PLS3 - New-wiki

Novel	Interactant Symbol	Name	Associated Pathways Hide	Binding Drugs Hide	Associated Diseases Hide
Novel	ACRV1	acrosomal vesicle protein 1
Novel	ASGR1	asialoglycoprotein receptor 1	Asparagine N-linked glycosylation	Von Willebrand factor human
Novel	CUL4B	cullin 4B	Recognition of DNA damage by PCNA-containing replication complex DNA Damage Recognition in GG-NER Formation of Incision Complex in GG-NER Dual Incision in GG-NER Formation of TC-NER Pre-Incision Complex Transcription-Coupled Nucleotide Excision Repair (TC-NER) Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER Neddylation		Syndromic X-linked mental retardation, including: Turner type (MRXST); Siderius type (MRXSSD) ; Cabezas type (MRXC); Raymond type (MRXSR); Type10 (MRXS10); Type14 (MRXS14); Mental retardation with isolated growth hormone deficiency (MRGH)
Novel	CXCR5	C-X-C motif chemokine receptor 5	Chemokine receptors bind chemokines G alpha (i) signalling events
Novel	FRYL	FRY like transcription coactivator
Novel	LRCH2	leucine rich repeats and calponin homology domain containing 2
Novel	NRSN1	neurensin 1
Novel	PTPN5	protein tyrosine phosphatase non-receptor type 5	Interleukin-37 signaling
Novel	TGIF2	TGFB induced factor homeobox 2	Downregulation of SMAD2/3:SMAD4 transcriptional activity SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription Negative Regulation of CDH1 Gene Transcription
Novel	TRPC5	transient receptor potential cation channel subfamily C member 5	TRP channels Role of second messengers in netrin-1 signaling
Novel	TSPAN32	tetraspanin 32
Novel	WFDC2	WAP four-disulfide core domain 2	Formation of the nephric duct
Novel	ZBTB33	zinc finger and BTB domain containing 33	Negative Regulation of CDH1 Gene Transcription
Novel	ZNF195	zinc finger protein 195	Generic Transcription Pathway
	APP	amyloid beta precursor protein	Platelet degranulation ECM proteoglycans Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) G alpha (q) signalling events G alpha (i) signalling events Lysosome Vesicle Biogenesis Formyl peptide receptors bind formyl peptides and many other ligands TAK1-dependent IKK and NF-kappa-B activation The NLRP3 inflammasome Advanced glycosylation endproduct receptor signaling Advanced glycosylation endproduct receptor signaling Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models Post-translational protein phosphorylation TRAF6 mediated NF-kB activation Insertion of tail-anchored proteins into the endoplasmic reticulum membrane Insertion of tail-anchored proteins into the endoplasmic reticulum membrane Purinergic signaling in leishmaniasis infection Amyloid fiber formation	Deferoxamine Aluminium Zinc L-methionine (R)-S-oxide Resveratrol Tromethamine Phenserine Tetrathiomolybdate CAD106 Mito-4509 Edonerpic Dimercaprol Copper Florbetaben (18F) Florbetapir (18F) Flutemetamol (18F) Gantenerumab Aducanumab Zinc acetate Aluminium phosphate Aluminum acetate Zinc chloride Zinc sulfate, unspecified form Lecanemab	Alzheimer's disease (AD)
	ATXN2	ataxin 2			Spinocerebellar ataxia (SCA); Machado-Joseph disease (SCA3)
	FILNC1	FOXO induced long non-coding RNA 1
	OGT	O-linked N-acetylglucosamine (GlcNAc) transferase	HATs acetylate histones RIPK1-mediated regulated necrosis Regulation of necroptotic cell death UCH proteinases Formation of WDR5-containing histone-modifying complexes
	SNCA	synuclein alpha	Amyloid fiber formation PKR-mediated signaling	Resveratrol Dequalinium Copper	Lewy body dementia (LBD); Dementia with Lewy bodies (DLB) Parkinson's disease (PD)

Search Results for: PLS3