THOC1 and THOC5

Number of citations of the paper that reports this interaction (PMID 22365833)
24

Data Source:
BioGRID (two hybrid, two hybrid)

		THOC1	THOC5
Gene Name		THO complex 1	THO complex 5
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Transcription Export Complex THO Complex THO Complex Part Of Transcription Export Complex Nucleus Nucleoplasm Cytoplasm Nuclear Matrix Nuclear Speck Intercellular Bridge	Transcription Export Complex THO Complex THO Complex Part Of Transcription Export Complex Nucleus Nucleoplasm Cytoplasm Nuclear Speck
	Molecular Function	DNA Binding RNA Binding Protein Binding	MRNA Binding Protein Binding
	Biological Process	Regulation Of DNA Recombination Transcription, DNA-templated RNA Processing MRNA Processing MRNA Export From Nucleus Apoptotic Process Signal Transduction RNA Splicing Replication Fork Processing Regulation Of DNA-templated Transcription, Elongation Positive Regulation Of DNA-templated Transcription, Elongation Viral MRNA Export From Host Cell Nucleus Negative Regulation Of Isotype Switching To IgA Isotypes Negative Regulation Of DNA Damage Checkpoint	Cell Morphogenesis Blastocyst Development MRNA Processing MRNA Export From Nucleus RNA Splicing Regulation Of MRNA Export From Nucleus Stem Cell Division Monocyte Differentiation Positive Regulation Of DNA-templated Transcription, Elongation Negative Regulation Of Macrophage Differentiation Viral MRNA Export From Host Cell Nucleus Primitive Hemopoiesis Negative Regulation Of DNA Damage Checkpoint Regulation Of Stem Cell Division
Pathways
Drugs
Diseases
GWAS		Bipolar disorder and major depressive disorder (combined) ( 20351715)	Carotid atherosclerosis in HIV infection ( 20009918)
Protein-Protein Interactions		13 interactors: ALYREF DHX8 FRA10AC1 IK MOAP1 RABGEF1 RB1 SAP30BP SF3B2 THOC5 TRIM54 USHBP1 WDR77	11 interactors: CSF1R CSNK2A1 DDX39B LIG4 LSM3 NXF1 PPIL1 PRKCA THOC1 THOC7 ZNF830
Entrez ID		9984	8563
HPRD ID		09498	16650
Ensembl ID		ENSG00000079134	ENSG00000100296
Uniprot IDs		Q96FV9	Q13769
PDB IDs		1WXP
Enriched GO Terms of Interacting Partners?		RNA Splicing MRNA Processing MRNA Metabolic Process MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions RNA Processing Viral MRNA Export From Host Cell Nucleus Intracellular Transport Of Virus Positive Regulation Of DNA-templated Transcription, Elongation Viral Process RNA Metabolic Process Gene Expression Regulation Of DNA-templated Transcription, Elongation MRNA Export From Nucleus Negative Regulation Of Kit Signaling Pathway RNA Export From Nucleus Negative Regulation Of Transcription From RNA Polymerase II Promoter During Mitosis Sister Chromatid Biorientation Regulation Of Myeloid Leukocyte Differentiation Establishment Of Localization In Cell Nuclear Export MRNA Transport Regulation Of Centromere Complex Assembly Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Negative Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Nucleobase-containing Compound Metabolic Process Negative Regulation Of Epithelial Cell Proliferation Regulation Of Stem Cell Division Negative Regulation Of DNA Damage Checkpoint Maintenance Of Mitotic Sister Chromatid Cohesion Protein Insertion Into Mitochondrial Membrane Regulation Of Cohesin Localization To Chromatin Secretory Columnal Luminar Epithelial Cell Differentiation Involved In Prostate Glandular Acinus Development RNA Transport Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process RNA Localization Negative Regulation Of Interleukin-6 Secretion Attachment Of Mitotic Spindle Microtubules To Kinetochore Negative Regulation Of Mast Cell Degranulation Cellular Nitrogen Compound Metabolic Process Regulation Of MRNA Export From Nucleus Negative Regulation Of Mast Cell Activation Involved In Immune Response Regulation Of Myeloid Cell Differentiation Cellular Localization Primitive Hemopoiesis Viral Life Cycle Positive Regulation Of Mitotic Metaphase/anaphase Transition Glial Cell Apoptotic Process Intracellular Transport	Viral MRNA Export From Host Cell Nucleus MRNA Export From Nucleus RNA Export From Nucleus MRNA Transport Nuclear Export Intracellular Transport Of Virus RNA Splicing RNA Transport RNA Localization MRNA Processing Negative Regulation Of DNA Damage Checkpoint MRNA Metabolic Process Viral Process RNA Processing Nucleocytoplasmic Transport Nuclear Transport Regulation Of DNA Damage Checkpoint Gene Expression Regulation Of Cell Cycle Negative Regulation Of Cell Cycle Positive Regulation Of DNA-templated Transcription, Elongation Viral Life Cycle Regulation Of Cell Cycle Checkpoint MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Cytoplasmic Transport DNA Replication Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of DNA-templated Transcription, Elongation Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Cell Proliferation DNA Ligation Involved In DNA Recombination Positive Regulation Of Dense Core Granule Biogenesis Negative Regulation Of Isotype Switching To IgA Isotypes Nitrogen Compound Metabolic Process Apoptotic Process Regulation Of Mitotic Cell Cycle Programmed Cell Death Histone H3-T6 Phosphorylation Macrophage Colony-stimulating Factor Signaling Pathway Cell Death Death DNA-dependent DNA Replication Regulation Of Cell Cycle Process Cellular Metabolic Process Intestinal Epithelial Structure Maintenance RNA Secondary Structure Unwinding
Tagcloud ?		biogenesis compromises conjunction coordinated degraded destabilization elongation evolutionarily export inspired mammals manipulated manipulation modest molecularly nascent nedd4 package proteasome reconstituted ribonucleoprotein rnp rnps specify tend transcripts ubiquitinated
Tagcloud (Difference) ?		biogenesis compromises conjunction coordinated degraded destabilization elongation evolutionarily export inspired mammals manipulated manipulation modest molecularly nascent nedd4 package proteasome reconstituted ribonucleoprotein rnp rnps specify tend transcripts ubiquitinated
Tagcloud (Intersection) ?