| ATRX and HDAC4 |
alpha thalassemia/mental retardation syndrome X-linked |
histone deacetylase 4 |
|
- Signaling by NOTCH1 HD Domain Mutants in Cancer
- Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer
- Signaling by NOTCH
- Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant
- NOTCH1 Intracellular Domain Regulates Transcription
- Signaling by NOTCH1
- Signaling by NOTCH1 PEST Domain Mutants in Cancer
- Signaling by NOTCH1 in Cancer
- Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
- Constitutive Signaling by NOTCH1 PEST Domain Mutants
- FBXW7 Mutants and NOTCH1 in Cancer
|
|
|
|
|
| DLG3 and KCNJ2 |
discs, large homolog 3 (Drosophila) |
potassium channel, inwardly rectifying subfamily J, member 2 |
- Axon guidance
- L1CAM interactions
- NrCAM interactions
- Activation of Kainate Receptors upon glutamate binding
- Activation of Ca-permeable Kainate Receptor
- Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
- Ionotropic activity of Kainate Receptors
- Transmission across Chemical Synapses
|
- GABA B receptor activation
- Inwardly rectifying K+ channels
- GABA receptor activation
- Activation of G protein gated Potassium channels
- Classical Kir channels
- Activation of GABAB receptors
- Potassium Channels
- Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
- G protein gated Potassium channels
- Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
- Transmission across Chemical Synapses
|
|
|
|
|
| FLNA and TCF4 |
filamin A, alpha |
transcription factor 4 |
- Cell junction organization
- GP1b-IX-V activation signalling
- Response to elevated platelet cytosolic Ca2+
- Platelet degranulation
- Platelet activation, signaling and aggregation
- Cell-extracellular matrix interactions
|
- CDO in myogenesis
- Myogenesis
|
|
|
|
|
| KCNJ2 and CASK |
potassium channel, inwardly rectifying subfamily J, member 2 |
calcium/calmodulin-dependent serine protein kinase (MAGUK family) |
- GABA B receptor activation
- Inwardly rectifying K+ channels
- GABA receptor activation
- Activation of G protein gated Potassium channels
- Classical Kir channels
- Activation of GABAB receptors
- Potassium Channels
- Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
- G protein gated Potassium channels
- Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
- Transmission across Chemical Synapses
|
- Syndecan interactions
- Nephrin interactions
- Non-integrin membrane-ECM interactions
|
|
|
|
|
| MEN1 and TCF4 |
multiple endocrine neoplasia I |
transcription factor 4 |
- Loss of Function of TGFBR2 in Cancer
- SMAD2/3 MH2 Domain Mutants in Cancer
- Signaling by Wnt
- TGFBR1 LBD Mutants in Cancer
- deactivation of the beta-catenin transactivating complex
- SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
- Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
- Generic Transcription Pathway
- RNF mutants show enhanced WNT signaling and proliferation
