| Novel |
CCN1
|
cellular communication network factor 1 |
- Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
- Post-translational protein phosphorylation
|
|
|
| Novel |
GPA33
|
glycoprotein A33 |
|
|
|
| Novel |
KCNMA1
|
potassium calcium-activated channel subfamily M alpha 1 |
- Ca2+ activated K+ channels
- cGMP effects
- Sensory processing of sound by inner hair cells of the cochlea
- Acetylcholine inhibits contraction of outer hair cells
|
- Chlorzoxazone
- Bendroflumethiazide
- Procaine
- Hydroflumethiazide
- Ritodrine
- Hydrochlorothiazide
- Nitrendipine
- Miconazole
- Diazoxide
- Halothane
- Colforsin
- Dequalinium
- Trimebutine
|
|
| Novel |
LBR
|
lamin B receptor |
- Cholesterol biosynthesis
- Initiation of Nuclear Envelope (NE) Reformation
- RHOA GTPase cycle
- RHOC GTPase cycle
- CDC42 GTPase cycle
- RAC1 GTPase cycle
- RAC2 GTPase cycle
- RHOD GTPase cycle
- RHOG GTPase cycle
- RAC3 GTPase cycle
- Regulation of MECP2 expression and activity
|
|
- HEM skeletal dysplasia; Greenberg dysplasia
- Pelger-Huet anomaly
|
| Novel |
PLAU
|
plasminogen activator, urokinase |
- Neutrophil degranulation
- Dissolution of Fibrin Clot
|
- Amiloride
- 2-{2-hydroxy-[1,1'-biphenyl]-3-yl}-1H-1,3-benzodiazole-5-carboximidamide
- 2-(2-Hydroxy-5-Methoxy-Phenyl)-1h-Benzoimidazole-5-Carboxamidine
- 6-(N-Phenylcarbamyl)-2-Naphthalenecarboxamidine
- 2-(2-hydroxy-phenyl)-3H-benzoimidazole-5-carboxamidine
- 6-[N-(4-(Aminomethyl)Phenyl)Carbamyl]-2-Naphthalenecarboxamidine
- 6-[N-(1-Isopropyl-3,4-Dihydro-7-Isoquinolinyl)Carbamyl]-2-Naphthalenecarboxamidine
- CRA_10655
- 6-[N-(4-Ethyl-1,2,3,4-Tetrahydro-6-Isoquinolinyl)Carbamyl]-2-Naphthalenecarboxamidine
- 6-[N-(1-Isopropyl-1,2,3,4-Tetrahydro-7-Isoquinolinyl)Carbamyl]-2-Naphthalenecarboxamidine
- 7-Methoxy-8-[1-(Methylsulfonyl)-1h-Pyrazol-4-Yl]Naphthalene-2-Carboximidamide
- 6-[(Z)-Amino(Imino)Methyl]-N-[4-(Aminomethyl)Phenyl]-4-(Pyrimidin-2-Ylamino)-2-Naphthamide
- Benzamidine
- 4-Iodobenzo[B]Thiophene-2-Carboxamidine
- CRA_8696
- Trans-6-(2-Phenylcyclopropyl)-Naphthalene-2-Carboxamidine
- 2-Amino-1H-benzimidazol-5-ol
- N-(1-adamantyl)-N'-(4-guanidinobenzyl)urea
- 6-Chloro-2-(2-Hydroxy-Biphenyl-3-Yl)-1h-Indole-5-Carboxamidine
- Thieno[2,3-B]Pyridine-2-Carboxamidine
- 8-(Pyrimidin-2-Ylamino)Naphthalene-2-Carboximidamide
- [2,4,6-Triisopropyl-Phenylsulfonyl-L-[3-Amidino-Phenylalanine]]-Piperazine-N'-Beta-Alanine
- Fibrinolysin
- 6-fluoro-2-(2-hydroxy-3-isobutoxy-phenyl)-1H-benzoimidazole-5-carboxamidine
- 6-FLUORO-2-[2-HYDROXY-3-(2-METHYL-CYCLOHEXYLOXY)-PHENYL]-1H-INDOLE-5-CARBOXAMIDINE
- N-(4-CARBAMIMIDOYL-3-CHORO-PHENYL)-2-HYDROXY-3-IODO-5-METHYL-BENZAMIDE
- 6-[(Z)-AMINO(IMINO)METHYL]-N-[3-(CYCLOPENTYLOXY)PHENYL]-2-NAPHTHAMIDE
- 1-[4-(2-oxo-2-phenylethyl)phenyl]guanidine
- (2R)-1-(2,6-dimethylphenoxy)propan-2-amine
- 4-(2-aminoethoxy)-N-(2,5-diethoxyphenyl)-3,5-dimethylbenzamide
- 4-(2-aminoethoxy)-N-(3-chloro-2-ethoxy-5-piperidin-1-ylphenyl)-3,5-dimethylbenzamide
- 4-(2-AMINOETHOXY)-3,5-DICHLORO-N-[3-(1-METHYLETHOXY)PHENYL]BENZAMIDE
- 4-(2-aminoethoxy)-N-(3-chloro-5-piperidin-1-ylphenyl)-3,5-dimethylbenzamide
|
|
| Novel |
PLXNA3
|
plexin A3 |
- Sema3A PAK dependent Axon repulsion
- SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
- SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
- CRMPs in Sema3A signaling
- CRMPs in Sema3A signaling
|
|
|
| Novel |
RBX1
|
ring-box 1 |
- Recognition of DNA damage by PCNA-containing replication complex
- Prolactin receptor signaling
- Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
- Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
- Vif-mediated degradation of APOBEC3G
- Degradation of beta-catenin by the destruction complex
- NOTCH1 Intracellular Domain Regulates Transcription
- Constitutive Signaling by NOTCH1 PEST Domain Mutants
- Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling
- Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
- Degradation of DVL
- Degradation of GLI1 by the proteasome
- Degradation of GLI2 by the proteasome
- GLI3 is processed to GLI3R by the proteasome
- Hedgehog 'on' state
- Regulation of RAS by GAPs
- DNA Damage Recognition in GG-NER
- Formation of Incision Complex in GG-NER
- Dual Incision in GG-NER
- Formation of TC-NER Pre-Incision Complex
- Transcription-Coupled Nucleotide Excision Repair (TC-NER)
- Dual incision in TC-NER
- Gap-filling DNA repair synthesis and ligation in TC-NER
- Orc1 removal from chromatin
- Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A
- FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
- Regulation of RUNX2 expression and activity
- Neddylation
- Regulation of expression of SLITs and ROBOs
- Interleukin-1 signaling
- Negative regulation of NOTCH4 signaling
- Potential therapeutics for SARS
- Regulation of BACH1 activity
- Nuclear events stimulated by ALK signaling in cancer
- KEAP1-NFE2L2 pathway
- GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2
- Antigen processing: Ubiquitination & Proteasome degradation
- Evasion by RSV of host interferon responses
- GSK3B-mediated proteasomal degradation of PD-L1(CD274)
- SPOP-mediated proteasomal degradation of PD-L1(CD274)
- Degradation of CRY and PER proteins
- Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide
|
|
|
| Novel |
SFTPA1
|
surfactant protein A1 |
- Toll Like Receptor 4 (TLR4) Cascade
- Toll Like Receptor TLR1:TLR2 Cascade
- Signal regulatory protein family interactions
- Surfactant metabolism
- Regulation of TLR by endogenous ligand
- Defective CSF2RB causes SMDP5
- Defective CSF2RA causes SMDP4
|
- 2-(N-morpholino)ethanesulfonic acid
|
|
| Novel |
SMR3B
|
submaxillary gland androgen regulated protein 3B |
|
|
|
|
DCN
|
decorin |
- Degradation of the extracellular matrix
- Glycosaminoglycan-protein linkage region biosynthesis
- CS-GAG biosynthesis
- DS-GAG biosynthesis
- CS/DS degradation
- ECM proteoglycans
- ECM proteoglycans
- Defective B4GALT7 causes EDS, progeroid type
- Defective B3GAT3 causes JDSSDHD
- Defective CHST3 causes SEDCJD
- Defective CHST14 causes EDS, musculocontractural type
- Defective CHSY1 causes TPBS
- Defective B3GALT6 causes EDSP2 and SEMDJL1
|
|
- Congenital stromal corneal dystrophy (CSCD); Congenital hereditary stromal dystrophy; Witschel dystrophy
|
|
DMBT1
|
deleted in malignant brain tumors 1 |
|
|
|
|
MFAP4
|
microfibril associated protein 4 |
- Molecules associated with elastic fibres
|
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|