THOC5 and CSF1R

Number of citations of the paper that reports this interaction (PMID 10597251)
12

Data Source:
HPRD (in vivo, two hybrid)

		THOC5	CSF1R
Gene Name		THO complex 5	colony stimulating factor 1 receptor
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Transcription Export Complex THO Complex THO Complex Part Of Transcription Export Complex Nucleus Nucleoplasm Cytoplasm Nuclear Speck	Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Receptor Complex
	Molecular Function	MRNA Binding Protein Binding	Macrophage Colony-stimulating Factor Receptor Activity ATP Binding Protein Phosphatase Binding Cytokine Binding Protein Homodimerization Activity
	Biological Process	Cell Morphogenesis Blastocyst Development MRNA Processing MRNA Export From Nucleus RNA Splicing Regulation Of MRNA Export From Nucleus Stem Cell Division Monocyte Differentiation Positive Regulation Of DNA-templated Transcription, Elongation Negative Regulation Of Macrophage Differentiation Viral MRNA Export From Host Cell Nucleus Primitive Hemopoiesis Negative Regulation Of DNA Damage Checkpoint Regulation Of Stem Cell Division	Positive Regulation Of Protein Phosphorylation Inflammatory Response Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Multicellular Organismal Development Cell Proliferation Positive Regulation Of Cell Proliferation Regulation Of Cell Shape Peptidyl-tyrosine Phosphorylation Cytokine-mediated Signaling Pathway Hemopoiesis Monocyte Differentiation Macrophage Differentiation Osteoclast Differentiation Positive Regulation Of Cell Migration Ruffle Organization Cellular Response To Macrophage Colony-stimulating Factor Stimulus Macrophage Colony-stimulating Factor Signaling Pathway Positive Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Innate Immune Response Regulation Of Bone Resorption Cell-cell Junction Maintenance Phosphatidylinositol Metabolic Process Protein Autophosphorylation Phosphatidylinositol-mediated Signaling Mammary Gland Duct Morphogenesis Positive Regulation Of Protein Tyrosine Kinase Activity Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Cytokine Stimulus Positive Regulation Of Protein Serine/threonine Kinase Activity Positive Regulation Of Chemokine Secretion Positive Regulation Of Cell Motility Regulation Of Actin Cytoskeleton Reorganization
Pathways
Drugs			Imatinib Sunitinib 5-CYANO-FURAN-2-CARBOXYLIC ACID [5-HYDROXYMETHYL-2-(4-METHYL-PIPERIDIN-1-YL)-PHENYL]-AMIDE 6-CHLORO-3-(3-METHYLISOXAZOL-5-YL)-4-PHENYLQUINOLIN-2(1H)-ONE
Diseases
GWAS		Carotid atherosclerosis in HIV infection ( 20009918)
Protein-Protein Interactions		11 interactors: CSF1R CSNK2A1 DDX39B LIG4 LSM3 NXF1 PPIL1 PRKCA THOC1 THOC7 ZNF830	18 interactors: CBL CSF1 FYN GRAP2 GRB2 INPP5D INPPL1 LYN PIK3R1 PIK3R2 RASA1 SHC1 SOCS1 SOCS3 SOS1 STAP2 THOC5 YES1
Entrez ID		8563	1436
HPRD ID		16650	01269
Ensembl ID		ENSG00000100296	ENSG00000182578
Uniprot IDs		Q13769	P07333
PDB IDs			2I0V 2I0Y 2I1M 2OGV 3BEA 3DPK 3KRJ 3KRL 3LCD 3LCO 4DKD 4HW7
Enriched GO Terms of Interacting Partners?		Viral MRNA Export From Host Cell Nucleus MRNA Export From Nucleus RNA Export From Nucleus MRNA Transport Nuclear Export Intracellular Transport Of Virus RNA Splicing RNA Transport RNA Localization MRNA Processing Negative Regulation Of DNA Damage Checkpoint MRNA Metabolic Process Viral Process RNA Processing Nucleocytoplasmic Transport Nuclear Transport Regulation Of DNA Damage Checkpoint Gene Expression Regulation Of Cell Cycle Negative Regulation Of Cell Cycle Positive Regulation Of DNA-templated Transcription, Elongation Viral Life Cycle Regulation Of Cell Cycle Checkpoint MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Cytoplasmic Transport DNA Replication Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of DNA-templated Transcription, Elongation Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Cell Proliferation DNA Ligation Involved In DNA Recombination Positive Regulation Of Dense Core Granule Biogenesis Negative Regulation Of Isotype Switching To IgA Isotypes Nitrogen Compound Metabolic Process Apoptotic Process Regulation Of Mitotic Cell Cycle Programmed Cell Death Histone H3-T6 Phosphorylation Macrophage Colony-stimulating Factor Signaling Pathway Cell Death Death DNA-dependent DNA Replication Regulation Of Cell Cycle Process Cellular Metabolic Process Intestinal Epithelial Structure Maintenance RNA Secondary Structure Unwinding	Response To Peptide Hormone Regulation Of Immune System Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cellular Response To Peptide Hormone Stimulus Response To Peptide Cellular Response To Peptide Innate Immune Response Leukocyte Migration Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune System Process Regulation Of Immune Response Enzyme Linked Receptor Protein Signaling Pathway Fc Receptor Signaling Pathway Immune Response Cellular Response To Organonitrogen Compound Immune Response-regulating Signaling Pathway Response To Organonitrogen Compound Cellular Response To Hormone Stimulus Fc-epsilon Receptor Signaling Pathway Response To Hormone Blood Coagulation Hemostasis Defense Response Immune Response-activating Cell Surface Receptor Signaling Pathway T Cell Costimulation Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Regulation Of Signal Transduction Regulation Of Body Fluid Levels Wound Healing Regulation Of Signaling Cell Surface Receptor Signaling Pathway Intracellular Signal Transduction Response To Wounding Antigen Receptor-mediated Signaling Pathway Response To Insulin Positive Regulation Of Cell Activation Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc Receptor Mediated Stimulatory Signaling Pathway Fc-gamma Receptor Signaling Pathway Cell Migration Cellular Response To Growth Factor Stimulus Locomotion Growth Hormone Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Cell Motility Positive Regulation Of Immune System Process
Tagcloud ?			abl1 abl2 adding amenable charities crizotinib crlf2 dasatinib epor etv6 flt3 funded fusions il7r lebanese lymphoblastic ntrk3 pdgfrb ph philadelphia ptk2b rearrangements responsiveness ruxolitinib sh2b3 syrian tslp tyk2 undefined
Tagcloud (Difference) ?			abl1 abl2 adding amenable charities crizotinib crlf2 dasatinib epor etv6 flt3 funded fusions il7r lebanese lymphoblastic ntrk3 pdgfrb ph philadelphia ptk2b rearrangements responsiveness ruxolitinib sh2b3 syrian tslp tyk2 undefined
Tagcloud (Intersection) ?