SRSF5 and TNK2

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
HPRD (two hybrid)

		SRSF5	TNK2
Gene Name		serine/arginine-rich splicing factor 5	tyrosine kinase, non-receptor, 2
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Nuclear Speck	Nucleus Cytoplasm Endosome Plasma Membrane Coated Pit Adherens Junction Membrane Clathrin-coated Vesicle Axon Dendrite Growth Cone Cytoplasmic Vesicle Membrane Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Neuronal Cell Body Grb2-EGFR Complex
	Molecular Function	Nucleotide Binding Protein Binding Poly(A) RNA Binding RS Domain Binding	Protein Serine/threonine Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity GTPase Inhibitor Activity Epidermal Growth Factor Receptor Binding Protein Binding ATP Binding Metal Ion Binding WW Domain Binding Hormone Receptor Binding
	Biological Process	MRNA Splicing, Via Spliceosome Transcription From RNA Polymerase II Promoter Termination Of RNA Polymerase II Transcription MRNA Splice Site Selection MRNA Processing MRNA Export From Nucleus RNA Splicing Response To Wounding Gene Expression MRNA 3'-end Processing Regulation Of Cell Cycle	Endocytosis Cell Surface Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Small GTPase Mediated Signal Transduction Phosphorylation Cell Migration Cell Differentiation Peptidyl-tyrosine Autophosphorylation Regulation Of Cell Proliferation Negative Regulation Of Catalytic Activity Innate Immune Response Positive Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Clathrin-mediated Endocytosis
Pathways		mRNA Splicing Processing of Capped Intron-Containing Pre-mRNA RNA Polymerase II Transcription Transport of Mature mRNA derived from an Intron-Containing Transcript mRNA Splicing - Major Pathway Transport of Mature Transcript to Cytoplasm Cleavage of Growing Transcript in the Termination Region RNA Polymerase II Transcription Termination mRNA 3'-end processing
Drugs			Adenosine triphosphate Debromohymenialdisine
Diseases
GWAS
Protein-Protein Interactions		16 interactors: CALM1 CD101 DYRK1A HIPK3 MAPK14 MAPK6 OLFM2 PPARGC1A RPS6KA1 SMURF1 SNRPF SREK1 SRPK1 SRPK2 SRSF1 TNK2	41 interactors: AQP1 AR ARSE BAG3 CDC42 CLTC CSPG4 CTTN EGFR FYN GALT GRB2 HCK HECW1 HSH2D HSP90AB2P ITFG2 KCNA5 KRTAP10-3 MAGI3 MCF2 MERTK NCK1 NEK6 NOTCH2NL NPHP1 RASGEF1C RASGRF1 RPL18A SEZ6 SH2D1A SIAH1 SMURF1 SNX9 SRC SRSF5 VTI1B WAS WWOX WWP2 YES1
Entrez ID		6430	10188
HPRD ID		02948	06104
Ensembl ID		ENSG00000100650	ENSG00000061938
Uniprot IDs		Q13243 Q86U32	B3KXJ4 C9J1X3 Q07912
PDB IDs			1CF4 1U46 1U4D 1U54 3EQP 3EQR 4EWH 4HZR 4HZS 4ID7
Enriched GO Terms of Interacting Partners?		RNA Splicing Regulation Of MRNA Splicing, Via Spliceosome MRNA Processing Regulation Of MRNA Processing Regulation Of RNA Splicing Protein Phosphorylation Phosphorylation MRNA Metabolic Process RNA Processing Innate Immune Response Regulation Of Cellular Protein Metabolic Process Phosphate-containing Compound Metabolic Process Regulation Of Protein Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Peptidyl-serine Phosphorylation Cellular Protein Modification Process Positive Regulation Of Viral Genome Replication Intracellular Signal Transduction Glucose Metabolic Process Immune Response Defense Response Posttranscriptional Regulation Of Gene Expression Ribonucleoprotein Complex Assembly Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Protein Modification Process Cellular Metabolic Process Termination Of RNA Polymerase II Transcription Hexose Metabolic Process Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Peptidyl-threonine Phosphorylation MAPK Cascade Negative Regulation Of Viral Genome Replication MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions RNA Metabolic Process Cellular Response To Growth Factor Stimulus Signal Transduction Monosaccharide Metabolic Process Regulation Of MRNA Stability Response To Growth Factor Toll-like Receptor 5 Signaling Pathway Positive Regulation Of Cellular Protein Metabolic Process Regulation Of RNA Stability Toll-like Receptor 10 Signaling Pathway Cellular Protein Metabolic Process Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Nuclear Speck Organization P38MAPK Cascade	Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Regulation Of Signaling Regulation Of Signal Transduction Phagocytosis Endocytosis Fc Receptor Signaling Pathway Signaling Positive Regulation Of Signal Transduction Cell Communication Immune Response-regulating Cell Surface Receptor Signaling Pathway Cell Differentiation Developmental Process Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Cellular Component Organization Neuron Development Positive Regulation Of Cellular Component Biogenesis Regulation Of Apoptotic Process Anatomical Structure Development Neuron Projection Development Locomotion Immune Response-regulating Signaling Pathway Cell Migration Regulation Of Cell Death Leukocyte Migration Regulation Of Cellular Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cell Motility Enzyme Linked Receptor Protein Signaling Pathway Response To Stimulus Neuron Differentiation T Cell Costimulation Cell Projection Organization Neurogenesis Axon Guidance Nervous System Development Vesicle-mediated Transport Positive Regulation Of Protein Complex Assembly Regulation Of Intracellular Signal Transduction Movement Of Cell Or Subcellular Component System Development Positive Regulation Of Intracellular Signal Transduction Peptidyl-tyrosine Autophosphorylation Generation Of Neurons Neuron Projection Morphogenesis Cellular Response To Platelet-derived Growth Factor Stimulus Multicellular Organismal Development Positive Regulation Of Immune Response Negative Regulation Of Signal Transduction
Tagcloud ?		a014418 antiapoptotic anxa7 ar bcl2 bmi1 deregulation downregulating downregulation escape factual glioblastoma glycogen gsk3 gsk3alpha gsk3beta hnrnp manzamine mcl1 posttreatment ptpb1 reflected splicing srsf1 tyr u373 u87 va xl	ack1 acquire addiction cdc42 demethylase deprivation deregulated doi explosion facets fuel functionality genotoxic hoxa1 insults jhdm2a kdm3a modifies onc publication reality rtk rtks shuttles soon transduce uncovered unfold wherein
Tagcloud (Difference) ?		a014418 antiapoptotic anxa7 ar bcl2 bmi1 deregulation downregulating downregulation escape factual glioblastoma glycogen gsk3 gsk3alpha gsk3beta hnrnp manzamine mcl1 posttreatment ptpb1 reflected splicing srsf1 tyr u373 u87 va xl	ack1 acquire addiction cdc42 demethylase deprivation deregulated doi explosion facets fuel functionality genotoxic hoxa1 insults jhdm2a kdm3a modifies onc publication reality rtk rtks shuttles soon transduce uncovered unfold wherein
Tagcloud (Intersection) ?