CTDSP2 and POLR2A

Number of citations of the paper that reports this interaction (PMID 12721286)
49

Data Source:
BioGRID (enzymatic study)

		CTDSP2	POLR2A
Gene Name		CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 2	polymerase (RNA) II (DNA directed) polypeptide A, 220kDa
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Gene Ontology Annotations	Cellular Component	Nucleoplasm	Prp19 Complex Nucleus Nucleoplasm DNA-directed RNA Polymerase II, Core Complex Nucleolus
	Molecular Function	Protein Binding CTD Phosphatase Activity Metal Ion Binding	RNA Polymerase II Activity DNA Binding DNA-directed RNA Polymerase Activity RNA-directed RNA Polymerase Activity Protein Binding Ubiquitin Protein Ligase Binding Poly(A) RNA Binding Metal Ion Binding
	Biological Process	Negative Regulation Of Protein Phosphorylation Protein Dephosphorylation Activation Of Signaling Protein Activity Involved In Unfolded Protein Response Endoplasmic Reticulum Unfolded Protein Response Cellular Protein Metabolic Process Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle	MRNA Splicing, Via Spliceosome Transcription, RNA-templated DNA Repair Transcription-coupled Nucleotide-excision Repair Nucleotide-excision Repair Regulation Of Transcription, DNA-templated Transcription From RNA Polymerase II Promoter Transcription Initiation From RNA Polymerase II Promoter Transcription Elongation From RNA Polymerase II Promoter 7-methylguanosine MRNA Capping RNA Splicing Gene Expression Viral Process Positive Regulation Of RNA Splicing PiRNA Metabolic Process Somatic Stem Cell Maintenance Positive Regulation Of Viral Transcription
Pathways		IRE1alpha activates chaperones XBP1(S) activates chaperone genes Unfolded Protein Response (UPR)	RNA Polymerase II Promoter Escape mRNA Splicing Formation of HIV-1 elongation complex containing HIV-1 Tat PIWI-interacting RNA (piRNA) biogenesis Nucleotide Excision Repair RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA Polymerase II Transcription Abortive elongation of HIV-1 transcript in the absence of Tat HIV Infection Regulatory RNA pathways Formation of the Early Elongation Complex Tat-mediated elongation of the HIV-1 transcript Tat-mediated HIV elongation arrest and recovery Formation of transcription-coupled NER (TC-NER) repair complex RNA Pol II CTD phosphorylation and interaction with CE RNA Polymerase II Pre-transcription Events Dual incision reaction in TC-NER Influenza Life Cycle HIV elongation arrest and recovery HIV Life Cycle HIV Transcription Initiation Influenza Viral RNA Transcription and Replication RNA Pol II CTD phosphorylation and interaction with CE Transcriptional regulation of pluripotent stem cells RNA Polymerase II HIV Promoter Escape HIV Transcription Elongation POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation Transcriptional regulation by small RNAs Processing of Capped Intron-Containing Pre-mRNA mRNA Capping mRNA Splicing - Minor Pathway mRNA Splicing - Major Pathway MicroRNA (miRNA) biogenesis Influenza Infection Pausing and recovery of Tat-mediated HIV elongation Late Phase of HIV Life Cycle Formation of RNA Pol II elongation complex RNA Polymerase II Transcription Initiation And Promoter Clearance Pausing and recovery of HIV elongation Formation of HIV elongation complex in the absence of HIV Tat Transcription-coupled NER (TC-NER) Viral Messenger RNA Synthesis Formation of the HIV-1 Early Elongation Complex RNA Polymerase II Transcription Initiation Transcription of the HIV genome RNA Polymerase II Transcription Elongation
Drugs
Diseases
GWAS
Protein-Protein Interactions		4 interactors: AR CDCA3 POLR2A SNAI1	100 interactors: ABL1 ACTB ACTL6A ATM BARD1 BRCA1 CASP10 CCNH CCNK CCNL2 CCNT1 CDC14A CDK12 CDK7 CDK8 CDK9 CPSF1 CPSF2 CPSF3 CREBBP CSH2 CSNK2A1 CSTF1 CSTF2 CTCF CTD CTDP1 CTDSP1 CTDSP2 DHX9 ELL ERCC5 ERCC6 ERG FCP1 FUS GRB2 GTF2B GTF2E1 GTF2H4 HIST1H1C HNRNPF HNRNPU HTATSF1 ITCH IWS1 KAT2B KLK2 KMT2D LEO1 MCM3 MED21 MNAT1 MYC NEDD4 NELFA NONO NR0B2 PCIF1 PHF8 PIN1 POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2K POLR2L PPIG PPP1CA PQBP1 PRPF19 RECQL5 SAFB SETD2 SMN1 SMN2 SMURF1 SND1 SUB1 SUPT5H TAF10 TBP TCEA1 TCEB3 TCERG1 TRAK1 TRAM2 U2AF2 UBC UBE2L3 UPF1 WAC WWP2 XAB2 XRCC5 ZNF74
Entrez ID		10106	5430
HPRD ID		12281	08916
Ensembl ID		ENSG00000175215	ENSG00000181222
Uniprot IDs		O14595	P24928
PDB IDs		2Q5E	2GHQ 2GHT 2LTO 3D9K 3D9L 3D9M 3D9N 3D9O 3D9P
