GPC1 and COL18A1

Number of citations of the paper that reports this interaction (PubMedID 11336704)
0

Data Source:
HPRD (in vitro, in vivo)

		GPC1	COL18A1
Description		glypican 1	collagen type XVIII alpha 1 chain
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleoplasm Endosome Golgi Lumen Cytosol Plasma Membrane Cell Surface Membrane Extracellular Matrix Lysosomal Lumen Membrane Raft Synapse Extracellular Exosome Side Of Membrane	Extracellular Region Collagen Trimer Basement Membrane Extracellular Space Endoplasmic Reticulum Lumen Extracellular Matrix Extracellular Exosome
	Molecular Function	Copper Ion Binding Protein Binding Fibroblast Growth Factor Binding Laminin Binding	Protein Binding Extracellular Matrix Structural Constituent Conferring Tensile Strength Identical Protein Binding Metal Ion Binding
	Biological Process	Regulation Of Signal Transduction Schwann Cell Differentiation Cell Migration Heparan Sulfate Proteoglycan Catabolic Process Myelin Assembly Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Regulation Of Protein Localization To Membrane Positive Regulation Of Skeletal Muscle Cell Differentiation	Skeletal System Development Angiogenesis Endothelial Cell Morphogenesis Cell Adhesion Visual Perception Negative Regulation Of Cell Population Proliferation Response To Xenobiotic Stimulus Anatomical Structure Morphogenesis Animal Organ Morphogenesis Regulation Of Cell Population Proliferation Response To Hydrostatic Pressure
Pathways		Glycosaminoglycan-protein linkage region biosynthesis HS-GAG biosynthesis HS-GAG biosynthesis HS-GAG degradation Cell surface interactions at the vascular wall Defective B4GALT7 causes EDS, progeroid type Defective B3GAT3 causes JDSSDHD Defective EXT2 causes exostoses 2 Defective EXT1 causes exostoses 1, TRPS2 and CHDS Signaling by ROBO receptors Defective B3GALT6 causes EDSP2 and SEMDJL1 Attachment and Entry Attachment and Entry Retinoid metabolism and transport Respiratory syncytial virus (RSV) attachment and entry RSV-host interactions	Collagen degradation Activation of Matrix Metalloproteinases Collagen biosynthesis and modifying enzymes Assembly of collagen fibrils and other multimeric structures Integrin cell surface interactions Laminin interactions Collagen chain trimerization
Drugs
Diseases			Vitreoretinal degeneration, including: Stickler syndrome type I (STL1); Stickler syndrome type II (STL2); Snowflake vitreoretinal degeneration (SVD); Wagner syndrome 1 (WGN1); Knobloch syndrome (KNO); Enhanced S-cone syndrome (ESCS); Autosomal dominant vitreoretinochoroidopathy (ADVIRC) Polymicrogyria; Bilateral frontal polymicrogyria (BFP); Bilateral frontoparietal polymicrogyria (BFPP); Bilateral perisylvian polymicrogyria (BPP); Bilateral parasagittal parieto-occipital polymicrogyria (BPOP); Bilateral generalised polymicrogyria (BGP); Unilateral Polymicrogyria (ULP)
GWAS		BMI x SSRI levels interaction in schizophrenia or bipolar disorder ( 33824429) Brain imaging in schizophrenia (dorsolateral prefrontal cortex interaction) ( 19023125)	Ankle injury ( 28957384) Apolipoprotein A1 levels ( 32203549) Blood protein levels ( 30072576) Bone mineral density (total hip) ( 29883787) Brain morphology (MOSTest) ( 32665545) Cardiorespiratory fitness (800m run time) ( 32572135) Early-onset Parkinson's disease ( 28256260) HDL cholesterol levels ( 32203549) Hippocampal atrophy ( 22745009) Left–right brain asymmetry ( 33723403) Platelet distribution width ( 32888494) Pursuit maintenance gain ( 29064472) Total cholesterol levels ( 30275531) Triglycerides ( 24507774 30275531)
