ANK3 and SCNN1B |
ankyrin 3, node of Ranvier (ankyrin G) |
sodium channel, non voltage gated 1 beta subunit |
- Interaction between L1 and Ankyrins
- Axon guidance
- L1CAM interactions
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- Ion channel transport
- Stimuli-sensing channels
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ANXA1 and DYSF |
annexin A1 |
dysferlin |
- G alpha (q) signalling events
- Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD)
- Signaling by GPCR
- Class A/1 (Rhodopsin-like receptors)
- GPCR ligand binding
- Metabolic disorders of biological oxidation enzymes
- Formyl peptide receptors bind formyl peptides and many other ligands
- G alpha (q) signalling events
- GPCR downstream signaling
- Peptide ligand-binding receptors
- Gastrin-CREB signalling pathway via PKC and MAPK
- G alpha (i) signalling events
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- Amcinonide
- Hydrocortisone
- Dexamethasone
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CDK4 and BAG6 |
cyclin-dependent kinase 4 |
BCL2-associated athanogene 6 |
- Meiotic recombination
- Chromatin organization
- Ubiquitin-dependent degradation of Cyclin D
- Cellular Senescence
- G1 Phase
- Senescence-Associated Secretory Phenotype (SASP)
- S Phase
- Oncogene Induced Senescence
- Cell Cycle, Mitotic
- Ubiquitin-dependent degradation of Cyclin D1
- RMTs methylate histone arginines
- Cyclin D associated events in G1
- Chromatin modifying enzymes
- Oxidative Stress Induced Senescence
- Transcriptional regulation of white adipocyte differentiation
- Mitotic G1-G1/S phases
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COL4A1 and DISC1 |
collagen, type IV, alpha 1 |
disrupted in schizophrenia 1 |
- Signaling by PDGF
- NCAM1 interactions
- Collagen formation
- Axon guidance
- Collagen degradation
- Anchoring fibril formation
- Non-integrin membrane-ECM interactions
- Degradation of the extracellular matrix
- Assembly of collagen fibrils and other multimeric structures
- Laminin interactions
- ECM proteoglycans
- Integrin cell surface interactions
- Collagen biosynthesis and modifying enzymes
- NCAM signaling for neurite out-growth
- Scavenging by Class A Receptors
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DCTN1 and DISC1 |
dynactin 1 |
disrupted in schizophrenia 1 |
- IRE1alpha activates chaperones
- MHC class II antigen presentation
- XBP1(S) activates chaperone genes
- Unfolded Protein Response (UPR)
- Adaptive Immune System
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DMD and DISC1 |
dystrophin |
disrupted in schizophrenia 1 |
- Striated Muscle Contraction
- Non-integrin membrane-ECM interactions
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FGA and PRRC2A |
fibrinogen alpha chain |
proline-rich coiled-coil 2A |
- p130Cas linkage to MAPK signaling for integrins
- Integrin alphaIIb beta3 signaling
- Platelet degranulation
- GRB2:SOS provides linkage to MAPK signaling for Integrins
- Platelet Aggregation (Plug Formation)
- Formation of Fibrin Clot (Clotting Cascade)
- Common Pathway
- Amyloids
- Response to elevated platelet cytosolic Ca2+
- Integrin cell surface interactions
- Platelet activation, signaling and aggregation
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- Alteplase
- Reteplase
- Anistreplase
- Tenecteplase
- Sucralfate
- Alpha-D-Mannose
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IGF2 and BAG6 |
insulin-like growth factor 2 |
BCL2-associated athanogene 6 |
- IRS-related events triggered by IGF1R
- Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
- Response to elevated platelet cytosolic Ca2+
- Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
- SHC-related events triggered by IGF1R
- Platelet degranulation
- Platelet activation, signaling and aggregation
- IGF1R signaling cascade
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L1CAM and NRP1 |
L1 cell adhesion molecule |
neuropilin 1 |
- Interaction between L1 and Ankyrins
- Signal transduction by L1
- Axon guidance
- L1CAM interactions
- Recycling pathway of L1
- Basigin interactions
- Cell surface interactions at the vascular wall
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- Signal transduction by L1
- CHL1 interactions
- Axon guidance
- Semaphorin interactions
- Signaling by VEGF
- Sema3A PAK dependent Axon repulsion
- Neurophilin interactions with VEGF and VEGFR
- L1CAM interactions
- SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
