DHX30 and OAS3

Number of citations of the paper that reports this interaction (PMID 21903422)
33

Data Source:
BioGRID (affinity chromatography technology, pull down)

		DHX30	OAS3
Gene Name		DEAH (Asp-Glu-Ala-His) box helicase 30	2-5-oligoadenylate synthetase 3, 100kDa
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrion Mitochondrial Nucleoid	Extracellular Space Nucleoplasm Cytoplasm Cytosol Plasma Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	Chromatin Binding Double-stranded RNA Binding ATP-dependent RNA Helicase Activity Protein Binding ATP Binding Poly(A) RNA Binding	2'-5'-oligoadenylate Synthetase Activity Double-stranded RNA Binding Protein Binding ATP Binding Metal Ion Binding
	Biological Process	RNA Processing	Nucleobase-containing Compound Metabolic Process Response To Virus Cytokine-mediated Signaling Pathway Negative Regulation Of Viral Genome Replication Defense Response To Virus Interferon-gamma-mediated Signaling Pathway Type I Interferon Signaling Pathway Regulation Of Ribonuclease Activity
Pathways			Interferon gamma signaling Interferon Signaling Cytokine Signaling in Immune system Interferon alpha/beta signaling
Drugs
Diseases
GWAS			Alcohol consumption ( 21270382) HDL cholesterol ( 21909109) Response to fenofibrate (adiponectin levels) ( 23149075)
Protein-Protein Interactions		17 interactors: CDK9 DHX58 EIF2AK2 HDAC1 HDAC3 HNRNPD MYBBP1A NCOR1 NEDD4 NR2E3 OAS3 RBBP4 RBBP7 RBL1 SIN3A SKIL TBL3	5 interactors: DHX30 EIF6 FTSJ3 IFRD2 MAVS
Entrez ID		22907	4940
HPRD ID		13142	04519
Ensembl ID		ENSG00000132153	ENSG00000111331
Uniprot IDs		Q7L2E3	Q9Y6K5
PDB IDs		2DB2
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Transcription, DNA-templated RNA Biosynthetic Process RNA Metabolic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Regulation Of RNA Metabolic Process Transcription Initiation From RNA Polymerase II Promoter Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Cellular Response To Organic Substance Cellular Nitrogen Compound Metabolic Process DNA-templated Transcription, Initiation Regulation Of Transcription, DNA-templated Gene Expression Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Nitrogen Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Transforming Growth Factor Beta Receptor Signaling Pathway Rhythmic Process Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Cell Cycle Regulation Of Gene Expression Chromatin Modification Circadian Rhythm Response To Organic Substance Cellular Response To Transforming Growth Factor Beta Stimulus Response To Transforming Growth Factor Beta Negative Regulation Of Gene Expression, Epigenetic Circadian Regulation Of Gene Expression Chromatin Organization Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Biosynthetic Process Transcription From RNA Polymerase II Promoter Viral Process Cellular Response To Growth Factor Stimulus Regulation Of Metabolic Process Response To Growth Factor Chromosome Organization Regulation Of Viral Process Cellular Response To Stimulus Response To Stimulus	Positive Regulation Of IP-10 Production Enzyme-directed RRNA 2'-O-methylation Ribosome Biogenesis Positive Regulation Of Chemokine (C-C Motif) Ligand 5 Production RIG-I Signaling Pathway Regulation Of Peroxisome Organization Mature Ribosome Assembly Cytoplasmic Pattern Recognition Receptor Signaling Pathway In Response To Virus Ribonucleoprotein Complex Biogenesis Cellular Response To Exogenous DsRNA Ribosomal Subunit Export From Nucleus Positive Regulation Of Protein Import Into Nucleus, Translocation RRNA Methylation Positive Regulation Of Type I Interferon-mediated Signaling Pathway RRNA Modification Cellular Response To Virus Positive Regulation Of Defense Response To Virus By Host Regulation Of Protein Import Into Nucleus, Translocation Positive Regulation Of Interferon-alpha Production Ribosomal Large Subunit Biogenesis Positive Regulation Of Interferon-beta Production Ribosome Assembly Positive Regulation Of Cytokine-mediated Signaling Pathway Positive Regulation Of Response To Cytokine Stimulus Regulation Of Defense Response To Virus By Host Positive Regulation Of Interleukin-8 Production Cellular Response To DsRNA Positive Regulation Of Transcription Factor Import Into Nucleus Regulation Of Interferon-beta Production Regulation Of Type I Interferon-mediated Signaling Pathway Positive Regulation Of Chemokine Production Negative Regulation Of Type I Interferon Production Negative Regulation Of Viral Genome Replication Response To Exogenous DsRNA Regulation Of Chemokine Production Positive Regulation Of Tumor Necrosis Factor Production RNA Methylation
Tagcloud ?		box brains called confirm dexh died e7 e9 embryogenesis embryonic encodes gastrulation growing headfold helg helicase homozygous identifying ie mutants named neural plate polynucleotides purification retarded somites tube untwisting	5as activate agrees antiviral baculovirus capability compelling considerably contrary dsrna harbors homogeneity intracellularly messengers mutagenesis oas1 oligoadenylate oligoadenylates purify redefines restrict rnase saxs scattering sensors synthesize synthesizes synthetase
Tagcloud (Difference) ?		box brains called confirm dexh died e7 e9 embryogenesis embryonic encodes gastrulation growing headfold helg helicase homozygous identifying ie mutants named neural plate polynucleotides purification retarded somites tube untwisting	5as activate agrees antiviral baculovirus capability compelling considerably contrary dsrna harbors homogeneity intracellularly messengers mutagenesis oas1 oligoadenylate oligoadenylates purify redefines restrict rnase saxs scattering sensors synthesize synthesizes synthetase
Tagcloud (Intersection) ?