TET2

Gene Name		tet methylcytosine dioxygenase 2
Image		No pdb structure
Gene Ontology Annotations	Cellular Component
	Molecular Function	DNA Binding Protein Binding Ferrous Iron Binding Zinc Ion Binding Methylcytosine Dioxygenase Activity
	Biological Process	Kidney Development Myeloid Progenitor Cell Differentiation 5-methylcytosine Catabolic Process Protein O-linked Glycosylation Cell Cycle Post-embryonic Development Gene Expression Cytosine Metabolic Process Hemoglobin Metabolic Process Myeloid Cell Differentiation Oxidative DNA Demethylation Regulation Of Gene Expression, Epigenetic Positive Regulation Of Transcription From RNA Polymerase II Promoter Spleen Development Hematopoietic Stem Cell Homeostasis Liver Morphogenesis DNA Demethylation Histone H3-K4 Trimethylation
Pathways		TET1,2,3 and TDG demethylate DNA Epigenetic regulation of gene expression
Drugs
Diseases
GWAS		Breast cancer ( 23535729) Height ( 20881960) Immune response to anthrax vaccine ( 22658931) Prostate cancer ( 19767753) Pulmonary function ( 21946350)
Protein-protein Interactions		2 interactors: OGT TBC1D4
Entrez ID		54790
HPRD ID		07876
Ensembl ID		ENSG00000168769
Uniprot IDs		Q6N021
PDB IDs
Enriched GO Terms of Interacting Partners?		Response To Insulin Regulation Of Gluconeogenesis Involved In Cellular Glucose Homeostasis Response To Peptide Hormone Response To Peptide Negative Regulation Of Vesicle Fusion Positive Regulation Of Granulocyte Differentiation Regulation Of Ras Protein Signal Transduction Positive Regulation Of Histone H3-K27 Methylation Regulation Of Small GTPase Mediated Signal Transduction Histone H3-K4 Trimethylation Histone H4-K5 Acetylation Histone H4-K8 Acetylation Regulation Of Histone H3-K27 Methylation Histone H4-K16 Acetylation Response To Organonitrogen Compound Positive Regulation Of Histone H3-K4 Methylation Regulation Of Organelle Organization Response To Hormone Regulation Of Histone H3-K4 Methylation Regulation Of Glycolytic Process Peptidyl-lysine Trimethylation Histone H3-K4 Methylation Regulation Of Rac Protein Signal Transduction Regulation Of Vesicle Fusion Positive Regulation Of Histone Methylation Regulation Of Gluconeogenesis Positive Regulation Of Myeloid Leukocyte Differentiation Positive Regulation Of Catalytic Activity Histone H4 Acetylation Regulation Of Histone Methylation Regulation Of Insulin Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Cellular Response To Retinoic Acid Positive Regulation Of Histone Modification Regulation Of Generation Of Precursor Metabolites And Energy Cellular Glucose Homeostasis Cellular Response To Organic Substance Positive Regulation Of Myeloid Cell Differentiation Circadian Regulation Of Gene Expression Regulation Of Cellular Component Organization Regulation Of Cellular Response To Insulin Stimulus Protein O-linked Glycosylation Histone Lysine Methylation Peptidyl-lysine Methylation Negative Regulation Of Protein Ubiquitination Regulation Of Glucose Metabolic Process Regulation Of Myeloid Leukocyte Differentiation Histone Acetylation Internal Peptidyl-lysine Acetylation Peptidyl-lysine Acetylation
Tagcloud ?		abstract advancements ascribed asxl1 attitude azacitidine challenging changing choices conditioning curative decitabine feasible haploidentical hematologists hypomethylating idh2 incurable optimize overview profoundly renders sf3b1 sibling spite stratify transplant video wider