- XAV939 inhibits tankyrase, stabilizing AXIN
- TGFBR2 MSI Frameshift Mutants in Cancer
- SMAD2/3 Phosphorylation Motif Mutants in Cancer
- misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
- Loss of Function of SMAD2/3 in Cancer
- TGFBR2 Kinase Domain Mutants in Cancer
- formation of the beta-catenin:TCF transactivating complex
- Loss of Function of SMAD4 in Cancer
- TGFBR1 KD Mutants in Cancer
- Loss of Function of TGFBR1 in Cancer
- Signaling by TGF-beta Receptor Complex
- Signaling by TGF-beta Receptor Complex in Cancer
- TCF dependent signaling in response to WNT
- Signaling by WNT in cancer
- SMAD4 MH2 Domain Mutants in Cancer
|
- CDO in myogenesis
- Myogenesis
|
|
|
|
|
| ANK3 and FAS |
ankyrin 3, node of Ranvier (ankyrin G) |
Fas cell surface death receptor |
- Interaction between L1 and Ankyrins
- Axon guidance
- L1CAM interactions
|
- Death Receptor Signalling
- FasL/ CD95L signaling
- Programmed Cell Death
- Extrinsic Pathway
|
|
|
|
|
| FAS and TRAF3 |
Fas cell surface death receptor |
TNF receptor-associated factor 3 |
- Death Receptor Signalling
- FasL/ CD95L signaling
- Programmed Cell Death
- Extrinsic Pathway
|
- Activated TLR4 signalling
- RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
- TRAF3-dependent IRF activation pathway
- Toll-Like Receptors Cascades
- Negative regulators of RIG-I/MDA5 signaling
- TRIF-mediated TLR3/TLR4 signaling
- Toll Like Receptor 4 (TLR4) Cascade
- Toll Like Receptor 3 (TLR3) Cascade
- MyD88-independent cascade
- Innate Immune System
- Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
|
|
|
|
|
| FAS and BAG6 |
Fas cell surface death receptor |
BCL2-associated athanogene 6 |
- Death Receptor Signalling
- FasL/ CD95L signaling
- Programmed Cell Death
- Extrinsic Pathway
|
|
|
|
|
|
| AR and DCAF6 |
androgen receptor |
DDB1 and CUL4 associated factor 6 |
- Generic Transcription Pathway
- Nuclear Receptor transcription pathway
|
|
- Levonorgestrel
- Spironolactone
- Flutamide
- Oxandrolone
- Testosterone
- Nilutamide
- Fludrocortisone
- Drostanolone
- Nandrolone phenpropionate
- Bicalutamide
- Fluoxymesterone
- Drospirenone
- Danazol
- Testosterone Propionate
- Delta1-dihydrotestosterone
- Boldenone
- Calusterone
- Flufenamic Acid
- Dihydrotestosterone
- (2r)-N-[4-Cyano-3-(Trifluoromethyl)Phenyl]-3-[(4-Fluorophenyl)Sulfonyl]-2-Hydroxy-2-Methylpropanamide
- Methyltrienolone
- (3AALPHA,4ALPHA,7ALPHA,7AALPHA)- 3A,4,7,7A-TETRAHYDRO-2-(4-NITRO-1-NAPHTHALENYL)-4,7-ETHANO-1H-ISOINDOLE-1,3(2H)-DIONE
- Cyproterone
- Methyltestosterone
- 17-HYDROXY-18A-HOMO-19-NOR-17ALPHA-PREGNA-4,9,11-TRIEN-3-ONE
- (2S)-N-(4-cyano-3-iodophenyl)-3-(4-cyanophenoxy)-2-hydroxy-2-methylpropanamide
- 2-CHLORO-4-[(7R,7AS)-7-HYDROXY-1,3-DIOXOTETRAHYDRO-1H-PYRROLO[1,2-C]IMIDAZOL-2(3H)-YL]-3-METHYLBENZONITRILE
- (2S)-3-(4-chloro-3-fluorophenoxy)-N-[4-cyano-3-(trifluoromethyl)phenyl]-2-hydroxy-2-methylpropanamide
