Schizophrenia - Wiki-Pi

Symbols	Name 1	Name 2	Pathways 1 Hide	Pathways 2 Hide	Drugs 1 Hide	Drugs 2 Hide
BMPR1B and DCAF6	bone morphogenetic protein receptor, type IB	DDB1 and CUL4 associated factor 6	Signaling by BMP
BRCA1 and SMARCA2	breast cancer 1, early onset	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2	ATM mediated phosphorylation of repair proteins Meiotic recombination Fanconi Anemia pathway ATM mediated response to DNA double-strand break Homologous Recombination Repair Meiotic synapsis Homologous recombination repair of replication-independent double-strand breaks Recruitment of repair and signaling proteins to double-strand breaks Double-Strand Break Repair	Chromatin modifying enzymes Chromatin organization RMTs methylate histone arginines
BRCA1 and NFKB1	breast cancer 1, early onset	nuclear factor of kappa light polypeptide gene enhancer in B-cells 1	ATM mediated phosphorylation of repair proteins Meiotic recombination Fanconi Anemia pathway ATM mediated response to DNA double-strand break Homologous Recombination Repair Meiotic synapsis Homologous recombination repair of replication-independent double-strand breaks Recruitment of repair and signaling proteins to double-strand breaks Double-Strand Break Repair	Signaling by the B Cell Receptor (BCR) NF-kB is activated and signals survival Downstream TCR signaling Toll Like Receptor 7/8 (TLR7/8) Cascade Cellular Senescence RIP-mediated NFkB activation via ZBP1 Toll Like Receptor TLR6:TLR2 Cascade DEx/H-box helicases activate type I IFN and inflammatory cytokines production Activated TLR4 signalling Toll Like Receptor TLR1:TLR2 Cascade Downstream signaling events of B Cell Receptor (BCR) FCERI mediated NF-kB activation MyD88 cascade initiated on plasma membrane Toll Like Receptor 5 (TLR5) Cascade ZBP1(DAI) mediated induction of type I IFNs p75NTR signals via NF-kB Transcriptional regulation of white adipocyte differentiation MyD88 dependent cascade initiated on endosome TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation MyD88:Mal cascade initiated on plasma membrane Toll Like Receptor 9 (TLR9) Cascade Innate Immune System Regulated proteolysis of p75NTR Signalling by NGF TRIF-mediated TLR3/TLR4 signaling Cytosolic sensors of pathogen-associated DNA Senescence-Associated Secretory Phenotype (SASP) Cytokine Signaling in Immune system p75 NTR receptor-mediated signalling MyD88-independent cascade Toll Like Receptor 2 (TLR2) Cascade RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways Signaling by Interleukins TCR signaling Toll-Like Receptors Cascades Toll Like Receptor 10 (TLR10) Cascade Interleukin-1 processing Toll Like Receptor 3 (TLR3) Cascade Toll Like Receptor 4 (TLR4) Cascade Activation of NF-kappaB in B cells Fc epsilon receptor (FCERI) signaling TRAF6 mediated NF-kB activation Interleukin-1 signaling Adaptive Immune System TAK1 activates NFkB by phosphorylation and activation of IKKs complex		Thalidomide Pranlukast Triflusal
BRCA1 and MAP4K4	breast cancer 1, early onset	mitogen-activated protein kinase kinase kinase kinase 4	ATM mediated phosphorylation of repair proteins Meiotic recombination Fanconi Anemia pathway ATM mediated response to DNA double-strand break Homologous Recombination Repair Meiotic synapsis Homologous recombination repair of replication-independent double-strand breaks Recruitment of repair and signaling proteins to double-strand breaks Double-Strand Break Repair	Oxidative Stress Induced Senescence Cellular Senescence
