SRSF5 and RPS6KA1

Number of citations of the paper that reports this interaction (PMID 21900206)
27

Data Source:
BioGRID (two hybrid)

		SRSF5	RPS6KA1
Gene Name		serine/arginine-rich splicing factor 5	ribosomal protein S6 kinase, 90kDa, polypeptide 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Nuclear Speck	Nucleus Nucleoplasm Cytoplasm Spindle Cytosol
	Molecular Function	Nucleotide Binding Protein Binding Poly(A) RNA Binding RS Domain Binding	Magnesium Ion Binding Protein Serine/threonine Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Binding ATP Binding Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process
	Biological Process	MRNA Splicing, Via Spliceosome Transcription From RNA Polymerase II Promoter Termination Of RNA Polymerase II Transcription MRNA Splice Site Selection MRNA Processing MRNA Export From Nucleus RNA Splicing Response To Wounding Gene Expression MRNA 3'-end Processing Regulation Of Cell Cycle	Toll-like Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Protein Phosphorylation Cell Cycle Signal Transduction Synaptic Transmission Axon Guidance Positive Regulation Of Cell Growth Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Toll-like Receptor 10 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Negative Regulation Of Apoptotic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Translation In Response To Stress Regulation Of DNA-templated Transcription In Response To Stress Innate Immune Response Positive Regulation Of Cell Differentiation Positive Regulation Of Transcription From RNA Polymerase II Promoter Neurotrophin TRK Receptor Signaling Pathway Stress-activated MAPK Cascade Positive Regulation Of Hepatic Stellate Cell Activation
Pathways		mRNA Splicing Processing of Capped Intron-Containing Pre-mRNA RNA Polymerase II Transcription Transport of Mature mRNA derived from an Intron-Containing Transcript mRNA Splicing - Major Pathway Transport of Mature Transcript to Cytoplasm Cleavage of Growing Transcript in the Termination Region RNA Polymerase II Transcription Termination mRNA 3'-end processing	Signaling by GPCR CREB phosphorylation Axon guidance Toll Like Receptor 7/8 (TLR7/8) Cascade Cellular Senescence CREB phosphorylation L1CAM interactions Recycling pathway of L1 CREB phosphorylation through the activation of Ras Toll Like Receptor TLR6:TLR2 Cascade Toll Like Receptor TLR1:TLR2 Cascade Activated TLR4 signalling MyD88 cascade initiated on plasma membrane Toll Like Receptor 5 (TLR5) Cascade Gastrin-CREB signalling pathway via PKC and MAPK RSK activation Activation of NMDA receptor upon glutamate binding and postsynaptic events MyD88 dependent cascade initiated on endosome TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation MyD88:Mal cascade initiated on plasma membrane Toll Like Receptor 9 (TLR9) Cascade Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell ERK/MAPK targets Post NMDA receptor activation events Innate Immune System Signalling by NGF MAP kinase activation in TLR cascade TRIF-mediated TLR3/TLR4 signaling Senescence-Associated Secretory Phenotype (SASP) NGF signalling via TRKA from the plasma membrane MyD88-independent cascade Toll Like Receptor 2 (TLR2) Cascade Toll-Like Receptors Cascades Toll Like Receptor 10 (TLR10) Cascade Toll Like Receptor 4 (TLR4) Cascade ERK/MAPK targets Toll Like Receptor 3 (TLR3) Cascade MAPK targets/ Nuclear events mediated by MAP kinases Transmission across Chemical Synapses Nuclear Events (kinase and transcription factor activation)
Drugs
Diseases
GWAS
Protein-Protein Interactions		16 interactors: CALM1 CD101 DYRK1A HIPK3 MAPK14 MAPK6 OLFM2 PPARGC1A RPS6KA1 SMURF1 SNRPF SREK1 SRPK1 SRPK2 SRSF1 TNK2	51 interactors: ATXN3 BAD CARHSP1 CCT4 CDKN1B CEBPB CFL1 CREB1 CREBBP DDAH2 DLC1 EEF1D EEF2K ESR1 ETV1 FGFR1 FOS GBP2 GMFB GRB2 GSK3B L1CAM MAGI1 MAPK1 MAPK3 MAPT METTL1 MITF MPP1 MTOR MXD1 NFKBIA NR4A1 NR4A2 NR4A3 PDCD4 PDPK1 PHAX POLDIP3 PPM1G PPP1R3A RPTOR SRF SRSF5 SYK TOB2 TSC2 TTK VCP YBX1 YWHAB
Entrez ID		6430	6195
HPRD ID		02948	03402
Ensembl ID		ENSG00000100650	ENSG00000117676
