FZD2 and ROR2

Number of citations of the paper that reports this interaction (PMID 12839624)
112

Data Source:
HPRD (in vivo, in vitro)

		FZD2	ROR2
Gene Name		frizzled class receptor 2	receptor tyrosine kinase-like orphan receptor 2
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Plasma Membrane Focal Adhesion Integral Component Of Membrane Clathrin-coated Endocytic Vesicle Membrane	Plasma Membrane Integral Component Of Plasma Membrane Clathrin-coated Endocytic Vesicle Membrane
	Molecular Function	G-protein Coupled Receptor Activity Wnt-protein Binding PDZ Domain Binding Wnt-activated Receptor Activity	Transmembrane Receptor Protein Tyrosine Kinase Activity Frizzled Binding Protein Binding ATP Binding Wnt-protein Binding
	Biological Process	Membranous Septum Morphogenesis Muscular Septum Morphogenesis Outflow Tract Morphogenesis G-protein Coupled Receptor Signaling Pathway Cell-cell Signaling Sensory Perception Of Smell Neuron Differentiation Positive Regulation Of CGMP Metabolic Process Epithelial Cell Differentiation Non-canonical Wnt Signaling Pathway Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Hard Palate Development Canonical Wnt Signaling Pathway Inner Ear Receptor Cell Development Cochlea Morphogenesis Planar Cell Polarity Pathway Involved In Neural Tube Closure Positive Regulation Of Canonical Wnt Signaling Pathway	Cartilage Condensation Somitogenesis Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Wnt Signaling Pathway, Calcium Modulating Pathway JNK Cascade Multicellular Organismal Development Negative Regulation Of Cell Proliferation Peptidyl-tyrosine Phosphorylation Cell Differentiation Positive Regulation Of Cell Migration Embryonic Genitalia Morphogenesis Inner Ear Morphogenesis Positive Regulation Of Transcription, DNA-templated Wnt Signaling Pathway, Planar Cell Polarity Pathway Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Canonical Wnt Signaling Pathway
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling Signaling by Wnt GPCR ligand binding Metabolic disorders of biological oxidation enzymes beta-catenin independent WNT signaling disassembly of the destruction complex and recruitment of AXIN to the membrane WNT5A-dependent internalization of FZD2, FZD5 and ROR2 Ca2+ pathway TCF dependent signaling in response to WNT RNF mutants show enhanced WNT signaling and proliferation Asymmetric localization of PCP proteins XAV939 inhibits tankyrase, stabilizing AXIN Signaling by WNT in cancer PCP/CE pathway Class B/2 (Secretin family receptors)	WNT5A-dependent internalization of FZD2, FZD5 and ROR2 Signaling by Wnt PCP/CE pathway beta-catenin independent WNT signaling
Drugs
Diseases
GWAS			Bipolar disorder and schizophrenia ( 22688191)
Protein-Protein Interactions		2 interactors: DLG4 ROR2	13 interactors: C1orf94 CRX DAB1 DAZAP2 FZD2 FZD5 IKBKG MAGED1 MAP3K7 PRR20A RBPMS WNT5A ZMYM4
Entrez ID		2535	4920
HPRD ID		02813	03822
Ensembl ID			ENSG00000169071
Uniprot IDs		Q14332 Q86UZ8	Q01974
PDB IDs			3ZZW 4GT4
Enriched GO Terms of Interacting Partners?		Wnt Signaling Pathway, Calcium Modulating Pathway Alpha-amino-3-hydroxy-5-methyl-4-isoxazole Propionate Selective Glutamate Receptor Clustering Regulation Of Grooming Behavior Maintenance Of Apical/basal Cell Polarity Embryonic Genitalia Morphogenesis Receptor Localization To Synapse Negative Regulation Of Receptor Internalization Locomotory Exploration Behavior Dendritic Spine Morphogenesis Maintenance Of Cell Polarity Synaptic Vesicle Maturation Vocalization Behavior Dendritic Spine Development Protein Localization To Synapse Negative Regulation Of Receptor-mediated Endocytosis Genitalia Morphogenesis Dendritic Spine Organization Regulation Of N-methyl-D-aspartate Selective Glutamate Receptor Activity Wnt Signaling Pathway, Planar Cell Polarity Pathway Cartilage Condensation Cortical Actin Cytoskeleton Organization Exploration Behavior Postsynaptic