- 4-{[(1R,2S)-1,2-dihydroxy-2-methyl-3-(4-nitrophenoxy)propyl]amino}-2-(trifluoromethyl)benzonitrile
- (2S)-2-hydroxy-2-methyl-N-[4-nitro-3-(trifluoromethyl)phenyl]-3-(pentafluorophenoxy)propanamide
- (2S)-3-[4-(acetylamino)phenoxy]-2-hydroxy-2-methyl-N-[4-nitro-3-(trifluoromethyl)phenyl]propanamide
- (R)-3-BROMO-2-HYDROXY-2-METHYL-N-[4-NITRO-3-(TRIFLUOROMETHYL)PHENYL]PROPANAMIDE
- (5S,8R,9S,10S,13R,14S,17S)-13-{2-[(3,5-DIFLUOROBENZYL)OXY]ETHYL}-17-HYDROXY-10-METHYLHEXADECAHYDRO-3H-CYCLOPENTA[A]PHENANTHREN-3-ONE
- S-3-(4-FLUOROPHENOXY)-2-HYDROXY-2-METHYL-N-[4-NITRO-3-(TRIFLUOROMETHYL)PHENYL]PROPANAMIDE
- 1-TERT-BUTYL-3-(2,5-DIMETHYLBENZYL)-1H-PYRAZOLO[3,4-D]PYRIMIDIN-4-AMINE
- 4-[(7R,7AS)-7-HYDROXY-1,3-DIOXOTETRAHYDRO-1H-PYRROLO[1,2-C]IMIDAZOL-2(3H)-YL]-1-NAPHTHONITRILE
- 2-chloro-4-{[(1R,3Z,7S,7aS)-7-hydroxy-1-(trifluoromethyl)tetrahydro-1H-pyrrolo[1,2-c][1,3]oxazol-3-ylidene]amino}-3-methylbenzonitrile
- 6-[BIS(2,2,2-TRIFLUOROETHYL)AMINO]-4-(TRIFLUOROMETHYL)QUINOLIN-2(1H)-ONE
- 3-[(4-AMINO-1-TERT-BUTYL-1H-PYRAZOLO[3,4-D]PYRIMIDIN-3-YL)METHYL]PHENOL
- Nandrolone decanoate
- Enzalutamide
|
|
|
|
| AR and NFKB1 |
androgen receptor |
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 |
- Generic Transcription Pathway
- Nuclear Receptor transcription pathway
|
- Signaling by the B Cell Receptor (BCR)
- NF-kB is activated and signals survival
- Downstream TCR signaling
- Toll Like Receptor 7/8 (TLR7/8) Cascade
- Cellular Senescence
- RIP-mediated NFkB activation via ZBP1
- Toll Like Receptor TLR6:TLR2 Cascade
- DEx/H-box helicases activate type I IFN and inflammatory cytokines production
- Activated TLR4 signalling
- Toll Like Receptor TLR1:TLR2 Cascade
- Downstream signaling events of B Cell Receptor (BCR)
- FCERI mediated NF-kB activation
- MyD88 cascade initiated on plasma membrane
- Toll Like Receptor 5 (TLR5) Cascade
- ZBP1(DAI) mediated induction of type I IFNs
- p75NTR signals via NF-kB
- Transcriptional regulation of white adipocyte differentiation
- MyD88 dependent cascade initiated on endosome
- TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
- MyD88:Mal cascade initiated on plasma membrane
- Toll Like Receptor 9 (TLR9) Cascade
- Innate Immune System
- Regulated proteolysis of p75NTR
- Signalling by NGF
- TRIF-mediated TLR3/TLR4 signaling
- Cytosolic sensors of pathogen-associated DNA
- Senescence-Associated Secretory Phenotype (SASP)
- Cytokine Signaling in Immune system
- p75 NTR receptor-mediated signalling
- MyD88-independent cascade
- Toll Like Receptor 2 (TLR2) Cascade
- RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
- Signaling by Interleukins
- TCR signaling
- Toll-Like Receptors Cascades
- Toll Like Receptor 10 (TLR10) Cascade
- Interleukin-1 processing
- Toll Like Receptor 3 (TLR3) Cascade
- Toll Like Receptor 4 (TLR4) Cascade
- Activation of NF-kappaB in B cells
- Fc epsilon receptor (FCERI) signaling
- TRAF6 mediated NF-kB activation
- Interleukin-1 signaling
