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FEM1B and HIF1AN
Number of citations of the paper that reports this interaction (PMID
17003112
)
43
Data Source:
BioGRID
(two hybrid)
FEM1B
HIF1AN
Gene Name
fem-1 homolog b (C. elegans)
hypoxia inducible factor 1, alpha subunit inhibitor
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Perinuclear Region Of Cytoplasm
Molecular Function
Ubiquitin-protein Transferase Activity
Death Receptor Binding
Protein Binding
Notch Binding
Iron Ion Binding
Protein Binding
Zinc Ion Binding
Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, 2-oxoglutarate As One Donor, And Incorporation Of One Atom Each Of Oxygen Into Both Donors
Oxygen Sensor Activity
Carboxylic Acid Binding
Peptidyl-histidine Dioxygenase Activity
Peptidyl-asparagine 3-dioxygenase Activity
Protein Homodimerization Activity
Cofactor Binding
NF-kappaB Binding
Ankyrin Repeat Binding
Biological Process
Apoptotic Process
Protein Ubiquitination
Regulation Of Ubiquitin-protein Transferase Activity
Branching Involved In Prostate Gland Morphogenesis
Epithelial Cell Maturation Involved In Prostate Gland Development
Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Regulation Of DNA Damage Checkpoint
Transcription, DNA-templated
Peptidyl-histidine Hydroxylation
Peptidyl-aspartic Acid Hydroxylation
Peptidyl-asparagine Hydroxylation
Positive Regulation Of Myoblast Differentiation
Negative Regulation Of Notch Signaling Pathway
Oxidation-reduction Process
Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia
Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia
Cellular Response To Hypoxia
Positive Regulation Of Vasculogenesis
Pathways
Cellular response to hypoxia
Regulation of Hypoxia-inducible Factor (HIF) by oxygen
Oxygen-dependent asparagine hydroxylation of Hypoxia-inducible Factor Alpha
Drugs
Diseases
GWAS
Major depressive disorder (
23377640
)
Palmitoleic acid (16:1n-7) plasma levels (
23362303
)
Protein-Protein Interactions
8 interactors:
APAF1
FAS
GLI1
HIF1AN
KIAA0319
NKX3-1
PPM1F
RAD9A
13 interactors:
ASB13
ASB4
ASB9
FBF1
FEM1B
HDAC1
HDAC2
HDAC3
HIF1A
INVS
NFKB1
UACA
VHL
Entrez ID
10116
55662
HPRD ID
16889
09426
Ensembl ID
Uniprot IDs
Q9UK73
Q9NWT6
PDB IDs
1H2K
1H2L
1H2M
1H2N
1IZ3
1MZE
1MZF
1YCI
2CGN
2CGO
2ILM
2W0X
2WA3
2WA4
2XUM
2Y0I
2YC0
2YDE
3D8C
3KCX
3KCY
3OD4
3P3N
3P3P
4AI8
4B7E
4B7K
4BIO
Enriched GO Terms of Interacting Partners
?
Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Positive Regulation Of Cysteine-type Endopeptidase Activity
Positive Regulation Of Endopeptidase Activity
Positive Regulation Of Peptidase Activity
Positive Regulation Of Apoptotic Signaling Pathway
Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Regulation Of Cysteine-type Endopeptidase Activity
Positive Regulation Of Apoptotic Process
Positive Regulation Of Programmed Cell Death
Positive Regulation Of Cell Death
Positive Regulation Of Proteolysis
Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Activation Of Cysteine-type Endopeptidase Activity
Regulation Of Endopeptidase Activity
Zymogen Activation
Cellular Response To Oxygen Levels
Regulation Of Peptidase Activity
Positive Regulation Of Signal Transduction
Regulation Of Proteolysis
Regulation Of Apoptotic Process
Protein Processing
Regulation Of Cell Death
Regulation Of Signal Transduction
Regulation Of Signaling
Cellular Response To Drug
Neuron Apoptotic Process
Apoptotic Signaling Pathway
Apoptotic Process
Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Programmed Cell Death
Neuron Death
Positive Regulation Of Hydrolase Activity
Positive Regulation Of Response To DNA Damage Stimulus
Cell Death
Death
Response To Abiotic Stimulus
Positive Regulation Of Cellular Protein Metabolic Process
Tube Morphogenesis
Peptidyl-histidine Hydroxylation
Response To G1 DNA Damage Checkpoint Signaling
Peptidyl-asparagine Hydroxylation
Positive Regulation Of Protein Metabolic Process
Cellular Response To Hypoxia
Cellular Response To Decreased Oxygen Levels
Positive Regulation Of Cellular Metabolic Process
Peptidyl-aspartic Acid Hydroxylation
Motor Neuron Apoptotic Process
Positive Regulation Of Androgen Secretion
Cellular Response To Stimulus
Regulation Of Response To DNA Damage Stimulus
Positive Regulation Of Receptor Biosynthetic Process
Regulation Of Receptor Biosynthetic Process
Histone H4 Deacetylation
Regulation Of Apoptotic Process
Regulation Of Cell Death
Histone H3 Deacetylation
Histone H3-K9 Modification
Histone Deacetylation
Negative Regulation Of Apoptotic Process
Neurotrophin TRK Receptor Signaling Pathway
Protein Deacetylation
Negative Regulation Of Programmed Cell Death
Neurotrophin Signaling Pathway
Negative Regulation Of Cell Death
Fungiform Papilla Formation
Circadian Regulation Of Gene Expression
Protein Ubiquitination
Fungiform Papilla Morphogenesis
Negative Regulation Of Signal Transduction
Protein Modification By Small Protein Conjugation
Fungiform Papilla Development
Eyelid Development In Camera-type Eye
Negative Regulation Of Signaling
Hair Follicle Placode Formation
Regulation Of Signal Transduction
Tongue Morphogenesis
Cellular Response To Stimulus
Positive Regulation Of Transcription, DNA-templated
Negative Regulation Of Transcription From RNA Polymerase II Promoter
Signal Transduction
Epithelial Cell Maturation
Notch Signaling Pathway
Negative Regulation Of Intracellular Signal Transduction
Regulation Of Signaling
Positive Regulation Of Cell Differentiation
Protein Metabolic Process
Positive Regulation Of Macromolecule Biosynthetic Process
Cellular Protein Modification Process
Signaling
Positive Regulation Of Gene Expression
Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia
Cell Communication
Circadian Rhythm
Positive Regulation Of Cellular Biosynthetic Process
Positive Regulation Of Metabolic Process
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Tongue Development
Epithelial Cell Differentiation
Positive Regulation Of Cellular Metabolic Process
Epithelium Development
Tagcloud
?
bomb
coimmunoprecipitation
collated
cytoskeleton
defines
depicts
dissect
evolutionarily
fate
fih
interacted
interesting
mib
mib2
mind
notch
protease
ran
screens
summarized
trabid
traf
ubiquitin
ubiquitylate
ubiquitylation
usp1
usp9
zebrafish
zranb1
Tagcloud (Difference)
?
bomb
coimmunoprecipitation
collated
cytoskeleton
defines
depicts
dissect
evolutionarily
fate
fih
interacted
interesting
mib
mib2
mind
notch
protease
ran
screens
summarized
trabid
traf
ubiquitin
ubiquitylate
ubiquitylation
usp1
usp9
zebrafish
zranb1
Tagcloud (Intersection)
?