Unfolded Protein Golgi To Plasma Membrane Protein Transport Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Canonical NF-kappaB Signal Transduction Innate Immune Response Defense Response To Gram-negative Bacterium Type 2 Mitophagy Golgi Ribbon Formation Positive Regulation Of Xenophagy
Pathways			Regulation of PLK1 Activity at G2/M Transition PINK1-PRKN Mediated Mitophagy TNFR1-induced proapoptotic signaling Regulation of TNFR1 signaling TNFR1-induced NF-kappa-B signaling pathway TBC/RABGAPs TICAM1-dependent activation of IRF3/IRF7 Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation
Drugs
Diseases			Amyotrophic lateral sclerosis (ALS); Lou Gehrig's disease Primary open angle glaucoma
GWAS		Refractive error ( 32231278) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Cerebrospinal fluid p-tau levels ( 29274321) Cerebrospinal fluid p-tau levels in mild cognitive impairment ( 29274321) Paget's disease ( 20436471 21623375)
Interacting Genes		8 interacting genes: BRAP GIGYF2 OPTN PRMT2 RBFOX2 RBM10 SNRPB TBC1D4	72 interacting genes: AIMP1 ARRDC3 ATG16L1 ATG5 CALM1 CCDC13 CDC23 CFTR CLTC CMYA5 DAZAP2 DYSF DZIP1 ENTREP1 FLII FOS FTH1 GABARAP GABARAPL1 GABARAPL2 GNAS GRM1 GTF3A HACE1 HSF2BP HSPB1 HTT IRAK1 KANSL1L LITAF LNX2 MAILR MAP1LC3A MAP1LC3B MAP1LC3C MPP1 MYH3 MYO6 PIAS4 PICK1 POU6F2 RAB11A RAB11B RAB12 RAB14 RAB25 RAB8A RBM12 RFFL RNF11 RNF216 SDCBP SLF2 SNCA SNX6 TBC1D15 TBC1D17 UBB UQCRQ USP2 VCP WASHC3 WIPI2 WWP2 ZNF17 ZNF181 ZNF302 ZNF329 ZNF398 ZNF426 ZNF670 ZNF711
Entrez ID		10137	10133
HPRD ID		06212	03891
Ensembl ID		ENSG00000244462	ENSG00000123240
Uniprot IDs		Q9NTZ6	Q96CV9
PDB IDs		1WEL 2CPY 2DNN 2EK1 2EK6	2LO4 2LUE 3VTV 3VTW 5AAZ 5B83 5EOA 5EOF 7CZM 9B0B 9B0Z 9B12 9IKQ
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Cell Cycle G1/S Phase Transition Protein Methylation Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Histone H3R8 Methyltransferase Activity RNA Splicing Regulation Of MRNA Metabolic Process Vascular Associated Smooth Muscle Cell Apoptotic Process Negative Regulation Of Ribosomal Large Subunit Export From Nucleus Negative Regulation Of Canonical NF-kappaB Signal Transduction Nuclear Progesterone Receptor Binding MRNA Processing U2 SnRNP Binding Macromolecule Methylation Regulation Of MRNA Splicing, Via Spliceosome SnRNP Binding Smooth Muscle Cell Apoptotic Process Negative Regulation Of Signal Transduction Nucleoplasm Protein-arginine Omega-N Asymmetric Methyltransferase Activity Negative Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Cell Communication Negative Regulation Of Macromolecule Metabolic Process Methylation Regulation Of Cell Cycle G1/S Phase Transition Regulation Of G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Signaling MRNA Splicing, Via Spliceosome RNA Binding U7 SnRNP Histone Pre-mRNA DCP Binding 7-methylguanosine Cap Hypermethylation Histone Pre-mRNA 3'end Processing Complex MRNA Metabolic Process U1 SnRNP Binding Regulation Of RNA Splicing Regulation Of Ribosome Biogenesis Regulation Of MRNA Stability Regulation Of MRNA Processing Negative Regulation Of Ribosome Biogenesis Nucleic Acid Binding Smooth Muscle Cell Proliferation Vascular Associated Smooth Muscle Cell Proliferation Negative Regulation Of Vesicle Fusion Vesicle Positive Regulation Of Xenophagy Negative Regulation Of Receptor Recycling Type 2 Mitophagy Proximal Dendrite Negative Regulation Of Metabolic Process Negative Regulation Of Mitotic Cell Cycle	Autophagosome Cellular Response To Nitrogen Starvation Cytoplasmic Vesicle Phosphatidylethanolamine Binding Autophagy Autophagosome Maturation Endosome Autophagosome Assembly Ubiquitin Protein Ligase Binding Autophagosome Organization Autophagy Of Mitochondrion Establishment Of Protein Localization Macroautophagy Protein Transport Phospholipid Binding Autophagosome Membrane Vacuole Organization Mitophagy Myosin V Binding Cellular Response To Starvation Establishment Of Localization In Cell Recycling Endosome Membrane Protein-containing Complex Disassembly Response To Starvation Organelle Assembly Intracellular Transport Recycling Endosome Cellular Response To Nutrient Levels Intracellular Protein Localization Endosomal Transport Cellular Localization Lysosome Beta-tubulin Binding Centriolar Satellite Amyloid-beta Clearance By Transcytosis Response To Iron(II) Ion Regulation Of Cilium Assembly Vesicle-mediated Transport Cellular Response To Stress Cytoplasmic Vesicle Membrane Cytosol G Protein Activity Cytoplasm Intracellular Protein Transport Endocytic Recycling Regulation Of Protein Localization Exocytosis Endosome Membrane Catabolic Process Response To Nutrient Levels
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