SRSF5 and RPS6KA1

Number of citations of the paper that reports this interaction (PubMedID 21900206)
0

Data Source:
BioGRID (two hybrid)

		SRSF5	RPS6KA1
Description		serine and arginine rich splicing factor 5	ribosomal protein S6 kinase A1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytosol Nuclear Speck	Nucleus Nucleoplasm Cytoplasm Cytosol Synapse
	Molecular Function	Nucleic Acid Binding RNA Binding MRNA Binding Protein Binding Protein Kinase B Binding	Nucleotide Binding Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Ribosomal Protein S6 Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Metal Ion Binding Protein Serine Kinase Activity
	Biological Process	RNA Splicing, Via Transesterification Reactions Regulation Of Alternative MRNA Splicing, Via Spliceosome Liver Development MRNA Splice Site Recognition MRNA Processing RNA Splicing Response To Insulin Cellular Response To Insulin Stimulus Positive Regulation Of RNA Splicing Liver Regeneration	Protein Phosphorylation Signal Transduction Chemical Synaptic Transmission Positive Regulation Of Cell Growth Negative Regulation Of TOR Signaling Intracellular Signal Transduction TORC1 Signaling Negative Regulation Of Apoptotic Process Regulation Of Translation In Response To Stress Positive Regulation Of Cell Differentiation Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Hepatocyte Proliferation Positive Regulation Of Hepatic Stellate Cell Activation
Pathways		Transport of Mature mRNA derived from an Intron-Containing Transcript mRNA Splicing - Major Pathway mRNA 3'-end processing Processing of Capped Intron-Containing Pre-mRNA RNA Polymerase II Transcription Termination	ERK/MAPK targets CREB phosphorylation Senescence-Associated Secretory Phenotype (SASP) Senescence-Associated Secretory Phenotype (SASP) Recycling pathway of L1 CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling RSK activation RSK activation Gastrin-CREB signalling pathway via PKC and MAPK Transcriptional and post-translational regulation of MITF-M expression and activity
Drugs			Purvalanol A Fostamatinib
Diseases
GWAS		Mean spheric corpuscular volume ( 32888494) Red blood cell count ( 32888494)	Amyotrophic lateral sclerosis (sporadic) ( 24529757) Fasting plasma glucose ( 31932636) Glucose homeostasis traits ( 25524916) Lymphocyte count ( 32888494) Mean corpuscular volume ( 27863252) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Rosacea symptom severity ( 29771307) Triglyceride levels ( 30108155) White blood cell count ( 32888494)
Interacting Genes		19 interacting genes: CALM1 CCR2 CD101 DYRK1A HIPK3 MAPK14 MAPK6 OLFM2 PPARGC1A RPS6KA1 SMURF1 SNRPF SREK1 SRPK1 SRSF1 TIAM1 TMEM132D TNK2 ZRSR2	88 interacting genes: ARHGEF11 ARHGEF12 ATM ATXN3 BAD CARHSP1 CCT4 CDKN1B CEBPB CFL1 CREB1 CREBBP DDAH2 DEPTOR DLC1 DLG4 EEF1D EEF2K ERBIN ESR1 ETV1 FGFR1 FOS GBP2 GMFB GOPC GORASP1 GORASP2 GRB2 GRID2IP GSK3B HTRA1 L1CAM LIMK2 LNX1 MAGI1 MAGI2 MAGI3 MAPK1 MAPK3 MAPT MAST1 MAST2 METTL1 MITF MPP1 MTOR MXD1 NFKBIA NHERF2 NR4A1 NR4A2 NR4A3 PARD3B PDCD4 PDPK1 PDZD7 PDZK1 PDZRN3 PDZRN4 PHAX POLDIP3 PPM1G PPP1R3A PPP1R9A PTPN3 RPTOR SHANK3 SHROOM2 SNTA1 SNTB1 SNTG2 SNX27 SRF SRSF5 STAT3 SYK SYNJ2BP TAMALIN TOB2 TP53 TSC2 TTK UBE2T VCP WHRN YBX1 YWHAB
Entrez ID		6430	6195
HPRD ID		02948	03402
Ensembl ID		ENSG00000100650	ENSG00000117676
Uniprot IDs		B4DUA4 Q13243 Q86U32	Q15418
PDB IDs			2WNT 2Z7Q 2Z7R 2Z7S 3RNY 3TEI 4H3P 4NIF 5CSF 5CSI 5CSJ 5CSN 5N7D 5N7F 5N7G 5V61 5V62 6TWY 7P74 7PC8 7QQL 8WF4 8XOV