- CRMPs in Sema3A signaling
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MECP2 and SMARCA2 |
methyl CpG binding protein 2 |
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 |
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- Chromatin modifying enzymes
- Chromatin organization
- RMTs methylate histone arginines
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MMP2 and CXCL12 |
matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) |
chemokine (C-X-C motif) ligand 12 |
- Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
- EPH-ephrin mediated repulsion of cells
- Axon guidance
- Collagen degradation
- Activation of Matrix Metalloproteinases
- EPH-Ephrin signaling
- Degradation of the extracellular matrix
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- Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD)
- Signaling by GPCR
- Class A/1 (Rhodopsin-like receptors)
- Signaling by ERBB4
- GPCR ligand binding
- Metabolic disorders of biological oxidation enzymes
- GPCR downstream signaling
- Nuclear signaling by ERBB4
- Peptide ligand-binding receptors
- Chemokine receptors bind chemokines
- G alpha (i) signalling events
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- Marimastat
- Captopril
- SC-74020
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NFKB1 and IKBKG |
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 |
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma |
- Signaling by the B Cell Receptor (BCR)
- NF-kB is activated and signals survival
- Downstream TCR signaling
- Toll Like Receptor 7/8 (TLR7/8) Cascade
- Cellular Senescence
- RIP-mediated NFkB activation via ZBP1
- Toll Like Receptor TLR6:TLR2 Cascade
- DEx/H-box helicases activate type I IFN and inflammatory cytokines production
- Activated TLR4 signalling
- Toll Like Receptor TLR1:TLR2 Cascade
- Downstream signaling events of B Cell Receptor (BCR)
- FCERI mediated NF-kB activation
- MyD88 cascade initiated on plasma membrane
- Toll Like Receptor 5 (TLR5) Cascade
- ZBP1(DAI) mediated induction of type I IFNs
- p75NTR signals via NF-kB
- Transcriptional regulation of white adipocyte differentiation
- MyD88 dependent cascade initiated on endosome
- TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
- MyD88:Mal cascade initiated on plasma membrane
- Toll Like Receptor 9 (TLR9) Cascade
- Innate Immune System
- Regulated proteolysis of p75NTR
- Signalling by NGF
- TRIF-mediated TLR3/TLR4 signaling
- Cytosolic sensors of pathogen-associated DNA
- Senescence-Associated Secretory Phenotype (SASP)
- Cytokine Signaling in Immune system
- p75 NTR receptor-mediated signalling
- MyD88-independent cascade
- Toll Like Receptor 2 (TLR2) Cascade
- RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
- Signaling by Interleukins
- TCR signaling
- Toll-Like Receptors Cascades
- Toll Like Receptor 10 (TLR10) Cascade
- Interleukin-1 processing
- Toll Like Receptor 3 (TLR3) Cascade
- Toll Like Receptor 4 (TLR4) Cascade
- Activation of NF-kappaB in B cells
- Fc epsilon receptor (FCERI) signaling
- TRAF6 mediated NF-kB activation
- Interleukin-1 signaling
- Adaptive Immune System
- TAK1 activates NFkB by phosphorylation and activation of IKKs complex
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- Signaling by the B Cell Receptor (BCR)
- Downstream TCR signaling
- Toll Like Receptor 7/8 (TLR7/8) Cascade
- RIP-mediated NFkB activation via ZBP1
- Toll Like Receptor TLR6:TLR2 Cascade
- IRAK1 recruits IKK complex
- Downstream signaling events of B Cell Receptor (BCR)
- Activated TLR4 signalling
- Toll Like Receptor TLR1:TLR2 Cascade
- FCERI mediated NF-kB activation
- MyD88 cascade initiated on plasma membrane
- Toll Like Receptor 5 (TLR5) Cascade
- ZBP1(DAI) mediated induction of type I IFNs
- NOD1/2 Signaling Pathway
- MyD88 dependent cascade initiated on endosome
- TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
- MyD88:Mal cascade initiated on plasma membrane
- Toll Like Receptor 9 (TLR9) Cascade
- IRAK1 recruits IKK complex
- JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
- Innate Immune System
- activated TAK1 mediates p38 MAPK activation
- TRIF-mediated TLR3/TLR4 signaling
- MAP kinase activation in TLR cascade
- IKK complex recruitment mediated by RIP1
- Cytosolic sensors of pathogen-associated DNA
- Cytokine Signaling in Immune system
- MyD88-independent cascade
- Toll Like Receptor 2 (TLR2) Cascade
- Signaling by Interleukins
- RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
- TCR signaling
- Toll-Like Receptors Cascades
- Toll Like Receptor 10 (TLR10) Cascade
- Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
- Activation of NF-kappaB in B cells
- Toll Like Receptor 3 (TLR3) Cascade
- Toll Like Receptor 4 (TLR4) Cascade
- Fc epsilon receptor (FCERI) signaling
- Interleukin-1 signaling
- TRAF6 mediated NF-kB activation
- NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
- IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation
- TAK1 activates NFkB by phosphorylation and activation of IKKs complex
- Adaptive Immune System
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- Thalidomide
- Pranlukast
- Triflusal
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NFKB1 and PPARG |
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 |
peroxisome proliferator-activated receptor gamma |
- Signaling by the B Cell Receptor (BCR)
- NF-kB is activated and signals survival
- Downstream TCR signaling
- Toll Like Receptor 7/8 (TLR7/8) Cascade
- Cellular Senescence
- RIP-mediated NFkB activation via ZBP1
- Toll Like Receptor TLR6:TLR2 Cascade
- DEx/H-box helicases activate type I IFN and inflammatory cytokines production
- Activated TLR4 signalling
- Toll Like Receptor TLR1:TLR2 Cascade
- Downstream signaling events of B Cell Receptor (BCR)
- FCERI mediated NF-kB activation
- MyD88 cascade initiated on plasma membrane
- Toll Like Receptor 5 (TLR5) Cascade
- ZBP1(DAI) mediated induction of type I IFNs
- p75NTR signals via NF-kB
- Transcriptional regulation of white adipocyte differentiation
- MyD88 dependent cascade initiated on endosome
- TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
- MyD88:Mal cascade initiated on plasma membrane
- Toll Like Receptor 9 (TLR9) Cascade
- Innate Immune System
- Regulated proteolysis of p75NTR
- Signalling by NGF
- TRIF-mediated TLR3/TLR4 signaling
- Cytosolic sensors of pathogen-associated DNA
- Senescence-Associated Secretory Phenotype (SASP)
- Cytokine Signaling in Immune system
- p75 NTR receptor-mediated signalling
- MyD88-independent cascade
- Toll Like Receptor 2 (TLR2) Cascade
- RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
- Signaling by Interleukins
- TCR signaling
- Toll-Like Receptors Cascades
- Toll Like Receptor 10 (TLR10) Cascade
- Interleukin-1 processing
- Toll Like Receptor 3 (TLR3) Cascade
- Toll Like Receptor 4 (TLR4) Cascade
- Activation of NF-kappaB in B cells
- Fc epsilon receptor (FCERI) signaling
- TRAF6 mediated NF-kB activation
- Interleukin-1 signaling
- Adaptive Immune System
- TAK1 activates NFkB by phosphorylation and activation of IKKs complex
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- PPARA activates gene expression
- Fatty acid, triacylglycerol, and ketone body metabolism
- Metabolism of lipids and lipoproteins
- Generic Transcription Pathway
- Transcriptional regulation of white adipocyte differentiation
- Nuclear Receptor transcription pathway
- Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
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- Thalidomide
- Pranlukast
- Triflusal
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- Icosapent
- Troglitazone
- Mesalazine
- Indomethacin
- Rosiglitazone
- Nateglinide
- Sulfasalazine
- Repaglinide
- Telmisartan
- Balsalazide
- Ibuprofen
- Glipizide
- Pioglitazone
- Mitiglinide
- Bezafibrate
- (S)-3-(4-(2-Carbazol-9-Yl-Ethoxy)-Phenyl)-2-Ethoxy-Propionic Acid
- 2-{5-[3-(6-BENZOYL-1-PROPYLNAPHTHALEN-2-YLOXY)PROPOXY]INDOL-1-YL}ETHANOIC ACID
- (2S)-3-(1-{[2-(2-CHLOROPHENYL)-5-METHYL-1,3-OXAZOL-4-YL]METHYL}-1H-INDOL-5-YL)-2-ETHOXYPROPANOIC ACID
- (9Z,11E,13S)-13-hydroxyoctadeca-9,11-dienoic acid
- 2-{5-[3-(7-PROPYL-3-TRIFLUOROMETHYLBENZO[D]ISOXAZOL-6-YLOXY)PROPOXY]INDOL-1-YL}ETHANOIC ACID
- (4S,5E,7Z,10Z,13Z,16Z,19Z)-4-hydroxydocosa-5,7,10,13,16,19-hexaenoic acid
- (5R,6E,8Z,11Z,14Z,17Z)-5-hydroxyicosa-6,8,11,14,17-pentaenoic acid
- (8E,10S,12Z)-10-hydroxy-6-oxooctadeca-8,12-dienoic acid
- (8R,9Z,12Z)-8-hydroxy-6-oxooctadeca-9,12-dienoic acid
- (9S,10E,12Z)-9-hydroxyoctadeca-10,12-dienoic acid
- difluoro(5-{2-[(5-octyl-1H-pyrrol-2-yl-kappaN)methylidene]-2H-pyrrol-5-yl-kappaN}pentanoato)boron
- (2S)-2-ETHOXY-3-{4-[2-(10H-PHENOXAZIN-10-YL)ETHOXY]PHENYL}PROPANOIC ACID
- 3-(5-methoxy-1H-indol-3-yl)propanoic acid
- 3-{5-methoxy-1-[(4-methoxyphenyl)sulfonyl]-1H-indol-3-yl}propanoic acid
- (2S)-2-(4-ethylphenoxy)-3-phenylpropanoic acid
