DAB1 and ROR2 |
Dab, reelin signal transducer, homolog 1 (Drosophila) |
receptor tyrosine kinase-like orphan receptor 2 |
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- WNT5A-dependent internalization of FZD2, FZD5 and ROR2
- Signaling by Wnt
- PCP/CE pathway
- beta-catenin independent WNT signaling
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FMR1 and FXR1 |
fragile X mental retardation 1 |
fragile X mental retardation, autosomal homolog 1 |
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FZD2 and ROR2 |
frizzled class receptor 2 |
receptor tyrosine kinase-like orphan receptor 2 |
- Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD)
- Signaling by GPCR
- misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
- Signaling by Wnt
- GPCR ligand binding
- Metabolic disorders of biological oxidation enzymes
- beta-catenin independent WNT signaling
- disassembly of the destruction complex and recruitment of AXIN to the membrane
- WNT5A-dependent internalization of FZD2, FZD5 and ROR2
- Ca2+ pathway
- TCF dependent signaling in response to WNT
- RNF mutants show enhanced WNT signaling and proliferation
- Asymmetric localization of PCP proteins
- XAV939 inhibits tankyrase, stabilizing AXIN
- Signaling by WNT in cancer
- PCP/CE pathway
- Class B/2 (Secretin family receptors)
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- WNT5A-dependent internalization of FZD2, FZD5 and ROR2
- Signaling by Wnt
- PCP/CE pathway
- beta-catenin independent WNT signaling
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GPC1 and COL18A1 |
glypican 1 |
collagen, type XVIII, alpha 1 |
- MPS IIIB - Sanfilippo syndrome B
- Diseases of glycosylation
- Defective B4GALT7 causes EDS, progeroid type
- Axon guidance
- Heparan sulfate/heparin (HS-GAG) metabolism
- MPS I - Hurler syndrome
- MPS IX - Natowicz syndrome
- Chondroitin sulfate/dermatan sulfate metabolism
- Defective SLC26A2 causes chondrodysplasias
- Glycosaminoglycan metabolism
- Inactivation of Cdc42 and Rac
- Defective CHST14 causes EDS, musculocontractural type
- Defective B4GALT1 causes B4GALT1-CDG (CDG-2d)
- Defective PAPSS2 causes SEMD-PA
- Activation of Rac
- MPS IIIA - Sanfilippo syndrome A
- Myoclonic epilepsy of Lafora
- Defective CHST6 causes MCDC1
- Glycogen storage diseases
- MPS IIID - Sanfilippo syndrome D
- A tetrasaccharide linker sequence is required for GAG synthesis
- MPS IIIC - Sanfilippo syndrome C
- Retinoid metabolism and transport
- Role of Abl in Robo-Slit signaling
- Diseases associated with glycosaminoglycan metabolism
- Mucopolysaccharidoses
- Defective EXT2 causes exostoses 2
- MPS II - Hunter syndrome
- Defective B3GAT3 causes JDSSDHD
- Defective CHST3 causes SEDCJD
- Defective EXT1 causes exostoses 1, TRPS2 and CHDS
- Diseases associated with visual transduction
- MPS IV - Morquio syndrome A
- Visual phototransduction
- MPS IV - Morquio syndrome B
- Defective CHSY1 causes TPBS
- MPS VII - Sly syndrome
- Metabolism of carbohydrates
- Signaling by Robo receptor
- HS-GAG biosynthesis
- HS-GAG degradation
- MPS VI - Maroteaux-Lamy syndrome
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- Collagen formation
- Laminin interactions
- Collagen degradation
- Activation of Matrix Metalloproteinases
- Integrin cell surface interactions
- Collagen biosynthesis and modifying enzymes
- Degradation of the extracellular matrix
- Assembly of collagen fibrils and other multimeric structures
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GSN and TNIK |
gelsolin |
TRAF2 and NCK interacting kinase |
- Amyloids
- Apoptotic cleavage of cellular proteins
- Programmed Cell Death
- Apoptotic execution phase
- Caspase-mediated cleavage of cytoskeletal proteins
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- Oxidative Stress Induced Senescence
- Cellular Senescence
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IL2RA and NFKB1 |
interleukin 2 receptor, alpha |
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 |
- Signaling by GPCR
