ROR2 and WNT5A

Number of citations of the paper that reports this interaction (PubMedID 12839624)
0

Data Source:
HPRD (in vitro)

		ROR2	WNT5A
Description		receptor tyrosine kinase like orphan receptor 2	Wnt family member 5A
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane Axon Clathrin-coated Endocytic Vesicle Membrane Receptor Complex	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Golgi Lumen Plasma Membrane Cell Surface Endocytic Vesicle Membrane Clathrin-coated Endocytic Vesicle Membrane Extracellular Matrix Extracellular Exosome Schaffer Collateral - CA1 Synapse Postsynapse Glutamatergic Synapse
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Protein Binding ATP Binding Coreceptor Activity Kinase Activity Transferase Activity Wnt-protein Binding Mitogen-activated Protein Kinase Kinase Kinase Binding Metal Ion Binding	Signaling Receptor Binding Frizzled Binding Receptor Tyrosine Kinase-like Orphan Receptor Binding Cytokine Activity Protein Binding Phospholipid Binding Protein Domain Specific Binding Receptor Ligand Activity Chemoattractant Activity Involved In Axon Guidance
	Biological Process	Signal Transduction Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Wnt Signaling Pathway Positive Regulation Of Cell Migration	Establishment Of Planar Polarity Somitogenesis Positive Regulation Of Cytokine Production Kidney Development Epithelial To Mesenchymal Transition Neural Tube Closure Positive Regulation Of Endothelial Cell Proliferation Heart Looping Morphogenesis Of An Epithelium Positive Regulation Of Mesenchymal Cell Proliferation Lens Development In Camera-type Eye Positive Regulation Of Cytokine Production Involved In Immune Response Primary Heart Field Specification Secondary Heart Field Specification Ventricular Septum Development Atrial Septum Development Type B Pancreatic Cell Development Pericardium Morphogenesis Axis Elongation Optic Cup Formation Involved In Camera-type Eye Development Inflammatory Response Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Wnt Signaling Pathway, Calcium Modulating Pathway JNK Cascade Determination Of Left/right Symmetry Axonogenesis Axon Guidance Hindgut Morphogenesis Midgut Development Intracellular Protein Localization Cell Population Proliferation Fibroblast Growth Factor Receptor Signaling Pathway Male Gonad Development Anterior/posterior Axis Specification, Embryo Anterior/posterior Pattern Specification Mesenchymal Cell Proliferation Positive Regulation Of Endothelial Cell Migration Positive Regulation Of Gene Expression Epithelial Cell Migration Macrophage Derived Foam Cell Differentiation Positive Regulation Of T Cell Chemotaxis Positive Regulation Of Neuron Projection Development Wnt Signaling Pathway Cell Migration Olfactory Bulb Interneuron Development Neural Tube Development Neurogenesis Cell Differentiation Neuron Differentiation Keratinocyte Differentiation Lung Development Embryonic Limb Morphogenesis BMP Signaling Pathway Negative Regulation Of BMP Signaling Pathway Midbrain Development Positive Regulation Of Chemokine Production Positive Regulation Of Type II Interferon Production Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of Tumor Necrosis Factor Production Regulation Of Protein Localization Positive Regulation Of Rac Protein Signal Transduction Limb Morphogenesis Non-canonical Wnt Signaling Pathway Post-anal Tail Morphogenesis Chemoattraction Of Serotonergic Neuron Axon Chemorepulsion Of Dopaminergic Neuron Axon Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Wound Healing Inner Ear Morphogenesis Embryonic Digit Morphogenesis Positive Regulation Of Macrophage Activation Negative Regulation Of Apoptotic Process Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of MAPK Cascade Cell Fate Commitment Establishment Of Epithelial Cell Apical/basal Polarity Negative Regulation Of Fat Cell Differentiation Positive Regulation Of Protein