Membrane Organization Establishment Or Maintenance Of Apical/basal Cell Polarity Cortical Cytoskeleton Organization Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Receptor Internalization Non-canonical Wnt Signaling Pathway Positive Regulation Of Excitatory Postsynaptic Membrane Potential Golgi To Plasma Membrane Transport Synaptic Vesicle Endocytosis Synaptic Vesicle Recycling Social Behavior Positive Regulation Of Membrane Potential Negative Regulation Of Endocytosis Receptor Clustering Regulation Of Neuronal Synaptic Plasticity Nucleotide Phosphorylation Genitalia Development Regulation Of Excitatory Postsynaptic Membrane Potential Regulation Of Postsynaptic Membrane Potential Phosphorylation Neuromuscular Process Controlling Balance Synapse Assembly Dendrite Morphogenesis Somitogenesis JNK Cascade Post-Golgi Vesicle-mediated Transport Somite Development Inner Ear Morphogenesis	Positive Regulation Of Protein Phosphorylation Positive Regulation Of Phosphorylation Regulation Of Phosphorus Metabolic Process Positive Regulation Of Protein Kinase Activity Positive Regulation Of Protein Modification Process Positive Regulation Of MAP Kinase Activity Positive Regulation Of Kinase Activity Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Transferase Activity Regulation Of Protein Phosphorylation Positive Regulation Of Protein Serine/threonine Kinase Activity Positive Regulation Of Cellular Protein Metabolic Process Regulation Of MAP Kinase Activity Positive Regulation Of Protein Metabolic Process Positive Regulation Of Signal Transduction Regulation Of Phosphorylation Regulation Of Protein Kinase Activity Positive Regulation Of Metabolic Process Non-canonical Wnt Signaling Pathway Regulation Of Kinase Activity Positive Regulation Of MAPK Cascade Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Signal Transduction Regulation Of Cellular Protein Metabolic Process Regulation Of MAPK Cascade Regulation Of Signaling Positive Regulation Of JUN Kinase Activity Regulation Of JUN Kinase Activity Positive Regulation Of Transcription, DNA-templated Regulation Of Protein Metabolic Process JNK Cascade Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Canonical Wnt Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Cytokine Production Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Catalytic Activity Positive Regulation Of Gene Expression Planar Cell Polarity Pathway Involved In Neural Tube Closure Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Regulation Of Establishment Of Planar Polarity Involved In Neural Tube Closure Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of JNK Cascade Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Stress-activated MAPK Cascade Positive Regulation Of Stress-activated Protein Kinase Signaling Cascade Activation Of MAPK Activity Regulation Of Intracellular Signal Transduction Anterior/posterior Axis Specification, Embryo
Tagcloud ?		acted analyzing arhgef6 bioinformatic constructed crc dataset david degs disturbed downloaded gse23878 hprd hub intend jup kegg module modules networks omnibus pdgfrb prkcb student theses uncovered wnt11 wnt2 wnt5a	alkaline alpi apical apicobasal applying border brush cathode coordinating created cue cytoskeleton determines electric electrical enterocytes erk1 ezrin faces lkb1 lumen mimic orienting polarity polarized polarizing remodeled stk11 transepithelial
Tagcloud (Difference) ?		acted analyzing arhgef6 bioinformatic constructed crc dataset david degs disturbed downloaded gse23878 hprd hub intend jup kegg module modules networks omnibus pdgfrb prkcb student theses uncovered wnt11 wnt2 wnt5a	alkaline alpi apical apicobasal applying border brush cathode coordinating created cue cytoskeleton determines electric electrical enterocytes erk1 ezrin faces lkb1 lumen mimic orienting polarity polarized polarizing remodeled stk11 transepithelial
Tagcloud (Intersection) ?