BRCA1 and NKAPL	breast cancer 1, early onset	NFKB activating protein-like	ATM mediated phosphorylation of repair proteins Meiotic recombination Fanconi Anemia pathway ATM mediated response to DNA double-strand break Homologous Recombination Repair Meiotic synapsis Homologous recombination repair of replication-independent double-strand breaks Recruitment of repair and signaling proteins to double-strand breaks Double-Strand Break Repair
BRCA1 and ENO1	breast cancer 1, early onset	enolase 1, (alpha)	ATM mediated phosphorylation of repair proteins Meiotic recombination Fanconi Anemia pathway ATM mediated response to DNA double-strand break Homologous Recombination Repair Meiotic synapsis Homologous recombination repair of replication-independent double-strand breaks Recruitment of repair and signaling proteins to double-strand breaks Double-Strand Break Repair	Gluconeogenesis Glucose metabolism Myoclonic epilepsy of Lafora Glycogen storage diseases Glycolysis Metabolism of carbohydrates
SERPING1 and BAG6	serpin peptidase inhibitor, clade G (C1 inhibitor), member 1	BCL2-associated athanogene 6	Intrinsic Pathway Response to elevated platelet cytosolic Ca2+ Platelet degranulation Platelet activation, signaling and aggregation Formation of Fibrin Clot (Clotting Cascade)
SERPING1 and ENO1	serpin peptidase inhibitor, clade G (C1 inhibitor), member 1	enolase 1, (alpha)	Intrinsic Pathway Response to elevated platelet cytosolic Ca2+ Platelet degranulation Platelet activation, signaling and aggregation Formation of Fibrin Clot (Clotting Cascade)	Gluconeogenesis Glucose metabolism Myoclonic epilepsy of Lafora Glycogen storage diseases Glycolysis Metabolism of carbohydrates
CACNA1C and GNB1	calcium channel, voltage-dependent, L type, alpha 1C subunit	guanine nucleotide binding protein (G protein), beta polypeptide 1	NCAM1 interactions Axon guidance Integration of energy metabolism Regulation of insulin secretion NCAM signaling for neurite out-growth Adrenaline,noradrenaline inhibits insulin secretion	Signaling by GPCR Glucagon-like Peptide-1 (GLP1) regulates insulin secretion ADP signalling through P2Y purinoceptor 1 Integration of energy metabolism G alpha (s) signalling events Activation of GABAB receptors Glucagon-type ligand receptors G beta:gamma signalling through PLC beta Signaling by Wnt Metabolic disorders of biological oxidation enzymes G protein gated Potassium channels Olfactory Signaling Pathway Gastrin-CREB signalling pathway via PKC and MAPK Thromboxane signalling through TP receptor G alpha (z) signalling events G alpha (i) signalling events Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell ADP signalling through P2Y purinoceptor 12 Glucagon signaling in metabolic regulation Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits Inwardly rectifying K+ channels G-protein beta:gamma signalling Opioid Signalling Activation of Kainate Receptors upon glutamate binding Diseases associated with visual transduction Aquaporin-mediated transport Adrenaline,noradrenaline inhibits insulin secretion G alpha (q) signalling events GPCR downstream signaling Platelet homeostasis Platelet activation, signaling and aggregation Transmission across Chemical Synapses G alpha (q) signalling events Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signal amplification Potassium Channels Activation of the phototransduction cascade Inactivation, recovery and regulation of the phototransduction cascade G beta:gamma signalling through PI3Kgamma The phototransduction cascade G alpha (12/13) signalling events Class B/2 (Secretin family receptors) Prostacyclin signalling through prostacyclin receptor GABA B receptor activation GABA receptor activation Activation of G protein gated Potassium channels Vasopressin regulates renal water homeostasis via Aquaporins Regulation of insulin secretion GPCR ligand binding beta-catenin independent WNT signaling Thrombin signalling through proteinase activated receptors (PARs) Presynaptic function of Kainate receptors Visual phototransduction Ca2+ pathway G-protein activation	Isradipine Ibutilide Amlodipine Nimodipine Nisoldipine Cinnarizine Nicardipine Magnesium Sulfate Verapamil Felodipine Nitrendipine Nifedipine Calcium Mibefradil Dronedarone Clevidipine Nilvadipine Drotaverine
