DIAPH3 and NCKIPSD

Number of citations of the paper that reports this interaction (PMID 11509578)
22

Data Source:
BioGRID (two hybrid, pull down, affinity chromatography technology)

		DIAPH3	NCKIPSD
Gene Name		diaphanous-related formin 3	NCK interacting protein with SH3 domain
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytosol	Cytosol Intermediate Filament COP9 Signalosome
	Molecular Function	Actin Binding Rho GTPase Binding	Protein Binding Cytoskeletal Protein Binding SH3 Domain Binding
	Biological Process	Spermatogenesis Actin Cytoskeleton Organization	NLS-bearing Protein Import Into Nucleus Cytoskeleton Organization Signal Transduction Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Innate Immune Response
Pathways			Fcgamma receptor (FCGR) dependent phagocytosis Regulation of actin dynamics for phagocytic cup formation Innate Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		5 interactors: CDC42 NCKIPSD RAC1 RHOA SMAD9	19 interactors: ARHGEF7 BAIAP2 DIAPH2 DIAPH3 DLG4 DMRTB1 FASLG GRB2 ITGB1 KHDRBS1 MAPK3 NCK1 NCK2 PSMD9 SORBS3 STAC WAS WASL YWHAG
Entrez ID		81624	51517
HPRD ID		10884	09450
Ensembl ID		ENSG00000139734	ENSG00000213672
Uniprot IDs		B4DPV3 Q9NSV4	Q9NZQ3
PDB IDs
Enriched GO Terms of Interacting Partners?		Midbrain Development Ephrin Receptor Signaling Pathway Vascular Endothelial Growth Factor Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Positive Regulation Of Cell Morphogenesis Involved In Differentiation Brain Development Head Development Cell-cell Junction Organization Positive Regulation Of Cell Differentiation Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Phosphatidylinositol 3-kinase Activity Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Phagocytosis Central Nervous System Development Fc Receptor Signaling Pathway Positive Regulation Of Cell Projection Organization Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Substrate Adhesion-dependent Cell Spreading Epithelium Development Positive Regulation Of Cellular Component Biogenesis Substantia Nigra Development Cytoskeleton Organization Positive Regulation Of Cytokinesis Positive Regulation Of Stress Fiber Assembly Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Actin Filament Bundle Assembly Cell Surface Receptor Signaling Pathway Axon Guidance Regulation Of Phosphatidylinositol 3-kinase Activity Neural Nucleus Development Blood Coagulation Hemostasis Regulation Of Cytokinesis Regulation Of Lipid Kinase Activity Response To Stress Regulation Of Stress Fiber Assembly Immune Response-regulating Signaling Pathway Positive Regulation Of DNA Replication Regulation Of Cell Morphogenesis Regulation Of Cell Projection Organization Positive Regulation Of Cell Development Regulation Of Cytoskeleton Organization Regulation Of Cell Differentiation T Cell Costimulation Axonogenesis Axon Development Tissue Development Regulation Of Body Fluid Levels	Actin Cytoskeleton Organization Actin Filament-based Process Axonogenesis Axon Development Cell Morphogenesis Involved In Neuron Differentiation Axon Guidance Positive Regulation Of Organelle Organization Neuron Projection Morphogenesis Cell Morphogenesis Involved In Differentiation Actin Filament Organization Regulation Of Cytoskeleton Organization Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Regulation Of Cellular Component Organization Cytoskeleton Organization Neuron Projection Development Cell Projection Morphogenesis Regulation Of Actin Cytoskeleton Organization Cell Part Morphogenesis Positive Regulation Of Cytoskeleton Organization Chemotaxis Positive Regulation Of Signal Transduction Regulation Of Organelle Organization Regulation Of Actin Filament-based Process Neuron Development Cell Development Cellular Component Assembly Regulation Of Signaling Cell Morphogenesis Phagocytosis Fc Receptor Signaling Pathway Neuron Differentiation Immune Response-activating Cell Surface Receptor Signaling Pathway Generation Of Neurons Cell Projection Organization Neurogenesis Immune System Process Regulation Of Signal Transduction Signal Transduction Response To External Stimulus Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Endocytosis Regulation Of ERBB Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Organelle Organization Protein Complex Assembly Signaling Regulation Of Endoplasmic Reticulum Stress-induced EIF2 Alpha Phosphorylation
Tagcloud ?		asd atp13a4 autistic cadherins catenins cdh13 cdh9 centrotemporal cntnap2 cnvs contactins cswss ctnna3 electroencephalography encephalopathies epileptic epilepticus grin2a kleffner landau lks mdga2 nongenetic overrepresentation protocadherins rolandic shank3 spikes unifying	2d 3d 4ebp1 adenocarcinomas atr atrip clearer concordant discordant egr emphasized gliomas growths gsk3alphabeta hypoxia look mek1 monolayer nfkappabetap65 normoxia phosphoprotein reflective s6 ser235 ser240 ser423 ser65 smad3 vegfr2
Tagcloud (Difference) ?		asd atp13a4 autistic cadherins catenins cdh13 cdh9 centrotemporal cntnap2 cnvs contactins cswss ctnna3 electroencephalography encephalopathies epileptic epilepticus grin2a kleffner landau lks mdga2 nongenetic overrepresentation protocadherins rolandic shank3 spikes unifying	2d 3d 4ebp1 adenocarcinomas atr atrip clearer concordant discordant egr emphasized gliomas growths gsk3alphabeta hypoxia look mek1 monolayer nfkappabetap65 normoxia phosphoprotein reflective s6 ser235 ser240 ser423 ser65 smad3 vegfr2
Tagcloud (Intersection) ?