BGLAP and ASPH

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		BGLAP	ASPH
Name		bone gamma-carboxyglutamate protein	aspartate beta-hydroxylase
Structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Endoplasmic Reticulum Lumen Golgi Lumen Dendrite Vesicle Cell Projection Perikaryon	Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Junctional Sarcoplasmic Reticulum Membrane Membrane Sarcoplasmic Reticulum Cortical Endoplasmic Reticulum Sarcoplasmic Reticulum Membrane Sarcoplasmic Reticulum Lumen Calcium Channel Complex
	Molecular Function	Hormone Activity Structural Molecule Activity Calcium Ion Binding Protein Binding Structural Constituent Of Bone Hydroxyapatite Binding Metal Ion Binding	Structural Molecule Activity Calcium Ion Binding Protein Binding Structural Constituent Of Muscle Electron Transfer Activity Oxidoreductase Activity Transmembrane Transporter Binding Metal Ion Binding Dioxygenase Activity Peptidyl-aspartic Acid 3-dioxygenase Activity
	Biological Process	Skeletal System Development Ossification Osteoblast Differentiation Positive Regulation Of Neurotransmitter Secretion Cell Adhesion Signal Transduction Brain Development Learning Or Memory Response To Xenobiotic Stimulus Response To Mechanical Stimulus Response To Gravity Response To Zinc Ion Response To Activity Bone Mineralization Regulation Of Bone Mineralization Biomineral Tissue Development Response To Nutrient Levels Response To Vitamin K Response To Insulin Cellular Response To Insulin Stimulus Response To Vitamin D Response To Testosterone Response To Hydroxyisoflavone Cellular Response To Zinc Ion Starvation Response To Macrophage Colony-stimulating Factor Glucose Homeostasis Response To Estrogen Type B Pancreatic Cell Proliferation Regulation Of Bone Resorption Response To Ethanol Regulation Of Osteoclast Differentiation System Development Stem Cell Differentiation Cognition Response To Glucocorticoid Bone Development Cellular Response To Vitamin D Cellular Response To Growth Factor Stimulus Regulation Of Cellular Response To Insulin Stimulus Negative Regulation Of Bone Development Regulation Of Testosterone Biosynthetic Process	Detection Of Calcium Ion Muscle Contraction Pattern Specification Process Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Positive Regulation Of Calcium Ion Transport Into Cytosol Regulation Of Cell Communication By Electrical Coupling Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Regulation Of Protein Stability Activation Of Store-operated Calcium Channel Activity Response To ATP Limb Morphogenesis Positive Regulation Of Proteolysis Positive Regulation Of DNA-templated Transcription Regulation Of Cytosolic Calcium Ion Concentration Calcium Ion Homeostasis Roof Of Mouth Development Face Morphogenesis Calcium Ion Transmembrane Transport Cellular Response To Calcium Ion Positive Regulation Of Intracellular Protein Transport Regulation Of Protein Depolymerization
Pathways		Gamma-carboxylation of protein precursors Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus Removal of aminoterminal propeptides from gamma-carboxylated proteins RUNX2 regulates osteoblast differentiation	Stimuli-sensing channels Ion homeostasis Protein hydroxylation
Drugs		Menadione Phylloquinone gamma-carboxy-L-glutamic acid Gallium nitrate	Aspartic acid