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Cell Differentiation Involved In Embryonic Placenta Development Negative Regulation Of Integrin Biosynthetic Process Transcription From RNA Polymerase II Promoter Transcription Initiation From RNA Polymerase II Promoter Transcription, RNA-templated Positive Regulation Of Integrin Biosynthetic Process DNA-templated Transcription, Initiation Regulation Of Integrin Biosynthetic Process Stem Cell Development Negative Regulation Of Apoptotic Signaling Pathway Negative Regulation Of Vitamin D Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Stem Cell Differentiation Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Notch Signaling Involved In Heart Development Positive Regulation Of Transcription From RNA Polymerase III Promoter Regulation Of Tight Junction Assembly Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Regulation Of Vitamin Metabolic Process Reproductive Structure Development Reproductive System Development Cartilage Morphogenesis Transcription, DNA-templated Trophoblast Giant Cell Differentiation Left/right Pattern Formation Regulation Of Transcription From RNA Polymerase III Promoter RNA Biosynthetic Process Negative Regulation Of Steroid Biosynthetic Process Negative Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of Steroid Metabolic Process Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Embryonic Development 7-methylguanosine MRNA Capping Developmental Process Involved In Reproduction PiRNA Metabolic Process Negative Regulation Of Cell Differentiation Positive Regulation Of Epithelial To Mesenchymal Transition Cell Differentiation Involved In Embryonic Placenta Development Hair Follicle Morphogenesis Positive Regulation Of RNA Splicing Androgen Receptor Signaling Pathway 7-methylguanosine RNA Capping Transcription-coupled Nucleotide-excision Repair Regulation Of Establishment Of Protein Localization To Plasma Membrane Epidermis Morphogenesis Negative Regulation Of Lipid Biosynthetic Process Regulation Of Signal Transduction By P53 Class Mediator	Transcription Elongation From RNA Polymerase II Promoter DNA-templated Transcription, Elongation RNA Metabolic Process Positive Regulation Of Viral Transcription Gene Expression Nucleobase-containing Compound Metabolic Process Transcription, DNA-templated Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process RNA Biosynthetic Process Transcription From RNA Polymerase II Promoter Cellular Nitrogen Compound Metabolic Process Regulation Of Viral Transcription Positive Regulation Of Viral Process Nitrogen Compound Metabolic Process Macromolecule Biosynthetic Process Viral Process MRNA Processing Cellular Macromolecule Biosynthetic Process RNA Processing MRNA Metabolic Process Transcription Initiation From RNA Polymerase II Promoter Regulation Of Gene Expression Transcription-coupled Nucleotide-excision Repair Regulation Of RNA Metabolic Process DNA-templated Transcription, Initiation RNA Splicing Biosynthetic Process Regulation Of Viral Process Regulation Of Nitrogen Compound Metabolic Process MRNA Splicing, Via Spliceosome Cellular Metabolic Process RNA Splicing, Via Transesterification Reactions 7-methylguanosine MRNA Capping Regulation Of RNA Biosynthetic Process 7-methylguanosine RNA Capping Cellular Response To DNA Damage Stimulus DNA Repair Nucleotide-excision Repair Regulation Of Metabolic Process Positive Regulation Of Gene Expression DNA-templated Transcription, Termination DNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Cellular Response To Stress Transcription From RNA Polymerase I Promoter Positive Regulation Of Cellular Biosynthetic Process Metabolic Process Transcription Elongation From RNA Polymerase I Promoter Transcription Initiation From RNA Polymerase I Promoter
Tagcloud ?			actb appropriately benchmark chosen confounding gapdh hormonal hprt1 hyperglycemia hyperglycemic lean myocardium normalization normalized obesity ppia predisposition reference reproducibility rpl13a scrutiny sdha select stably tbp tfrc underline ywhag zucker
Tagcloud (Difference) ?			actb appropriately benchmark chosen confounding gapdh hormonal hprt1 hyperglycemia hyperglycemic lean myocardium normalization normalized obesity ppia predisposition reference reproducibility rpl13a scrutiny sdha select stably tbp tfrc underline ywhag zucker
Tagcloud (Intersection) ?