- G-protein beta:gamma signalling
- Cytokine Signaling in Immune system
- Signaling by Interleukins
- GPCR downstream signaling
- Interleukin receptor SHC signaling
- G beta:gamma signalling through PI3Kgamma
- Interleukin receptor SHC signaling
- GPVI-mediated activation cascade
- Interleukin-2 signaling
- Platelet activation, signaling and aggregation
- Interleukin-3, 5 and GM-CSF signaling
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- Signaling by the B Cell Receptor (BCR)
- NF-kB is activated and signals survival
- Downstream TCR signaling
- Toll Like Receptor 7/8 (TLR7/8) Cascade
- Cellular Senescence
- RIP-mediated NFkB activation via ZBP1
- Toll Like Receptor TLR6:TLR2 Cascade
- DEx/H-box helicases activate type I IFN and inflammatory cytokines production
- Activated TLR4 signalling
- Toll Like Receptor TLR1:TLR2 Cascade
- Downstream signaling events of B Cell Receptor (BCR)
- FCERI mediated NF-kB activation
- MyD88 cascade initiated on plasma membrane
- Toll Like Receptor 5 (TLR5) Cascade
- ZBP1(DAI) mediated induction of type I IFNs
- p75NTR signals via NF-kB
- Transcriptional regulation of white adipocyte differentiation
- MyD88 dependent cascade initiated on endosome
- TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
- MyD88:Mal cascade initiated on plasma membrane
- Toll Like Receptor 9 (TLR9) Cascade
- Innate Immune System
- Regulated proteolysis of p75NTR
- Signalling by NGF
- TRIF-mediated TLR3/TLR4 signaling
- Cytosolic sensors of pathogen-associated DNA
- Senescence-Associated Secretory Phenotype (SASP)
- Cytokine Signaling in Immune system
- p75 NTR receptor-mediated signalling
- MyD88-independent cascade
- Toll Like Receptor 2 (TLR2) Cascade
- RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
- Signaling by Interleukins
- TCR signaling
- Toll-Like Receptors Cascades
- Toll Like Receptor 10 (TLR10) Cascade
- Interleukin-1 processing
- Toll Like Receptor 3 (TLR3) Cascade
- Toll Like Receptor 4 (TLR4) Cascade
- Activation of NF-kappaB in B cells
- Fc epsilon receptor (FCERI) signaling
- TRAF6 mediated NF-kB activation
- Interleukin-1 signaling
- Adaptive Immune System
- TAK1 activates NFkB by phosphorylation and activation of IKKs complex
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- Denileukin diftitox
- Aldesleukin
- Basiliximab
- Daclizumab
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- Thalidomide
- Pranlukast
- Triflusal
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KIT and PTPRU |
v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog |
protein tyrosine phosphatase, receptor type, U |
- Signaling by the B Cell Receptor (BCR)
- Signaling by FGFR in disease
- PIP3 activates AKT signaling
- Signaling by EGFRvIII in Cancer
- Signaling by SCF-KIT
- Downstream signaling events of B Cell Receptor (BCR)
- DAP12 signaling
- Regulation of KIT signaling
- PI3K/AKT activation
- PI-3K cascade
- PI3K events in ERBB2 signaling
- Downstream signaling of activated FGFR
- Innate Immune System
- Signaling by PDGF
- Signalling by NGF
- DAP12 interactions
- GAB1 signalosome
- Signaling by Ligand-Responsive EGFR Variants in Cancer
- NGF signalling via TRKA from the plasma membrane
- Signaling by ERBB4
- Signaling by Overexpressed Wild-Type EGFR in Cancer
- Role of LAT2/NTAL/LAB on calcium mobilization
- Constitutive PI3K/AKT Signaling in Cancer
- PI3K events in ERBB4 signaling
- Signaling by FGFR
- Signaling by ERBB2
- Signaling by EGFR
- Downstream signal transduction
- Fc epsilon receptor (FCERI) signaling
- Signaling by EGFR in Cancer
- PI3K/AKT Signaling in Cancer
- Adaptive Immune System
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- Sorafenib
- Imatinib
- Dasatinib
- Sunitinib
- Phosphonotyrosine
- Adenosine-5\'-Diphosphate
- Nilotinib
- Pazopanib
- Regorafenib
- Ponatinib
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NFKB1 and STAT3 |
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 |
signal transducer and activator of transcription 3 (acute-phase response factor) |
