CDC20 and BUB1B

Number of citations of the paper that reports this interaction (PubMedID 11535616)
48

Data Source:
HPRD (two hybrid, in vitro, in vivo)

		CDC20	BUB1B
Description		cell division cycle 20	BUB1 mitotic checkpoint serine/threonine kinase B
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GO Annotations	Cellular Component	Chromosome, Centromeric Region Kinetochore Spindle Pole Nucleoplasm Anaphase-promoting Complex Chromosome Cytoplasm Centrosome Spindle Cytosol Cytoskeleton Protein-containing Complex Mitotic Checkpoint Complex Perinuclear Region Of Cytoplasm	Chromosome, Centromeric Region Kinetochore Outer Kinetochore Nucleus Anaphase-promoting Complex Chromosome Cytoplasm Centrosome Spindle Cytosol Cytoskeleton Mitotic Checkpoint Complex Ciliary Basal Body Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Binding Anaphase-promoting Complex Binding Histone Deacetylase Binding Ubiquitin-protein Transferase Activator Activity Ubiquitin-like Ligase-substrate Adaptor Activity Ubiquitin Ligase Activator Activity	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Serine Kinase Activity
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Mitotic Sister Chromatid Cohesion Mitotic Spindle Assembly Checkpoint Signaling Regulation Of Mitotic Cell Cycle Nervous System Development Positive Regulation Of Cell Population Proliferation Protein Ubiquitination Protein Deubiquitination Cell Differentiation Anaphase-promoting Complex-dependent Catabolic Process SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Synaptic Plasticity Regulation Of Meiotic Nuclear Division Metaphase/anaphase Transition Of Cell Cycle Positive Regulation Of Mitotic Metaphase/anaphase Transition Regulation Of Dendrite Development Cell Division Regulation Of Meiotic Cell Cycle Positive Regulation Of Synapse Maturation Mitotic Spindle Assembly Positive Regulation Of Ubiquitin Protein Ligase Activity Positive Regulation Of Anaphase-promoting Complex-dependent Catabolic Process Metaphase/anaphase Transition Of Meiosis I	Apoptotic Process Metaphase/anaphase Transition Of Mitotic Cell Cycle Mitotic Spindle Assembly Checkpoint Signaling Regulation Of Sister Chromatid Segregation Cell Division Meiotic Sister Chromatid Cohesion, Centromeric Protein Localization To Chromosome, Centromeric Region
Pathways		Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components Inactivation of APC/C via direct inhibition of the APC/C complex Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal APC/C:Cdc20 mediated degradation of Cyclin B SCF-beta-TrCP mediated degradation of Emi1 APC/C:Cdc20 mediated degradation of Securin APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Cdc20:Phospho-APC/C mediated degradation of Cyclin A Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase Regulation of APC/C activators between G1/S and early anaphase APC/C:Cdc20 mediated degradation of mitotic proteins Phosphorylation of Emi1 APC-Cdc20 mediated degradation of Nek2A Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Ub-specific processing proteases Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation Antigen processing: Ubiquitination & Proteasome degradation	Inactivation of APC/C via direct inhibition of the APC/C complex Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Cdc20:Phospho-APC/C mediated degradation of Cyclin A APC/C:Cdc20 mediated degradation of mitotic proteins APC-Cdc20 mediated degradation of Nek2A Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation
Drugs
Diseases
GWAS		Asparaginase-induced acute pancreatitis in acute lymphoblastic leukemia (onset time) ( 27114598) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)	Chronic lymphocytic leukemia ( 24292274 28165464)
Interacting Genes		52 interacting genes: ANAPC1 ANAPC10 ANAPC11 ANAPC2 ANAPC7 APP AURKA BUB1 BUB1B CCNA1 CCNA2 CDC16 CDC27 CDC6 CDK1 CDR2 CDT1 DCPS DTYMK EGLN3 FADD FBXO5 GMNN H2BC3 H3C1 HDAC1 HDAC2 HSF1 HSF2 KIF18A MAD2L1 MAD2L2 MCL1 MKI67 NEK2 OTUD7B PIM1 PTTG1 RASSF1 SIRT2 SOSTDC1 SPATC1 TBK1 TCP1 TGFBR1 TK1 TP63 TRIP13 UBC UBE2C UBE2S UBR5	31 interacting genes: ANAPC7 AP1B1 AP2B1 AP3B1 AP4B1 APC BRCA2 BUB3 CCNA2 CDC16 CDC20 CDC27 CENPE COMMD4 DHX8 DNMBP FBXO7 HDAC1 HOPX KNL1 MAP3K4 PELI1 PPP2R5A PPP2R5B PPP2R5C PPP2R5D PPP2R5E RIPK3 SNCG TP73 TRIP13
