MFN2 and MARCH5

Number of citations of the paper that reports this interaction (PMID 16936636)
90

Data Source:
HPRD (in vitro, in vivo)

		MFN2	MARCH5
Gene Name		mitofusin 2	membrane-associated ring finger (C3HC4) 5
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Mitochondrion Mitochondrial Outer Membrane Cytosol Microtubule Cytoskeleton Integral Component Of Membrane Intrinsic Component Of Mitochondrial Outer Membrane	Mitochondrial Outer Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Integral Component Of Membrane
	Molecular Function	GTPase Activity Protein Binding GTP Binding Ubiquitin Protein Ligase Binding	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Ligase Activity GTPase Binding
	Biological Process	Blastocyst Formation Protein Targeting To Mitochondrion Autophagy Apoptotic Process Response To Unfolded Protein Mitochondrial Membrane Organization Cell Cycle Arrest Blood Coagulation Mitochondrial Fusion Protein Localization To Pre-autophagosomal Structure Negative Regulation Of Ras Protein Signal Transduction Camera-type Eye Morphogenesis Negative Regulation Of Smooth Muscle Cell Proliferation Mitochondrion Localization	Protein Polyubiquitination Protein Autoubiquitination Protein Localization To Mitochondrion Regulation Of Mitochondrial Fission Positive Regulation Of Mitochondrial Fission Negative Regulation Of Cell Aging
Pathways		Factors involved in megakaryocyte development and platelet production
Drugs
Diseases
GWAS		Platelet counts ( 22139419)
Protein-Protein Interactions		1 interactors: MARCH5	17 interactors: AKTIP FATE1 FIS1 MAP1B MFN2 SOD1 TANK UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2E3 UBE2I UBE2N UBE2T UBE2W UTRN
Entrez ID		9927	54708
HPRD ID		08495	07909
Ensembl ID		ENSG00000116688	ENSG00000198060
Uniprot IDs		O95140	B4DGV8 Q9NX47
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Mitochondrial Fission Regulation Of Mitochondrial Fission Negative Regulation Of Cell Aging Protein Autoubiquitination Positive Regulation Of Mitochondrion Organization Protein Localization To Mitochondrion Regulation Of Mitochondrion Organization Protein Polyubiquitination	Protein Polyubiquitination Protein K48-linked Ubiquitination Protein Ubiquitination Protein Modification By Small Protein Conjugation Protein K11-linked Ubiquitination Toll-like Receptor 4 Signaling Pathway Toll-like Receptor Signaling Pathway Protein Monoubiquitination Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Catabolic Process TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Positive Regulation Of Innate Immune Response Regulation Of Innate Immune Response Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Catabolic Process Proteasomal Protein Catabolic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Cellular Macromolecule Catabolic Process Protein K63-linked Ubiquitination Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of DNA-templated Transcription In Response To Stress Cellular Protein Modification Process Immune Response-regulating Signaling Pathway Positive Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Ligase Activity Positive Regulation Of Transferase Activity Regulation Of Ubiquitin-protein Transferase Activity Cellular Response To Stress Proteolysis Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Positive Regulation Of Immune Response Cellular Response To Oxygen Levels Positive Regulation Of Cellular Protein Metabolic Process Mitochondrial Fusion Positive Regulation Of Protein Metabolic Process Positive Regulation Of Protein Ubiquitination Cellular Protein Metabolic Process Response To Stress Regulation Of Immune System Process Innate Immune Response Regulation Of Immune Response
Tagcloud ?		app atrophy biogenesis cognitive compensate defect deficits drp1 dynamin feature fis1 fission injected mfn1 mitochondria mitochondrial mitofusion nsc nscs opa1 optic prominent ps1 rescue susceptible tg transplantation veh vehicle
Tagcloud (Difference) ?		app atrophy biogenesis cognitive compensate defect deficits drp1 dynamin feature fis1 fission injected mfn1 mitochondria mitochondrial mitofusion nsc nscs opa1 optic prominent ps1 rescue susceptible tg transplantation veh vehicle
Tagcloud (Intersection) ?