CACNA1C and CABP1	calcium channel, voltage-dependent, L type, alpha 1C subunit	calcium binding protein 1	NCAM1 interactions Axon guidance Integration of energy metabolism Regulation of insulin secretion NCAM signaling for neurite out-growth Adrenaline,noradrenaline inhibits insulin secretion		Isradipine Ibutilide Amlodipine Nimodipine Nisoldipine Cinnarizine Nicardipine Magnesium Sulfate Verapamil Felodipine Nitrendipine Nifedipine Calcium Mibefradil Dronedarone Clevidipine Nilvadipine Drotaverine
CACNA1C and COPS5	calcium channel, voltage-dependent, L type, alpha 1C subunit	COP9 signalosome subunit 5	NCAM1 interactions Axon guidance Integration of energy metabolism Regulation of insulin secretion NCAM signaling for neurite out-growth Adrenaline,noradrenaline inhibits insulin secretion		Isradipine Ibutilide Amlodipine Nimodipine Nisoldipine Cinnarizine Nicardipine Magnesium Sulfate Verapamil Felodipine Nitrendipine Nifedipine Calcium Mibefradil Dronedarone Clevidipine Nilvadipine Drotaverine
CACNA1C and CACNB3	calcium channel, voltage-dependent, L type, alpha 1C subunit	calcium channel, voltage-dependent, beta 3 subunit	NCAM1 interactions Axon guidance Integration of energy metabolism Regulation of insulin secretion NCAM signaling for neurite out-growth Adrenaline,noradrenaline inhibits insulin secretion	NCAM1 interactions Axon guidance Integration of energy metabolism Regulation of insulin secretion NCAM signaling for neurite out-growth Depolarization of the Presynaptic Terminal Triggers the Opening of Calcium Channels Transmission across Chemical Synapses Adrenaline,noradrenaline inhibits insulin secretion	Isradipine Ibutilide Amlodipine Nimodipine Nisoldipine Cinnarizine Nicardipine Magnesium Sulfate Verapamil Felodipine Nitrendipine Nifedipine Calcium Mibefradil Dronedarone Clevidipine Nilvadipine Drotaverine
CACNA1C and PRKACA	calcium channel, voltage-dependent, L type, alpha 1C subunit	protein kinase, cAMP-dependent, catalytic, alpha	NCAM1 interactions Axon guidance Integration of energy metabolism Regulation of insulin secretion NCAM signaling for neurite out-growth Adrenaline,noradrenaline inhibits insulin secretion	Signaling by GPCR Ca-dependent events CaM pathway Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Metabolism of lipids and lipoproteins Integration of energy metabolism Hedgehog 'off' state Phospholipase C-mediated cascade Signaling by FGFR in disease Signaling by EGFRvIII in Cancer Regulation of PLK1 Activity at G2/M Transition PLCG1 events in ERBB2 signaling Gluconeogenesis Glucose metabolism DAP12 signaling Rap1 signalling Myoclonic epilepsy of Lafora Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis Glycogen storage diseases PKA-mediated phosphorylation of key metabolic factors Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Recruitment of mitotic centrosome proteins and complexes Glucagon signaling in metabolic regulation Signaling by PDGF Calmodulin induced events DAP12 interactions PKA-mediated phosphorylation of CREB Opioid Signalling PKA activation Factors involved in megakaryocyte development and platelet production Aquaporin-mediated transport CREB phosphorylation through the activation of Adenylate Cyclase EGFR interacts with phospholipase C-gamma Signaling by ERBB2 PKA-mediated phosphorylation of CREB Signaling by EGFR Signaling