CTDSP2 and EPHA3

Number of citations of the paper that reports this interaction (PubMedID 28065597)
51

Data Source:
BioGRID (two hybrid)

		CTDSP2	EPHA3
Description		CTD small phosphatase 2	EPH receptor A3
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm	Extracellular Region Nucleoplasm Early Endosome Cytosol Plasma Membrane Actin Cytoskeleton Membrane Dendrite Nuclear Membrane
	Molecular Function	Phosphoprotein Phosphatase Activity Protein Serine/threonine Phosphatase Activity Protein Binding RNA Polymerase II CTD Heptapeptide Repeat Phosphatase Activity Hydrolase Activity Phosphatase Activity Metal Ion Binding	Nucleotide Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Ephrin Receptor Activity GPI-linked Ephrin Receptor Activity Transmembrane-ephrin Receptor Activity Protein Binding ATP Binding Kinase Activity Transferase Activity
	Biological Process	Regulation Of Transcription By RNA Polymerase II Protein Dephosphorylation Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle	Cell Adhesion Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Axon Guidance Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Neuron Projection Development Cell Migration Peptidyl-tyrosine Phosphorylation Regulation Of Actin Cytoskeleton Organization Regulation Of GTPase Activity Negative Regulation Of Endocytosis Ephrin Receptor Signaling Pathway Regulation Of Focal Adhesion Assembly Regulation Of Microtubule Cytoskeleton Organization Cellular Response To Retinoic Acid Fasciculation Of Sensory Neuron Axon Fasciculation Of Motor Neuron Axon Positive Regulation Of Protein Localization To Plasma Membrane
Pathways		XBP1(S) activates chaperone genes	EPH-Ephrin signaling EPH-Ephrin signaling EPHA-mediated growth cone collapse EPHA-mediated growth cone collapse EPH-ephrin mediated repulsion of cells EPH-ephrin mediated repulsion of cells
Drugs			Fostamatinib
Diseases
GWAS		Height ( 31562340) Hematocrit ( 32888494) Metabolite levels ( 23823483) Refractive error ( 32231278) Trochanter size ( 31053729)	Adult body size ( 32376654) Atrial fibrillation ( 30061737 29892015) BMI (adjusted for smoking behaviour) ( 28443625) BMI in non-smokers ( 28443625) Body mass index (joint analysis main effects and smoking interaction) ( 28443625) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Caffeine consumption from tea ( 33287642) Cortical surface area (MOSTest) ( 32665545) Diastolic blood pressure ( 27841878) Language functional connectivity ( 34929384) Lateral thalamic nuclei volume ( 34006833) Loneliness (multivariate analysis) ( 27629369) Lung function (FVC) ( 26635082) Orofacial clefts ( 22863734) Periodontitis (Mean PAL) ( 24024966) Post-bronchodilator FEV1 x air pollution (NO2) interaction in childhood asthma ( 31028280) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Systemic lupus erythematosus ( 28714469) Systolic blood pressure ( 27841878) Tea consumption ( 31046077) Thrombosis ( 26908601) Ventral thalamic nuclei volume ( 34006833) Vertical cup-disc ratio (multi-trait analysis) ( 31959993) Weight ( 34074324)
Interacting Genes		13 interacting genes: AKT1 AR CDCA3 CSF1R EPHA1 EPHA3 INSRR LCN2 N4BP3 POLR2A PTK7 SNAI1 TYRO3	30 interacting genes: ABL1 ADAM10 CDKN2A CRK CTDSP2 DUSP18 DUSP21 EFNA1 EFNA2 EFNA3 EFNA4 EFNA5 EFNB1 EFNB2 ERBB2 FBXO7 FYN ILKAP MTMR11 PIM1 RBM18 RNF5 RUFY1 RUFY2 SRC SRPK1 STAT3 STYX TP53 TPTE
Entrez ID		10106	2042
HPRD ID		12281	01555
Ensembl ID		ENSG00000175215	ENSG00000044524
Uniprot IDs		O14595	A0A140VJJ0 C9JXA2 P29320 Q6P4R6
PDB IDs		2Q5E	2GSF 2QO2 2QO7 2QO9 2QOB 2QOC 2QOD 2QOF 2QOI 2QOK 2QOL 2QON 2QOO 2QOQ 3DZQ 3FXX 3FY2 4G2F 4GK2 4GK3 4GK4 4L0P 4P4C 4P5Q 4P5Z 4TWN 4TWO 6IN0