Catabolic Process Positive Regulation Of Angiogenesis Positive Regulation Of Ossification Positive Regulation Of Endocytosis Positive Regulation Of Meiotic Nuclear Division Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of JNK Cascade Development Of Primary Male Sexual Characteristics Negative Regulation Of Melanin Biosynthetic Process Positive Regulation Of Fibroblast Proliferation Paraxial Mesoderm Formation Digestive Tract Morphogenesis Notochord Morphogenesis Embryonic Skeletal System Development Genitalia Development Neuron Projection Morphogenesis Negative Regulation Of Axon Extension Involved In Axon Guidance Axon Extension Involved In Axon Guidance Hypophysis Morphogenesis Epithelial Cell Proliferation Positive Regulation Of Epithelial Cell Proliferation Negative Regulation Of Epithelial Cell Proliferation Regulation Of Inflammatory Response Positive Regulation Of Inflammatory Response Regulation Of Synapse Organization Negative Chemotaxis Cartilage Development Positive Regulation Of Timing Of Anagen Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of Synapse Assembly Convergent Extension Convergent Extension Involved In Axis Elongation Convergent Extension Involved In Organogenesis Uterus Development Cervix Development Vagina Development Canonical Wnt Signaling Pathway Wnt Signaling Pathway, Planar Cell Polarity Pathway Urinary Bladder Development Face Development Positive Regulation Of Type I Interferon-mediated Signaling Pathway Lateral Sprouting Involved In Mammary Gland Duct Morphogenesis Tube Closure Mesenchymal-epithelial Cell Signaling Negative Regulation Of Prostatic Bud Formation Mammary Gland Branching Involved In Thelarche Epithelial Cell Proliferation Involved In Mammary Gland Duct Elongation Positive Regulation Of Response To Cytokine Stimulus Regulation Of Branching Involved In Mammary Gland Duct Morphogenesis Mesodermal To Mesenchymal Transition Involved In Gastrulation Positive Regulation Of Macrophage Cytokine Production Positive Regulation Of Cartilage Development Somite Development Secondary Palate Development Thymocyte Apoptotic Process Positive Regulation Of Thymocyte Apoptotic Process Cellular Response To Molecule Of Bacterial Origin Cellular Response To Lipopolysaccharide Cellular Response To Calcium Ion Cellular Response To Retinoic Acid Cellular Response To Type II Interferon Hematopoietic Stem Cell Proliferation Dopaminergic Neuron Differentiation Cellular Response To Transforming Growth Factor Beta Stimulus Stem Cell Proliferation Negative Regulation Of Mesenchymal Cell Proliferation Primitive Streak Formation Negative Regulation Of Canonical Wnt Signaling Pathway Cochlea Morphogenesis Melanocyte Proliferation Presynapse Assembly Postsynapse Assembly Postsynaptic Modulation Of Chemical Synaptic Transmission Regulation Of Postsynapse Organization Regulation Of Postsynaptic Cytosolic Calcium Ion Concentration Meiotic Nuclear Division Positive Regulation Of Neuron Projection Arborization Positive Regulation Of Protein Kinase C Activity Positive Regulation Of Hematopoietic Stem Cell Proliferation Positive Regulation Of Protein Localization To Synapse Excitatory Synapse Assembly Inhibitory Synapse Assembly Negative Regulation Of Cell Proliferation In Midbrain Midbrain Dopaminergic Neuron Differentiation Positive Regulation Of Cell-cell Adhesion Mediated By Cadherin Positive Regulation Of Non-canonical Wnt Signaling Pathway Positive Regulation Of Stem Cell Proliferation Positive Regulation Of Apoptotic Signaling Pathway
Pathways		PCP/CE pathway WNT5A-dependent internalization of FZD2, FZD5 and ROR2	TCF dependent signaling in response to WNT TCF dependent signaling in response to WNT WNT ligand biogenesis and trafficking WNT ligand biogenesis and trafficking Class B/2 (Secretin family receptors) Negative regulation of TCF-dependent signaling by WNT ligand antagonists Ca2+ pathway Ca2+ pathway PCP/CE pathway PCP/CE pathway Asymmetric localization of PCP proteins WNT5A-dependent internalization of FZD4 WNT5A-dependent internalization of FZD2, FZD5 and ROR2 Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis WNT5:FZD7-mediated leishmania damping WNT5:FZD7-mediated leishmania damping
