ANKRD11 and RAC3

Number of citations of the paper that reports this interaction (PubMedID 15184363)
0

Data Source:
HPRD (two hybrid, in vitro)

		ANKRD11	RAC3
Description		ankyrin repeat domain containing 11	Rac family small GTPase 3
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol	Cytoplasm Endoplasmic Reticulum Membrane Cytosol Cytoskeleton Plasma Membrane Endomembrane System Membrane Lamellipodium Growth Cone Cytoplasmic Vesicle Filamentous Actin Cell Projection Neuron Projection NADPH Oxidase Complex Neuronal Cell Body Perinuclear Region Of Cytoplasm Extracellular Exosome Cell Periphery Postsynapse Glutamatergic Synapse
	Molecular Function		Nucleotide Binding GTPase Activity G Protein Activity Protein Binding GTP Binding Hydrolase Activity Protein Kinase Binding Calcium-dependent Protein Binding
	Biological Process	Odontogenesis Of Dentin-containing Tooth Skeletal System Morphogenesis Head Morphogenesis Face Development Face Morphogenesis	Actin Filament Organization Establishment Or Maintenance Of Cell Polarity Small GTPase-mediated Signal Transduction Motor Neuron Axon Guidance Regulation Of Cell Shape Regulation Of Cell-substrate Adhesion Regulation Of Neuron Maturation Wnt Signaling Pathway Rac Protein Signal Transduction Cerebral Cortex GABAergic Interneuron Development Regulation Of Cell Morphogenesis Cell Projection Assembly Actin Cytoskeleton Organization Cortical Cytoskeleton Organization Neuron Projection Development Regulation Of Actin Cytoskeleton Organization Positive Regulation Of Cell Adhesion Mediated By Integrin Intracellular Signal Transduction Respiratory Burst Homeostasis Of Number Of Cells Within A Tissue Neuromuscular Process Controlling Balance Neuromuscular Process Synaptic Transmission, GABAergic Cell Chemotaxis Postsynaptic Actin Cytoskeleton Organization Regulation Of Postsynapse Assembly Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Regulation Of Neutrophil Migration
Pathways			PCP/CE pathway RAC3 GTPase cycle
Drugs
Diseases
GWAS		Eosinophil count ( 32888494) Femur bone mineral density x serum urate levels interaction ( 34046847) Hemoglobin levels ( 32327693) Hip circumference adjusted for BMI ( 34021172) Lymphocyte count ( 27863252 32888494) Waist circumference adjusted for body mass index ( 34021172)	Refractive error ( 32231278)
Interacting Genes		92 interacting genes: ABHD11 AGR2 ANKRD33 ARID3A ARID5A BRCC3 C18orf54 C1QTNF2 CALCA CCDC196 CCHCR1 CCN3 CDC23 CDCA7L CDR2L CEP44 CFAP68 COG4 DEPTOR FAM136A FAM221B FOLR3 FTO GOLGA2 GOLGA6L9 GPRASP3 GRIPAP1 HAUS3 HDAC3 HDAC4 HDAC5 HOMEZ HOOK2 HRAS IGFBP6 IKZF1 ITGB3BP KANK2 KRT34 LZTS2 MECOM MKRN3 MTFR1L MTUS2 MXRA8 MYF5 NAB2 NCOA1 NCOA2 NCOA3 NOTO NTAQ1 PDE4DIP PIH1D2 PLAGL2 PPARA RAC3 RCOR3 RINT1 RPH3AL RSPO4 RUBCN SERTAD3 SNRNP35 SPANXN2 SPATA2 SPMIP5 SPRY1 SRC STMN3 STRA8 SYTL3 TADA2B TFIP11 TLE5 TNNI1 TRAF2 TRIM37 TRIM54 TSPOAP1 TTC23L TXN UFC1 USH1G USP54 USP6 VDR VHL ZNF426 ZNF552 ZNF655 ZNF688	9 interacting genes: ANKRD11 AR ARFIP2 ARHGDIB CIB1 ESR1 HDAC7 HNF1A NRBP1
Entrez ID		29123	5881
HPRD ID		12456	03629
Ensembl ID		ENSG00000167522	ENSG00000169750
Uniprot IDs		Q6UB99	P60763
PDB IDs			2C2H 2G0N 2IC5 2OV2 2QME 6TM1
Enriched GO Terms of Interacting Partners?		Protein Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Histone Deacetylase Complex Negative Regulation Of Striated Muscle Cell Differentiation Negative Regulation Of Myotube Differentiation Regulation Of Myotube Differentiation Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Striated Muscle Cell Differentiation Histone Deacetylase Activity, Hydrolytic Mechanism Nuclear Receptor-mediated Signaling Pathway Regulation Of Transcription By RNA Polymerase II Peroxisome Proliferator Activated Receptor Signaling Pathway Negative Regulation Of Muscle Cell Differentiation Protein Lysine Deacetylase Activity Cellular Response To Thyroglobulin Triiodothyronine Nuclear Retinoid X Receptor Binding Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Metabolic Process Negative Regulation Of RNA Biosynthetic Process Centrosome Cycle Histone Deacetylase Activity Vitamin D Receptor Signaling Pathway Regulation Of Muscle Cell Differentiation Protein Deubiquitination DNA-binding Transcription Activator Activity Response To Thyroglobulin Triiodothyronine Regulation Of Primary Metabolic Process Protein Modification By Small Protein Removal	Regulation Of Reproductive Process Estrogen Response Element Binding Prostate Gland Growth Cellular Response To Estrogen Stimulus Mammary Gland Alveolus Development Prostate Gland Epithelium Morphogenesis Estrogen Receptor Signaling Pathway Nuclear Steroid Receptor Activity Positive Regulation Of Cell Migration Involved In Sprouting Angiogenesis Steroid Binding 14-3-3 Protein Binding Prostate Induction Organ Growth Transcription Coactivator Binding Nuclear Receptor Activity Response To Estrogen Male Somatic Sex Determination Regulation Of Morphogenesis Of A Branching Structure Small GTPase Binding Positive Regulation Of Male Germ Cell Proliferation Positive Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Cell Migration Involved In Sprouting Angiogenesis Regulation Of Morphogenesis Of An Epithelium Regulation Of MiRNA Transcription Steroid Hormone Receptor Signaling Pathway Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Positive Regulation Of Reproductive Process Lateral Sprouting Involved In Mammary Gland Duct Morphogenesis ATPase Binding Regulation Of MiRNA Metabolic Process Regulation Of Pronephros Size Beta-catenin Binding Regulation Of Protein Localization To Plasma Membrane Chromatin Binding Male Genitalia Morphogenesis Cytoplasm POU Domain Binding Male Gonad Development Nuclear Receptor-mediated Signaling Pathway Tertiary Branching Involved In Mammary Gland Duct Morphogenesis Positive Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Positive Regulation Of Integrin Biosynthetic Process Rho GDP-dissociation Inhibitor Activity Cellular Response To Redox State Nuclear Estrogen Receptor Activity TFIIB-class Transcription Factor Binding Prostate Epithelial Cord Elongation Positive Regulation Of Nitric-oxide Synthase Activity Positive Regulation Of DNA-binding Transcription Factor Activity
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