by Interleukins Signaling by VEGF Downstream signal transduction Calmodulin induced events Signaling by EGFR in Cancer Metabolism of carbohydrates PKA activation Interleukin-3, 5 and GM-CSF signaling Mitotic G2-G2/M phases Transmission across Chemical Synapses Adaptive Immune System Organelle biogenesis and maintenance G2/M Transition VEGFA-VEGFR2 Pathway DAG and IP3 signaling CaM pathway Activation of NMDA receptor upon glutamate binding and postsynaptic events Loss of Nlp from mitotic centrosomes Downstream signaling of activated FGFR DARPP-32 events Post NMDA receptor activation events Innate Immune System PKA activation in glucagon signalling Signalling by NGF PLC beta mediated events Vasopressin regulates renal water homeostasis via Aquaporins Regulation of insulin secretion Cytokine Signaling in Immune system Assembly of the primary cilium Signaling by Ligand-Responsive EGFR Variants in Cancer Lipid digestion, mobilization, and transport NGF signalling via TRKA from the plasma membrane G-protein mediated events Signaling by Overexpressed Wild-Type EGFR in Cancer Anchoring of the basal body to the plasma membrane Cell Cycle, Mitotic Signaling by FGFR Loss of proteins required for interphase microtubule organizationÂ from the centrosome PLC-gamma1 signalling Signaling by Hedgehog Degradation of GLI1 by the proteasome Centrosome maturation GLI3 is processed to GLI3R by the proteasome Degradation of GLI2 by the proteasome	Isradipine Ibutilide Amlodipine Nimodipine Nisoldipine Cinnarizine Nicardipine Magnesium Sulfate Verapamil Felodipine Nitrendipine Nifedipine Calcium Mibefradil Dronedarone Clevidipine Nilvadipine Drotaverine
CACNA1C and PPM1A	calcium channel, voltage-dependent, L type, alpha 1C subunit	protein phosphatase, Mg2+/Mn2+ dependent, 1A	NCAM1 interactions Axon guidance Integration of energy metabolism Regulation of insulin secretion NCAM signaling for neurite out-growth Adrenaline,noradrenaline inhibits insulin secretion	Loss of Function of TGFBR2 in Cancer IRS-mediated signalling mTOR signalling SMAD2/3 MH2 Domain Mutants in Cancer mTOR signalling TGFBR1 LBD Mutants in Cancer IGF1R signaling cascade Downregulation of SMAD2/3:SMAD4 transcriptional activity Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer IRS-related events triggered by IGF1R Generic Transcription Pathway Energy dependent regulation of mTOR by LKB1-AMPK PKB-mediated events PI3K Cascade Signaling by Insulin receptor TGFBR2 MSI Frameshift Mutants in Cancer Insulin receptor signalling cascade SMAD2/3 Phosphorylation Motif Mutants in Cancer Loss of Function of SMAD2/3 in Cancer Regulation of AMPK activity via LKB1 TGFBR2 Kinase Domain Mutants in Cancer Loss of Function of SMAD4 in Cancer TGFBR1 KD Mutants in Cancer IRS-related events Loss of Function of TGFBR1 in Cancer IRS-mediated signalling Signaling by TGF-beta Receptor Complex Signaling by TGF-beta Receptor Complex in Cancer Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) PKB-mediated events PI3K Cascade SMAD4 MH2 Domain Mutants in Cancer	Isradipine Ibutilide Amlodipine Nimodipine Nisoldipine Cinnarizine Nicardipine Magnesium Sulfate Verapamil Felodipine Nitrendipine Nifedipine Calcium Mibefradil Dronedarone Clevidipine Nilvadipine Drotaverine
CACNA1C and SRI	calcium channel, voltage-dependent, L type, alpha 1C subunit	sorcin	NCAM1 interactions Axon guidance Integration of energy metabolism Regulation of insulin secretion NCAM signaling for neurite out-growth Adrenaline,noradrenaline inhibits insulin secretion	Ion channel transport Stimuli-sensing channels	Isradipine Ibutilide Amlodipine Nimodipine Nisoldipine Cinnarizine Nicardipine Magnesium Sulfate Verapamil Felodipine Nitrendipine Nifedipine Calcium Mibefradil Dronedarone Clevidipine Nilvadipine Drotaverine