- Signaling by the B Cell Receptor (BCR)
- NF-kB is activated and signals survival
- Downstream TCR signaling
- Toll Like Receptor 7/8 (TLR7/8) Cascade
- Cellular Senescence
- RIP-mediated NFkB activation via ZBP1
- Toll Like Receptor TLR6:TLR2 Cascade
- DEx/H-box helicases activate type I IFN and inflammatory cytokines production
- Activated TLR4 signalling
- Toll Like Receptor TLR1:TLR2 Cascade
- Downstream signaling events of B Cell Receptor (BCR)
- FCERI mediated NF-kB activation
- MyD88 cascade initiated on plasma membrane
- Toll Like Receptor 5 (TLR5) Cascade
- ZBP1(DAI) mediated induction of type I IFNs
- p75NTR signals via NF-kB
- Transcriptional regulation of white adipocyte differentiation
- MyD88 dependent cascade initiated on endosome
- TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
- MyD88:Mal cascade initiated on plasma membrane
- Toll Like Receptor 9 (TLR9) Cascade
- Innate Immune System
- Regulated proteolysis of p75NTR
- Signalling by NGF
- TRIF-mediated TLR3/TLR4 signaling
- Cytosolic sensors of pathogen-associated DNA
- Senescence-Associated Secretory Phenotype (SASP)
- Cytokine Signaling in Immune system
- p75 NTR receptor-mediated signalling
- MyD88-independent cascade
- Toll Like Receptor 2 (TLR2) Cascade
- RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
- Signaling by Interleukins
- TCR signaling
- Toll-Like Receptors Cascades
- Toll Like Receptor 10 (TLR10) Cascade
- Interleukin-1 processing
- Toll Like Receptor 3 (TLR3) Cascade
- Toll Like Receptor 4 (TLR4) Cascade
- Activation of NF-kappaB in B cells
- Fc epsilon receptor (FCERI) signaling
- TRAF6 mediated NF-kB activation
- Interleukin-1 signaling
- Adaptive Immune System
- TAK1 activates NFkB by phosphorylation and activation of IKKs complex
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- Signaling by PDGF
- Signalling by NGF
- Signaling by FGFR in disease
- Cellular Senescence
- Interleukin-6 signaling
- Senescence-Associated Secretory Phenotype (SASP)
- Cytokine Signaling in Immune system
- NGF signalling via TRKA from the plasma membrane
- Signaling by SCF-KIT
- Signaling by Interleukins
- Transcriptional regulation of pluripotent stem cells
- Downstream signal transduction
- Signaling by FGFR1 mutants
- Signalling to STAT3
- Signaling by FGFR mutants
- Signaling by FGFR1 fusion mutants
- POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation
- Signaling by Leptin
- Growth hormone receptor signaling
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- Thalidomide
- Pranlukast
- Triflusal
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NFKB1 and NFKBIA |
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 |
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha |
- Signaling by the B Cell Receptor (BCR)
- NF-kB is activated and signals survival
- Downstream TCR signaling
- Toll Like Receptor 7/8 (TLR7/8) Cascade
- Cellular Senescence
- RIP-mediated NFkB activation via ZBP1
- Toll Like Receptor TLR6:TLR2 Cascade
- DEx/H-box helicases activate type I IFN and inflammatory cytokines production
- Activated TLR4 signalling
- Toll Like Receptor TLR1:TLR2 Cascade
- Downstream signaling events of B Cell Receptor (BCR)
- FCERI mediated NF-kB activation
- MyD88 cascade initiated on plasma membrane
- Toll Like Receptor 5 (TLR5) Cascade
- ZBP1(DAI) mediated induction of type I IFNs
- p75NTR signals via NF-kB
- Transcriptional regulation of white adipocyte differentiation
- MyD88 dependent cascade initiated on endosome
- TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
- MyD88:Mal cascade initiated on plasma membrane
- Toll Like Receptor 9 (TLR9) Cascade
- Innate Immune System
- Regulated proteolysis of p75NTR
- Signalling by NGF
- TRIF-mediated TLR3/TLR4 signaling
- Cytosolic sensors of pathogen-associated DNA
- Senescence-Associated Secretory Phenotype (SASP)
- Cytokine Signaling in Immune system
- p75 NTR receptor-mediated signalling
- MyD88-independent cascade
- Toll Like Receptor 2 (TLR2) Cascade
- RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
- Signaling by Interleukins
- TCR signaling
- Toll-Like Receptors Cascades
- Toll Like Receptor 10 (TLR10) Cascade
- Interleukin-1 processing
- Toll Like Receptor 3 (TLR3) Cascade
- Toll Like Receptor 4 (TLR4) Cascade
- Activation of NF-kappaB in B cells
- Fc epsilon receptor (FCERI) signaling
- TRAF6 mediated NF-kB activation
- Interleukin-1 signaling
- Adaptive Immune System
- TAK1 activates NFkB by phosphorylation and activation of IKKs complex
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- Signaling by the B Cell Receptor (BCR)
- NF-kB is activated and signals survival
- Downstream TCR signaling
- Toll Like Receptor 7/8 (TLR7/8) Cascade
- RIP-mediated NFkB activation via ZBP1
- Toll Like Receptor TLR6:TLR2 Cascade
- Downstream signaling events of B Cell Receptor (BCR)
- Toll Like Receptor TLR1:TLR2 Cascade
- Activated TLR4 signalling
- FCERI mediated NF-kB activation
- MyD88 cascade initiated on plasma membrane
- Toll Like Receptor 5 (TLR5) Cascade
- ZBP1(DAI) mediated induction of type I IFNs
- p75NTR signals via NF-kB
- MyD88 dependent cascade initiated on endosome
- MyD88:Mal cascade initiated on plasma membrane
- TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
- Toll Like Receptor 9 (TLR9) Cascade
- Innate Immune System
- Signalling by NGF
- TRIF-mediated TLR3/TLR4 signaling
- Cytosolic sensors of pathogen-associated DNA
- p75 NTR receptor-mediated signalling
- MyD88-independent cascade
- Toll Like Receptor 2 (TLR2) Cascade
- RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
- TCR signaling
- Toll-Like Receptors Cascades
- Toll Like Receptor 10 (TLR10) Cascade
- Activation of NF-kappaB in B cells
- Toll Like Receptor 4 (TLR4) Cascade
- Toll Like Receptor 3 (TLR3) Cascade
- Fc epsilon receptor (FCERI) signaling
- TRAF6 mediated NF-kB activation
- Adaptive Immune System
- TAK1 activates NFkB by phosphorylation and activation of IKKs complex
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- Thalidomide
- Pranlukast
- Triflusal
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NFKB1 and NOTCH1 |
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 |
notch 1 |
- Signaling by the B Cell Receptor (BCR)
- NF-kB is activated and signals survival
- Downstream TCR signaling
- Toll Like Receptor 7/8 (TLR7/8) Cascade
- Cellular Senescence
- RIP-mediated NFkB activation via ZBP1
- Toll Like Receptor TLR6:TLR2 Cascade
- DEx/H-box helicases activate type I IFN and inflammatory cytokines production
- Activated TLR4 signalling
- Toll Like Receptor TLR1:TLR2 Cascade
- Downstream signaling events of B Cell Receptor (BCR)
- FCERI mediated NF-kB activation
- MyD88 cascade initiated on plasma membrane
- Toll Like Receptor 5 (TLR5) Cascade
- ZBP1(DAI) mediated induction of type I IFNs
- p75NTR signals via NF-kB
- Transcriptional regulation of white adipocyte differentiation
- MyD88 dependent cascade initiated on endosome
- TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
- MyD88:Mal cascade initiated on plasma membrane
- Toll Like Receptor 9 (TLR9) Cascade
- Innate Immune System
- Regulated proteolysis of p75NTR
- Signalling by NGF
- TRIF-mediated TLR3/TLR4 signaling
- Cytosolic sensors of pathogen-associated DNA
- Senescence-Associated Secretory Phenotype (SASP)
- Cytokine Signaling in Immune system
- p75 NTR receptor-mediated signalling
- MyD88-independent cascade
- Toll Like Receptor 2 (TLR2) Cascade
- RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
- Signaling by Interleukins
- TCR signaling
- Toll-Like Receptors Cascades
- Toll Like Receptor 10 (TLR10) Cascade
- Interleukin-1 processing
- Toll Like Receptor 3 (TLR3) Cascade
- Toll Like Receptor 4 (TLR4) Cascade
- Activation of NF-kappaB in B cells
- Fc epsilon receptor (FCERI) signaling
- TRAF6 mediated NF-kB activation
- Interleukin-1 signaling
- Adaptive Immune System
- TAK1 activates NFkB by phosphorylation and activation of IKKs complex
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- Signaling by NOTCH1 HD Domain Mutants in Cancer