- Adaptive Immune System
- TAK1 activates NFkB by phosphorylation and activation of IKKs complex
|
- Levonorgestrel
- Spironolactone
- Flutamide
- Oxandrolone
- Testosterone
- Nilutamide
- Fludrocortisone
- Drostanolone
- Nandrolone phenpropionate
- Bicalutamide
- Fluoxymesterone
- Drospirenone
- Danazol
- Testosterone Propionate
- Delta1-dihydrotestosterone
- Boldenone
- Calusterone
- Flufenamic Acid
- Dihydrotestosterone
- (2r)-N-[4-Cyano-3-(Trifluoromethyl)Phenyl]-3-[(4-Fluorophenyl)Sulfonyl]-2-Hydroxy-2-Methylpropanamide
- Methyltrienolone
- (3AALPHA,4ALPHA,7ALPHA,7AALPHA)- 3A,4,7,7A-TETRAHYDRO-2-(4-NITRO-1-NAPHTHALENYL)-4,7-ETHANO-1H-ISOINDOLE-1,3(2H)-DIONE
- Cyproterone
- Methyltestosterone
- 17-HYDROXY-18A-HOMO-19-NOR-17ALPHA-PREGNA-4,9,11-TRIEN-3-ONE
- (2S)-N-(4-cyano-3-iodophenyl)-3-(4-cyanophenoxy)-2-hydroxy-2-methylpropanamide
- 2-CHLORO-4-[(7R,7AS)-7-HYDROXY-1,3-DIOXOTETRAHYDRO-1H-PYRROLO[1,2-C]IMIDAZOL-2(3H)-YL]-3-METHYLBENZONITRILE
- (2S)-3-(4-chloro-3-fluorophenoxy)-N-[4-cyano-3-(trifluoromethyl)phenyl]-2-hydroxy-2-methylpropanamide
- 4-{[(1R,2S)-1,2-dihydroxy-2-methyl-3-(4-nitrophenoxy)propyl]amino}-2-(trifluoromethyl)benzonitrile
- (2S)-2-hydroxy-2-methyl-N-[4-nitro-3-(trifluoromethyl)phenyl]-3-(pentafluorophenoxy)propanamide
- (2S)-3-[4-(acetylamino)phenoxy]-2-hydroxy-2-methyl-N-[4-nitro-3-(trifluoromethyl)phenyl]propanamide
- (R)-3-BROMO-2-HYDROXY-2-METHYL-N-[4-NITRO-3-(TRIFLUOROMETHYL)PHENYL]PROPANAMIDE
- (5S,8R,9S,10S,13R,14S,17S)-13-{2-[(3,5-DIFLUOROBENZYL)OXY]ETHYL}-17-HYDROXY-10-METHYLHEXADECAHYDRO-3H-CYCLOPENTA[A]PHENANTHREN-3-ONE
- S-3-(4-FLUOROPHENOXY)-2-HYDROXY-2-METHYL-N-[4-NITRO-3-(TRIFLUOROMETHYL)PHENYL]PROPANAMIDE
- 1-TERT-BUTYL-3-(2,5-DIMETHYLBENZYL)-1H-PYRAZOLO[3,4-D]PYRIMIDIN-4-AMINE
- 4-[(7R,7AS)-7-HYDROXY-1,3-DIOXOTETRAHYDRO-1H-PYRROLO[1,2-C]IMIDAZOL-2(3H)-YL]-1-NAPHTHONITRILE
- 2-chloro-4-{[(1R,3Z,7S,7aS)-7-hydroxy-1-(trifluoromethyl)tetrahydro-1H-pyrrolo[1,2-c][1,3]oxazol-3-ylidene]amino}-3-methylbenzonitrile
- 6-[BIS(2,2,2-TRIFLUOROETHYL)AMINO]-4-(TRIFLUOROMETHYL)QUINOLIN-2(1H)-ONE
- 3-[(4-AMINO-1-TERT-BUTYL-1H-PYRAZOLO[3,4-D]PYRIMIDIN-3-YL)METHYL]PHENOL
- Nandrolone decanoate
- Enzalutamide
|
- Thalidomide
- Pranlukast
- Triflusal
|
|
|
| AR and ZMIZ1 |
androgen receptor |
zinc finger, MIZ-type containing 1 |
- Generic Transcription Pathway
- Nuclear Receptor transcription pathway
|
|
- Levonorgestrel
- Spironolactone
- Flutamide
- Oxandrolone
- Testosterone
- Nilutamide
- Fludrocortisone
- Drostanolone
- Nandrolone phenpropionate
- Bicalutamide
- Fluoxymesterone
- Drospirenone
- Danazol
- Testosterone Propionate
- Delta1-dihydrotestosterone
- Boldenone
- Calusterone
- Flufenamic Acid
- Dihydrotestosterone
- (2r)-N-[4-Cyano-3-(Trifluoromethyl)Phenyl]-3-[(4-Fluorophenyl)Sulfonyl]-2-Hydroxy-2-Methylpropanamide
- Methyltrienolone
- (3AALPHA,4ALPHA,7ALPHA,7AALPHA)- 3A,4,7,7A-TETRAHYDRO-2-(4-NITRO-1-NAPHTHALENYL)-4,7-ETHANO-1H-ISOINDOLE-1,3(2H)-DIONE