Enriched GO Terms of Interacting Partners?		Protein Serine Kinase Activity Protein Serine/threonine Kinase Activity Protein Kinase Activity Kinase Activity Phosphorylation RNA Splicing MRNA Metabolic Process Nucleoplasm Protein Serine/threonine/tyrosine Kinase Activity MRNA Processing Spliceosomal Complex Assembly Protein Phosphorylation Spliceosomal Complex RNA Metabolic Process Protein-RNA Complex Assembly Nuclear Speck Nucleic Acid Metabolic Process MAP Kinase Activity Response To Dietary Excess Negative Regulation Of MRNA Metabolic Process Intracellular Signaling Cassette Protein-containing Complex Assembly Regulation Of MRNA Splicing, Via Spliceosome RNA Processing Positive Regulation Of Cell Differentiation Transferase Activity Intracellular Signal Transduction Positive Regulation Of Developmental Process Protein Tyrosine Kinase Activity U12-type Spliceosomal Complex Regulation Of MRNA Metabolic Process Regulation Of MRNA Processing Signal Transduction ATP Binding Protein-containing Complex Organization Wnt Signaling Pathway, Planar Cell Polarity Pathway Cell Surface Receptor Signaling Pathway Nucleobase-containing Compound Metabolic Process Cytoplasm Cellular Response To Cytokine Stimulus Regulation Of Cell Differentiation Regulation Of RNA Splicing Positive Regulation Of RNA Splicing Non-membrane Spanning Protein Tyrosine Kinase Activity Histone H3T45 Kinase Activity Engulfment Of Target By Autophagosome Negative Regulation Of Eosinophil Degranulation Positive Regulation Of Astrocyte Chemotaxis T-helper 17 Cell Chemotaxis Chemokine (C-C Motif) Ligand 12 Binding	Intracellular Signal Transduction Signal Transduction Intracellular Signaling Cassette Cytoplasm Phosphatase Binding Regulation Of Cell Development Positive Regulation Of Cellular Component Organization Cellular Response To Oxygen-containing Compound Regulation Of Cellular Component Organization Nuclear Glucocorticoid Receptor Binding Regulation Of Cell Population Proliferation Regulation Of Cell Differentiation Regulation Of Cellular Response To Heat Positive Regulation Of Protein-containing Complex Assembly Cellular Response To Nutrient Levels TOR Signaling Negative Regulation Of Signaling Negative Regulation Of Cell Communication Phosphorylation Regulation Of Signaling Regulation Of Cell Communication Negative Regulation Of TOR Signaling Regulation Of Multicellular Organismal Process Cellular Response To Hormone Stimulus Cellular Response To Peptide Hormone Stimulus Protein Phosphorylation Cellular Response To Stress TORC1 Signaling Regulation Of TORC1 Signaling Negative Regulation Of TORC1 Signaling Developmental Process Negative Regulation Of Signal Transduction Regulation Of Osteoclast Differentiation Response To Peptide Hormone Regulation Of Multicellular Organismal Development Negative Regulation Of Autophagy Response To Decreased Oxygen Levels Regulation Of TOR Signaling Negative Regulation Of Catabolic Process Intracellular Protein Localization Negative Regulation Of Intracellular Signal Transduction Regulation Of Signal Transduction Organelle Organization Response To Oxygen Levels Regulation Of Developmental Process PDZ Domain Binding Response To Nutrient Levels Cellular Response To Cytokine Stimulus Regulation Of Apoptotic Process Regulation Of Intracellular Signal Transduction
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