TLR8 and UTP18

		TLR8	UTP18
Description		toll like receptor 8	UTP18 small subunit processome component
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GO Annotations	Cellular Component	Golgi Membrane Endosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane External Side Of Plasma Membrane Endosome Membrane Membrane Endolysosome Membrane	Nucleus Nucleoplasm Nucleolus Nuclear Membrane Small-subunit Processome Pwp2p-containing Subcomplex Of 90S Preribosome
	Molecular Function	DNA Binding RNA Binding Double-stranded RNA Binding Single-stranded RNA Binding Protein Binding Signaling Receptor Activity Pattern Recognition Receptor Activity Identical Protein Binding	RNA Binding Protein Binding
	Biological Process	Toll-like Receptor Signaling Pathway Immune System Process Inflammatory Response Immune Response Signal Transduction Canonical NF-kappaB Signal Transduction Response To Virus Immunoglobulin Mediated Immune Response Negative Regulation Of Interleukin-12 Production Positive Regulation Of Interferon-alpha Production Positive Regulation Of Interferon-beta Production Positive Regulation Of Type II Interferon Production Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Interleukin-8 Production Toll-like Receptor 8 Signaling Pathway Positive Regulation Of Canonical NF-kappaB Signal Transduction Innate Immune Response Positive Regulation Of Innate Immune Response Defense Response To Virus Cellular Response To Mechanical Stimulus Defense Response To Other Organism Endolysosomal Toll-like Receptor Signaling Pathway	RRNA Processing Ribosomal Small Subunit Biogenesis
Pathways		Trafficking and processing of endosomal TLR Toll Like Receptor 7/8 (TLR7/8) Cascade SARS-CoV-2 activates/modulates innate and adaptive immune responses	rRNA modification in the nucleus and cytosol Major pathway of rRNA processing in the nucleolus and cytosol
Drugs		Imiquimod Resiquimod Selgantolimod Afimetoran
Diseases
GWAS		Celiac disease ( 20190752)	Bipolar disorder ( 31043756) Hip circumference adjusted for BMI ( 34021172) Menarche (age at onset) ( 27182965) Metabolite levels ( 23823483)
Interacting Genes		3 interacting genes: BTK MYD88 RNF10	3 interacting genes: CSNK2A1 ERBB2 OGT
Entrez ID		51311	51096
HPRD ID		02296	10825
Ensembl ID		ENSG00000101916	ENSG00000011260
Uniprot IDs		A0AA49X8T4 Q9NR97	Q9Y5J1
PDB IDs		3W3G 3W3J 3W3K 3W3L 3W3M 3W3N 3WN4 4QBZ 4QC0 4R07 4R08 4R09 4R0A 4R6A 5AWA 5AWB 5AWC 5AWD 5AZ5 5HDH 5WYX 5WYZ 5Z14 5Z15 6KYA 6TY5 6V9U 6WML 6ZJZ 7CRF 7R52 7R53 7R54 7RC9 7YTX 8PFI 9MHW 9MHX 9MHY	7MQ8 7MQ9 7MQA
Enriched GO Terms of Interacting Partners?		Response To Molecule Of Fungal Origin MyD88-dependent Toll-like Receptor Signaling Pathway Positive Regulation Of Interleukin-17 Production Positive Regulation Of NLRP3 Inflammasome Complex Assembly Toll-like Receptor Signaling Pathway Regulation Of NLRP3 Inflammasome Complex Assembly Regulation Of B Cell Cytokine Production Monocyte Proliferation Positive Regulation Of Interleukin-17A Production Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of DNA-binding Transcription Factor Activity Cytoplasmic Pattern Recognition Receptor Signaling Pathway Positive Regulation Of Type I Interferon Production Positive Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production TIR Domain Binding Toll Binding ATP-dependent Histone Chaperone Activity Induced Systemic Resistance Regulation Of Cytokine Production Involved In Immune Response Regulation Of Type I Interferon Production Positive Regulation Of Type I Hypersensitivity Positive Regulation Of Lymphocyte Proliferation Regulation Of Interleukin-6 Production Positive Regulation Of Mononuclear Cell Proliferation B Cell Affinity Maturation Toll-like Receptor 5 Signaling Pathway Regulation Of DNA-binding Transcription Factor Activity Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signaling Pathway Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Leukocyte Proliferation Eosinophil Homeostasis Positive Regulation Of Type III Hypersensitivity Toll-like Receptor 8 Signaling Pathway Regulation Of Production Of Molecular Mediator Of Immune Response Positive Regulation Of Protein-containing Complex Assembly Positive Regulation Of Synoviocyte Proliferation Cellular Response To Molecule Of Fungal Origin Activation Of Innate Immune Response Toll-like Receptor TLR6:TLR2 Signaling Pathway Positive Regulation Of Canonical NF-kappaB Signal Transduction Intracellular Receptor Signaling Pathway Histamine Secretion By Mast Cell Postsynapse To Nucleus Signaling Pathway Extrinsic Component Of Postsynaptic Density Membrane Pwp2p-containing Subcomplex Of 90S Preribosome Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Mononuclear Cell Proliferation	Positive Regulation Of Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Sebum Secreting Cell Proliferation Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Metabolic Process Positive Regulation Of Gene Expression Response To Stress Adaptive Immune Response Regulation Of RNA Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Gene Expression Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Sin3-type Complex Negative Regulation Of Translational Initiation Negative Regulation Of Proteasomal Protein Catabolic Process Double-strand Break Repair Via Nonhomologous End Joining Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Skeletal Muscle Contraction Via Regulation Of Action Potential Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Regulation Of RNA Metabolic Process Negative Regulation Of Biosynthetic Process Regulation Of Gene Expression Cellular Response To Mechanical Stimulus Positive Regulation Of Type II Interferon Production Negative Regulation Of Nucleobase-containing Compound Metabolic Process Neuron Differentiation Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Double-strand Break Repair Via Homologous Recombination Regulation Of Extrathymic T Cell Differentiation Protein Localization To Vacuole Positive Regulation Of Signal Transduction ERBB3:ERBB2 Complex Relaxation Of Skeletal Muscle Coproporphyrinogen Oxidase Activity Negative Regulation Of Macromolecule Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of Translation Transferase Activity Regulation Of Translational Initiation Protein Kinase CK2 Complex Symbiont-mediated Disruption Of Host Cell PML Body RNA Polymerase I Core Binding Protein O-acetylglucosaminyltransferase Activity Toll-like Receptor 8 Signaling Pathway Identical Protein Binding
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