NRIP1 and NR2C1

Number of citations of the paper that reports this interaction (PubMedID 9774688)
45

Data Source:
HPRD (two hybrid, in vitro, in vivo)

		NRIP1	NR2C1
Description		nuclear receptor interacting protein 1	nuclear receptor subfamily 2 group C member 1
Image			No pdb structure
GO Annotations	Cellular Component	Histone Deacetylase Complex Chromatin Fibrillar Center Nucleus Nucleoplasm Nucleolus Cytosol Nuclear Speck	Chromatin Nucleus Nucleoplasm PML Body
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Transcription Coregulator Activity Transcription Coactivator Activity Transcription Corepressor Activity Signaling Receptor Binding Protein Binding Nuclear Receptor Binding Nuclear Estrogen Receptor Binding Nuclear Glucocorticoid Receptor Binding Histone Deacetylase Binding Nuclear Retinoic Acid Receptor Binding Nuclear Retinoid X Receptor Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Nuclear Steroid Receptor Activity Nuclear Receptor Activity Protein Binding Zinc Ion Binding Signaling Receptor Activity Protein Homodimerization Activity Histone Deacetylase Binding Sequence-specific DNA Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Ovarian Follicle Rupture Regulation Of Transcription By RNA Polymerase II Circadian Rhythm Lipid Storage Ovulation Circadian Regulation Of Gene Expression Positive Regulation Of Transcription By RNA Polymerase II Rhythmic Process Cellular Response To Estradiol Stimulus	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Cell Differentiation Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Intracellular Receptor Signaling Pathway Negative Regulation Of DNA-templated Transcription Positive Regulation Of Retinoic Acid Receptor Signaling Pathway
Pathways		SUMOylation of transcription cofactors Estrogen-dependent gene expression NR1H2 & NR1H3 regulate gene expression linked to lipogenesis NR1H2 & NR1H3 regulate gene expression linked to gluconeogenesis Heme signaling Expression of BMAL (ARNTL), CLOCK, and NPAS2 RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression	Nuclear Receptor transcription pathway SUMOylation of intracellular receptors
Drugs		4-HYDROXY-N'-(4-ISOPROPYLBENZYL)BENZOHYDRAZIDE
Diseases
GWAS		Alcohol dependence ( 26365420) Birth weight ( 27680694 31043758) Blood urea nitrogen levels ( 31152163) Breast cancer ( 23535729 29059683) Chronic kidney disease ( 31152163) Cognitive performance ( 19734545) Crohn's disease ( 25489960) Depression in smokers ( 30219690) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) Estimated glomerular filtration rate ( 31152163 31451708 30604766 31015462) Estimated glomerular filtration rate in non-diabetics ( 31451708) Gastroesophageal reflux disease ( 31527586) HDL cholesterol levels ( 32203549) Hematocrit ( 32888494) Hemoglobin ( 32888494) Lymphocyte count ( 32888494) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (diuretics) ( 31015401) Monocyte count ( 32888494) Monocyte percentage of white cells ( 32888494) Mosaic loss of chromosome Y (Y chromosome dosage) ( 31624269) Platelet count ( 32888494) Platelet distribution width ( 27863252 32888494) Plateletcrit ( 32888494) Pulse pressure ( 27841878) Red blood cell count ( 32888494) Refractive error ( 32231278) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Systolic blood pressure ( 27841878) White blood cell count ( 32888494)	Body fat mass ( 28552196) Chromosomal aberration frequency (chromosome type) ( 31586183) Coronary artery disease ( 32469254) Intracranial aneurysm ( 33199917) Trunk fat mass ( 28552196)
