NRIP1 and PPARD

Number of citations of the paper that reports this interaction (PubMedID 15001550)
0

Data Source:
HPRD (in vitro)

		NRIP1	PPARD
Description		nuclear receptor interacting protein 1	peroxisome proliferator activated receptor delta
Image
GO Annotations	Cellular Component	Histone Deacetylase Complex Chromatin Fibrillar Center Nucleus Nucleoplasm Nucleolus Cytosol Nuclear Speck	Chromatin Nucleus Nucleoplasm RNA Polymerase II Transcription Regulator Complex
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Transcription Coregulator Activity Transcription Coactivator Activity Transcription Corepressor Activity Signaling Receptor Binding Protein Binding Nuclear Receptor Binding Nuclear Estrogen Receptor Binding Nuclear Glucocorticoid Receptor Binding Histone Deacetylase Binding Nuclear Retinoic Acid Receptor Binding Nuclear Retinoid X Receptor Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Transcription Coactivator Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Nuclear Steroid Receptor Activity Nuclear Receptor Activity Fatty Acid Binding Protein Binding Zinc Ion Binding Lipid Binding Sequence-specific DNA Binding Metal Ion Binding NF-kappaB Binding Linoleic Acid Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Ovarian Follicle Rupture Regulation Of Transcription By RNA Polymerase II Circadian Rhythm Lipid Storage Ovulation Circadian Regulation Of Gene Expression Positive Regulation Of Transcription By RNA Polymerase II Rhythmic Process Cellular Response To Estradiol Stimulus	Negative Regulation Of Transcription By RNA Polymerase II Placenta Development Glucose Metabolic Process Proteoglycan Metabolic Process Generation Of Precursor Metabolites And Energy Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Lipid Metabolic Process Fatty Acid Metabolic Process Fatty Acid Beta-oxidation Apoptotic Process Heart Development Embryo Implantation Cholesterol Metabolic Process Cell Population Proliferation Axon Ensheathment Phospholipid Biosynthetic Process Fatty Acid Catabolic Process Response To Glucose Hormone-mediated Signaling Pathway Positive Regulation Of Gene Expression Negative Regulation Of Cholesterol Storage Response To Activity Regulation Of Skeletal Muscle Satellite Cell Proliferation Negative Regulation Of Smooth Muscle Cell Migration Fatty Acid Transport Fatty Acid Oxidation Cell Differentiation Negative Regulation Of Cell Growth Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Intracellular Receptor Signaling Pathway Cell-substrate Adhesion Cellular Response To Nutrient Levels Negative Regulation Of Collagen Biosynthetic Process Response To Vitamin A Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Wound Healing Regulation Of Cell Population Proliferation Vasodilation Negative Regulation Of Apoptotic Process Positive Regulation Of Skeletal Muscle Tissue Regeneration Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Keratinocyte Proliferation Regulation Of Fat Cell Differentiation Positive Regulation Of Fat Cell Differentiation Negative Regulation Of Myoblast Differentiation Positive Regulation Of Epidermis Development Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Fatty Acid Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Fatty Acid Oxidation Decidualization Negative Regulation Of Smooth Muscle Cell Proliferation Epithelial Cell Proliferation Regulation Of Epithelial Cell Proliferation Negative Regulation Of Epithelial Cell Proliferation Negative Regulation Of Inflammatory Response Keratinocyte Migration Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Adipose Tissue Development Fat Cell Proliferation Positive Regulation Of Fat Cell Proliferation Cellular Response To Lipopolysaccharide Cellular Response To Hypoxia Energy Homeostasis Apoptotic Signaling Pathway Negative Regulation Of MiRNA Transcription D-glucose Transmembrane Transport Positive Regulation Of Myoblast Proliferation
