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TET2
Description
tet methylcytosine dioxygenase 2
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Chromosome
Molecular Function
DNA Binding
Protein Binding
Ferrous Iron Binding
Zinc Ion Binding
Oxidoreductase Activity
2-oxoglutarate-dependent Dioxygenase Activity
Metal Ion Binding
Dioxygenase Activity
DNA 5-methylcytosine Dioxygenase Activity
Biological Process
Leukocyte Differentiation
Chromatin Organization
Protein O-linked Glycosylation
Regulation Of Gene Expression
Positive Regulation Of Macromolecule Biosynthetic Process
Myeloid Cell Differentiation
Epigenetic Regulation Of Gene Expression
Positive Regulation Of Gene Expression Via Chromosomal CpG Island Demethylation
Positive Regulation Of Transcription By RNA Polymerase II
Pathways
TET1,2,3 and TDG demethylate DNA
Specification of primordial germ cells
Drugs
Diseases
GWAS
A body shape index (
34021172
)
Adventurousness (
30643258
)
Apolipoprotein A1 levels (
32203549
)
Appendicular lean mass (
33097823
)
Birth weight (
31043758
)
Blond vs. brown/black hair color (
30531825
)
Breast cancer (
29059683
23535729
)
Breast cancer, ovarian cancer or prostate cancer (pleiotropy) (
27432226
)
Caffeine consumption from coffee (
33287642
)
Caffeine consumption from coffee or tea (
33287642
)
Chronic obstructive pulmonary disease (
33909500
28166215
30804561
)
Coffee consumption (
31046077
)
Cognitive ability (
29186694
)
Cognitive ability (MTAG) (
29186694
)
Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) (
31374203
)
Colorectal or endometrial cancer (
26621817
)
Estimated glomerular filtration rate (
31451708
)
Extremely high intelligence (
29520040
)
Fasting insulin (
34059833
)
FEV1 (
30804560
)
General cognitive ability (
29844566
)
General risk tolerance (MTAG) (
30643258
)
Haemorrhoidal disease (
33888516
)
HDL cholesterol levels (
32203549
)
Heel bone mineral density (
30598549
)
Height (
20881960
25429064
31562340
)
Hip circumference adjusted for BMI (
34021172
)
Hip index (
34021172
)
Household income (MTAG) (
31844048
)
Immune response to anthrax vaccine (
22658931
)
Intelligence (MTAG) (
29326435
)
Liver enzyme levels (alkaline phosphatase) (
33972514
)
Lung function (FEV1) (
28166213
)
Lung function (FEV1/FVC) (
30804560
28166213
)
Lung function (low FEV1 vs high FEV1) (
26423011
)
Lung function in never smokers (low FEV1 vs high FEV1) (
26423011
)
Lymphocyte count (
29403010
27863252
)
Lymphocyte percentage of white cells (
27863252
32888494
)
Melanoma (
24980573
)
Molybdenum levels (
26025379
)
Multiple sclerosis (
24076602
31604244
)
Myeloproliferative neoplasms (
33057200
)
Neutrophil percentage of white cells (
32888494
27863252
)
Offspring birth weight (
31043758
)
Peak expiratory flow (
30804560
)
Platelet count (
32888494
)
Plateletcrit (
27863252
)
Post bronchodilator FEV1 (
26634245
)
Post bronchodilator FEV1/FVC ratio (
26634245
)
Prostate cancer (
25939597
19767753
)
Pulmonary function (
21946350
)
Regular attendance at a religious group (
29970889
)
Response to esketamine in treatment resistant depression (
32724131
)
Self-reported risk-taking behaviour (
30271922
)
Serum alkaline phosphatase levels (
33547301
)
Tonsillectomy (
27182965
28928442
)
Waist circumference adjusted for body mass index (
34021172
)
Waist-hip index (
34021172
)
Waist-to-hip ratio adjusted for BMI (
34021172
)
Western dietary pattern (
28644415
)
Interacting Genes
20 interacting genes:
DCAF1
ECD
EIF2B2
HLF
HOXB9
KEAP1
MED1
MNAT1
OGT
PHC1
PKNOX1
RAI1
SMAD1
STAT5A
TBC1D4
TFEC
VPS26C
VPS72
ZCCHC14
ZNF207
Entrez ID
54790
HPRD ID
07876
Ensembl ID
ENSG00000168769
Uniprot IDs
A0A158SIU0
Q6N021
PDB IDs
4NM6
5D9Y
5DEU
7NE3
7NE6
Enriched GO Terms of Interacting Partners
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Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
Regulation Of Transcription By RNA Polymerase II
Regulation Of RNA Metabolic Process
Regulation Of Nucleobase-containing Compound Metabolic Process
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of RNA Biosynthetic Process
Nucleoplasm
Positive Regulation Of RNA Metabolic Process
Regulation Of Gene Expression
Regulation Of Macromolecule Biosynthetic Process
Regulation Of Primary Metabolic Process
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Macromolecule Metabolic Process
Regulation Of Macromolecule Metabolic Process
Nucleus
Positive Regulation Of Metabolic Process
Positive Regulation Of Macromolecule Biosynthetic Process
DNA Binding
Regulation Of Metabolic Process
Positive Regulation Of Biosynthetic Process
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-templated Transcription
Macromolecule Biosynthetic Process
Chromatin
Rhythmic Process
Transcription By RNA Polymerase II
Nucleobase-containing Compound Biosynthetic Process
Response To Peptide Hormone
Histone Acetyltransferase Binding
Negative Regulation Of DNA-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
RNA Polymerase II Transcription Regulator Complex
Mononuclear Cell Differentiation
Negative Regulation Of Transcription By RNA Polymerase II
Response To Hormone
RNA Metabolic Process
Negative Regulation Of RNA Metabolic Process
Animal Organ Development
Regulation Of Epithelial Cell Differentiation
DNA-binding Transcription Factor Activity
Mammary Gland Development
Leukocyte Differentiation
Nuclear Estrogen Receptor Binding
Developmental Process
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
Regulation Of Cell Cycle
Hemopoiesis
Lactation
Tagcloud
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