GPAA1 - New-wiki

Novel	Interactant Symbol	Name	Associated Pathways Hide	Binding Drugs Hide	Associated Diseases Hide
Novel	ADAMDEC1	ADAM like decysin 1
Novel	CACNG8	calcium voltage-gated channel auxiliary subunit gamma 8	Trafficking of AMPA receptors Phase 0 - rapid depolarisation Phase 2 - plateau phase LGI-ADAM interactions	Ergocalciferol Enflurane Spironolactone Nicardipine Verapamil Efonidipine Butamben Bioallethrin
Novel	DGAT1	diacylglycerol O-acyltransferase 1	Acyl chain remodeling of DAG and TAG Neutrophil degranulation Triglyceride biosynthesis
Novel	GIT1	GIT ArfGAP 1	Ephrin signaling Ephrin signaling CDC42 GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle RHOQ GTPase cycle RHOJ GTPase cycle RHOU GTPase cycle RAC3 GTPase cycle RHOV GTPase cycle Activation of RAC1 downstream of NMDARs
Novel	LRRC14	leucine rich repeat containing 14	Regulation of NF-kappa B signaling
Novel	LY6E	lymphocyte antigen 6 family member E	Post-translational modification: synthesis of GPI-anchored proteins
Novel	NDRG1	N-myc downstream regulated 1	TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain		Charcot-Marie-Tooth disease (CMT); Hereditary motor and sensory neuropathy; Peroneal muscular atrophy
Novel	TERF2IP	TERF2 interacting protein	Recognition and association of DNA glycosylase with site containing an affected pyrimidine Cleavage of the damaged pyrimidine Recognition and association of DNA glycosylase with site containing an affected purine Recognition and association of DNA glycosylase with site containing an affected purine Cleavage of the damaged purine Cleavage of the damaged purine Meiotic synapsis Packaging Of Telomere Ends Telomere Extension By Telomerase Polymerase switching on the C-strand of the telomere Processive synthesis on the C-strand of the telomere Telomere C-strand (Lagging Strand) Synthesis Telomere C-strand synthesis initiation Removal of the Flap Intermediate from the C-strand DNA Damage/Telomere Stress Induced Senescence Inhibition of DNA recombination at telomere
Novel	TONSL	tonsoku like, DNA repair protein
	AGTR1	angiotensin II receptor type 1	Peptide ligand-binding receptors G alpha (q) signalling events Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis	Valsartan Olmesartan Losartan Candesartan cilexetil Eprosartan Telmisartan Irbesartan Forasartan Saprisartan Tasosartan CYT006-AngQb Azilsartan medoxomil Fimasartan Angiotensin II Candesartan	Renal tubular dysgenesis
	AQP2	aquaporin 2	Vasopressin regulates renal water homeostasis via Aquaporins Passive transport by Aquaporins		Congenital nephrogenic diabetes insipidus (NDI)
	EIF3E	eukaryotic translation initiation factor 3 subunit E	L13a-mediated translational silencing of Ceruloplasmin expression Translation initiation complex formation Formation of a pool of free 40S subunits Formation of the ternary complex, and subsequently, the 43S complex Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit
	GNRHR	gonadotropin releasing hormone receptor	Hormone ligand-binding receptors G alpha (q) signalling events	Leuprolide Goserelin Cetrorelix Abarelix Gonadorelin Nafarelin Danazol Teverelix Sufugolix Degarelix Buserelin Ganirelix Histrelin Triptorelin Gestrinone Relugolix Elagolix Linzagolix	Hypogonadotropic hypogonadism; Kallmann syndrome (KAL)
	GRIK5	glutamate ionotropic receptor kainate type subunit 5	Activation of Ca-permeable Kainate Receptor	Glutamic acid Butabarbital Topiramate
	PIGK	phosphatidylinositol glycan anchor biosynthesis class K	Attachment of GPI anchor to uPAR
	PIGT	phosphatidylinositol glycan anchor biosynthesis class T	Attachment of GPI anchor to uPAR
	PIGU	phosphatidylinositol glycan anchor biosynthesis class U	Attachment of GPI anchor to uPAR
	PIN1	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	ISG15 antiviral mechanism RHO GTPases Activate NADPH Oxidases Regulation of TP53 Activity through Phosphorylation PI5P Regulates TP53 Acetylation Negative regulators of DDX58/IFIH1 signaling	Beta-(2-Naphthyl)-Alanine 3,6,9,12,15,18-HEXAOXAICOSANE
	PRR13	proline rich 13

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