Pathways		SUMOylation of transcription cofactors Estrogen-dependent gene expression NR1H2 & NR1H3 regulate gene expression linked to lipogenesis NR1H2 & NR1H3 regulate gene expression linked to gluconeogenesis Heme signaling Expression of BMAL (ARNTL), CLOCK, and NPAS2 RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression	Carnitine shuttle Nuclear Receptor transcription pathway Signaling by Retinoic Acid
Drugs		4-HYDROXY-N'-(4-ISOPROPYLBENZYL)BENZOHYDRAZIDE	alpha-Linolenic acid Icosapent Troglitazone Valproic acid Treprostinil Rosiglitazone Sulindac Bezafibrate Phthalic Acid Heptyl glucoside Oleic Acid cis-Vaccenic acid Elafibranor KD3010 Cardarine (2S)-2-{3-[({[2-fluoro-4-(trifluoromethyl)phenyl]carbonyl}amino)methyl]-4-methoxybenzyl}butanoic acid 2-({[3-(3,4-dihydroisoquinolin-2(1H)-ylsulfonyl)phenyl]carbonyl}amino)benzoic acid Indeglitazar {4-[3-(4-acetyl-3-hydroxy-2-propylphenoxy)propoxy]phenoxy}acetic acid Clinofibrate Glycerin Fenofibric acid Fish oil
Diseases
GWAS		Alcohol dependence ( 26365420) Birth weight ( 27680694 31043758) Blood urea nitrogen levels ( 31152163) Breast cancer ( 23535729 29059683) Chronic kidney disease ( 31152163) Cognitive performance ( 19734545) Crohn's disease ( 25489960) Depression in smokers ( 30219690) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) Estimated glomerular filtration rate ( 31152163 31451708 30604766 31015462) Estimated glomerular filtration rate in non-diabetics ( 31451708) Gastroesophageal reflux disease ( 31527586) HDL cholesterol levels ( 32203549) Hematocrit ( 32888494) Hemoglobin ( 32888494) Lymphocyte count ( 32888494) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (diuretics) ( 31015401) Monocyte count ( 32888494) Monocyte percentage of white cells ( 32888494) Mosaic loss of chromosome Y (Y chromosome dosage) ( 31624269) Platelet count ( 32888494) Platelet distribution width ( 27863252 32888494) Plateletcrit ( 32888494) Pulse pressure ( 27841878) Red blood cell count ( 32888494) Refractive error ( 32231278) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Systolic blood pressure ( 27841878) White blood cell count ( 32888494)	Appendicular lean mass ( 33097823) Cataracts in type 2 diabetes ( 23137000) Childhood body mass index ( 33045005) Gout ( 22179738) Heel bone mineral density ( 30598549) Height ( 21998595 28552196) Hip circumference adjusted for BMI ( 34021172) Lymphocyte count ( 27863252) Platelet count ( 32888494) Pulmonary function (smoking interaction) ( 23284291) Response to antipsychotic treatment ( 20195266) Serum alkaline phosphatase levels ( 33547301) Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		124 interacting genes: ACBD3 ACTN2 AGR2 AHR AKAP6 ANKRD24 APP AR ARPC3 BAIAP2 BRCA1 CCDC85B CDK8 CEP70 CIB1 CLPB COG4 CREBZF CRNKL1 CTBP1 CTBP2 DNMT1 DNMT3A DNMT3B DST DYNC2I1 E2F1 ERC2 ESR1 ESR2 ESRRA ESRRB ESRRG EXOC7 FEZ1 FMNL2 GPRASP3 GPSM2 HDAC1 HDAC2 HDAC3 HDAC5 HDAC9 HECTD1 HNF4A HSPA5 HUWE1 IMMT IPO5 IQGAP1 JAKMIP3 JUN KALRN KANK2 KAT2B KDM5B KIF3A KIF5A KLHL7 KPNA3 KPNA4 LDOC1 LRRCC1 MACF1 MAP3K7 MAPK8IP3 MLLT3 MTMR10 NCKAP5 NR0B1 NR1H2 NR1H3 NR2C1 NR3C1 NR5A1 NR5A2 NSUN2 OAZ1 ODF2 PIAS1 PIAS3 PKNOX1 PKNOX2 PLAAT3 PLK2 PPARA PPARD PPARG PRMT1 PSMD1 RABEP1 RARA RARB RORB RXRA RXRB RXRG SCG2 SCG3 SESTD1 SF3B1 SHTN1 SNX1 SPTB SPTBN1 TERF1 TEX11 THRA THRB TMEM131 TNFRSF14 TRAF2 TRIM8 TRIM9 TRIP12 TTLL5 TULP3 TXLNG TXNDC11 UBE2I VDR YWHAH ZNF365 ZNF821	44 interacting genes: BCL6 CEP350 DUT EP300 GADD45B GADD45G GLUL HDAC1 HDAC2 HDAC3 HDAC4 HDAC7 HSP90AA1 ITGB5 KDM1A KRTAP10-3 KRTAP10-7 NCOA1 NCOA2 NCOA3 NCOR1 NCOR2 NR0B2 NR1H2 NR1H3 NRIP1 OTUD3 PEBP1 PPARGC1A PRDX6 PRMT3 PROX1 PSMC5 RANBP9 RXRA RXRB RXRG SHMT2 SMAD9 SPEN SRC STAT3 TNP1 ZNF837
