TOM1L1 and TOLLIP

Number of citations of the paper that reports this interaction (PubMedID 15047686)
0

Data Source:
HPRD (in vitro)

		TOM1L1	TOLLIP
Description		target of myb1 like 1 membrane trafficking protein	toll interacting protein
Image
GO Annotations	Cellular Component	Cytoplasm Lysosome Endosome Golgi Apparatus Golgi Stack Cytosol Endosome Membrane Membrane Extracellular Exosome	Extracellular Region Cytoplasm Endosome Early Endosome Cytosol Nuclear Body Extrinsic Component Of Plasma Membrane Protein-containing Complex Azurophil Granule Lumen Specific Granule Lumen Perinuclear Region Of Cytoplasm Extracellular Exosome
	Molecular Function	Protein Binding SH3 Domain Binding Protein Kinase Binding Clathrin Binding Protein Kinase Activator Activity Phosphatidylinositol Binding Ubiquitin Binding	Interleukin-1, Type I Receptor Binding Protein Binding Kinase Binding Ubiquitin Conjugating Enzyme Binding Ubiquitin Protein Ligase Binding SUMO Binding Toll-like Receptor Binding Ubiquitin Binding Molecular Adaptor Activity
	Biological Process	Signal Transduction Protein Transport Positive Regulation Of Protein Autophosphorylation Activation Of Protein Kinase Activity Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Negative Regulation Of Mitotic Nuclear Division Regulation Of DNA Biosynthetic Process	Immune System Process Ubiquitin-dependent Protein Catabolic Process Autophagy Inflammatory Response Signal Transduction Phosphorylation Epithelial Cell Differentiation Positive Regulation Of Protein Sumoylation Protein Localization To Endosome Innate Immune Response Leukocyte Activation Interleukin-1-mediated Signaling Pathway
Pathways			Neutrophil degranulation Interleukin-1 signaling
Drugs
Diseases
GWAS		Carotid intima media thickness x smoking interaction ( 32117412) Metabolite levels ( 23823483) Obesity-related traits ( 23251661) Photic sneeze reflex ( 27182965) Systolic blood pressure ( 34074324) Urinary albumin-to-creatinine ratio ( 32600054)	Gout ( 32238385) Idiopathic pulmonary fibrosis ( 24429156)
Interacting Genes		29 interacting genes: AMFR CCDC47 CELF1 COPS7A CWF19L1 DNAJB13 FYN GLUD2 GRB2 GSN HGS HNRNPH1 MAP3K3 NDC80 NOMO1 PDPN PELP1 PHYH PIK3R1 PWP2 RAB18 TASOR TOLLIP TSG101 TUBA1B UBC UBXN4 VAV2 VCP	78 interacting genes: ACTMAP ACTN2 ARRDC3 ATXN1 BHLHE40 CDIP1 CHD6 CIMIP2B CPSF6 CSN1S1 CSN2 DAB1 DAZAP2 DCDC2 DDIT4L DZIP3 FAM168A FTH1 GGA1 GGA2 GGA3 GUCD1 HERPUD1 IL1R1 IL1RAP IRAK1 IRAK2 KRTAP13-3 KRTAP15-1 KRTAP19-7 KRTAP6-1 KRTAP6-2 KRTAP7-1 LDB1 MEDAG MSS51 MSX2 MVP N4BP2 NEDD8 NRF1 NTAQ1 ODAM PEG10 PHAF1 PRPF39 PRR20A PRR20B PRR20C PRR20D PRR20E PSMB1 RBFOX1 RBFOX2 RBPMS RHOXF2 RNF167 RNF26 RSPH1 RUNX1 SEPTIN1 SETDB1 SIAH1 STN1 TBX3 TENT5A TLR2 TLR4 TOM1 TOM1L1 TTC9C USP54 WBP2 WRNIP1 XRN2 ZBTB16 ZHX1 ZMYND19
Entrez ID		10040	54472
HPRD ID		05266	05887
Ensembl ID		ENSG00000141198	ENSG00000078902
Uniprot IDs		O75674	B3KR28 E9PNS3 F2Z2Y8 Q6FIE9 Q8N8J5 Q9H0E2
PDB IDs		3RRU	1WGL 2N31
Enriched GO Terms of Interacting Partners?		BAT3 Complex Binding ERAD Pathway Proteolysis Involved In Protein Catabolic Process Cytosol Ubiquitin Binding Response To Endoplasmic Reticulum Stress Neurotrophin TRKA Receptor Binding Endosome Transport Via Multivesicular Body Sorting Pathway Intracellular Signaling Cassette Derlin-1 Retrotranslocation Complex Phosphotyrosine Residue Binding Multivesicular Body Sorting Pathway Intracellular Signal Transduction Multi-pass Transmembrane Protein Insertion Into ER Membrane Multi-pass Translocon Complex Ubiquitin Protein Ligase Binding SUMO Binding Catabolic Process Insulin Receptor Substrate Binding Macromolecule Catabolic Process Modification-dependent Protein Catabolic Process Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Protein Transport To Vacuole Involved In Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Positive Regulation Of Exosomal Secretion Phosphatidylinositol 3-kinase Binding Ubiquitin-specific Protease Binding Regulation Of Exosomal Secretion Protein-folding Chaperone Binding Macromolecule Metabolic Process Proteolysis Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Regulation Of Protein Modification Process Cell Activation Protein Phosphatase Binding RNA Binding Regulation Of Post-translational Protein Modification Fc Receptor Mediated Stimulatory Signaling Pathway Ubiquitin-like Protein Ligase Binding Protein Binding Late Endosome To Vacuole Transport Via Multivesicular Body Sorting Pathway Endoplasmic Reticulum Membrane Proteasomal Protein Catabolic Process Vascular Endothelial Growth Factor Receptor Signaling Pathway Ephrin Receptor Binding Fc-gamma Receptor Signaling Pathway Cellular Response To Glycine Response To Singlet Oxygen Epidermal Growth Factor Receptor Binding COP9 Signalosome Positive Regulation Of Cellular Component Biogenesis	NAD+ Nucleosidase Activity, Cyclic ADP-ribose Generating Interleukin-1-mediated Signaling Pathway Endosome Membrane Ubiquitin Binding Positive Regulation Of Cellular Response To Macrophage Colony-stimulating Factor Stimulus Golgi To Plasma Membrane Protein Transport Lipopolysaccharide-mediated Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Cell Surface Toll-like Receptor Signaling Pathway Positive Regulation Of Matrix Metallopeptidase Secretion Protein Binding Toll-like Receptor Signaling Pathway Intermediate Filament Cell Surface Pattern Recognition Receptor Signaling Pathway Establishment Of Protein Localization To Plasma Membrane Phosphatidylinositol Binding Golgi To Plasma Membrane Transport Interleukin-1 Receptor Activity Toll-like Receptor 2 Signaling Pathway Embryonic Hindlimb Morphogenesis Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Protein Localization To Cell Surface LIM Domain Binding Toll Signaling Pathway Lipopolysaccharide Immune Receptor Activity Interleukin-33-mediated Signaling Pathway Hindlimb Morphogenesis Forelimb Morphogenesis Identical Protein Binding
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