TROAP and DYRK1A

Number of citations of the paper that reports this interaction (PMID 23602568)
8

Data Source:
BioGRID (affinity chromatography technology, fluorescent resonance energy transfer, affinity chromatography technology)

		TROAP	DYRK1A
Gene Name		trophinin associated protein	dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm	Nucleus Nucleoplasm Nuclear Speck Ribonucleoprotein Complex
	Molecular Function	Protein Binding	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Protein Binding ATP Binding Identical Protein Binding Protein Self-association Tau Protein Binding
	Biological Process	Cell Adhesion	Mitotic Cell Cycle Regulation Of Alternative MRNA Splicing, Via Spliceosome Protein Phosphorylation Nervous System Development Circadian Rhythm Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Peptidyl-tyrosine Phosphorylation Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Protein Autophosphorylation Positive Regulation Of Protein Deacetylation
Pathways			G0 and Early G1 Mitotic G1-G1/S phases Cell Cycle, Mitotic
Drugs
Diseases
GWAS			HIV-1 replication ( 21364930) Metabolic syndrome ( 20694148)
Protein-Protein Interactions		13 interactors: BANP BYSL DYNLT1 DYRK1A DYRK1B KRT31 KRT40 KRT8 MAPRE1 MAPRE3 TRAF2 TRIM23 TRO	26 interactors: AMPH APP CCNL2 CLASRP CREB1 FOXO1 GLI1 HIST1H2BB HIST1H3A HIST1H4A LATS2 LIN52 LZTS2 PHYHIP PRD RB1 RBL1 SF3B1 SNCA SRSF1 SRSF4 SRSF5 TROAP YWHAB YWHAE YWHAG
Entrez ID		10024	1859
HPRD ID		04849	09018
Ensembl ID		ENSG00000135451	ENSG00000157540
Uniprot IDs		F8VSF9 Q12815	F8WAP0 Q13627
PDB IDs			2VX3 2WO6 3ANQ 3ANR 4AZE
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Microtubule Plus-end Binding Positive Regulation Of Protein Binding Positive Regulation Of Binding Regulation Of Protein Binding Tumor Necrosis Factor-mediated Signaling Pathway Regulation Of Binding Cell Cycle Mitotic Cell Cycle Mitotic Nuclear Division Microtubule-dependent Intracellular Transport Of Viral Material Towards Nucleus Cellular Response To Tumor Necrosis Factor Cell Division Developmental Process Response To Tumor Necrosis Factor Viral Process Intracellular Transport Of Viral Protein In Host Cell Negative Regulation Of Glial Cell Apoptotic Process Multicellular Organismal Development Response To Hydrostatic Pressure Protein Localization To Microtubule Mitotic Cell Cycle Process	Gene Expression Negative Regulation Of Cellular Metabolic Process Mitotic Cell Cycle Regulation Of Kinase Activity Regulation Of Phosphorus Metabolic Process Nucleobase-containing Compound Metabolic Process RNA Processing MRNA 3'-end Processing Cellular Localization Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Establishment Of Localization In Cell Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Nitrogen Compound Metabolic Process Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Hippo Signaling Regulation Of Phosphorylation Cellular Nitrogen Compound Metabolic Process MRNA Processing Negative Regulation Of Gene Expression RNA 3'-end Processing RNA Metabolic Process Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Nuclear Export Regulation Of Protein Kinase Activity Negative Regulation Of Transcription, DNA-templated Termination Of RNA Polymerase II Transcription Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Protein Dephosphorylation MRNA Metabolic Process Negative Regulation Of Canonical Wnt Signaling Pathway Transcription From RNA Polymerase II Promoter Cellular Response To Growth Factor Stimulus Negative Regulation Of Protein Metabolic Process RNA Splicing Response To Growth Factor Positive Regulation Of Mitochondrion Organization Regulation Of Cell Cycle Regulation Of Protein Metabolic Process Cellular Macromolecular Complex Assembly DNA Replication-dependent Nucleosome Assembly Cellular Response To Fibroblast Growth Factor Stimulus Negative Regulation Of Biosynthetic Process Apoptotic Process Cell Cycle Negative Regulation Of Wnt Signaling Pathway
Tagcloud ?		adenocarcinomas aimed biomarkers blot capg carcinomas clu deceased differently expressed expressions ihc immunohistochemistry insufficient itgb3 localize microarray muc5b none ovarian prame prediction prognostic qpcr semiquantitative serous survivors tacc1 tumors	abolished aimed alteration caused colony direct explore finding fluorescent hcc hepatocellular hepg2 mir modulated nfat nfib oncogene overexpression p53 propose regulated reporter suggests suppresses syndrome target targeting tumorigenesis wild
Tagcloud (Difference) ?		adenocarcinomas biomarkers blot capg carcinomas clu deceased differently expressed expressions ihc immunohistochemistry insufficient itgb3 localize microarray muc5b none ovarian prame prediction prognostic qpcr semiquantitative serous survivors tacc1 tumors	abolished alteration caused colony direct explore finding fluorescent hcc hepatocellular hepg2 mir modulated nfat nfib oncogene overexpression p53 propose regulated reporter suggests suppresses syndrome target targeting tumorigenesis wild
Tagcloud (Intersection) ?		aimed