Interacting Genes		6 interacting genes: APP COL18A1 SLIT1 SLIT2 UBC VEGFA	19 interacting genes: APP BGN COL1A1 COL4A1 COL6A1 CTSL FBLN2 GPC1 GPC4 HNRNPD ITGA5 ITGAV ITGB1 KDR LAMA1 MMP2 SPARC TGM2 THBS1
Entrez ID		2817	80781
HPRD ID		02671	00382
Ensembl ID		ENSG00000063660	ENSG00000182871
Uniprot IDs		A0A384NPH9 H7C410 P35052	A0AAG2UW65 A0AAG2UXZ5 P39060
PDB IDs		4ACR 4AD7 4BWE 4YWT	1BNL 3HON 3HSH
Enriched GO Terms of Interacting Partners?		Retinal Ganglion Cell Axon Guidance Heparin Binding Extracellular Space Regulation Of Chemotaxis Chemorepulsion Involved In Embryonic Olfactory Bulb Interneuron Precursor Migration Chemotaxis Roundabout Binding Locomotion System Development Axon Extension Involved In Axon Guidance Developmental Cell Growth Neuron Projection Development Developmental Growth Involved In Morphogenesis Positive Regulation Of Chemotaxis Regulation Of Axonogenesis Regulation Of Axon Extension Involved In Axon Guidance Heparan Sulfate Proteoglycan Binding Negative Regulation Of Vascular Permeability Regulation Of Growth Anatomical Structure Morphogenesis Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Cell Projection Organization Olfactory Bulb Development Motor Neuron Axon Guidance Cell Migration Involved In Sprouting Angiogenesis Negative Regulation Of MiRNA Transcription Positive Regulation Of Receptor Internalization Neuron Projection Guidance Axon Guidance Regulation Of Leukocyte Migration Regulation Of Monocyte Chemotaxis Chemoattractant Activity Blood Vessel Endothelial Cell Migration Regulation Of Cell Junction Assembly Negative Chemotaxis Plasma Membrane Bounded Cell Projection Organization Telencephalon Cell Migration Positive Chemotaxis Forebrain Cell Migration Axon Extension Regulation Of Vascular Permeability Regulation Of Developmental Growth Negative Regulation Of Chemotaxis Positive Regulation Of Receptor-mediated Endocytosis Extracellular Region Regulation Of Neurogenesis Developmental Growth Regulation Of Locomotion Platelet Alpha Granule Lumen Cell Projection Organization	Extracellular Matrix Extracellular Region Extracellular Matrix Structural Constituent Extracellular Matrix Binding Fibronectin Binding Cell Surface Regulation Of Cell Migration Regulation Of Cell Motility Regulation Of Locomotion Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Regulation Of Cell Adhesion Anatomical Structure Formation Involved In Morphogenesis Anatomical Structure Morphogenesis Positive Regulation Of Locomotion Integrin Binding Developmental Process Cellular Response To Amino Acid Stimulus Angiogenesis Endodermal Cell Differentiation External Side Of Plasma Membrane Regulation Of Cell-substrate Adhesion Response To Amino Acid Cellular Developmental Process Platelet-derived Growth Factor Binding Cell Migration Extracellular Matrix Organization Extracellular Structure Organization Positive Regulation Of Signal Transduction Coreceptor Activity Wound Healing, Spreading Of Epidermal Cells Collagen Metabolic Process Positive Regulation Of Cell Communication Positive Regulation Of Signaling Cell Motility Animal Organ Development Platelet Alpha Granule Integrin Alpha5-beta1 Complex Integrin Alphav-beta1 Complex Regulation Of Angiogenesis Laminin Binding Regulation Of Vasculature Development Positive Regulation Of Angiogenesis Positive Regulation Of Vasculature Development Response To Activity Fibroblast Growth Factor Binding Regulation Of Developmental Process Response To Mechanical Stimulus Cell Adhesion Cell Surface Receptor Signaling Pathway
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