SV2A and LAMA5

Number of citations of the paper that reports this interaction (PubMedID 10617638)
0

Data Source:
HPRD (in vivo)

		SV2A	LAMA5
Description		synaptic vesicle glycoprotein 2A	laminin subunit alpha 5
Image
GO Annotations	Cellular Component	Endoplasmic Reticulum Plasma Membrane Cell-cell Junction Synaptic Vesicle Membrane Synaptic Vesicle Membrane Cytoplasmic Vesicle Neuromuscular Junction Cell Projection Neuron Projection Synapse Presynaptic Active Zone Presynapse Glutamatergic Synapse GABA-ergic Synapse	Extracellular Region Basement Membrane Laminin-5 Complex Extracellular Space Nucleus Extracellular Matrix Neuromuscular Junction Synaptic Cleft Laminin-10 Complex Laminin-11 Complex Extracellular Exosome Extracellular Matrix Of Synaptic Cleft Glutamatergic Synapse
	Molecular Function	Protein Kinase Binding Transmembrane Transporter Activity	Signaling Receptor Binding Integrin Binding Extracellular Matrix Structural Constituent Receptor Ligand Activity Cell Adhesion Mediator Activity
	Biological Process	Neurotransmitter Transport Intracellular Calcium Ion Homeostasis Chemical Synaptic Transmission Synaptic Vesicle Priming Transmembrane Transport	Branching Involved In Ureteric Bud Morphogenesis Morphogenesis Of A Polarized Epithelium Neural Crest Cell Migration Kidney Development Hair Follicle Development Cell Adhesion Integrin-mediated Signaling Pathway Muscle Organ Development Animal Organ Morphogenesis Morphogenesis Of Embryonic Epithelium Cell Migration Regulation Of Cell Adhesion Lung Development Regulation Of Cell Migration Substrate Adhesion-dependent Cell Spreading Trunk Neural Crest Cell Migration Odontogenesis Of Dentin-containing Tooth Regulation Of Embryonic Development Skeletal System Morphogenesis System Development Branching Morphogenesis Of An Epithelial Tube Regulation Of Epithelial Cell Proliferation Cilium Assembly Branching Involved In Salivary Gland Morphogenesis Protein Localization To Plasma Membrane Postsynapse Organization
Pathways		Toxicity of botulinum toxin type D (botD) Toxicity of botulinum toxin type A (botA) Toxicity of botulinum toxin type F (botF) Toxicity of botulinum toxin type E (botE)	Degradation of the extracellular matrix Laminin interactions Laminin interactions Non-integrin membrane-ECM interactions ECM proteoglycans Interleukin-4 and Interleukin-13 signaling MET activates PTK2 signaling Attachment of bacteria to epithelial cells Formation of the dystrophin-glycoprotein complex (DGC) Formation of the dystrophin-glycoprotein complex (DGC) Developmental Lineage of Pancreatic Ductal Cells
Drugs		Levetiracetam Brivaracetam Seletracetam	Lanoteplase
Diseases
GWAS		Anthropometric traits ( 30166351) Anthropometric traits (multi-trait analysis) ( 30166351) Height ( 18391951 25429064 31562340) Hip circumference adjusted for BMI ( 34021172) Lung function (FEV1) ( 26635082)	Colorectal cancer ( 20972440 24737748 25990418) Colorectal cancer or advanced adenoma ( 30510241) Estimated glomerular filtration rate ( 31152163) Femur bone mineral density x serum urate levels interaction ( 34046847) Neuroblastoma (pediatric) ( 32599975) Pelvic organ prolapse ( 26545240) Plateletcrit ( 32888494) Prostate cancer ( 23535732)
Interacting Genes		4 interacting genes: ATXN1 DNAJC5 LAMA5 LTB4R2	16 interacting genes: ATF7IP BCAM BTBD10 COL7A1 CRKL DAG1 FBLN2 HOXA1 LAMC1 MEP1A MTDH MYOC SMAD2 SV2A UBC USP4
Entrez ID		9900	3911
HPRD ID		08922	03020
Ensembl ID		ENSG00000159164	ENSG00000130702
Uniprot IDs		B4E000 Q7L0J3	O15230
PDB IDs		4V11 8JLC 8JLE 8JLF 8JLG 8JLH 8JLI 8JS8 8JS9 8K77 8UO9 8UOA 8YF0 8YF1	5XAU 7CEC
Enriched GO Terms of Interacting Partners?		Extracellular Matrix Of Synaptic Cleft Laminin-5 Complex Laminin-11 Complex Ameboidal-type Cell Migration Laminin-10 Complex Neuromuscular Junction Synaptic Vesicle Leukotriene B4 Receptor Activity Leukotriene Receptor Activity POZ Domain Binding Leukotriene Signaling Pathway Trunk Neural Crest Cell Migration Morphogenesis Of A Polarized Epithelium Keratinocyte Migration Poly(G) Binding ATP-dependent Protein Binding Clathrin-sculpted Gamma-aminobutyric Acid Transport Vesicle Membrane Chromaffin Granule Membrane Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Branching Involved In Salivary Gland Morphogenesis Cell Adhesion Mediator Activity Nuclear Inclusion Body Negative Regulation Of Adenylate Cyclase Activity	Positive Regulation Of Cell-substrate Adhesion Extracellular Matrix Positive Regulation Of Signal Transduction Regulation Of Cell-substrate Adhesion Extracellular Matrix Constituent Conferring Elasticity Basement Membrane Positive Regulation Of Cell Adhesion Positive Regulation Of Cell Communication Positive Regulation Of Signaling Myelination In Peripheral Nervous System Node Of Ranvier Laminin Binding Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Response To Cholesterol Extracellular Space Cell-substrate Adhesion Endoderm Development Positive Regulation Of Intracellular Signal Transduction Collagen Type VII Trimer Regulation Of Cell Adhesion RNA Polymerase II-specific DNA-binding Transcription Factor Binding Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Muscle Attachment Semicircular Canal Formation Skeletal Muscle Hypertrophy Adenosine Receptor Binding Regulation Of Signal Transduction Neuron Projection Development Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Extracellular Region Endoplasmic Reticulum Lumen Heart Development Helper T Cell Diapedesis Chordate Pharynx Development Regulation Of Substrate Adhesion-dependent Cell Spreading Regulation Of Cell Communication Cerebellar Neuron Development Regulation Of Intracellular Signal Transduction Receptor Tyrosine Kinase Binding Neuromuscular Junction Regulation Of Signaling Response To Transforming Growth Factor Beta Retrograde Trans-synaptic Signaling By Trans-synaptic Protein Complex Nerve Maturation Positive Regulation Of Cell-matrix Adhesion Calcium-dependent Cell-matrix Adhesion Peptide Hormone Secretion Endothelin B Receptor Binding Peptide Secretion Abducens Nerve Formation
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