- Cyproterone
- Methyltestosterone
- 17-HYDROXY-18A-HOMO-19-NOR-17ALPHA-PREGNA-4,9,11-TRIEN-3-ONE
- (2S)-N-(4-cyano-3-iodophenyl)-3-(4-cyanophenoxy)-2-hydroxy-2-methylpropanamide
- 2-CHLORO-4-[(7R,7AS)-7-HYDROXY-1,3-DIOXOTETRAHYDRO-1H-PYRROLO[1,2-C]IMIDAZOL-2(3H)-YL]-3-METHYLBENZONITRILE
- (2S)-3-(4-chloro-3-fluorophenoxy)-N-[4-cyano-3-(trifluoromethyl)phenyl]-2-hydroxy-2-methylpropanamide
- 4-{[(1R,2S)-1,2-dihydroxy-2-methyl-3-(4-nitrophenoxy)propyl]amino}-2-(trifluoromethyl)benzonitrile
- (2S)-2-hydroxy-2-methyl-N-[4-nitro-3-(trifluoromethyl)phenyl]-3-(pentafluorophenoxy)propanamide
- (2S)-3-[4-(acetylamino)phenoxy]-2-hydroxy-2-methyl-N-[4-nitro-3-(trifluoromethyl)phenyl]propanamide
- (R)-3-BROMO-2-HYDROXY-2-METHYL-N-[4-NITRO-3-(TRIFLUOROMETHYL)PHENYL]PROPANAMIDE
- (5S,8R,9S,10S,13R,14S,17S)-13-{2-[(3,5-DIFLUOROBENZYL)OXY]ETHYL}-17-HYDROXY-10-METHYLHEXADECAHYDRO-3H-CYCLOPENTA[A]PHENANTHREN-3-ONE
- S-3-(4-FLUOROPHENOXY)-2-HYDROXY-2-METHYL-N-[4-NITRO-3-(TRIFLUOROMETHYL)PHENYL]PROPANAMIDE
- 1-TERT-BUTYL-3-(2,5-DIMETHYLBENZYL)-1H-PYRAZOLO[3,4-D]PYRIMIDIN-4-AMINE
- 4-[(7R,7AS)-7-HYDROXY-1,3-DIOXOTETRAHYDRO-1H-PYRROLO[1,2-C]IMIDAZOL-2(3H)-YL]-1-NAPHTHONITRILE
- 2-chloro-4-{[(1R,3Z,7S,7aS)-7-hydroxy-1-(trifluoromethyl)tetrahydro-1H-pyrrolo[1,2-c][1,3]oxazol-3-ylidene]amino}-3-methylbenzonitrile
- 6-[BIS(2,2,2-TRIFLUOROETHYL)AMINO]-4-(TRIFLUOROMETHYL)QUINOLIN-2(1H)-ONE
- 3-[(4-AMINO-1-TERT-BUTYL-1H-PYRAZOLO[3,4-D]PYRIMIDIN-3-YL)METHYL]PHENOL
- Nandrolone decanoate
- Enzalutamide
|
|
|
|
| AR and SMARCA2 |
androgen receptor |
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 |
- Generic Transcription Pathway
- Nuclear Receptor transcription pathway
|
- Chromatin modifying enzymes
- Chromatin organization
- RMTs methylate histone arginines
|
- Levonorgestrel
- Spironolactone
- Flutamide
- Oxandrolone
- Testosterone
- Nilutamide
- Fludrocortisone
- Drostanolone
- Nandrolone phenpropionate
- Bicalutamide
- Fluoxymesterone
- Drospirenone
- Danazol
- Testosterone Propionate
- Delta1-dihydrotestosterone
- Boldenone
- Calusterone
- Flufenamic Acid
- Dihydrotestosterone
- (2r)-N-[4-Cyano-3-(Trifluoromethyl)Phenyl]-3-[(4-Fluorophenyl)Sulfonyl]-2-Hydroxy-2-Methylpropanamide
- Methyltrienolone
- (3AALPHA,4ALPHA,7ALPHA,7AALPHA)- 3A,4,7,7A-TETRAHYDRO-2-(4-NITRO-1-NAPHTHALENYL)-4,7-ETHANO-1H-ISOINDOLE-1,3(2H)-DIONE
- Cyproterone
- Methyltestosterone
- 17-HYDROXY-18A-HOMO-19-NOR-17ALPHA-PREGNA-4,9,11-TRIEN-3-ONE
- (2S)-N-(4-cyano-3-iodophenyl)-3-(4-cyanophenoxy)-2-hydroxy-2-methylpropanamide
- 2-CHLORO-4-[(7R,7AS)-7-HYDROXY-1,3-DIOXOTETRAHYDRO-1H-PYRROLO[1,2-C]IMIDAZOL-2(3H)-YL]-3-METHYLBENZONITRILE
- (2S)-3-(4-chloro-3-fluorophenoxy)-N-[4-cyano-3-(trifluoromethyl)phenyl]-2-hydroxy-2-methylpropanamide
- 4-{[(1R,2S)-1,2-dihydroxy-2-methyl-3-(4-nitrophenoxy)propyl]amino}-2-(trifluoromethyl)benzonitrile
- (2S)-2-hydroxy-2-methyl-N-[4-nitro-3-(trifluoromethyl)phenyl]-3-(pentafluorophenoxy)propanamide
