RBM22 and PRC1

Number of citations: 84 (PubMedID 34133714)
Data Source: BioGRID (two hybrid)

		RBM22	PRC1
Name		RNA binding motif protein 22	protein regulator of cytokinesis 1
Structure
GO Annotations	Cellular Component	Prp19 Complex Nucleus Nucleoplasm Spliceosomal Complex Cytoplasm U2-type Catalytic Step 1 Spliceosome U2-type Catalytic Step 2 Spliceosome Catalytic Step 2 Spliceosome	Spindle Pole Nucleus Nucleoplasm Chromosome Cytoplasm Spindle Cytosol Cytoskeleton Microtubule Spindle Microtubule Plasma Membrane Microtubule Cytoskeleton Midbody Intercellular Bridge Contractile Ring Mitotic Spindle Midzone
	Molecular Function	Nucleic Acid Binding RNA Binding Protein Binding Zinc Ion Binding U6 SnRNA Binding Pre-mRNA Binding Metal Ion Binding Calcium-dependent Protein Binding	Protein Binding Microtubule Binding Kinesin Binding Protein Kinase Binding Identical Protein Binding
	Biological Process	MRNA Splicing, Via Spliceosome MRNA Processing RNA Splicing Positive Regulation Of RNA Splicing Positive Regulation Of Protein Import Into Nucleus MRNA Cis Splicing, Via Spliceosome Positive Regulation Of Protein Export From Nucleus Cellular Response To Xenobiotic Stimulus	Mitotic Spindle Elongation Microtubule Cytoskeleton Organization Positive Regulation Of Cell Population Proliferation Regulation Of Cytokinesis Mitotic Spindle Midzone Assembly Cell Division
Pathways		mRNA Splicing - Major Pathway	RHO GTPases activate CIT
GWAS		Cholangiocarcinoma in primary sclerosing cholangitis ( 28779025 ) Crohn's disease ( 28067908 ) Inflammatory bowel disease ( 28067908 )	Breast cancer ( 25038754 29059683 ) Mean platelet volume ( 27863252 32888494 ) Multisite chronic pain ( 31194737 33830993 ) Red cell distribution width ( 32888494 ) Type 2 diabetes ( 20581827 22885922 24509480 26818947 28869590 30054458 30297969 30718926 32499647 )
Interacting Genes		45 interacting genes: AQR BAG4 BCAS2 BICD2 BMI1 CEBPA CEP55 CTBP1 CYSRT1 DMRTB1 EIF4ENIF1 ESS2 EXOSC7 EXOSC8 GIGYF1 GOLGA2 HNRNPUL1 HOMER3 HOOK1 KRT31 NCKIPSD NOA1 NXF1 OGT PQBP1 PRC1 PRMT2 PRNP PRPF39 PRPF6 RBFOX2 RBM4 RBPMS RNU6-1 RNU6-50P RNU6-6P SNRPA SNW1 TFIP11 TXNL4A VIM WBP4 YBX2 YTHDF1 YTHDF3	43 interacting genes: AKAP9 BICD2 CASK CCDC85B CCNA2 CCNB1 CCNE1 CDK1 CDK2 CEBPA CINP EMG1 EXOSC7 EXOSC8 FXR2 KIF3B KIF4A KLC2 KLC4 KRT20 LARP4 MAT2A NDEL1 NUDT16 OGT PBK PCM1 PKIA PLK1 PPIE RACGAP1 RBM10 RBM17 RBM22 RPA2 SF3B2 SLAIN1 SUMO2 TFIP11 THOC1 TRIM37 USHBP1 YWHAE
Entrez ID		55696	9055
HPRD ID		10186	17899
Ensembl ID		ENSG00000086589	ENSG00000198901
Uniprot IDs		Q9NW64	O43663
PDB IDs		2YTC 5MQF 5XJC 5YZG 5Z56 5Z57 6FF4 6FF7 6ICZ 6ID0 6ID1 6QDV 6ZYM 7A5P 7AAV 7ABG 7ABI 7QTT 7W59 7W5A 7W5B 8C6J 8CH6 8I0P 8I0R 8I0S 8I0T 8I0U 8I0V 8I0W 8RO2 9FMD	3NRX 3NRY 4L3I 4L6Y 5KMG 7VBG
GO Terms Enriched among Interactors		RNA Splicing MRNA Metabolic Process MRNA Processing MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions RNA Processing Spliceosomal Complex RNA Binding RNA Metabolic Process Catalytic Step 2 Spliceosome Regulation Of MRNA Metabolic Process Cytoplasmic Stress Granule MRNA Binding Nuclear Speck Nucleic Acid Metabolic Process U4/U6 X U5 Tri-snRNP Complex Membraneless Organelle Assembly U5 SnRNA 3'-end Processing U1 SnRNA 3'-end Processing Nucleus Identical Protein Binding Alternative MRNA Splicing, Via Spliceosome Negative Regulation Of Metabolic Process Nucleobase-containing Compound Metabolic Process Nucleoplasm U2-type Catalytic Step 2 Spliceosome Cellular Component Assembly Exoribonuclease Complex Regulation Of RNA Splicing Nucleic Acid Binding P-body Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) TRAMP-dependent TRNA Surveillance Pathway TRNA Surveillance Nuclear Polyadenylation-dependent RRNA Catabolic Process Negative Regulation Of Macromolecule Metabolic Process Regulation Of Translational Initiation U4 SnRNA 3'-end Processing Regulation Of Long-term Synaptic Potentiation Regulation Of MRNA Splicing, Via Spliceosome Positive Regulation Of Translational Initiation Memory RRNA 3'-end Processing Nucleolar Exosome (RNase Complex) U2-type Precatalytic Spliceosome TRNA Decay Nuclear MRNA Surveillance Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of MRNA Processing Pre-mRNA Intronic Binding	Microtubule-based Process Nucleic Acid Metabolic Process Organelle Organization Microtubule Cytoskeleton Organization G2/M Transition Of Mitotic Cell Cycle Cytoskeleton Cell Cycle G2/M Phase Transition Cytoskeleton Organization Nucleobase-containing Compound Metabolic Process Microtubule Cytoskeleton Organization Involved In Mitosis Regulation Of Cell Cycle Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Cell Cycle Process Mitotic Cell Cycle Phase Transition Cytoplasm G1/S Transition Of Mitotic Cell Cycle Regulation Of Intracellular Protein Transport MRNA Metabolic Process Cell Cycle G1/S Phase Transition Nucleoplasm Nucleus Cell Cycle Phase Transition Centrosome Separation Centrosome Spindle Microtubule Microtubule Organizing Center RNA Metabolic Process Regulation Of Intracellular Transport Cyclin-dependent Protein Kinase Holoenzyme Complex Regulation Of Ubiquitin-dependent Protein Catabolic Process Kinesin Complex Cyclin A2-CDK1 Complex Cyclin B1-CDK1 Complex Regulation Of G2/M Transition Of Mitotic Cell Cycle MRNA Splicing, Via Spliceosome Regulation Of Proteasomal Protein Catabolic Process RNA Binding Regulation Of Cell Cycle G2/M Phase Transition Regulation Of Nucleocytoplasmic Transport RNA Splicing, Via Transesterification Reactions Cell Division Cyclin A2-CDK2 Complex Cyclin E1-CDK2 Complex Cyclin-dependent Protein Kinase Activity U5 SnRNA 3'-end Processing U1 SnRNA 3'-end Processing Regulation Of Mitotic Cell Cycle Phase Transition Protein Localization To Organelle Regulation Of Attachment Of Spindle Microtubules To Kinetochore Mitotic DNA Damage Checkpoint Signaling