CAPN1 and SYNE1	calpain 1, (mu/I) large subunit	spectrin repeat containing, nuclear envelope 1	Degradation of the extracellular matrix	Meiotic synapsis
CD40 and TRAF3	CD40 molecule, TNF receptor superfamily member 5	TNF receptor-associated factor 3		Activated TLR4 signalling RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways TRAF3-dependent IRF activation pathway Toll-Like Receptors Cascades Negative regulators of RIG-I/MDA5 signaling TRIF-mediated TLR3/TLR4 signaling Toll Like Receptor 4 (TLR4) Cascade Toll Like Receptor 3 (TLR3) Cascade MyD88-independent cascade Innate Immune System Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
CDC5L and SYNE1	cell division cycle 5-like	spectrin repeat containing, nuclear envelope 1	Processing of Capped Intron-Containing Pre-mRNA mRNA Splicing mRNA Splicing - Major Pathway	Meiotic synapsis
CDC42 and SYNE1	cell division cycle 42	spectrin repeat containing, nuclear envelope 1	Signaling by GPCR Costimulation by the CD28 family Axon guidance DCC mediated attractive signaling Signaling by EGFRvIII in Cancer VEGFA-VEGFR2 Pathway Inactivation of Cdc42 and Rac Rho GTPase cycle EPHB-mediated forward signaling EPH-Ephrin signaling G alpha (12/13) signalling events Sema4D in semaphorin signaling Netrin-1 signaling Fcgamma receptor (FCGR) dependent phagocytosis Sema4D induced cell migration and growth-cone collapse Regulation of actin dynamics for phagocytic cup formation Innate Immune System EGFR downregulation CDO in myogenesis Semaphorin interactions CD28 co-stimulation Signaling by Ligand-Responsive EGFR Variants in Cancer Factors involved in megakaryocyte development and platelet production Signaling by Overexpressed Wild-Type EGFR in Cancer CD28 dependent Vav1 pathway Signaling by EGFR GPCR downstream signaling Myogenesis Signaling by VEGF Signaling by Rho GTPases Signaling by EGFR in Cancer GPVI-mediated activation cascade Platelet activation, signaling and aggregation Signaling by Robo receptor Adaptive Immune System	Meiotic synapsis
CSF2RA and KIT	colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage)	v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog	Signaling by GPCR G-protein beta:gamma signalling Cytokine Signaling in Immune system GPCR downstream signaling Signaling by Interleukins Interleukin receptor SHC signaling G beta:gamma signalling through PI3Kgamma Interleukin receptor SHC signaling GPVI-mediated activation cascade Interleukin-2 signaling Platelet activation, signaling and aggregation Interleukin-3, 5 and GM-CSF signaling	Signaling by the B Cell Receptor (BCR) Signaling by FGFR in disease PIP3 activates AKT signaling Signaling by EGFRvIII in Cancer Signaling by SCF-KIT Downstream signaling events of B Cell Receptor (BCR) DAP12 signaling Regulation of KIT signaling PI3K/AKT activation PI-3K cascade PI3K events in ERBB2 signaling Downstream signaling of activated FGFR Innate Immune System Signaling by PDGF Signalling by NGF DAP12 interactions GAB1 signalosome Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane Signaling by ERBB4 Signaling by Overexpressed Wild-Type EGFR in Cancer Role of LAT2/NTAL/LAB on calcium mobilization Constitutive PI3K/AKT Signaling in Cancer PI3K events in ERBB4 signaling Signaling by FGFR Signaling by ERBB2 Signaling by EGFR Downstream signal transduction Fc epsilon receptor (FCERI) signaling Signaling by EGFR in Cancer PI3K/AKT Signaling in Cancer Adaptive Immune System	Sargramostim	Sorafenib Imatinib Dasatinib Sunitinib Phosphonotyrosine Adenosine-5\'-Diphosphate Nilotinib Pazopanib Regorafenib Ponatinib

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