FAM20B and TIMMDC1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		FAM20B	TIMMDC1
Description		FAM20B glycosaminoglycan xylosylkinase	translocase of inner mitochondrial membrane domain containing 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Nucleoplasm Cytoplasm Golgi Apparatus Membrane	Nucleoplasm Mitochondrion Mitochondrial Inner Membrane Membrane Mitochondrial Membrane
	Molecular Function	Nucleotide Binding Protein Binding ATP Binding Kinase Activity Transferase Activity Phosphotransferase Activity, Alcohol Group As Acceptor Metal Ion Binding	Protein Binding
	Biological Process	Proteoglycan Biosynthetic Process	Mitochondrial Respiratory Chain Complex I Assembly
Pathways		Glycosaminoglycan-protein linkage region biosynthesis	Complex I biogenesis
Drugs
Diseases
GWAS		Systemic lupus erythematosus ( 32771030)	Autoimmune thyroid disease ( 32581359) Juvenile idiopathic arthritis (oligoarticular or rheumatoid factor-negative polyarticular) ( 23603761) Medication use (thyroid preparations) ( 31015401) Multiple sclerosis ( 24076602 31604244) Primary biliary cholangitis ( 30643196) Primary biliary cirrhosis ( 22961000) Systemic lupus erythematosus ( 28714469 33272962) Systemic sclerosis ( 31672989)
Interacting Genes		9 interacting genes: FAM209A FFAR2 GOLPH3 GOLPH3L GPR152 KCNJ6 SLC7A14 TIMMDC1 TMEM80	82 interacting genes: AGR3 ANKRD46 APOC2 APOC4 APOL2 APOL3 APP ARL6IP6 ARLN ATP6AP2 BCAP31 C14orf180 C3orf52 C5orf46 CCL4 CDS2 CMTM2 CREB3L1 CYB561D2 CYP4F12 DCBLD2 DIABLO DRAM1 EPGN FAM20B FAM210B FATE1 FXYD3 GJB2 GPR151 GPR152 GPX8 HGS HSD17B13 IFNA2 IGFBP5 KIR2DL4 LHFPL5 MARCHF5 NDUFB11 NINJ1 ORMDL1 ORMDL2 PEX16 PEX5 PIGF PTPN1 PTPRN REEP6 RNF24 SCAMP5 SCD SERF1A SERF1B SERP1 SERP2 SLC35E4 SLC35F6 SLC61A1 SLC71A2 SMO ST6GAL2 STX12 STX6 TMEM144 TMEM14B TMEM176A TMEM203 TMEM239 TMEM31 TMEM54 TMEM65 TMEM86A TVP23B UBIAD1 UNC50 UNC93A VAPB VMA12 YIF1A YIPF1 YIPF4
Entrez ID		9917	51300
HPRD ID		13297	12817
Ensembl ID		ENSG00000116199	ENSG00000113845
Uniprot IDs		O75063	C9JU35 Q9NPL8
PDB IDs
Enriched GO Terms of Interacting Partners?		Golgi Vesicle Budding Cargo Adaptor Activity Protein Targeting To Golgi Apparatus Golgi Cisterna Positive Regulation Of Protein Secretion Phosphatidylinositol-4-phosphate Binding Golgi To Plasma Membrane Protein Transport Vesicle Budding From Membrane Regulation Of Protein Secretion Positive Regulation Of Protein Transport Membrane Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Positive Regulation Of Secretion By Cell Establishment Of Protein Localization To Plasma Membrane Positive Regulation Of Secretion Positive Regulation Of Establishment Of Protein Localization Golgi Cisterna Membrane Golgi To Plasma Membrane Transport Lipid Binding Positive Regulation Of Acute Inflammatory Response To Non-antigenic Stimulus Asymmetric Golgi Ribbon Formation Positive Regulation Of Protein Localization Regulation Of Protein Transport Post-Golgi Vesicle-mediated Transport Cell Adhesion Molecule Production Cellular Response To Rapamycin Golgi Organization Regulation Of Establishment Of Protein Localization G-protein Activated Inward Rectifier Potassium Channel Activity Vesicle-mediated Transport To The Plasma Membrane Protein Retention In Golgi Apparatus Regulation Of Secretion By Cell Gamma-aminobutyric Acid Import Gamma-aminobutyric Acid Transmembrane Transporter Activity Response To Rapamycin Regulation Of Secretion Trans-Golgi Network Leukocyte Chemotaxis Involved In Inflammatory Response Protein Localization To Plasma Membrane Protein Targeting Establishment Of Protein Localization To Membrane Golgi Ribbon Formation Cellular Response To Ether Protein Localization To Cell Periphery Regulation Of Transport	Membrane Endoplasmic Reticulum Membrane Endoplasmic Reticulum Protein Binding Lipoprotein Metabolic Process Endoplasmic Reticulum Unfolded Protein Response Golgi Membrane Response To Unfolded Protein Very-low-density Lipoprotein Particle Golgi Apparatus Response To Endoplasmic Reticulum Stress High-density Lipoprotein Particle Chemical Homeostasis Intermediate-density Lipoprotein Particle Intracellular Sphingolipid Homeostasis Negative Regulation Of Ceramide Biosynthetic Process Amyloid Fibril Formation Protein Import Into Peroxisome Membrane Negative Regulation Of Sphingolipid Biosynthetic Process Menaquinone Metabolic Process Synaptic Vesicle Membrane Serine Palmitoyltransferase Complex Endoplasmic Reticulum-Golgi Intermediate Compartment
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