Entrez ID		991	701
HPRD ID		04686	04176
Ensembl ID		ENSG00000117399	ENSG00000156970
Uniprot IDs		Q12834	O60566
PDB IDs		4GGA 4GGC 4GGD 4N14 5G04 5KHR 5KHU 5LCW 6F0X 6Q6G 6Q6H 9I68 9I69 9I6A	2WVI 3SI5 4GGD 5JJA 5K6S 5KHU 5LCW 5SWF 6TLJ
Enriched GO Terms of Interacting Partners?		Cell Division Regulation Of Mitotic Cell Cycle Anaphase-promoting Complex Regulation Of Chromosome Segregation Regulation Of Sister Chromatid Segregation Regulation Of Cell Cycle Regulation Of Chromosome Organization Regulation Of Nuclear Division Anaphase-promoting Complex-dependent Catabolic Process Protein K11-linked Ubiquitination Regulation Of Mitotic Nuclear Division Regulation Of Cell Cycle Process Protein Branched Polyubiquitination Regulation Of Mitotic Sister Chromatid Separation Regulation Of Mitotic Metaphase/anaphase Transition Regulation Of Meiotic Cell Cycle Regulation Of Cell Cycle Phase Transition Regulation Of Chromosome Separation Positive Regulation Of Cell Cycle Regulation Of Organelle Organization Regulation Of Reproductive Process Nucleoplasm Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Mitotic Cell Cycle Nucleus Protein Modification Process Positive Regulation Of Cell Cycle Process Mitotic Cell Cycle Phase Transition Protein K48-linked Ubiquitination Cytosol Cell Cycle Phase Transition Spindle Negative Regulation Of Mitotic Metaphase/anaphase Transition Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Mitotic Nuclear Division Post-translational Protein Modification Positive Regulation Of Cell Cycle Phase Transition Metaphase/anaphase Transition Of Mitotic Cell Cycle Metaphase/anaphase Transition Of Cell Cycle Negative Regulation Of Cell Cycle Mitotic Spindle Negative Regulation Of Cell Cycle Process Macromolecule Metabolic Process Regulation Of Cellular Component Organization Protein Polyubiquitination Modification-dependent Protein Catabolic Process Regulation Of Ubiquitin-protein Transferase Activity Proteasomal Protein Catabolic Process Positive Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Cell Cycle Phase Transition	Regulation Of Sister Chromatid Segregation Regulation Of Chromosome Segregation Regulation Of Mitotic Metaphase/anaphase Transition Regulation Of Chromosome Organization Regulation Of Mitotic Sister Chromatid Separation Regulation Of Mitotic Cell Cycle Regulation Of Chromosome Separation Protein Phosphatase Type 2A Complex Protein Phosphatase Activator Activity Cytosol Regulation Of Mitotic Nuclear Division Regulation Of Meiotic Cell Cycle Regulation Of Cell Cycle Process Regulation Of Cell Cycle Phase Transition Clathrin Adaptor Complex Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Nuclear Division Protein Phosphatase Regulator Activity Regulation Of Cell Cycle Anaphase-promoting Complex Anaphase-promoting Complex-dependent Catabolic Process Membrane Coat Mitotic Spindle Assembly Checkpoint Signaling Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Mitotic Metaphase/anaphase Transition Chromosome, Centromeric Region Negative Regulation Of Mitotic Nuclear Division Regulation Of Reproductive Process Cell Division Protein K48-linked Ubiquitination Proteasomal Protein Catabolic Process Chromosome Organization Chromosome Spindle Positive Regulation Of Mitotic Metaphase/anaphase Transition Ubiquitin-dependent Protein Catabolic Process Protein Branched Polyubiquitination Modification-dependent Protein Catabolic Process Positive Regulation Of Mitotic Sister Chromatid Separation Negative Regulation Of Cell Cycle Process Protein Catabolic Process Kinetochore Negative Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Chromosome Organization Centrosome Mitotic Checkpoint Complex Proteolysis Involved In Protein Catabolic Process Regulation Of Meiotic Nuclear Division Regulation Of Organelle Organization Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator
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