FEM1B and TLE3

		FEM1B	TLE3
Description		fem-1 homolog B	TLE family member 3, transcriptional corepressor
Image			No pdb structure
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol Cul2-RING Ubiquitin Ligase Complex	Nucleus Nucleoplasm Transcription Regulator Complex Beta-catenin-TCF Complex
	Molecular Function	Death Receptor Binding Protein Binding Metal Ion Binding Ubiquitin-like Ligase-substrate Adaptor Activity	Transcription Corepressor Activity Protein Binding
	Biological Process	Epithelial Cell Maturation Apoptotic Process Protein Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Ubiquitin-protein Transferase Activity Branching Involved In Prostate Gland Morphogenesis Epithelial Cell Maturation Involved In Prostate Gland Development Ubiquitin-dependent Protein Catabolic Process Via The C-end Degron Rule Pathway Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of DNA Damage Checkpoint	Regulation Of DNA-templated Transcription Signal Transduction Animal Organ Morphogenesis Wnt Signaling Pathway Negative Regulation Of DNA-templated Transcription Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Cold-induced Thermogenesis
Pathways		Neddylation	Formation of the beta-catenin:TCF transactivating complex Deactivation of the beta-catenin transactivating complex Repression of WNT target genes Repression of WNT target genes Estrogen-dependent gene expression
Drugs
Diseases
GWAS		Hematocrit ( 32888494) Hemoglobin ( 32888494) Major depressive disorder ( 23377640) Systolic blood pressure ( 26969751)	Alcoholic chronic pancreatitis ( 28754779) Atrial fibrillation ( 29892015) Cognitive function ( 24684796) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) Heel bone mineral density ( 30598549 28869591) Height ( 20881960 31562340 28552196 25282103) Hip circumference adjusted for BMI ( 34021172) L-selectin levels ( 25576479) Lumbar spine bone mineral density (integral) ( 27476799) Lung adenocarcinoma ( 28604730) Macular thickness ( 30535121) Male-pattern baldness ( 27182965) Monocyte percentage of white cells ( 32888494) Non-albumin protein levels ( 29403010) Non-response to citalopram or escitalopram and depression ( 27622933) PR interval ( 32439900 30046033) Pulmonary function ( 23932459) Red blood cell count ( 32888494) Rheumatoid arthritis ( 23143596) Rheumatoid arthritis (ACPA-positive) ( 24532676 23143596) Schizophrenia ( 30285260 29483656 25056061) Serum total protein levels ( 29403010) Triglyceride levels ( 29403010 33339817) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for body mass index ( 28448500 34021172) White blood cell count ( 32888494)
Interacting Genes		9 interacting genes: APAF1 CDK5R1 FAS GLI1 KIAA0319 NKX3-1 PPM1F RAD9A SMCR8	17 interacting genes: APP CHERP CSTF2 FBXO7 FOXG1 H2AC1 H3C1 H4C1 HINFP KRTAP15-1 NDRG1 NOTCH1 PIN1 SIX1 SIX3 TCF4 USP47
Entrez ID		10116	7090
HPRD ID		16889	02558
Ensembl ID		ENSG00000169018	ENSG00000140332
Uniprot IDs		Q9UK73	B3KUA2 H0YL70 Q04726 Q6PRX3
PDB IDs		6LBF 7CNG 7EL6 8IJ1 8JE1 8JE2 8WQA 8WQB 8WQC 8WQD 8WQE 8WQF 8WQG 8WQH 8WQI
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Cysteine-type Endopeptidase Activator Activity Involved In Apoptotic Process Prostate Gland Development Regulation Of Apoptotic Signaling Pathway Signal Transduction Response To G1 DNA Damage Checkpoint Signaling Notochord Regression Positive Regulation Of Androgen Secretion MADS Box Domain Binding Positive Regulation Of Intrinsic Apoptotic Signaling Pathway Cellular Response To Xenobiotic Stimulus Regulation Of Apoptotic Process Apoptotic Signaling Pathway Regulation Of Programmed Cell Death Response To Oxygen Levels Apoptotic Process Dorsal Aorta Development Superior Olivary Nucleus Maturation Negative Regulation Of Axon Extension Involved In Regeneration Cell Death Programmed Cell Death Apoptosome Neuron Apoptotic Process Fas Signaling Pathway Ventral Midline Development Protein Kinase 5 Complex Protein Kinase Binding GLI-SUFU Complex Salivary Gland Development Cellular Response To Hyperoxia Negative Regulation Of Canonical Wnt Signaling Pathway Cerebellar Cortex Morphogenesis Epithelial Cell Proliferation Involved In Salivary Gland Morphogenesis Positive Regulation Of Intracellular Signal Transduction Histone Deacetylase Binding Checkpoint Clamp Complex Positive Regulation Of Organelle Organization G1 To G0 Transition Involved In Cell Differentiation Calmodulin-dependent Protein Phosphatase Activity Regulation Of Cellular Response To Stress Neuron Migration Regulation Of Intracellular Signal Transduction	Protein Heterodimerization Activity Regulation Of Neuron Differentiation Nucleus Regulation Of Cell Cycle Regulation Of Cell Cycle Phase Transition Axon Midline Choice Point Recognition Regulation Of Neuroblast Proliferation Regulation Of Cell Cycle Process Axon Choice Point Recognition Regulation Of Mitotic Cell Cycle Regulation Of Wnt Signaling Pathway Regulation Of Cardioblast Proliferation Establishment Of Protein Localization To Organelle Mitogen-activated Protein Kinase Kinase Binding Apoptotic Process Nucleoplasm Negative Regulation Of Neuron Differentiation Cell Death Programmed Cell Death Positive Regulation Of Transcription By RNA Polymerase II Protein Targeting Structural Constituent Of Chromatin Negative Regulation Of Cell Cycle Phase Transition Positive Regulation Of Neuron Differentiation Regulation Of Neural Precursor Cell Proliferation Regulation Of Cell Proliferation Involved In Heart Morphogenesis Regulation Of Canonical Wnt Signaling Pathway Cell Morphogenesis Involved In Neuron Differentiation Notch Signaling Pathway Prostate Gland Epithelium Morphogenesis Negative Regulation Of Cell Cycle Process Epithelial Cell Maturation Nucleosome Cellular Developmental Process Regulation Of Cell Differentiation Positive Regulation Of Neuroblast Proliferation Survivin Complex Negative Regulation Of DNA-templated Transcription Negative Regulation Of Cell Cycle Regulation Of Intracellular Signal Transduction Regulation Of Cell Population Proliferation Negative Regulation Of RNA Biosynthetic Process Amyloid-beta Complex Growth Cone Lamellipodium Positive Regulation Of RNA Biosynthetic Process DNA Binding Regulation Of Response To Calcium Ion Amylin Binding Cell Maturation Positive Regulation Of Toll Signaling Pathway
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