CTDSP2 and PTK7

Number of citations of the paper that reports this interaction (PubMedID 28065597)
51

Data Source:
BioGRID (two hybrid)

		CTDSP2	PTK7
Description		CTD small phosphatase 2	protein tyrosine kinase 7 (inactive)
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm	Cytosol Plasma Membrane Cell-cell Junction Focal Adhesion Membrane Axon Neuronal Cell Body Anchoring Junction
	Molecular Function	Phosphoprotein Phosphatase Activity Protein Serine/threonine Phosphatase Activity Protein Binding RNA Polymerase II CTD Heptapeptide Repeat Phosphatase Activity Hydrolase Activity Phosphatase Activity Metal Ion Binding	Protein Kinase Activity Protein Binding ATP Binding Axon Guidance Receptor Activity Coreceptor Activity
	Biological Process	Regulation Of Transcription By RNA Polymerase II Protein Dephosphorylation Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle	Establishment Of Planar Polarity Kidney Development Neural Tube Closure Ventricular Septum Development Axis Elongation Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Signal Transduction Axon Guidance Heart Development Positive Regulation Of Neuron Projection Development Wnt Signaling Pathway Cell Migration Actin Cytoskeleton Organization Wound Healing Establishment Of Epithelial Cell Apical/basal Polarity Synapse Organization Convergent Extension Lung-associated Mesenchyme Development Regulation Of Canonical Wnt Signaling Pathway Coronary Vasculature Development Cellular Response To Retinoic Acid Cochlea Morphogenesis Positive Regulation Of Canonical Wnt Signaling Pathway
Pathways		XBP1(S) activates chaperone genes
Drugs
Diseases
GWAS		Height ( 31562340) Hematocrit ( 32888494) Metabolite levels ( 23823483) Refractive error ( 32231278) Trochanter size ( 31053729)	Coronary artery disease ( 29212778)
Interacting Genes		13 interacting genes: AKT1 AR CDCA3 CSF1R EPHA1 EPHA3 INSRR LCN2 N4BP3 POLR2A PTK7 SNAI1 TYRO3	41 interacting genes: CDC14A CLNK CTDSP2 CYSRT1 DUSP10 DUSP14 DUSP15 DUSP18 DUSP19 DUSP21 DUSP26 DUSP29 ERBB2 ILKAP KRTAP1-1 KRTAP1-3 KRTAP10-8 KRTAP5-9 MDFI MTMR1 MTMR10 MTMR6 MTMR9 MTUS2 NBPF19 NOTCH2NLA PPM1A PPM1B PPM1F PPM1K PPP3CA PPP3CB PTEN PTPN11 PTPN12 PTPN6 PTPN7 PTPRR STYX TPTE TPTE2
Entrez ID		10106	5754
HPRD ID		12281	03534
Ensembl ID		ENSG00000175215	ENSG00000112655
Uniprot IDs		O14595	Q13308
PDB IDs		2Q5E	6VG3
Enriched GO Terms of Interacting Partners?		Transmembrane Receptor Protein Tyrosine Kinase Activity Protein Kinase Activity Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Protein Tyrosine Kinase Activity Kinase Activity Enzyme-linked Receptor Protein Signaling Pathway Cell Surface Receptor Signaling Pathway Cellular Response To Lipid ATP Binding Receptor Complex Transferase Activity Response To Lipid Negative Regulation Of Apoptotic Process Cellular Response To Oxygen-containing Compound Cell Migration Cellular Response To Ether Signal Transduction Negative Regulation Of Programmed Cell Death Positive Regulation Of Cell Migration Male Sex Determination Ephrin Receptor Activity Transmembrane-ephrin Receptor Activity Positive Regulation Of Cell Motility Kinase Binding Positive Regulation Of Locomotion Phosphatidylinositol 3-kinase Binding Cell Motility Regulation Of Protein Localization To Plasma Membrane Protein Autophosphorylation Protein Phosphorylation Response To Ether Negative Regulation Of Toll-like Receptor Signaling Pathway Sex Determination Positive Regulation Of Cellular Component Organization Positive Regulation Of Cell Projection Organization Nucleotide Binding Phosphorylation Regulation Of Cellular Component Organization Regulation Of Protein Localization To Cell Periphery Tissue Morphogenesis Cellular Response To Cytokine Stimulus Insulin-like Growth Factor Receptor Signaling Pathway Negative Regulation Of Neuron Apoptotic Process Regulation Of Protein Localization To Membrane Positive Regulation Of Morphogenesis Of An Epithelium Regulation Of Toll-like Receptor Signaling Pathway Developmental Process Involved In Reproduction Regulation Of Apoptotic Process Cellular Response To Nerve Growth Factor Stimulus Response To Nerve Growth Factor	Phosphoprotein Phosphatase Activity Dephosphorylation Protein Serine/threonine Phosphatase Activity Protein Dephosphorylation Protein Tyrosine Phosphatase Activity Hydrolase Activity Phosphate-containing Compound Metabolic Process Phosphatase Activity Protein Tyrosine/serine/threonine Phosphatase Activity Calmodulin-dependent Protein Phosphatase Activity Cation Binding Peptidyl-tyrosine Dephosphorylation Non-membrane Spanning Protein Tyrosine Phosphatase Activity MAP Kinase Tyrosine/serine/threonine Phosphatase Activity Regulation Of ERK1 And ERK2 Cascade Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase Activity Protein Modification Process MAP Kinase Phosphatase Activity Phosphatidylinositol Dephosphorylation Regulation Of MAPK Cascade Cytoplasm Phospholipid Dephosphorylation Regulation Of Intracellular Signal Transduction Phosphatidylinositol-3-phosphate Phosphatase Activity Phosphatidylinositol-3,4-bisphosphate 3-phosphatase Activity Negative Regulation Of MAPK Cascade Negative Regulation Of Epithelial Cell Migration Cytosol Phosphatidylinositol Metabolic Process N-terminal Protein Myristoylation Regulation Of Epithelial Cell Migration Negative Regulation Of T Cell Proliferation Negative Regulation Of Signaling Phosphatidylinositol Phosphate Phosphatase Activity Negative Regulation Of ERK1 And ERK2 Cascade Regulation Of Phosphatidylinositol Dephosphorylation Regulation Of Mononuclear Cell Proliferation Regulation Of Cell Adhesion Regulation Of Cell-cell Adhesion Negative Regulation Of Calcium Ion Import Across Plasma Membrane Calcineurin Complex Regulation Of Lymphocyte Activation Protein Metabolic Process Negative Regulation Of Lymphocyte Proliferation Regulation Of Leukocyte Proliferation Negative Regulation Of Lymphocyte Activation Negative Regulation Of Mononuclear Cell Proliferation Negative Regulation Of Neutrophil Activation Negative Regulation Of Developmental Growth Regulation Of Oligodendrocyte Differentiation
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