SV2A and LAMA5

Number of citations of the paper that reports this interaction (PMID 10617638)
7

Data Source:
HPRD (in vivo)

		SV2A	LAMA5
Gene Name		synaptic vesicle glycoprotein 2A	laminin, alpha 5
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Plasma Membrane Cell-cell Junction Synaptic Vesicle Integral Component Of Membrane Synaptic Vesicle Membrane Neuromuscular Junction Neuron Projection Presynaptic Active Zone	Extracellular Region Basement Membrane Basal Lamina Laminin-1 Complex Laminin-5 Complex Extracellular Space Nucleus Extracellular Matrix Laminin-10 Complex Laminin-11 Complex Extracellular Vesicular Exosome
	Molecular Function	Receptor Activity Protein Kinase Binding Transmembrane Transporter Activity	Integrin Binding Structural Molecule Activity
	Biological Process	Neurotransmitter Transport Cellular Calcium Ion Homeostasis Pathogenesis Transmembrane Transport	Angiogenesis Branching Involved In Ureteric Bud Morphogenesis Morphogenesis Of A Polarized Epithelium Neural Crest Cell Migration Hair Follicle Development Cytoskeleton Organization Integrin-mediated Signaling Pathway Muscle Organ Development Cell Recognition Cell Proliferation Embryo Development Morphogenesis Of Embryonic Epithelium Cell Migration Extracellular Matrix Disassembly Cell Differentiation Regulation Of Cell Adhesion Extracellular Matrix Organization Lung Development Regulation Of Cell Migration Substrate Adhesion-dependent Cell Spreading Regulation Of Cell Proliferation Cilium Assembly Odontogenesis Of Dentin-containing Tooth Endothelial Cell Differentiation Regulation Of Embryonic Development Focal Adhesion Assembly Branching Involved In Salivary Gland Morphogenesis Establishment Of Protein Localization To Plasma Membrane
Pathways		Uptake and actions of bacterial toxins Toxicity of botulinum toxin type E (BoNT/E) Toxicity of botulinum toxin type D (BoNT/D) Toxicity of botulinum toxin type A (BoNT/A) Toxicity of botulinum toxin type F (BoNT/F) Neurotoxicity of clostridium toxins	Laminin interactions ECM proteoglycans Non-integrin membrane-ECM interactions Degradation of the extracellular matrix
Drugs		Levetiracetam
Diseases
GWAS		Height ( 18391951)	Colorectal cancer ( 20972440) Prostate cancer ( 23535732)
Protein-Protein Interactions		2 interactors: ATXN1 LAMA5	15 interactors: ATF7IP BCAM BTBD10 COL7A1 CRKL DAG1 FBLN2 LAMC1 MEP1A MYOC PLAT PLG SMAD2 SV2A USP4
Entrez ID		9900	3911
HPRD ID		08922	03020
Ensembl ID		ENSG00000159164	ENSG00000130702
Uniprot IDs		B4E000 Q7L0J3	O15230
PDB IDs
Enriched GO Terms of Interacting Partners?		Lung Development Respiratory Tube Development Respiratory System Development Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Tube Development Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Morphogenesis Of A Polarized Epithelium Branching Involved In Salivary Gland Morphogenesis Focal Adhesion Assembly Substrate Adhesion-dependent Cell Spreading Salivary Gland Morphogenesis Adherens Junction Assembly Salivary Gland Development Neural Crest Cell Migration Cell-substrate Junction Assembly Lung Alveolus Development Exocrine System Development Visual Learning Branching Involved In Ureteric Bud Morphogenesis Visual Behavior Neural Crest Cell Development Ureteric Bud Morphogenesis Regulation Of Excitatory Postsynaptic Membrane Potential Regulation Of Postsynaptic Membrane Potential Endothelial Cell Differentiation Establishment Of Protein Localization To Plasma Membrane Neural Crest Cell Differentiation Nephron Morphogenesis Associative Learning Renal Tubule Morphogenesis Adherens Junction Organization Endothelium Development Extracellular Matrix Disassembly Hair Follicle Development Hair Cycle Process Renal Tubule Development Kidney Morphogenesis Odontogenesis Of Dentin-containing Tooth Hair Cycle Adult Locomotory Behavior Mesenchymal Cell Development Regulation Of Embryonic Development Membrane Depolarization Ureteric Bud Development Nuclear Export Mesonephric Tubule Development Mesonephric Epithelium Development Cell Recognition Integrin-mediated Signaling Pathway Cellular Localization	Extracellular Matrix Organization Extracellular Structure Organization Endoderm Development Extracellular Matrix Disassembly Fibrinolysis Regulation Of Cell-substrate Adhesion Cell-substrate Adhesion Myelination In Peripheral Nervous System Schwann Cell Development Negative Regulation Of Cell-substrate Adhesion Endoderm Formation Negative Regulation Of Blood Coagulation Schwann Cell Differentiation Negative Regulation Of Coagulation Nerve Maturation Skeletal Muscle Hypertrophy ERBB2-ERBB3 Signaling Pathway Negative Regulation Of Wound Healing Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Nodal Signaling Pathway Involved In Determination Of Lateral Mesoderm Left/right Asymmetry Calcium-dependent Cell-matrix Adhesion ERBB2 Signaling Pathway Glial Cell Development Regulation Of Blood Coagulation Proteolysis Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Nodal Signaling Pathway Involved In Determination Of Lateral Mesoderm Left/right Asymmetry Positive Regulation Of Ovulation Mononuclear Cell Migration Zygotic Specification Of Dorsal/ventral Axis Peripheral Nervous System Development Negative Regulation Of Cell-cell Adhesion Mediated By Cadherin Positive Regulation Of Fibrinolysis Positive Regulation Of Cell-substrate Adhesion Regulation Of Protein Kinase B Signaling Formation Of Primary Germ Layer Regulation Of Wound Healing Tissue Development Myelination Regulation Of Cellular Process Positive Regulation Of Mesoderm Development Non-canonical Wnt Signaling Pathway Via JNK Cascade Primary MiRNA Processing Axon Ensheathment Regulation Of Nodal Signaling Pathway Non-canonical Wnt Signaling Pathway Via MAPK Cascade Common-partner SMAD Protein Phosphorylation Positive Regulation Of Cell Morphogenesis Involved In Differentiation Regulation Of RNA Polymerase II Transcriptional Preinitiation Complex Assembly Positive Regulation Of Activin Receptor Signaling Pathway
Tagcloud ?		abundance allocated analyzing aplp1 aplp2 app apparatus appsalpha attached compartments corresponds endosomal golgi homozygous immunopurification impacts knockout ko organellar pool presynaptic residing synaptic synaptogamin synaptophysin synaptotagmin vesicle zone	anencephaly aperta arches axd bifida breadth cart1 curly ectoderm exencephaly faulty floorplate folds gja1 jmj macs mlp neuroepithelial neuroepithelium nonsyndromic notochord ntds occulta rachischisis rostro selh spina tcfap2a terc
Tagcloud (Difference) ?		abundance allocated analyzing aplp1 aplp2 app apparatus appsalpha attached compartments corresponds endosomal golgi homozygous immunopurification impacts knockout ko organellar pool presynaptic residing synaptic synaptogamin synaptophysin synaptotagmin vesicle zone	anencephaly aperta arches axd bifida breadth cart1 curly ectoderm exencephaly faulty floorplate folds gja1 jmj macs mlp neuroepithelial neuroepithelium nonsyndromic notochord ntds occulta rachischisis rostro selh spina tcfap2a terc
Tagcloud (Intersection) ?