Uniprot IDs		Q13243 Q86U32	E9PRI4 Q15418
PDB IDs			2WNT 2Z7Q 2Z7R 2Z7S 3RNY 3TEI 4H3P
Enriched GO Terms of Interacting Partners?		RNA Splicing Regulation Of MRNA Splicing, Via Spliceosome MRNA Processing Regulation Of MRNA Processing Regulation Of RNA Splicing Protein Phosphorylation Phosphorylation MRNA Metabolic Process RNA Processing Innate Immune Response Regulation Of Cellular Protein Metabolic Process Phosphate-containing Compound Metabolic Process Regulation Of Protein Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Peptidyl-serine Phosphorylation Cellular Protein Modification Process Positive Regulation Of Viral Genome Replication Intracellular Signal Transduction Glucose Metabolic Process Immune Response Defense Response Posttranscriptional Regulation Of Gene Expression Ribonucleoprotein Complex Assembly Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Protein Modification Process Cellular Metabolic Process Termination Of RNA Polymerase II Transcription Hexose Metabolic Process Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Peptidyl-threonine Phosphorylation MAPK Cascade Negative Regulation Of Viral Genome Replication MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions RNA Metabolic Process Cellular Response To Growth Factor Stimulus Signal Transduction Monosaccharide Metabolic Process Regulation Of MRNA Stability Response To Growth Factor Toll-like Receptor 5 Signaling Pathway Positive Regulation Of Cellular Protein Metabolic Process Regulation Of RNA Stability Toll-like Receptor 10 Signaling Pathway Cellular Protein Metabolic Process Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Nuclear Speck Organization P38MAPK Cascade	Fc Receptor Signaling Pathway Fc-epsilon Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Cellular Metabolic Process Fibroblast Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Neurotrophin Signaling Pathway Immune Response-regulating Signaling Pathway Cellular Response To Fibroblast Growth Factor Stimulus Innate Immune Response Response To Fibroblast Growth Factor Response To Organonitrogen Compound Cellular Response To Organic Substance Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Metabolic Process Response To Organic Substance Enzyme Linked Receptor Protein Signaling Pathway Response To Hormone Cellular Response To Growth Factor Stimulus Regulation Of Immune System Process Immune Response Response To Growth Factor Regulation Of Immune Response Defense Response Positive Regulation Of Cellular Biosynthetic Process Response To Abiotic Stimulus Phosphatidylinositol-mediated Signaling Response To External Stimulus Cellular Response To Hormone Stimulus Regulation Of Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Insulin Receptor Signaling Pathway Response To Peptide Cellular Response To Heat Immune System Process Cell Communication Regulation Of Phosphorylation Response To Temperature Stimulus Response To Peptide Hormone Positive Regulation Of Transcription, DNA-templated Signal Transduction Signaling Positive Regulation Of Gene Expression Response To Stress Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Chemotaxis Cellular Response To Insulin Stimulus
Tagcloud ?		a014418 antiapoptotic anxa7 ar bcl2 bmi1 deregulation downregulating downregulation escape factual glioblastoma glycogen gsk3 gsk3alpha gsk3beta hnrnp manzamine mcl1 posttreatment ptpb1 reflected splicing srsf1 tyr u373 u87 va xl	alkenes azotic constructions gnai1 gnao1 heterocycle hm hms htr1b htr2a htr2b htr4 htr6 htr7 kpnb1 pharmacopeia prkaca prkca prkcb prkcd prkce prkcg prkd1 propertied pubchem rock2 tlr8 tradition
Tagcloud (Difference) ?		a014418 antiapoptotic anxa7 ar bcl2 bmi1 deregulation downregulating downregulation escape factual glioblastoma glycogen gsk3 gsk3alpha gsk3beta hnrnp manzamine mcl1 posttreatment ptpb1 reflected splicing srsf1 tyr u373 u87 va xl	alkenes azotic constructions gnai1 gnao1 heterocycle hm hms htr1b htr2a htr2b htr4 htr6 htr7 kpnb1 pharmacopeia prkaca prkca prkcb prkcd prkce prkcg prkd1 propertied pubchem rock2 tlr8 tradition
Tagcloud (Intersection) ?