Interacting Genes		124 interacting genes: ACBD3 ACTN2 AGR2 AHR AKAP6 ANKRD24 APP AR ARPC3 BAIAP2 BRCA1 CCDC85B CDK8 CEP70 CIB1 CLPB COG4 CREBZF CRNKL1 CTBP1 CTBP2 DNMT1 DNMT3A DNMT3B DST DYNC2I1 E2F1 ERC2 ESR1 ESR2 ESRRA ESRRB ESRRG EXOC7 FEZ1 FMNL2 GPRASP3 GPSM2 HDAC1 HDAC2 HDAC3 HDAC5 HDAC9 HECTD1 HNF4A HSPA5 HUWE1 IMMT IPO5 IQGAP1 JAKMIP3 JUN KALRN KANK2 KAT2B KDM5B KIF3A KIF5A KLHL7 KPNA3 KPNA4 LDOC1 LRRCC1 MACF1 MAP3K7 MAPK8IP3 MLLT3 MTMR10 NCKAP5 NR0B1 NR1H2 NR1H3 NR2C1 NR3C1 NR5A1 NR5A2 NSUN2 OAZ1 ODF2 PIAS1 PIAS3 PKNOX1 PKNOX2 PLAAT3 PLK2 PPARA PPARD PPARG PRMT1 PSMD1 RABEP1 RARA RARB RORB RXRA RXRB RXRG SCG2 SCG3 SESTD1 SF3B1 SHTN1 SNX1 SPTB SPTBN1 TERF1 TEX11 THRA THRB TMEM131 TNFRSF14 TRAF2 TRIM8 TRIM9 TRIP12 TTLL5 TULP3 TXLNG TXNDC11 UBE2I VDR YWHAH ZNF365 ZNF821	8 interacting genes: AR ESR1 HDAC3 HDAC4 NR2C2 NRIP1 NUDT3 RARA
Entrez ID		8204	7181
HPRD ID		03927	03318
Ensembl ID		ENSG00000180530	ENSG00000120798
Uniprot IDs		A8K171 P48552	H9NIM2 H9NIM3 P13056
PDB IDs		2GPO 2GPP 4S14 4S15 5NTI 5NTN 5NTW 5NU1 6FZU 6G05 6G07 9CWN
Enriched GO Terms of Interacting Partners?		Nuclear Receptor Activity Intracellular Receptor Signaling Pathway Nuclear Receptor-mediated Signaling Pathway Hormone-mediated Signaling Pathway Nuclear Steroid Receptor Activity Steroid Hormone Receptor Signaling Pathway Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Negative Regulation Of Nucleobase-containing Compound Metabolic Process Chromatin Negative Regulation Of RNA Metabolic Process Sequence-specific DNA Binding Retinoic Acid Receptor Signaling Pathway Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process RNA Polymerase II Transcription Regulator Complex DNA-binding Transcription Factor Activity Intracellular Signal Transduction Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Regulation Of RNA Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Positive Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Biosynthetic Process Positive Regulation Of Metabolic Process Nucleoplasm Estrogen Response Element Binding Transcription Coregulator Binding Sequence-specific Double-stranded DNA Binding Enzyme Binding Regulation Of Primary Metabolic Process Regulation Of Developmental Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Cytoplasm Nucleus Negative Regulation Of Biosynthetic Process DNA Binding Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Regulation Of Metabolic Process	Nuclear Receptor Activity Cellular Response To Estrogen Stimulus Negative Regulation Of Transcription By RNA Polymerase II Chromatin Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Histone Deacetylase Binding Negative Regulation Of RNA Metabolic Process Histone Deacetylase Complex Negative Regulation Of Nucleobase-containing Compound Metabolic Process Transcription Coactivator Binding Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Intracellular Receptor Signaling Pathway Response To Estrogen Positive Regulation Of RNA Metabolic Process Regulation Of MiRNA Transcription Positive Regulation Of Nucleobase-containing Compound Metabolic Process Transcription By RNA Polymerase II Regulation Of MiRNA Metabolic Process Prostate Gland Growth Histone Deacetylase Activity, Hydrolytic Mechanism Estrogen Response Element Binding Negative Regulation Of Macromolecule Biosynthetic Process Nuclear Receptor-mediated Signaling Pathway Negative Regulation Of Biosynthetic Process Cellular Response To Hormone Stimulus Protein Deacetylation Protein Lysine Deacetylase Activity Male Gonad Development Response To Lipid Response To Estradiol Enzyme Binding Mammary Gland Alveolus Development Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Myotube Differentiation DNA-templated Transcription Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Gonad Development Histone Deacetylase Activity Hormone-mediated Signaling Pathway Positive Regulation Of Biosynthetic Process Sequence-specific DNA Binding Nucleoplasm Nuclear Steroid Receptor Activity Cellular Response To Lipid Prostate Gland Epithelium Morphogenesis
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