- Constitutive Signaling by NOTCH1 HD Domain Mutants
- Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer
- Pre-NOTCH Processing in the Endoplasmic Reticulum
- Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant
- Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant
- Regulation of beta-cell development
- Generic Transcription Pathway
- Pre-NOTCH Transcription and Translation
- Signaling by NOTCH1
- Pre-NOTCH Expression and Processing
- Signaling by NOTCH1 in Cancer
- Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
- Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling
- FBXW7 Mutants and NOTCH1 in Cancer
- Pre-NOTCH Processing in Golgi
- Signaling by NOTCH
- Notch-HLH transcription pathway
- Activated NOTCH1 Transmits Signal to the Nucleus
- NOTCH1 Intracellular Domain Regulates Transcription
- Signaling by NOTCH1 PEST Domain Mutants in Cancer
- Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells
- Constitutive Signaling by NOTCH1 PEST Domain Mutants
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- Thalidomide
- Pranlukast
- Triflusal
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ROR2 and PRR20A |
receptor tyrosine kinase-like orphan receptor 2 |
proline rich 20A |
- WNT5A-dependent internalization of FZD2, FZD5 and ROR2
- Signaling by Wnt
- PCP/CE pathway
- beta-catenin independent WNT signaling
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ROR2 and DAZAP2 |
receptor tyrosine kinase-like orphan receptor 2 |
DAZ associated protein 2 |
- WNT5A-dependent internalization of FZD2, FZD5 and ROR2
- Signaling by Wnt
- PCP/CE pathway
- beta-catenin independent WNT signaling
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ROR2 and WNT5A |
receptor tyrosine kinase-like orphan receptor 2 |
wingless-type MMTV integration site family, member 5A |
- WNT5A-dependent internalization of FZD2, FZD5 and ROR2
- Signaling by Wnt
- PCP/CE pathway
- beta-catenin independent WNT signaling
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- Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD)
- Signaling by GPCR
- misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
- negative regulation of TCF-dependent signaling by WNT ligand antagonists
- Signaling by Wnt
- GPCR ligand binding
- Metabolic disorders of biological oxidation enzymes
- WNT ligand biogenesis and trafficking
- beta-catenin independent WNT signaling
- WNT ligand secretion is abrogated by the PORCN inhibitor LGK974
- WNT5A-dependent internalization of FZD2, FZD5 and ROR2
- Ca2+ pathway
- TCF dependent signaling in response to WNT
- RNF mutants show enhanced WNT signaling and proliferation
- Asymmetric localization of PCP proteins
- WNT5A-dependent internalization of FZD4
- XAV939 inhibits tankyrase, stabilizing AXIN
- Signaling by WNT in cancer
- PCP/CE pathway
- Class B/2 (Secretin family receptors)
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ROR2 and ZMYM4 |
receptor tyrosine kinase-like orphan receptor 2 |
zinc finger, MYM-type 4 |
- WNT5A-dependent internalization of FZD2, FZD5 and ROR2
- Signaling by Wnt
- PCP/CE pathway
- beta-catenin independent WNT signaling
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ROR2 and RBPMS |
receptor tyrosine kinase-like orphan receptor 2 |
RNA binding protein with multiple splicing |
- WNT5A-dependent internalization of FZD2, FZD5 and ROR2
- Signaling by Wnt
- PCP/CE pathway
- beta-catenin independent WNT signaling
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ROR2 and FZD5 |
receptor tyrosine kinase-like orphan receptor 2 |
frizzled class receptor 5 |
- WNT5A-dependent internalization of FZD2, FZD5 and ROR2
- Signaling by Wnt
- PCP/CE pathway
- beta-catenin independent WNT signaling
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- Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD)
- Signaling by GPCR
- misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
- Signaling by Wnt
- GPCR ligand binding