- (2S)-3-[4-(acetylamino)phenoxy]-2-hydroxy-2-methyl-N-[4-nitro-3-(trifluoromethyl)phenyl]propanamide
- (R)-3-BROMO-2-HYDROXY-2-METHYL-N-[4-NITRO-3-(TRIFLUOROMETHYL)PHENYL]PROPANAMIDE
- (5S,8R,9S,10S,13R,14S,17S)-13-{2-[(3,5-DIFLUOROBENZYL)OXY]ETHYL}-17-HYDROXY-10-METHYLHEXADECAHYDRO-3H-CYCLOPENTA[A]PHENANTHREN-3-ONE
- S-3-(4-FLUOROPHENOXY)-2-HYDROXY-2-METHYL-N-[4-NITRO-3-(TRIFLUOROMETHYL)PHENYL]PROPANAMIDE
- 1-TERT-BUTYL-3-(2,5-DIMETHYLBENZYL)-1H-PYRAZOLO[3,4-D]PYRIMIDIN-4-AMINE
- 4-[(7R,7AS)-7-HYDROXY-1,3-DIOXOTETRAHYDRO-1H-PYRROLO[1,2-C]IMIDAZOL-2(3H)-YL]-1-NAPHTHONITRILE
- 2-chloro-4-{[(1R,3Z,7S,7aS)-7-hydroxy-1-(trifluoromethyl)tetrahydro-1H-pyrrolo[1,2-c][1,3]oxazol-3-ylidene]amino}-3-methylbenzonitrile
- 6-[BIS(2,2,2-TRIFLUOROETHYL)AMINO]-4-(TRIFLUOROMETHYL)QUINOLIN-2(1H)-ONE
- 3-[(4-AMINO-1-TERT-BUTYL-1H-PYRAZOLO[3,4-D]PYRIMIDIN-3-YL)METHYL]PHENOL
- Nandrolone decanoate
- Enzalutamide
|
|
|
|
| DLG1 and KCNJ2 |
discs, large homolog 1 (Drosophila) |
potassium channel, inwardly rectifying subfamily J, member 2 |
- Axon guidance
- Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity
- L1CAM interactions
- NrCAM interactions
- Activation of Kainate Receptors upon glutamate binding
- Activation of Ca-permeable Kainate Receptor
- Trafficking of AMPA receptors
- Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
- Ionotropic activity of Kainate Receptors
- Transmission across Chemical Synapses
|
- GABA B receptor activation
- Inwardly rectifying K+ channels
- GABA receptor activation
- Activation of G protein gated Potassium channels
- Classical Kir channels
- Activation of GABAB receptors
- Potassium Channels
- Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
- G protein gated Potassium channels
- Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
- Transmission across Chemical Synapses
|
|
|
|
|
| DLG2 and KCNJ2 |
discs, large homolog 2 (Drosophila) |
potassium channel, inwardly rectifying subfamily J, member 2 |
|
- GABA B receptor activation
- Inwardly rectifying K+ channels
- GABA receptor activation
- Activation of G protein gated Potassium channels
- Classical Kir channels
- Activation of GABAB receptors
- Potassium Channels
- Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
- G protein gated Potassium channels
- Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
- Transmission across Chemical Synapses
|
|
|
|
|
| DLG4 and KCNJ2 |
discs, large homolog 4 (Drosophila) |
potassium channel, inwardly rectifying subfamily J, member 2 |
- Axon guidance
- L1CAM interactions
- Activation of Kainate Receptors upon glutamate binding
- CREB phosphorylation through the activation of Ras
- Trafficking of AMPA receptors
- Activation of NMDA receptor upon glutamate binding and postsynaptic events
- CREB phosphorylation through the activation of CaMKII
- NrCAM interactions
- Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity
- Activation of Ca-permeable Kainate Receptor
- Unblocking of NMDA receptor, glutamate binding and activation
- Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
- Ionotropic activity of Kainate Receptors
- Ras activation uopn Ca2+ infux through NMDA receptor
- Post NMDA receptor activation events
- Transmission across Chemical Synapses
|
- GABA B receptor activation
- Inwardly rectifying K+ channels
- GABA receptor activation
- Activation of G protein gated Potassium channels
- Classical Kir channels
- Activation of GABAB receptors
- Potassium Channels
- Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
- G protein gated Potassium channels
- Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
- Transmission across Chemical Synapses
|
|
|
|
|
| EWSR1 and TRAF3 |
EWS RNA-binding protein 1 |
TNF receptor-associated factor 3 |
|
- Activated TLR4 signalling
- RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
- TRAF3-dependent IRF activation pathway
- Toll-Like Receptors Cascades
- Negative regulators of RIG-I/MDA5 signaling
- TRIF-mediated TLR3/TLR4 signaling
- Toll Like Receptor 4 (TLR4) Cascade
- Toll Like Receptor 3 (TLR3) Cascade
- MyD88-independent cascade
- Innate Immune System
- Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
|
|
|
|
|
| EWSR1 and ZNF184 |
EWS RNA-binding protein 1 |
zinc finger protein 184 |
|
- Generic Transcription Pathway
|
|
|
|
|
| EWSR1 and PRRC2A |
EWS RNA-binding protein 1 |
proline-rich coiled-coil 2A |
|
|
|
|
|
|
| FGFR1 and NRP1 |
fibroblast growth factor receptor 1 |
neuropilin 1 |
- Signaling by FGFR in disease
- Signaling by activated point mutants of FGFR1
- Signaling by FGFR1 mutants
- Signaling by FGFR mutants
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- Signal transduction by L1
- CHL1 interactions
- Axon guidance
- Semaphorin interactions
- Signaling by VEGF
- Sema3A PAK dependent Axon repulsion
- Neurophilin interactions with VEGF and VEGFR
- L1CAM interactions
- SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
- CRMPs in Sema3A signaling
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| FLNA and GRIK1 |
filamin A, alpha |
glutamate receptor, ionotropic, kainate 1 |
- Cell junction organization
- GP1b-IX-V activation signalling
- Response to elevated platelet cytosolic Ca2+
- Platelet degranulation
- Platelet activation, signaling and aggregation
- Cell-extracellular matrix interactions
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- Activation of Kainate Receptors upon glutamate binding
- Activation of Ca-permeable Kainate Receptor
- Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
- Activation of Na-permeable Kainate Receptors
- Ionotropic activity of Kainate Receptors
- Transmission across Chemical Synapses
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- L-Glutamic Acid
- Topiramate
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