- 2-chloro-5-nitro-N-phenylbenzamide
- (2S)-2-(biphenyl-4-yloxy)-3-phenylpropanoic acid
- 3-[5-(2-nitropent-1-en-1-yl)furan-2-yl]benzoic acid
- 2-[(2,4-DICHLOROBENZOYL)AMINO]-5-(PYRIMIDIN-2-YLOXY)BENZOIC ACID
- (5E,14E)-11-oxoprosta-5,9,12,14-tetraen-1-oic acid
- 3-FLUORO-N-[1-(4-FLUOROPHENYL)-3-(2-THIENYL)-1H-PYRAZOL-5-YL]BENZENESULFONAMIDE
- (2S)-2-(4-chlorophenoxy)-3-phenylpropanoic acid
- ALEGLITAZAR
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NOTCH4 and PSEN1 |
notch 4 |
presenilin 1 |
- Notch-HLH transcription pathway
- Signaling by NOTCH4
- Generic Transcription Pathway
- Pre-NOTCH Processing in Golgi
- Pre-NOTCH Transcription and Translation
- Signaling by NOTCH
- Pre-NOTCH Processing in the Endoplasmic Reticulum
- Pre-NOTCH Expression and Processing
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- Degradation of the extracellular matrix
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PAX3 and POU3F2 |
paired box 3 |
POU class 3 homeobox 2 |
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RPGR and IFT88 |
retinitis pigmentosa GTPase regulator |
intraflagellar transport 88 |
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- Organelle biogenesis and maintenance
- Hedgehog 'off' state
- Signaling by Hedgehog
- Assembly of the primary cilium
- Intraflagellar transport
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TGFBR2 and NRP1 |
transforming growth factor, beta receptor II (70/80kDa) |
neuropilin 1 |
- Loss of Function of TGFBR2 in Cancer
- TGFBR2 MSI Frameshift Mutants in Cancer
- TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
- SMAD2/3 Phosphorylation Motif Mutants in Cancer
- Loss of Function of SMAD2/3 in Cancer
- TGFBR2 Kinase Domain Mutants in Cancer
- Downregulation of TGF-beta receptor signaling
- SMAD2/3 MH2 Domain Mutants in Cancer
- Loss of Function of SMAD4 in Cancer
- TGFBR1 KD Mutants in Cancer
- TGF-beta receptor signaling activates SMADs
- TGFBR1 LBD Mutants in Cancer
- Loss of Function of TGFBR1 in Cancer
- Signaling by TGF-beta Receptor Complex in Cancer
- Signaling by TGF-beta Receptor Complex
- SMAD4 MH2 Domain Mutants in Cancer
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- Signal transduction by L1
- CHL1 interactions
- Axon guidance
- Semaphorin interactions
- Signaling by VEGF
- Sema3A PAK dependent Axon repulsion
- Neurophilin interactions with VEGF and VEGFR
- L1CAM interactions
- SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
- CRMPs in Sema3A signaling
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CACNA1C and RYR2 |
calcium channel, voltage-dependent, L type, alpha 1C subunit |
ryanodine receptor 2 (cardiac) |
- NCAM1 interactions
- Axon guidance
- Integration of energy metabolism
- Regulation of insulin secretion
- NCAM signaling for neurite out-growth
- Adrenaline,noradrenaline inhibits insulin secretion
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- Ion channel transport
- Stimuli-sensing channels
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- Isradipine
- Ibutilide
- Amlodipine
- Nimodipine
- Nisoldipine
- Cinnarizine
- Nicardipine
- Magnesium Sulfate
- Verapamil
- Felodipine
- Nitrendipine
- Nifedipine
- Calcium
- Mibefradil
- Dronedarone
- Clevidipine
- Nilvadipine
- Drotaverine
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CRX and ROR2 |
cone-rod homeobox |
receptor tyrosine kinase-like orphan receptor 2 |
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- WNT5A-dependent internalization of FZD2, FZD5 and ROR2
- Signaling by Wnt
- PCP/CE pathway
- beta-catenin independent WNT signaling
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CACNA1C and PCBD1 |
calcium channel, voltage-dependent, L type, alpha 1C subunit |
pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha |
- NCAM1 interactions
- Axon guidance
- Integration of energy metabolism
- Regulation of insulin secretion
- NCAM signaling for neurite out-growth
- Adrenaline,noradrenaline inhibits insulin secretion
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- Phenylalanine and tyrosine catabolism
- Metabolism of amino acids and derivatives
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- Isradipine
- Ibutilide
- Amlodipine
- Nimodipine
- Nisoldipine
- Cinnarizine
- Nicardipine
- Magnesium Sulfate
- Verapamil
- Felodipine
- Nitrendipine
- Nifedipine
- Calcium
- Mibefradil
- Dronedarone
- Clevidipine
- Nilvadipine
- Drotaverine
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