Enriched GO Terms of Interacting Partners?		Transmembrane Receptor Protein Tyrosine Kinase Activity Protein Kinase Activity Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Protein Tyrosine Kinase Activity Kinase Activity Enzyme-linked Receptor Protein Signaling Pathway Cell Surface Receptor Signaling Pathway Cellular Response To Lipid ATP Binding Receptor Complex Transferase Activity Response To Lipid Negative Regulation Of Apoptotic Process Cellular Response To Oxygen-containing Compound Cell Migration Cellular Response To Ether Signal Transduction Negative Regulation Of Programmed Cell Death Positive Regulation Of Cell Migration Male Sex Determination Ephrin Receptor Activity Transmembrane-ephrin Receptor Activity Positive Regulation Of Cell Motility Kinase Binding Positive Regulation Of Locomotion Phosphatidylinositol 3-kinase Binding Cell Motility Regulation Of Protein Localization To Plasma Membrane Protein Autophosphorylation Protein Phosphorylation Response To Ether Negative Regulation Of Toll-like Receptor Signaling Pathway Sex Determination Positive Regulation Of Cellular Component Organization Positive Regulation Of Cell Projection Organization Nucleotide Binding Phosphorylation Regulation Of Cellular Component Organization Regulation Of Protein Localization To Cell Periphery Tissue Morphogenesis Cellular Response To Cytokine Stimulus Insulin-like Growth Factor Receptor Signaling Pathway Negative Regulation Of Neuron Apoptotic Process Regulation Of Protein Localization To Membrane Positive Regulation Of Morphogenesis Of An Epithelium Regulation Of Toll-like Receptor Signaling Pathway Developmental Process Involved In Reproduction Regulation Of Apoptotic Process Cellular Response To Nerve Growth Factor Stimulus Response To Nerve Growth Factor	Ephrin Receptor Binding Ephrin Receptor Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Neuron Projection Guidance Axon Guidance Neuron Projection Development Regulation Of Cell Adhesion Regulation Of Cellular Component Organization Plasma Membrane Bounded Cell Projection Organization T Cell Proliferation Cell Surface Receptor Signaling Pathway Signal Transduction Regulation Of Growth SH2 Domain Binding Response To Hydrogen Peroxide Protein Modification Process Regulation Of Anatomical Structure Morphogenesis Cell Projection Organization T Cell Costimulation Regulation Of Vasculature Development Positive Regulation Of Intracellular Signal Transduction Lymphocyte Proliferation Regulation Of Cell-cell Adhesion Regulation Of Multicellular Organismal Development Mononuclear Cell Proliferation Side Of Membrane Regulation Of Lymphocyte Activation Cell Population Proliferation Regulation Of Protein Stability Regulation Of Developmental Process Regulation Of Catalytic Activity Regulation Of T Cell Activation Regulation Of Leukocyte Cell-cell Adhesion Leukocyte Proliferation Leukocyte Activation Cellular Response To Transforming Growth Factor Beta Stimulus Phosphoprotein Phosphatase Activity Regulation Of Cell Growth Regulation Of Phosphorus Metabolic Process Signaling Receptor Binding Cellular Response To Hydrogen Peroxide Regulation Of Immune System Process Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Positive Regulation Of Signal Transduction Response To Transforming Growth Factor Beta Regulation Of Neuron Projection Development Regulation Of Biological Quality Response To Reactive Oxygen Species Negative Regulation Of Hydrogen Peroxide Biosynthetic Process
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?