SV2A and DNAJC5

Number of citations of the paper that reports this interaction (PubMedID 29997244)
64

Data Source:
BioGRID (fluorescent resonance energy transfer)

		SV2A	DNAJC5
Description		synaptic vesicle glycoprotein 2A	DnaJ heat shock protein family (Hsp40) member C5
Image
GO Annotations	Cellular Component	Endoplasmic Reticulum Plasma Membrane Cell-cell Junction Synaptic Vesicle Membrane Synaptic Vesicle Membrane Cytoplasmic Vesicle Neuromuscular Junction Cell Projection Neuron Projection Synapse Presynaptic Active Zone Presynapse Glutamatergic Synapse GABA-ergic Synapse	Cytoplasm Mitochondrion Lysosomal Membrane Cytosol Plasma Membrane Synaptic Vesicle Membrane Synaptic Vesicle Membrane Cytoplasmic Vesicle Neuromuscular Junction Azurophil Granule Membrane Specific Granule Membrane Melanosome Chromaffin Granule Membrane Intracellular Membrane-bounded Organelle Clathrin-sculpted Gamma-aminobutyric Acid Transport Vesicle Membrane Presynapse
	Molecular Function	Protein Kinase Binding Transmembrane Transporter Activity	Protein Binding ATP-dependent Protein Binding
	Biological Process	Neurotransmitter Transport Intracellular Calcium Ion Homeostasis Chemical Synaptic Transmission Synaptic Vesicle Priming Transmembrane Transport	Protein Folding Exocytosis Synaptic Vesicle Exocytosis Negative Regulation Of Neuron Apoptotic Process Regulated Exocytosis Neuron Apoptotic Process Regulation Of Synaptic Vesicle Cycle
Pathways		Toxicity of botulinum toxin type D (botD) Toxicity of botulinum toxin type A (botA) Toxicity of botulinum toxin type F (botF) Toxicity of botulinum toxin type E (botE)	Neutrophil degranulation GABA synthesis, release, reuptake and degradation Sensory processing of sound by inner hair cells of the cochlea
Drugs		Levetiracetam Brivaracetam Seletracetam
Diseases
GWAS		Anthropometric traits ( 30166351) Anthropometric traits (multi-trait analysis) ( 30166351) Height ( 18391951 25429064 31562340) Hip circumference adjusted for BMI ( 34021172) Lung function (FEV1) ( 26635082)	Immature fraction of reticulocytes ( 32888494) Mean platelet volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Prostate cancer ( 23535732)
Interacting Genes		4 interacting genes: ATXN1 DNAJC5 LAMA5 LTB4R2	49 interacting genes: AGFG1 AP2B1 ARHGEF15 BTC CADM1 CADPS CD2 CFTR CGB5 CLCN3 ERC1 FAS FCHO1 GRM8 HBA2 KHDC4 LIN7A LIN7C NECAP1 NRXN3 PPFIA4 PRKACA PRKCG PRRC2B PSMD12 RABGEF1 RBSN SCAMP3 SCAMP5 SH3GL3 SLC17A8 SLC18A2 SLC30A3 SLC32A1 SNAP29 SNAP91 SNCA STX12 STX3 STX4 STX6 SV2A SYT12 SYT5 SYT9 VAMP1 VAMP3 VAMP4 VAMP7
Entrez ID		9900	80331
HPRD ID		08922	08539
Ensembl ID		ENSG00000159164	ENSG00000101152
Uniprot IDs		B4E000 Q7L0J3	Q9H3Z4
PDB IDs		4V11 8JLC 8JLE 8JLF 8JLG 8JLH 8JLI 8JS8 8JS9 8K77 8UO9 8UOA 8YF0 8YF1	2N04 2N05
Enriched GO Terms of Interacting Partners?		Extracellular Matrix Of Synaptic Cleft Laminin-5 Complex Laminin-11 Complex Ameboidal-type Cell Migration Laminin-10 Complex Neuromuscular Junction Synaptic Vesicle Leukotriene B4 Receptor Activity Leukotriene Receptor Activity POZ Domain Binding Leukotriene Signaling Pathway Trunk Neural Crest Cell Migration Morphogenesis Of A Polarized Epithelium Keratinocyte Migration Poly(G) Binding ATP-dependent Protein Binding Clathrin-sculpted Gamma-aminobutyric Acid Transport Vesicle Membrane Chromaffin Granule Membrane Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Branching Involved In Salivary Gland Morphogenesis Cell Adhesion Mediator Activity Nuclear Inclusion Body Negative Regulation Of Adenylate Cyclase Activity	Synaptic Vesicle Membrane Vesicle-mediated Transport Synapse SNARE Binding Neurotransmitter Transport SNARE Complex Secretion By Cell Exocytosis Cytoplasmic Vesicle Establishment Of Localization In Cell SNAP Receptor Activity Synaptic Vesicle Secretion Regulation Of Vesicle-mediated Transport Presynapse Protein Transport Regulation Of Exocytosis Plasma Membrane Membrane Establishment Of Protein Localization Organelle Fusion SNARE Complex Assembly Neuron Projection Vesicle Fusion Organelle Membrane Fusion Clathrin-coated Endocytic Vesicle Membrane Vesicle Organization Neurotransmitter Secretion Organelle Localization By Membrane Tethering Regulation Of Regulated Secretory Pathway Phagocytic Vesicle Glutamatergic Synapse Regulation Of Secretion By Cell Organelle Localization Membrane Docking Vesicle-mediated Transport In Synapse Membrane Fusion Regulation Of Secretion Recycling Endosome Membrane Endosome Signal Release Vesicle Docking Intracellular Protein Localization Regulation Of Transport Positive Regulation Of Exocytosis Membrane Organization Regulation Of Endocytosis Chemical Synaptic Transmission Trans-synaptic Signaling Long-term Synaptic Potentiation
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