Drugs
Diseases		Robinow syndrome Brachydactyly, including: type A; type B; type D; type E
GWAS		Bipolar disorder (inflammation and infection response interaction) ( 25781172) Bipolar disorder and schizophrenia ( 22688191) Birth weight ( 31043758) Bone mineral density (hip) ( 26911590) Facial morphology ( 31763980) Iris color (L* coordinate) ( 30895295) Nose size ( 27182965) Offspring birth weight ( 31043758) Serum immune biomarker levels ( 32066700) Type 2 diabetes ( 25483131)	Carboplatin disposition in epthelial ovarian cancer ( 29367611) Height ( 28552196) Lung function (FEV1/FVC) ( 28166213) Metabolite levels ( 23823483) Type 2 diabetes ( 30130595)
Interacting Genes		73 interacting genes: ACTMAP ALG13 ARID5A ATXN7L1 BHLHE40 C10orf55 C1orf94 CDC14A CDC25C CREM CRX DAB1 DAZAP2 DUSP1 DUSP10 DUSP14 DUSP18 DUSP19 DUSP21 DUSP29 DUSP6 ERBB2 EYA2 FAM168B FOSB FZD2 FZD5 HIVEP1 IKBKG ILKAP ISX KRTAP19-7 KRTAP6-2 KRTAP7-1 LHX6 MAGED1 MAP3K7 MTMR1 MTMR2 MTMR6 MTMR9 PITX1 PLA2G10 POU2AF1 PPM1A PPM1B PPM1F PPP3CB PRKAB2 PRR20A PRR20B PRR20C PRR20D PRR20E PRR23E PTPN11 PTPN12 PTPN20 PTPN6 PTPN7 PTPRR RBPMS SOX14 STOX1 STYX TAB1 TENT5A TLX3 TPTE VENTX WNT5A ZMYM4 ZNF34	3 interacting genes: FZD1 FZD5 ROR2
Entrez ID		4920	7474
HPRD ID		03822	01293
Ensembl ID		ENSG00000169071	ENSG00000114251
Uniprot IDs		Q01974	A0A384N611 B3KQX9 P41221
PDB IDs		3ZZW 4GT4 6OSH 6OSN 6OSV 9FSE
Enriched GO Terms of Interacting Partners?		Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity Dephosphorylation Protein Serine/threonine Phosphatase Activity Protein Dephosphorylation Peptidyl-tyrosine Dephosphorylation Hydrolase Activity MAP Kinase Tyrosine/serine/threonine Phosphatase Activity Protein Tyrosine/serine/threonine Phosphatase Activity Phosphate-containing Compound Metabolic Process Non-membrane Spanning Protein Tyrosine Phosphatase Activity Cation Binding Calmodulin-dependent Protein Phosphatase Activity Regulation Of Phosphatidylinositol Dephosphorylation Intracellular Signaling Cassette Phosphatidylinositol Dephosphorylation Regulation Of ERK1 And ERK2 Cascade Regulation Of MAPK Cascade Peptidyl-threonine Dephosphorylation MAPK Cascade Negative Regulation Of MAPK Cascade Positive Regulation Of Macromolecule Biosynthetic Process Phosphatidylinositol-3,5-bisphosphate 3-phosphatase Activity Negative Regulation Of ERK1 And ERK2 Cascade Phospholipid Dephosphorylation Positive Regulation Of Biosynthetic Process Phosphatidylinositol-3-phosphate Phosphatase Activity Positive Regulation Of Metabolic Process Sequence-specific Double-stranded DNA Binding Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Linear Polyubiquitin Binding Regulation Of Metabolic Process N-terminal Protein Myristoylation Protein Serine/threonine Kinase Binding Regulation Of DNA-templated Transcription Regulation Of Dephosphorylation Regulation Of RNA Biosynthetic Process Regulation Of Primary Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Metabolic Process Neuron Differentiation Negative Regulation Of Signaling Receptor Tyrosine Kinase Binding Protein Binding Regulation Of Protein Serine/threonine Kinase Activity Phosphatidylinositol Phosphate Phosphatase Activity Positive Regulation Of Nucleobase-containing Compound Metabolic Process	Wnt-protein Binding Wnt Receptor Activity Endothelial Cell Differentiation Wnt Signaling Pathway Non-canonical Wnt Signaling Pathway Vasculature Development Positive Regulation Of Osteoblast Differentiation Clathrin-coated Endocytic Vesicle Membrane Methanethiol Oxidase Activity G Protein-coupled Receptor Activity
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