TROAP and DYRK1B

Number of citations of the paper that reports this interaction (PubMedID 32707033)
104

Data Source:
BioGRID (two hybrid, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfer, affinity chromatography technology)

		TROAP	DYRK1B
Description		trophinin associated protein	dual specificity tyrosine phosphorylation regulated kinase 1B
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm	Nucleus Nucleoplasm Chromosome Nucleolus
	Molecular Function	Protein Binding	Nucleotide Binding Transcription Coactivator Activity Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Tyrosine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Serine Kinase Activity
	Biological Process	Cell Adhesion	DNA Repair Protein Phosphorylation DNA Damage Response Myoblast Fusion Positive Regulation Of DNA-templated Transcription Adipose Tissue Development
Pathways
Drugs			Fostamatinib
Diseases
GWAS			Macular thickness ( 30535121)
Interacting Genes		18 interacting genes: ACTMAP BANP BYSL DYNLT1 DYRK1A DYRK1B GIGYF1 KRT31 KRT40 KRT8 NBPF19 NOTCH2NLA OIP5 SSC4D TP53BP2 TRAF2 TRIM23 TRO	12 interacting genes: DCAF7 GSC2 HDAC5 ID2 MAP2K3 MAPK1 MAPK14 MBP PAK1 PCBD1 RANBP9 TROAP
Entrez ID		10024	9149
HPRD ID		04849	05188
Ensembl ID		ENSG00000135451	ENSG00000105204
Uniprot IDs		F8W130 Q12815	A0A9H4CVU7 Q9Y463
PDB IDs			8C2Z
Enriched GO Terms of Interacting Partners?			MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Regulation Of Muscle Cell Differentiation Cellular Senescence NLRP1 Inflammasome Complex Assembly Negative Regulation Of Muscle Cell Differentiation Regulation Of Striated Muscle Cell Differentiation Cellular Response To UV-B MAP Kinase Activity MAP Kinase Kinase Activity Response To Lipopolysaccharide Mammary Gland Epithelial Cell Proliferation Response To Molecule Of Bacterial Origin Regulation Of Blood Vessel Endothelial Cell Migration Protein Serine Kinase Activity Response To UV-B Stress-activated MAPK Cascade Protein-containing Complex Negative Regulation Of Hippo Signaling P38MAPK Cascade Protein Serine/threonine Kinase Activity Intracellular Signaling Cassette Cellular Response To Vascular Endothelial Growth Factor Stimulus Response To Insulin Nucleoplasm Cellular Response To Lipopolysaccharide Astrocyte Differentiation Canonical Inflammasome Complex Assembly Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Erythrocyte Differentiation Cellular Response To Molecule Of Bacterial Origin Regulation Of Endothelial Cell Migration Cytosol Protein Kinase Activity Lipopolysaccharide-mediated Signaling Pathway Regulation Of Cell Migration Negative Regulation Of Striated Muscle Cell Differentiation Pyroptotic Inflammatory Response Regulation Of Cell Motility Regulation Of Hippo Signaling Regulation Of Myotube Differentiation Positive Regulation Of Cell Migration Regulation Of Locomotion Positive Regulation Of Cell Motility Regulation Of Erythrocyte Differentiation Positive Regulation Of Locomotion Positive Regulation Of Metabolic Process Kinase Activity Positive Regulation Of Metalloendopeptidase Activity Heart Development
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