DIAPH3

Description		diaphanous related formin 3
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GO Annotations	Cellular Component	ESCRT I Complex Spindle Pole Nucleus Cytoplasm Microtubule Organizing Center Cytosol Actin Filament Filamentous Actin Cleavage Furrow Actin Filament Bundle Ribbon Synapse Stereocilia Tip-link Density
	Molecular Function	Actin Binding Microtubule Binding Cytoskeletal Protein Binding Small GTPase Binding Protein Homodimerization Activity Cadherin Binding
	Biological Process	Microtubule Cytoskeleton Organization In Utero Embryonic Development Cytoskeleton Organization Actin Filament Organization Negative Regulation Of Microtubule Depolymerization Chromosome Segregation Integrin-mediated Signaling Pathway Sensory Perception Of Sound Gene Expression Endosomal Transport Establishment Of Cell Polarity Cell Projection Organization Actin Cytoskeleton Organization Actin Filament Polymerization Neuron Differentiation Erythrocyte Differentiation Macrophage Differentiation Protein-containing Complex Remodeling Erythrocyte Enucleation Actin Nucleation Microtubule Polymerization Actin Filament Bundle Assembly Actin Crosslink Formation Inner Ear Receptor Cell Differentiation Head Development Autophagosome-lysosome Fusion Podosome Assembly
Pathways		RHO GTPases Activate Formins RHOA GTPase cycle RHOB GTPase cycle RHOC GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle RHOD GTPase cycle RHOQ GTPase cycle RHOG GTPase cycle RHOJ GTPase cycle RAC3 GTPase cycle RHOF GTPase cycle
Drugs
Diseases
GWAS		Age at first sexual intercourse ( 27089180 34211149) Body mass index ( 28892062) Breast milk fatty acid composition (infant genotype effect) ( 29514873) Breast milk fatty acid composition (maternal genotype effect) ( 29514873) Chronotype ( 30696823) General risk tolerance (MTAG) ( 30643258) Gut microbiota (functional units) ( 27694959) HOMA-B (corrected for HOMA-IR) ( 30369944) Metabolite levels ( 23823483) Neonatal total 25-hydroxyvitamin D levels (maternal genetic effect) ( 32047095) Number of sexual partners ( 30643258) Smoking initiation ( 33082346) Smoking status (ever vs never smokers) ( 30643258)
Interacting Genes		6 interacting genes: CDC42 NCKIPSD PDCD6 RAC1 RHOA SMAD9
Entrez ID		81624
HPRD ID		10884
Ensembl ID		ENSG00000139734
Uniprot IDs		B4DPV3 Q9NSV4
PDB IDs		5UWP 6X2Y
Enriched GO Terms of Interacting Partners?		Postsynapse Positive Regulation Of Stress Fiber Assembly Wnt Signaling Pathway, Planar Cell Polarity Pathway Membrane Invagination Non-canonical Wnt Signaling Pathway Positive Regulation Of Actin Filament Bundle Assembly Regulation Of Synapse Organization G Protein Activity G Protein-coupled Receptor Signaling Pathway Involved In Heart Process Regulation Of Stress Fiber Assembly Thioesterase Binding Regulation Of Postsynapse Organization Positive Regulation Of Cell Migration Establishment Or Maintenance Of Cell Polarity Establishment Of Epithelial Cell Apical/basal Polarity Glutamatergic Synapse Positive Regulation Of Supramolecular Fiber Organization Positive Regulation Of Cell Motility Cell-cell Junction Organization Positive Regulation Of Locomotion GTP-dependent Protein Binding Establishment Of Apical/basal Cell Polarity Positive Regulation Of Cytoskeleton Organization Regulation Of Plasma Membrane Bounded Cell Projection Organization Establishment Of Monopolar Cell Polarity Establishment Or Maintenance Of Monopolar Cell Polarity Regulation Of Endothelial Cell Migration Polarized Epithelial Cell Differentiation Regulation Of Cell Projection Organization Positive Regulation Of Lamellipodium Assembly Regulation Of Cell-substrate Adhesion Establishment Of Epithelial Cell Polarity Cerebral Cortex Cell Migration Phagocytosis, Engulfment Positive Regulation Of Lamellipodium Organization Regulation Of Cell Junction Assembly Actin Filament Organization Regulation Of Actin Filament Organization Small GTPase-mediated Signal Transduction Regulation Of Lamellipodium Assembly Wnt Signaling Pathway Telencephalon Cell Migration Intracellular Signaling Cassette Semaphorin-plexin Signaling Pathway Positive Regulation Of Cytokinesis Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Substantia Nigra Development Regulation Of Postsynapse Assembly Substrate Adhesion-dependent Cell Spreading Forebrain Cell Migration
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