DDX46 and APBB1

Number of citations of the paper that reports this interaction (PMID 16055720)
52

Data Source:
BioGRID (pull down)

		DDX46	APBB1
Gene Name		DEAD (Asp-Glu-Ala-Asp) box polypeptide 46	amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cajal Body Nuclear Speck	Nucleus Cytoplasm Plasma Membrane Nuclear Speck Lamellipodium Growth Cone Synapse
	Molecular Function	Helicase Activity ATP Binding Poly(A) RNA Binding	Beta-amyloid Binding Chromatin Binding Protein Binding Transcription Factor Binding Histone Binding Proline-rich Region Binding
	Biological Process	MRNA Processing RNA Splicing	Neuron Migration Double-strand Break Repair Transcription, DNA-templated Regulation Of Transcription, DNA-templated Apoptotic Process Cellular Response To DNA Damage Stimulus Cell Cycle Arrest Signal Transduction Axonogenesis Axon Guidance Visual Learning Extracellular Matrix Organization Negative Regulation Of Cell Growth Positive Regulation Of Apoptotic Process Histone H4 Acetylation Negative Regulation Of Neuron Differentiation Positive Regulation Of DNA Repair Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Thymidylate Synthase Biosynthetic Process
Pathways
Drugs
Diseases
GWAS		Height ( 18391951)
Protein-Protein Interactions		3 interactors: APBB1 PRPF40A SRPK2	66 interactors: ABI1 ABL1 ANXA1 APLP1 APLP2 APP ATXN1 ATXN1L CCDC97 CHERP CLSTN1 CPSF6 CPSF7 CYFIP1 CYFIP2 DDX17 DDX3X DDX46 DHX15 DHX9 DIAPH1 DIAPH2 EGFR ENAH ERBB2 EVL FASLG HNRNPH1 HNRNPK HTATSF1 KAT5 KHDRBS1 KHSRP LRP1 LRP2 NONO PABPC1 PQBP1 PRNP PTBP1 RBM17 RPL4 SF1 SF3A1 SF3A2 SF3A3 SF3B1 SF3B2 SF3B3 SF3B4 SFPQ TFCP2 THRAP3 TSHZ1 TSHZ2 TSHZ3 U2AF2 VASP WAS WASF2 WASL WBP11 WIPF1 WIPF2 YBX1 YLPM1
Entrez ID		9879	322
HPRD ID		10862	04087
Ensembl ID		ENSG00000145833	ENSG00000166313
Uniprot IDs		Q7L014	O00213
PDB IDs			2E45 2HO2 2IDH 2OEI 3D8D 3D8E 3D8F 3DXC 3DXD 3DXE
Enriched GO Terms of Interacting Partners?		Regulation Of Cell Cycle Nuclear Speck Organization Negative Regulation Of Thymidylate Synthase Biosynthetic Process RNA Splicing MRNA Processing MRNA Metabolic Process RNA Processing Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Organelle Organization RNA Metabolic Process Positive Regulation Of Viral Genome Replication Gene Expression Cell Migration Cell Motility Positive Regulation Of DNA Repair	RNA Processing MRNA Processing MRNA Metabolic Process RNA Splicing RNA Splicing, Via Transesterification Reactions MRNA Splicing, Via Spliceosome RNA Metabolic Process Gene Expression Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Actin Polymerization Or Depolymerization RNA Biosynthetic Process MRNA 3'-splice Site Recognition Immune Response-regulating Cell Surface Receptor Signaling Pathway Transcription, DNA-templated Fc Receptor Signaling Pathway Regulation Of Nitrogen Compound Metabolic Process Cellular Metabolic Process Immune Response-regulating Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Actin Filament Organization Cellular Macromolecule Biosynthetic Process Regulation Of Gene Expression Cellular Component Assembly Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Phagocytosis MRNA 3'-end Processing Cellular Process Regulation Of Metabolic Process Endocytosis Innate Immune Response Multicellular Organismal Development Negative Regulation Of Cellular Metabolic Process Regulation Of RNA Splicing RNA 3'-end Processing Actin Cytoskeleton Organization Positive Regulation Of Arp2/3 Complex-mediated Actin Nucleation Developmental Process Actin Filament-based Process MRNA Stabilization Axon Guidance Positive Regulation Of Actin Nucleation MRNA Polyadenylation
Tagcloud ?		balanced box caudal cht cmyb dead definitive elucidated encoding erythrocyte erythropoiesis gata1a helicase hematopoiesis hscs lineages lymphocytic lymphopoiesis massive multilineage mutants myelopoiesis postfertilization precisely renewal spi1 tal1 vertebrate zebrafish	a4 additive aging amyloid apba3 aplp1 apolipoprotein c57bl clues dysregulation elusive fe65 hippocampal hypertension hypertensive impairments m1 manifestation maze mint3 mo muscarinic object precursor predisposes secretases signature tauopathy wk
Tagcloud (Difference) ?		balanced box caudal cht cmyb dead definitive elucidated encoding erythrocyte erythropoiesis gata1a helicase hematopoiesis hscs lineages lymphocytic lymphopoiesis massive multilineage mutants myelopoiesis postfertilization precisely renewal spi1 tal1 vertebrate zebrafish	a4 additive aging amyloid apba3 aplp1 apolipoprotein c57bl clues dysregulation elusive fe65 hippocampal hypertension hypertensive impairments m1 manifestation maze mint3 mo muscarinic object precursor predisposes secretases signature tauopathy wk
Tagcloud (Intersection) ?