GWAS		Estimated glomerular filtration rate ( 30604766 ) Mean corpuscular hemoglobin concentration ( 20139978 ) Mosaic loss of chromosome Y (Y chromosome dosage) ( 31624269 ) White matter hyperintensity burden ( 25663218 )	Blood protein levels ( 30072576 ) BRCA1/2-negative high-risk breast cancer ( 30323354 ) Resting heart rate ( 28270201 ) Serum omega-6 to omega-3 polyunsaturated fatty acid ratio in metabolic syndrome ( 31991592 ) Urate levels in overweight individuals ( 25811787 )
Interacting Genes		6 interacting genes: ASPH CTSB CTSD CTSH CTSS GGCX	73 interacting genes: - AGR2 APP BGLAP CDSN CHRM5 CST1 CTSA CXorf66 DCD DEFB1 DHRSX ENPP6 FBXO7 FDCSP FGFBP1 FKBP7 GAL GAST GET3 GOLM1 GPR119 GPX7 GPX8 GSC2 GUCA2A IL21 INSL5 KCNIP1 KCNIP3 KCNIP4 LCN2 LINC00632 LRPAP1 LTA NUCB2 OCIAD1 OGT PCSK4 PDGFA PDGFRL PLAAT2 PLEKHF2 PRAP1 PRB1 PRB2 PRB4 PRH1 PTH PTN RCN1 RELL2 RNASEH1 SCGB1C2 SDC2 SF3A2 SGTB SHISAL1 SLC51B SMIM11 SMIM19 SOD3 SPINK1 TMEM167B TMX2 TNFRSF10B TRDN TUFM TXNDC15 UGT2B11 WFDC12 WFDC5 ZG16
Entrez ID		632	444
HPRD ID		00205	08996
Ensembl ID		ENSG00000242252	ENSG00000198363
Uniprot IDs		P02818	B4DQ07 B7ZM96 G3XAN5 Q12797
PDB IDs		8XS1 9BUR 9BUX	5APA 5JQY 5JTC 5JZ6 5JZ8 5JZA 5JZU 6Q9F 6Q9I 6QA5 6RK9 6YYU 6YYV 6YYW 6YYX 6YYY 6Z6Q 6Z6R 7BMI 7BMJ 7E6J 7YB8 7YB9 7YBA 7YBB 7YBC 8RE5 8RE6 8RE7 8RE8 8RE9
GO Terms Enriched among Interactors		Cysteine-type Endopeptidase Activity Cellular Response To Thyroid Hormone Stimulus Ficolin-1-rich Granule Lumen Response To Thyroid Hormone Tertiary Granule Lumen Endolysosome Lumen Endopeptidase Activity Antigen Processing And Presentation Extracellular Matrix Peptidase Activity Proteoglycan Binding Lysosome Cysteine-type Peptidase Activity Positive Regulation Of Cation Channel Activity Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Positive Regulation Of Ion Transmembrane Transporter Activity Positive Regulation Of Transporter Activity Collagen Catabolic Process Antigen Processing And Presentation Of Exogenous Peptide Antigen Antigen Processing And Presentation Of Exogenous Antigen Protein Maturation Cellular Response To Hormone Stimulus Collagen Metabolic Process Collagen Binding Antigen Processing And Presentation Of Peptide Antigen Proteolysis Regulation Of Transmembrane Transporter Activity Regulation Of Monoatomic Ion Transmembrane Transporter Activity HLA-A Specific Activating MHC Class I Receptor Activity Gamma-glutamyl Carboxylase Activity Lysosomal Lumen Melanosome Peptidyl-aspartic Acid 3-dioxygenase Activity Positive Regulation Of Cation Transmembrane Transport Extracellular Space Aspartic-type Peptidase Activity Kininogen Binding Vitamin Binding Negative Regulation Of Bone Development Positive Regulation Of Monoatomic Ion Transmembrane Transport Protein Metabolic Process Response To Hormone Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Hydrolase Activity Response To Odorant Dichotomous Subdivision Of Terminal Units Involved In Lung Branching Basement Membrane Disassembly Negative Regulation Of Testosterone Biosynthetic Process	Extracellular Region Golgi Lumen Extracellular Space Endoplasmic Reticulum Lumen Hormone Activity Defense Response To Bacterium Response To Bacterium Endoplasmic Reticulum Antibacterial Humoral Response Defense Response To Gram-positive Bacterium Regulation Of Metal Ion Transport Peptidase Inhibitor Activity Regulation Of Monoatomic Cation Transmembrane Transport Regulation Of Potassium Ion Transmembrane Transport Regulation Of Monoatomic Ion Transmembrane Transport