THOC5

Description		THO complex subunit 5
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GO Annotations	Cellular Component	Transcription Export Complex THO Complex THO Complex Part Of Transcription Export Complex Chromosome, Telomeric Region Nucleus Nucleoplasm Cytoplasm
	Molecular Function	RNA Binding MRNA Binding Protein Binding
	Biological Process	MRNA Processing MRNA Export From Nucleus RNA Splicing Cell Differentiation Monocyte Differentiation MRNA Transport Primitive Hemopoiesis
Pathways		Transport of Mature mRNA derived from an Intron-Containing Transcript mRNA 3'-end processing RNA Polymerase II Transcription Termination Signaling by CSF1 (M-CSF) in myeloid cells
Drugs
Diseases
GWAS		Apolipoprotein A1 levels ( 32203549) Carotid atherosclerosis in HIV infection ( 20009918) HDL cholesterol levels ( 32203549) Lipid traits ( 24023261)
Interacting Genes		11 interacting genes: CSF1R CSNK2A1 HSPB1 LIG4 LSM3 NXF1 OXTR PPIL1 PRKCA THOC7 ZNF830
Entrez ID		8563
HPRD ID		16650
Ensembl ID		ENSG00000100296
Uniprot IDs		Q13769
PDB IDs		7APK 7ZNK 7ZNL
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Programmed Cell Death Negative Regulation Of Apoptotic Process Double-strand Break Repair Via Classical Nonhomologous End Joining MRNA Metabolic Process Transcription Export Complex Nucleoplasm RNA Splicing Regulation Of Programmed Cell Death Regulation Of Apoptotic Process MRNA Processing Spliceosomal Complex Regulation Of Bone Resorption Protein Folding Regulation Of Bone Remodeling Double-strand Break Repair Via Nonhomologous End Joining Negative Regulation Of Protein Kinase C Signaling Establishment Of Integrated Proviral Latency Oxytocin Receptor Activity Nucleic Acid Metabolic Process Positive Regulation Of Blood Vessel Endothelial Cell Migration MRNA Export From Nucleus Positive Regulation Of Cell Population Proliferation CSF1-CSF1R Complex Positive Regulation Of Multicellular Organismal Process Macrophage Colony-stimulating Factor Receptor Activity Regulation Of Tissue Remodeling Macrophage Colony-stimulating Factor Signaling Pathway Regulation Of Translational Initiation Nucleobase-containing Compound Metabolic Process Protein Kinase CK2 Complex RNA Metabolic Process Symbiont-mediated Disruption Of Host Cell PML Body Regulation Of Translation DNA Damage Checkpoint Signaling Protein Kinase C Inhibitor Activity Positive Regulation Of Endothelial Cell Migration Regulation Of Blood Vessel Endothelial Cell Migration DNA Ligase (ATP) Activity DNA Ligase IV Complex Pro-B Cell Differentiation T Cell Receptor V(D)J Recombination Establishment Of Viral Latency DNA Ligase Activity DN2 Thymocyte Differentiation Calcium,diacylglycerol-dependent Serine/threonine Kinase Activity Positive Regulation Of Dense Core Granule Biogenesis Positive Regulation Of Angiotensin-activated Signaling Pathway Histone H3T6 Kinase Activity Alphav-beta3 Integrin-PKCalpha Complex Protein Kinase C Signaling
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