- Metabolic disorders of biological oxidation enzymes
- beta-catenin independent WNT signaling
- disassembly of the destruction complex and recruitment of AXIN to the membrane
- WNT5A-dependent internalization of FZD2, FZD5 and ROR2
- Ca2+ pathway
- TCF dependent signaling in response to WNT
- regulation of FZD by ubiquitination
- RNF mutants show enhanced WNT signaling and proliferation
- Asymmetric localization of PCP proteins
- XAV939 inhibits tankyrase, stabilizing AXIN
- Signaling by WNT in cancer
- PCP/CE pathway
- Class B/2 (Secretin family receptors)
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ROR2 and MAGED1 |
receptor tyrosine kinase-like orphan receptor 2 |
melanoma antigen family D, 1 |
- WNT5A-dependent internalization of FZD2, FZD5 and ROR2
- Signaling by Wnt
- PCP/CE pathway
- beta-catenin independent WNT signaling
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- Signalling by NGF
- Cell death signalling via NRAGE, NRIF and NADE
- NRAGE signals death through JNK
- Programmed Cell Death
- p75 NTR receptor-mediated signalling
- Role of DCC in regulating apoptosis
- Extrinsic Pathway
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ROR2 and C1orf94 |
receptor tyrosine kinase-like orphan receptor 2 |
chromosome 1 open reading frame 94 |
- WNT5A-dependent internalization of FZD2, FZD5 and ROR2
- Signaling by Wnt
- PCP/CE pathway
- beta-catenin independent WNT signaling
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ROR2 and MAP3K7 |
receptor tyrosine kinase-like orphan receptor 2 |
mitogen-activated protein kinase kinase kinase 7 |
- WNT5A-dependent internalization of FZD2, FZD5 and ROR2
- Signaling by Wnt
- PCP/CE pathway
- beta-catenin independent WNT signaling
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- Signaling by the B Cell Receptor (BCR)
- Downstream TCR signaling
- IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
- TRAF6 mediated induction of TAK1 complex
- Toll Like Receptor 7/8 (TLR7/8) Cascade
- Signaling by Wnt
- Toll Like Receptor TLR6:TLR2 Cascade
- Downstream signaling events of B Cell Receptor (BCR)
- Toll Like Receptor TLR1:TLR2 Cascade
- Activated TLR4 signalling
- FCERI mediated NF-kB activation
- MyD88 cascade initiated on plasma membrane
- Toll Like Receptor 5 (TLR5) Cascade
- NOD1/2 Signaling Pathway
- MyD88 dependent cascade initiated on endosome
- MyD88:Mal cascade initiated on plasma membrane
- TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
- Toll Like Receptor 9 (TLR9) Cascade
- activated TAK1 mediates p38 MAPK activation
- JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
- Innate Immune System
- IRAK2 mediated activation of TAK1 complex
- IRAK2 mediated activation of TAK1 complex
- MAP kinase activation in TLR cascade
- TRIF-mediated TLR3/TLR4 signaling
- Cytokine Signaling in Immune system
- MyD88-independent cascade
- beta-catenin independent WNT signaling
- Toll Like Receptor 2 (TLR2) Cascade
- Signaling by Interleukins
- TCR signaling
- Toll-Like Receptors Cascades
- Toll Like Receptor 10 (TLR10) Cascade
- Ca2+ pathway
- Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
- Activation of NF-kappaB in B cells
- Toll Like Receptor 4 (TLR4) Cascade
- Toll Like Receptor 3 (TLR3) Cascade
- Fc epsilon receptor (FCERI) signaling
- Interleukin-1 signaling
- Adaptive Immune System
- TAK1 activates NFkB by phosphorylation and activation of IKKs complex
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PCNT and DISC1 |
pericentrin |
disrupted in schizophrenia 1 |
- Organelle biogenesis and maintenance
- Loss of proteins required for interphase microtubule organization from the centrosome
- Loss of Nlp from mitotic centrosomes
- G2/M Transition
- Assembly of the primary cilium
- Centrosome maturation
- Regulation of PLK1 Activity at G2/M Transition
- Mitotic G2-G2/M phases
- Anchoring of the basal body to the plasma membrane
- Recruitment of mitotic centrosome proteins and complexes
- Cell Cycle, Mitotic
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