Entrez ID		8204	5467
HPRD ID		03927	02679
Ensembl ID		ENSG00000180530	ENSG00000112033
Uniprot IDs		A8K171 P48552	F1D8S7 Q03181
PDB IDs		2GPO 2GPP 4S14 4S15 5NTI 5NTN 5NTW 5NU1 6FZU 6G05 6G07 9CWN	1GWX 1Y0S 2AWH 2B50 2BAW 2ENV 2GWX 2J14 2Q5G 2XYJ 2XYW 2XYX 2ZNP 2ZNQ 3D5F 3DY6 3ET2 3GWX 3GZ9 3OZ0 3PEQ 3SP9 3TKM 5U3Q 5U3R 5U3S 5U3T 5U3U 5U3V 5U3W 5U3X 5U3Y 5U3Z 5U40 5U41 5U42 5U43 5U44 5U45 5U46 5XMX 5Y7X 5ZXI 6A6P 7F80 7VWE 7VWF 7VWG 7VWH 7W0G 7WGL 7WGN 8HF8 8HUL 8HUO
Enriched GO Terms of Interacting Partners?		Nuclear Receptor Activity Intracellular Receptor Signaling Pathway Nuclear Receptor-mediated Signaling Pathway Hormone-mediated Signaling Pathway Nuclear Steroid Receptor Activity Steroid Hormone Receptor Signaling Pathway Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Negative Regulation Of Nucleobase-containing Compound Metabolic Process Chromatin Negative Regulation Of RNA Metabolic Process Sequence-specific DNA Binding Retinoic Acid Receptor Signaling Pathway Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process RNA Polymerase II Transcription Regulator Complex DNA-binding Transcription Factor Activity Intracellular Signal Transduction Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Regulation Of RNA Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Positive Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Biosynthetic Process Positive Regulation Of Metabolic Process Nucleoplasm Estrogen Response Element Binding Transcription Coregulator Binding Sequence-specific Double-stranded DNA Binding Enzyme Binding Regulation Of Primary Metabolic Process Regulation Of Developmental Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Cytoplasm Nucleus Negative Regulation Of Biosynthetic Process DNA Binding Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Regulation Of Metabolic Process	Nuclear Receptor Binding Chromatin Regulation Of Transcription By RNA Polymerase II Nucleus Regulation Of RNA Metabolic Process Negative Regulation Of RNA Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Negative Regulation Of Transcription By RNA Polymerase II Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Metabolic Process DNA-binding Transcription Factor Binding Circadian Rhythm Rhythmic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Primary Metabolic Process Nuclear Receptor-mediated Signaling Pathway Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Gene Expression Intracellular Receptor Signaling Pathway Histone Deacetylase Complex Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Histone Deacetylase Activity, Hydrolytic Mechanism MRNA Transcription By RNA Polymerase II RNA Polymerase II-specific DNA-binding Transcription Factor Binding Chromatin DNA Binding Positive Regulation Of Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Metabolic Process Epigenetic Regulation Of Gene Expression Regulation Of Macromolecule Metabolic Process Hormone-mediated Signaling Pathway Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Protein Lysine Deacetylase Activity Transcription By RNA Polymerase II MRNA Transcription Regulation Of Metabolic Process Nucleoplasm Positive Regulation Of Macromolecule Metabolic Process Circadian Regulation Of Gene Expression Positive Regulation Of Metabolic Process Regulation Of Small Molecule Metabolic Process Nuclear Retinoid X Receptor Binding Negative Regulation Of Biosynthetic Process Histone Deacetylase Activity Histone Deacetylase Binding RNA Polymerase II Transcription Regulator Complex
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