TOM1L1 and PWP2

Number of citations of the paper that reports this interaction (PubMedID 16169070)
0

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		TOM1L1	PWP2
Description		target of myb1 like 1 membrane trafficking protein	PWP2 small subunit processome component
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GO Annotations	Cellular Component	Cytoplasm Lysosome Endosome Golgi Apparatus Golgi Stack Cytosol Endosome Membrane Membrane Extracellular Exosome	Nucleus Nucleoplasm Nucleolus Small-subunit Processome Pwp2p-containing Subcomplex Of 90S Preribosome
	Molecular Function	Protein Binding SH3 Domain Binding Protein Kinase Binding Clathrin Binding Protein Kinase Activator Activity Phosphatidylinositol Binding Ubiquitin Binding	RNA Binding Protein Binding
	Biological Process	Signal Transduction Protein Transport Positive Regulation Of Protein Autophosphorylation Activation Of Protein Kinase Activity Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Negative Regulation Of Mitotic Nuclear Division Regulation Of DNA Biosynthetic Process	Ribosomal Small Subunit Assembly Maturation Of SSU-rRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) Ribosomal Small Subunit Biogenesis
Pathways			rRNA modification in the nucleus and cytosol Major pathway of rRNA processing in the nucleolus and cytosol
Drugs
Diseases
GWAS		Carotid intima media thickness x smoking interaction ( 32117412) Metabolite levels ( 23823483) Obesity-related traits ( 23251661) Photic sneeze reflex ( 27182965) Systolic blood pressure ( 34074324) Urinary albumin-to-creatinine ratio ( 32600054)
Interacting Genes		29 interacting genes: AMFR CCDC47 CELF1 COPS7A CWF19L1 DNAJB13 FYN GLUD2 GRB2 GSN HGS HNRNPH1 MAP3K3 NDC80 NOMO1 PDPN PELP1 PHYH PIK3R1 PWP2 RAB18 TASOR TOLLIP TSG101 TUBA1B UBC UBXN4 VAV2 VCP	5 interacting genes: CFTR DCAF7 MAPT MTDH TOM1L1
Entrez ID		10040	5822
HPRD ID		05266	03279
Ensembl ID		ENSG00000141198	ENSG00000241945
Uniprot IDs		O75674	Q15269
PDB IDs		3RRU	7MQ8 7MQ9 7MQA
Enriched GO Terms of Interacting Partners?		BAT3 Complex Binding ERAD Pathway Proteolysis Involved In Protein Catabolic Process Cytosol Ubiquitin Binding Response To Endoplasmic Reticulum Stress Neurotrophin TRKA Receptor Binding Endosome Transport Via Multivesicular Body Sorting Pathway Intracellular Signaling Cassette Derlin-1 Retrotranslocation Complex Phosphotyrosine Residue Binding Multivesicular Body Sorting Pathway Intracellular Signal Transduction Multi-pass Transmembrane Protein Insertion Into ER Membrane Multi-pass Translocon Complex Ubiquitin Protein Ligase Binding SUMO Binding Catabolic Process Insulin Receptor Substrate Binding Macromolecule Catabolic Process Modification-dependent Protein Catabolic Process Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Protein Transport To Vacuole Involved In Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Positive Regulation Of Exosomal Secretion Phosphatidylinositol 3-kinase Binding Ubiquitin-specific Protease Binding Regulation Of Exosomal Secretion Protein-folding Chaperone Binding Macromolecule Metabolic Process Proteolysis Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Regulation Of Protein Modification Process Cell Activation Protein Phosphatase Binding RNA Binding Regulation Of Post-translational Protein Modification Fc Receptor Mediated Stimulatory Signaling Pathway Ubiquitin-like Protein Ligase Binding Protein Binding Late Endosome To Vacuole Transport Via Multivesicular Body Sorting Pathway Endoplasmic Reticulum Membrane Proteasomal Protein Catabolic Process Vascular Endothelial Growth Factor Receptor Signaling Pathway Ephrin Receptor Binding Fc-gamma Receptor Signaling Pathway Cellular Response To Glycine Response To Singlet Oxygen Epidermal Growth Factor Receptor Binding COP9 Signalosome Positive Regulation Of Cellular Component Biogenesis	SH3 Domain Binding Protein-folding Chaperone Binding Positive Regulation Of Anion Channel Activity Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Histone-dependent DNA Binding Phosphatidylinositol Binding Tubulin Complex Neurofibrillary Tangle Assembly Microtubule Lateral Binding Positive Regulation Of Monoatomic Anion Transport Positive Regulation Of Tooth Mineralization Chloride Channel Inhibitor Activity Positive Regulation Of Enamel Mineralization Transepithelial Water Transport Chloride Channel Regulator Activity Regulation Of Enamel Mineralization Membrane Hyperpolarization Main Axon Regulation Of Tubulin Deacetylation Protein-macromolecule Adaptor Activity Negative Regulation Of Mitochondrial Fission Negative Regulation Of Tubulin Deacetylation Intracellular Distribution Of Mitochondria Neurofibrillary Tangle Positive Regulation Of Protein Localization To Synapse Plus-end-directed Organelle Transport Along Microtubule Positive Regulation Of Protein Autophosphorylation Intercellular Canaliculus Bicarbonate Transmembrane Transporter Activity Intracellular PH Elevation Lipoprotein Particle Binding Negative Regulation Of Establishment Of Protein Localization To Mitochondrion Amelogenesis Cellular Response To Brain-derived Neurotrophic Factor Stimulus Inclusion Body Assembly Minor Groove Of Adenine-thymine-rich DNA Binding ATPase-coupled Inorganic Anion Transmembrane Transporter Activity Regulation Of Protein Deacetylation Regulation Of Monoatomic Anion Transport Epithelial Fluid Transport Endosome Membrane Phosphatidylinositol Bisphosphate Binding Negative Regulation Of Membrane Potential Axolemma Negative Regulation Of Mitochondrial Membrane Potential Regulation Of Protein Autophosphorylation Cytoplasm Cellular Response To Forskolin
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