DHX30 and PRPF39

Number of citations of the paper that reports this interaction (PubMedID 34133714)
84

Data Source:
BioGRID (two hybrid)

		DHX30	PRPF39
Description		DExH-box helicase 30	pre-mRNA processing factor 39
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrion Mitochondrial Matrix Cytosol Ribonucleoprotein Granule Mitochondrial Nucleoid	Commitment Complex Nucleus U1 SnRNP U2-type Prespliceosome
	Molecular Function	Nucleotide Binding G-quadruplex RNA Binding Nucleic Acid Binding DNA Helicase Activity Chromatin Binding RNA Binding RNA Helicase Activity Double-stranded RNA Binding Helicase Activity Protein Binding ATP Binding Hydrolase Activity ATP Hydrolysis Activity	Protein Binding Pre-mRNA 5'-splice Site Binding
	Biological Process	Central Nervous System Development Ribosome Biogenesis Mitochondrial Large Ribosomal Subunit Assembly	MRNA 5'-splice Site Recognition RNA Processing MRNA Processing RNA Splicing
Pathways
Drugs
Diseases
GWAS			Lead levels ( 26025379)
Interacting Genes		23 interacting genes: CDK9 CFTR DHX58 DUX4 HDAC1 HDAC3 HNRNPD HSPA13 MYBBP1A NCOR1 NEDD4 NEIL3 NR2E3 OAS3 OGT PRPF39 RBBP4 RBBP7 RBL1 SIN3A SKIL TBL3 USP7	14 interacting genes: BANP CEBPA DHX30 DMRTB1 GTSE1 LARP4 MBNL1 PRRC2B QKI RBM22 RNU1-1 SF1 TOLLIP TRNAU1AP
Entrez ID		22907	55015
HPRD ID		13142	17913
Ensembl ID		ENSG00000132153	ENSG00000185246
Uniprot IDs		H7BXY3 Q7L2E3	Q86UA1
PDB IDs		2DB2
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Biosynthetic Process Histone Deacetylase Complex Negative Regulation Of Macromolecule Biosynthetic Process Sin3-type Complex Negative Regulation Of Stem Cell Population Maintenance Negative Regulation Of Metabolic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Rhythmic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Chromatin Organization Positive Regulation Of Stem Cell Population Maintenance Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Nucleoplasm Negative Regulation Of Transcription By RNA Polymerase II Circadian Rhythm Nucleus Regulation Of Stem Cell Population Maintenance Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Signal Transduction Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of RNA Metabolic Process Negative Regulation Of Cell Communication Negative Regulation Of Signaling Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Cellular Response To Growth Factor Stimulus Cellular Response To Stress Regulation Of Nucleobase-containing Compound Metabolic Process Protein-containing Complex Histone Deacetylase Binding NuRD Complex Regulation Of Gene Expression Transcription Repressor Complex Chromatin Remodeling Response To Stress Circadian Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Primary Metabolic Process Regulation Of Cell Fate Specification Protein Lysine Delactylase Activity Positive Regulation Of Metabolic Process Transcription Corepressor Activity Regulation Of Metabolic Process Protein Decrotonylase Activity Histone Decrotonylase Activity	RNA Binding Nucleic Acid Binding Protein Localization To Endosome Cytoplasmic Stress Granule MRNA Cis Splicing, Via Spliceosome RNA Splicing Erythrocyte Apoptotic Process Macrophage Differentiation RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding MRNA Processing Regulation Of RNA Splicing MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Internal N(7)-methylguanine-containing RNA Reader Activity
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